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https://www.readbyqxmd.com/read/28797748/renal-trials-in-diabetes-need-a-platform-time-for-a-global-approach
#1
Dick de Zeeuw, Hiddo J L Heerspink, Meg Jardine, Vlado Perkovic
No abstract text is available yet for this article.
August 7, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28781159/preface
#2
EDITORIAL
Horacio D Espinosa, Vlado A Lubarda
No abstract text is available yet for this article.
July 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28763548/effect-of-oral-methylprednisolone-on-clinical-outcomes-in-patients-with-iga-nephropathy-the-testing-randomized-clinical-trial
#3
RANDOMIZED CONTROLLED TRIAL
Jicheng Lv, Hong Zhang, Muh Geot Wong, Meg J Jardine, Michelle Hladunewich, Vivek Jha, Helen Monaghan, Minghui Zhao, Sean Barbour, Heather Reich, Daniel Cattran, Richard Glassock, Adeera Levin, David Wheeler, Mark Woodward, Laurent Billot, Tak Mao Chan, Zhi-Hong Liu, David W Johnson, Alan Cass, John Feehally, Jürgen Floege, Giuseppe Remuzzi, Yangfeng Wu, Rajiv Agarwal, Hai-Yan Wang, Vlado Perkovic
Importance: Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain. Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression. Design, Setting, and Participants: The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1...
August 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28723325/reanalysis-of-the-crystalloid-versus-hydroxyethyl-starch-trial-chest
#4
LETTER
Anushka Patel, Karen Pieper, John A Myburgh, Vlado Perkovic, Simon Finfer, Qinghong Yang, Qiang Li, Laurent Billot
New England Journal of Medicine, Volume 377, Issue 3, Page 298-300, July 2017.
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28709600/challenges-in-conducting-clinical-trials-in-nephrology-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#5
Colin Baigent, William G Herrington, Josef Coresh, Martin J Landray, Adeera Levin, Vlado Perkovic, Marc A Pfeffer, Peter Rossing, Michael Walsh, Christoph Wanner, David C Wheeler, Wolfgang C Winkelmayer, John J V McMurray
Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment effects of a magnitude that would be realistic to achieve with a single intervention. Therefore, KDIGO convened an international, multidisciplinary controversies conference titled "Challenges in the Conduct of Clinical Trials in Nephrology" to identify the key barriers to conducting trials in patients with kidney disease...
August 2017: Kidney International
https://www.readbyqxmd.com/read/28697252/association-of-positive-airway-pressure-with-cardiovascular-events-and-death-in-adults-with-sleep-apnea-a-systematic-review-and-meta-analysis
#6
REVIEW
Jie Yu, Zien Zhou, R Doug McEvoy, Craig S Anderson, Anthony Rodgers, Vlado Perkovic, Bruce Neal
Importance: Sleep apnea (obstructive and central) is associated with adverse cardiovascular risk factors and increased risks of cardiovascular disease. Positive airway pressure (PAP) provides symptomatic relief, whether delivered continuously (CPAP) or as adaptive servo-ventilation (ASV), but the associations with cardiovascular outcomes and death are unclear. Objective: To assess the association of PAP vs control with cardiovascular events and death in patients with sleep apnea...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28695740/electronic-structure-and-band-alignment-at-the-nio-and-srtio3-p-n-heterojunctions
#7
Kelvin H L Zhang, Rui Wu, Fengzai Tang, Weiwei Li, Freddy E Oropeza, Liang Qiao, Vlado K Lazarov, Yingge Du, David J Payne, Judith L MacManus-Driscoll, Mark G Blamire
Understanding the energetics at the interface, including the alignment of valence and conduction bands, built-in potentials, and ionic and electronic reconstructions, is an important challenge in designing oxide interfaces that have controllable multifunctionalities for novel (opto-)electronic devices. In this work, we report detailed investigations on the heterointerface of wide-band-gap p-type NiO and n-type SrTiO3 (STO). We show that despite a large lattice mismatch (∼7%) and dissimilar crystal structure, high-quality NiO and Li-doped NiO (LNO) thin films can be epitaxially grown on STO(001) substrates through a domain-matching epitaxy mechanism...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28684663/a-spatial-data-infrastructure-for-environmental-noise-data-in-europe
#8
Andrej Abramic, Alexander Kotsev, Vlado Cetl, Stylianos Kephalopoulos, Marco Paviotti
Access to high quality data is essential in order to better understand the environmental and health impact of noise in an increasingly urbanised world. This paper analyses how recent developments of spatial data infrastructures in Europe can significantly improve the utilization of data and streamline reporting on a pan-European scale. The Infrastructure for Spatial Information in the European Community (INSPIRE), and Environmental Noise Directive (END) described in this manuscript provide principles for data management that, once applied, would lead to a better understanding of the state of environmental noise...
July 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28605608/canagliflozin-and-cardiovascular-and-renal-events-in-type-2-diabetes
#9
Bruce Neal, Vlado Perkovic, Kenneth W Mahaffey, Dick de Zeeuw, Greg Fulcher, Ngozi Erondu, Wayne Shaw, Gordon Law, Mehul Desai, David R Matthews
Background Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that reduces glycemia as well as blood pressure, body weight, and albuminuria in people with diabetes. We report the effects of treatment with canagliflozin on cardiovascular, renal, and safety outcomes. Methods The CANVAS Program integrated data from two trials involving a total of 10,142 participants with type 2 diabetes and high cardiovascular risk. Participants in each trial were randomly assigned to receive canagliflozin or placebo and were followed for a mean of 188...
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28439785/influence-of-environmental-conditions-on-norovirus-presence-in-mussels-harvested-in-montenegro
#10
Nevena Ilic, Branko Velebit, Vlado Teodorovic, Vesna Djordjevic, Nedjeljko Karabasil, Dragan Vasilev, Spomenka Djuric, Bojan Adzic, Mirjana Dimitrijevic
This study comprises the first systematic survey of the occurrence of Norovirus in Mediterranean mussels from harvesting areas in Montenegro coast of Adriatic Sea. Mussels may accumulate contaminants of public health concern, including pathogenic bacteria and viruses. Microbiological monitoring of harvesting areas is based on count of Escherichia coli in bivalve molluscs in the European Union. It is assumed that E. coli does not reflect contamination with enteric viruses. A structured field study was undertaken at six locations in Bay of Kotor, Montenegro, in order to investigate plausible influence of environmental factors on the variability of E...
April 24, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28434650/global-kidney-health-2017-and-beyond-a-roadmap-for-closing-gaps-in-care-research-and-policy
#11
REVIEW
Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wheeler, Kai-Uwe Eckardt
The global nephrology community recognises the need for a cohesive plan to address the problem of chronic kidney disease (CKD). In July, 2016, the International Society of Nephrology hosted a CKD summit of more than 85 people with diverse expertise and professional backgrounds from around the globe. The purpose was to identify and prioritise key activities for the next 5-10 years in the domains of clinical care, research, and advocacy and to create an action plan and performance framework based on ten themes: strengthen CKD surveillance; tackle major risk factors for CKD; reduce acute kidney injury-a special risk factor for CKD; enhance understanding of the genetic causes of CKD; establish better diagnostic methods in CKD; improve understanding of the natural course of CKD; assess and implement established treatment options in patients with CKD; improve management of symptoms and complications of CKD; develop novel therapeutic interventions to slow CKD progression and reduce CKD complications; and increase the quantity and quality of clinical trials in CKD...
April 20, 2017: Lancet
https://www.readbyqxmd.com/read/28393876/origin-of-reduced-magnetization-and-domain-formation-in-small-magnetite-nanoparticles
#12
Zlatko Nedelkoski, Demie Kepaptsoglou, Leonardo Lari, Tianlong Wen, Ryan A Booth, Samuel D Oberdick, Pedro L Galindo, Quentin M Ramasse, Richard F L Evans, Sara Majetich, Vlado K Lazarov
The structural, chemical, and magnetic properties of magnetite nanoparticles are compared. Aberration corrected scanning transmission electron microscopy reveals the prevalence of antiphase boundaries in nanoparticles that have significantly reduced magnetization, relative to the bulk. Atomistic magnetic modelling of nanoparticles with and without these defects reveals the origin of the reduced moment. Strong antiferromagnetic interactions across antiphase boundaries support multiple magnetic domains even in particles as small as 12-14 nm...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28334667/redox-controlled-release-dynamics-of-thallium-in-periodically-flooded-arable-soil
#13
Svetlana Antić-Mladenović, Tina Frohne, Mirjana Kresović, Hans-Joachim Stärk, Dubravka Savić, Vlado Ličina, Jörg Rinklebe
To our knowledge, this is the first work to mechanistically study the impact of the redox potential (EH) and principal factors, such as pH, iron (Fe), manganese (Mn), dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), chlorides (Cl(-)) and sulfates (SO4(2-)), on the release dynamics of thallium (Tl) in periodically flooded soil. We simulated flooding using an automated biogeochemical microcosm system that allows for systematical control of pre-defined redox windows. The EH value was increased mechanistically at intervals of approximately 100 mV from reducing (-211 mV) to oxidizing (475 mV) conditions...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28327978/a-dataset-of-images-and-morphological-profiles-of-30-000-small-molecule-treatments-using-the-cell-painting-assay
#14
Mark-Anthony Bray, Sigrun M Gustafsdottir, Vebjorn Ljosa, Shantanu Singh, Katherine L Sokolnicki, Joshua A Bittker, Nicole E Bodycombe, Vlado Dancík, Thomas P Hasaka, C Suk-Yee Hon, Melissa M Kemp, Kejie Li, Deepika Walpita, Mathias J Wawer, Todd R Golub, Stuart L Schreiber, Paul A Clemons, Alykhan F Shamji, Anne E Carpenter
Background: Large-scale image sets acquired by automated microscopy of perturbed samples enable a detailed comparison of cell states induced by each perturbation, such as a small molecule from a diverse library. Highly multiplexed measurements of cellular morphology can be extracted from each image and subsequently mined for a number of applications. Findings: This microscopy data set includes 919,874 five-channel fields of view representing 30,616 tested compounds, available at 'The Cell Image Library' repository...
January 7, 2017: GigaScience
https://www.readbyqxmd.com/read/28315055/determination-of-heavy-metals-in-muscle-tissue-of-six-fish-species-with-different-feeding-habits-from-the-danube-river-belgrade-public-health-and-environmental-risk-assessment
#15
Dragoljub A Jovanović, Radmila V Marković, Vlado B Teodorović, Dragan S Šefer, Milena P Krstić, Stamen B Radulović, Jelena S Ivanović Ćirić, Jelena M Janjić, Milan Ž Baltić
The aim of this study was to investigate the presence of heavy metals/metalloids (Pb, Cd, Hg, Cu, Fe, Zn, As) in the muscle tissue of fish from the Danube River (two locations: Zemun and Grocka). For the purpose of heavy metal determination in fish muscle, 120 samples of six different fish species, Prussian carp, barbel, bream, carp, pike perch, and catfish were collected. For determining heavy metals, we used microwave oven digestion and atomic absorption spectrometer methods. The highest average content of Pb (0...
April 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28293748/assessing-trace-metal-contamination-and-organic-matter-in-the-brackish-lakes-as-the-major-source-of-potable-water
#16
Vlado Cuculić, Neven Cukrov, Željko Kwokal, Slađana Strmečki, Marta Plavšić
On small and medium karstic coastal islands in the Adriatic Sea, brackish lakes are often the only source of freshwater. Therefore, it is important to adequately evaluate the biogeochemical processes occurring in these complex water systems, as well as to determine the origin of contaminants present. In this study, the distribution and origin of trace metals (Tl, Hg, Cd, Pb, Cu, Zn, Ni, Co) and organic matter in the water column, sediment, and surrounding soil of the brackish lakes on Mljet Island, South Adriatic Sea, Croatia, were evaluated...
March 14, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28274703/spines-of-the-porcupine-fish-structure-composition-and-mechanical-properties
#17
Frances Y Su, Eric A Bushong, Thomas J Deerinck, Kyungah Seo, Steven Herrera, Olivia A Graeve, David Kisailus, Vlado A Lubarda, Joanna McKittrick
This paper explores the structure, composition, and mechanical properties of porcupine fish spines for the first time. The spine was found to be composed of nanocrystalline hydroxyapatite, protein (collagen), and water using X-ray diffraction, energy-dispersive X-ray spectroscopy, and thermogravimetric analysis. Microstructures have mineralized fibrillar sheets in the longitudinal direction and in a radial orientation in the transverse direction that were observed using light and electron microscopy. Based on the images, the hierarchical structure of the spine shows both concentric and radial reinforcement...
February 28, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28244644/optimizing-the-analysis-strategy-for-the-canvas-program-a-prespecified-plan-for-the-integrated-analyses-of-the-canvas-and-canvas-r-trials
#18
Bruce Neal, Vlado Perkovic, Kenneth W Mahaffey, Greg Fulcher, Ngozi Erondu, Mehul Desai, Wayne Shaw, Gordon Law, Marc K Walton, Norm Rosenthal, Dick de Zeeuw, David R Matthews
Two large cardiovascular outcome trials of canagliflozin, comprising the CANVAS Program, will complete in early 2017: the CANagliflozin cardioVascular Assessment Study (CANVAS) and the CANagliflozin cardioVascular Assessment Study-Renal (CANVAS-R). Accruing data for the sodium glucose co-transporter 2 (SGLT2) inhibitor class has identified questions and opportunities that were not apparent when the trials were designed. Accordingly, a series of modifications have been made to the planned analyses. These updates will ensure that the data from the CANVAS Program will maximize advances in scientific knowledge and patient care...
July 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28238223/glucose-lowering-agents-for-treating-pre-existing-and-new-onset-diabetes-in-kidney-transplant-recipients
#19
REVIEW
Clement Lo, Min Jun, Sunil V Badve, Helen Pilmore, Sarah L White, Carmel Hawley, Alan Cass, Vlado Perkovic, Sophia Zoungas
BACKGROUND: Kidney transplantation is the preferred form of kidney replacement therapy for patients with end-stage kidney disease (ESKD) and is often complicated by worsening or new-onset diabetes. Management of hyperglycaemia is important to reduce post-transplant and diabetes-related complications. The safety and efficacy of glucose-lowering agents after kidney transplantation is largely unknown. OBJECTIVES: To evaluate the efficacy and safety of pharmacological interventions for lowering glucose levels in patients who have undergone kidney transplantation and have diabetes...
February 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28169881/side-effects-and-tolerability-of-combination-blood-pressure-lowering-according-to-blood-pressure-levels-an-analysis-of-the-progress-and-advance-trials
#20
Emily R Atkins, Yoichiro Hirakawa, Abdul Salam, Mark Woodward, Mark Cooper, Pavel Hamet, Stephen Harrap, Kennedy Lees, Lisheng Liu, Giuseppe Mancia, Michel Marre, Vlado Perkovic, Neil Poulter, Bryan Williams, John Chalmers, Anthony Rodgers
OBJECTIVE: To measure the placebo-controlled effects of combination therapy on hypotension, treatment discontinuation, and major renal outcomes, according to baseline blood pressure. METHODS: We conducted an analysis of the action in diabetes and vascular disease: preterax and diamicron-MR controlled evaluation ADVANCE and perindopril protection against recurrent stroke study PROGRESS trials, including 14 684 participants allocated combination therapy or placebo...
June 2017: Journal of Hypertension
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