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Diabetes, metabolism, endocrinology, osteoporosis

SatyaVati Rana, Rajesh Kumar Morya, Aastha Malik, Sanjay Kumar Bhadada, Naresh Sachdeva, Gaurav Sharma
BACKGROUND: Type 2 diabetes mellitus is chronic metabolic disorder. Common gastrointestinal symptoms in type 2 diabetic patients are flatulence, constipation and/or diarrhea. Reason for these may be lactose intolerance leading to change in vitamin D, Calcium and parathyroid hormone which further regulate bone mineralization. AIM: To measure lactose intolerance, vitamin D, calcium and parathyroid hormone in type 2 diabetic patients. MATERIAL AND METHODS: 150 type 2 diabetic patients attending Endocrinology Clinic in PGI, Chandigarh and 150 age and sex matched healthy controls were enrolled...
November 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Márcio Carlos Machado, Maria Candida Barisson Vilares Fragoso, Ayrton Custódio Moreira, César Luiz Boguszewski, Leonardo Vieira, Luciana A Naves, Lucio Vilar, Luiz Antônio de Araújo, Mauro A Czepielewski, Monica R Gadelha, Nina Rosa Castro Musolino, Paulo Augusto C Miranda, Marcello Delano Bronstein, Antônio Ribeiro-Oliveira
Although it is a rare condition, the accurate diagnosis and treatment of Cushing's disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing's syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas...
June 2016: Archives of Endocrinology and Metabolism
Stuart A Morgan, Zaki K Hassan-Smith, Gareth G Lavery
Glucocorticoids are widely prescribed for their anti-inflammatory properties, but have 'Cushingoid' side effects including visceral obesity, muscle myopathy, hypertension, insulin resistance, type 2 diabetes mellitus, osteoporosis, and hepatic steatosis. These features are replicated in patients with much rarer endogenous glucocorticoid (GC) excess (Cushing's syndrome), which has devastating consequences if left untreated. Current medical therapeutic options that reverse the tissue-specific consequences of hypercortisolism are limited...
August 2016: European Journal of Endocrinology
Radojka Bijelic, Milorad Balaban, Snjezana Milicevic
INTRODUCTION: A great number of clinical studies has indicated that the patients with calcium urolithiasis have a reduced mineral bone density. AIM: The aim of our research was to establish representation of osteoporosis, by measuring mineral bone density using the DEXA method, in patients with calcium urolithiasis, by gender. MATERIAL AND METHODS: The research was a prospective one, performed at the University Hospital of the Clinical Center of Banja Luka, at the Urology Clinic and Clinic for Endocrinology, Diabetes and Metabolic Diseases...
October 2015: Medical Archives
F S Hough, D D Pierroz, C Cooper, S L Ferrari
Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. Insulin/IGF1 deficiency appears to be a major pathogenetic mechanism involved, along with glucose toxicity, marrow adiposity, inflammation, adipokine and other metabolic alterations that may all play a role on altering bone turnover...
April 2016: European Journal of Endocrinology
Radojka Bijelic, Snjezana Milicevic, Jagoda Balaban
INTRODUCTION: Clinical researches have shown an increased bone disintegration and lower bone mass in patients with calcium urolithiasis. GOAL: The goal of our research was to establish the incidence of osteoporosis in adult patients with calcium urolithiasis, on the basis of measuring mineral bone density, using DEXA method, with a special reflection on age subgroups. MATERIAL AND METHODS: Clinical research was prospective and it was implemented at the University Clinical Center of Banja Luka, at the Clinic for Endocrinology, Diabetes and Metabolic Diseases and at the Urology Clinic...
October 2014: Medical Archives
Farid Saad, Louis J Gooren
Some men between the ages 45 and 60 years develop complaints and symptoms reminiscent of menopausal complaints in women. So, parallels were sought between the changes in female and male endocrinology during that period of life. Indeed, men do show a decline of serum testosterone from age 40 to 50 years onwards but it is a slow decline of 1-2% per year and over time it may amount to hypogonadism. The mechanism of a decline in serum testosterone in men does not resemble the menopause; it is partially an aging neuroendocrine system with a less efficient testosterone production but equally or more important, the result of inhibition of testosterone production by metabolic factors in relation to visceral obesity...
September 2014: Maturitas
Vanishree Shriraam, Shriraam Mahadevan, M Anitharani, Selvavinayagam, Bwc Sathiyasekaran
The endocrine and metabolic diseases of childhood obesity, diabetes mellitus, hypertension, iodine deficiency disorders, vitamin D deficiency, and osteoporosis are major public health problems. Different programs including National Program for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases, and Stroke address these problems although some are yet to be addressed. National surveys have shown high prevalence of these disorders and their risk factors. Most of the programs aim at awareness raising, lifestyle modification, (primary prevention) and screening (secondary prevention) for the disease conditions as these are proven to be cost-effective compared to late diagnosis and treatment of various complications...
January 2014: Indian Journal of Endocrinology and Metabolism
Kyung-Eun Song, Yong-Ki Min, Jeong-Keun Lee, Kyi Beom Lee, Hee Jae Joo, Kyu-Sung Kwack, Yoon-Sok Chung
INTRODUCTION: Bisphosphonates are effective for treating osteoporosis, Paget's disease of bone, and malignancy-associated bone diseases. Bisphosphonate-associated osteonecrosis of the jaw (ONJ) is a rare but serious adverse effect of bisphosphonate therapy. Due to inhibitory actions on bone turnover, bisphosphonate therapy may result in the accumulation of microdamage. CASE SUMMARY: A 74-year-old Korean woman (height, 150 cm; weight, 51 kg) was referred to the Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea, for evaluation of pain and persistent abnormal exposure of jaw bone after extraction of teeth...
August 2008: Current Therapeutic Research, Clinical and Experimental
Janet A Schlechte
No abstract text is available yet for this article.
June 4, 2013: Annals of Internal Medicine
Sherita Hill Golden, Arleen Brown, Jane A Cauley, Marshall H Chin, Tiffany L Gary-Webb, Catherine Kim, Julie Ann Sosa, Anne E Sumner, Blair Anton
OBJECTIVE: The aim was to provide a scholarly review of the published literature on biological, clinical, and nonclinical contributors to race/ethnic and sex disparities in endocrine disorders and to identify current gaps in knowledge as a focus for future research needs. PARTICIPANTS IN DEVELOPMENT OF SCIENTIFIC STATEMENT: The Endocrine Society's Scientific Statement Task Force (SSTF) selected the leader of the statement development group (S.H.G.). She selected an eight-member writing group with expertise in endocrinology and health disparities, which was approved by the Society...
September 2012: Journal of Clinical Endocrinology and Metabolism
Rebeca Reyes García, Esteban Jódar Gimeno, Antonia García Martín, Manuel Romero Muñoz, José Manuel Gómez Sáez, Inés Luque Fernández, Mariela Varsavsky, Sonsoles Guadalix Iglesias, Isidoro Cano Rodriguez, María Dolores Ballesteros Pomar, Alfonso Vidal Casariego, Pedro Rozas Moreno, María Cortés Berdonces, Diego Fernández García, Amparo Calleja Canelas, Mercedes Palma Moya, Guillermo Martínez Díaz-Guerra, José J Jimenez Moleón, Manuel Muñoz Torres et al.
OBJECTIVE: To provide practical recommendations for evaluation and treatment of osteoporosis associated to endocrine diseases and nutritional conditions. PARTICIPANTS: Members of the Bone Metabolism Working Group of the Spanish Society of Endocrinology, a methodologist, and a documentalist. METHODS: Recommendations were formulated according to the GRADE system (Grading of Recommendations, Assessment, Development, and Evaluation) to describe both the strength of recommendations and the quality of evidence...
March 2012: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Elizabeth Kos, Mary Jo Liszek, Mary Ann Emanuele, Ramon Durazo-Arvizu, Pauline Camacho
OBJECTIVE: To determine the effect of metformin on 25-hydroxyvitamin D [25(OH)D] and vitamin B₁₂ levels in patients with type 2 diabetes mellitus. METHODS: We performed a retrospective review of medical records of patients treated between 2003 and 2009 at Loyola University Medical Center, Maywood, Illinois, in both ambulatory primary care and endocrinology clinics. The study cohort consisted of 706 patients with type 2 diabetes mellitus who were 20 to 93 years old (mean age, 63 ± 13) and had a mean body mass index of 33...
March 2012: Endocrine Practice
María Jesús Chillón Martín, Javier de Miguel Díez, Alicia Ferreira Moreno, Gema Sánchez Muñoz
The clinical course and therapeutic management of chronic obstructive pulmonary disease (COPD) may be affected by the presence of comorbid diseases, which also usually worsen prognosis. Among the endocrinological and metabolic alterations that can be associated with COPD are diabetes mellitus, osteoporosis, metabolic syndrome and malnutrition. There are several possible etiopathogenic mechanisms that intervene in the association between COPD and distinct endocrine and metabolic disorders, such as smoking and systemic inflammation, influenced by distinct cytokines among other factors...
2009: Archivos de Bronconeumología
Matthew R Smith
PURPOSE OF REVIEW: The aim of this review is to summarize new concepts and concerns regarding treatment-related osteoporosis, diabetes, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer. RECENT FINDINGS: Gonadotropin-releasing hormone agonists increase bone turnover, decrease bone mineral density, and increase fracture risk. Bisphosphonates, selective and estrogen receptor modulators significantly increase bone mineral density during androgen deprivation therapy...
June 2007: Current Opinion in Endocrinology, Diabetes, and Obesity
Mann Klaus
No abstract text is available yet for this article.
March 2, 2006: MMW Fortschritte der Medizin
H Lehnert
No abstract text is available yet for this article.
June 24, 2005: Deutsche Medizinische Wochenschrift
B Zantour, R Messaoud, M Zouali, A Ladjimi, H Braham, H Hamza, A Zebidi, M H Sfar
Werner's syndrome is a rare autosomal recessive disease caused by the mutation of DNA helicase gene (WRN), characterized by the premature onset of multiple age-related disorders and skin changes similar to those observed in scleroderma. Some endocrinologic and metabolic disorders have been described in patients with Werner's syndrome. We report one case in a 41-year-old man issuing from consanguineous parents, who presented for exploration of hypoglycemic episodes and sexual impotence. Werner's syndrome was diagnosed on the basis of his characteristic clinical appearance...
June 2003: Annales D'endocrinologie
Charlotte Höybye, Agneta Hilding, Hans Jacobsson, Marja Thorén
Previous investigations of adults with the Prader-Willi syndrome (PWS) are few and have demonstrated severe obesity with increased morbidity and mortality in cardiovascular disease. It is, thus, important to identify risk factors and, if possible, start prevention. We studied the clinical, genetic, endocrinological, and metabolic findings in 19 adult PWS patients (10 men; mean age, 25 yr). The PWS karyotype was demonstrated in 13 patients. The mean body mass index was 35.6 kg/m(2), and total body fat was increased...
August 2002: Journal of Clinical Endocrinology and Metabolism
C Gennari, G Martini, R Nuti
Generalized osteoporosis currently represents a heterogeneous group of conditions with many different causes and pathogenetic mechanisms, that often are variably associated. The term "secondary" is applied to all patients with osteoporosis in whom the identifiable causal factors are other than menopause and aging. In this heterogeneous group of conditions, produced by many different pathogenetic mechanisms, a negative bone balance may be variably associated with low, normal or increased bone remodeling states...
June 1998: Aging: Clinical and Experimental Research
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