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https://www.readbyqxmd.com/read/28069513/structure-and-mechanical-implications-of-the-pectoral-fin-skeleton-in-the-longnose-skate-chondrichthyes-batoidea
#1
Wei Huang, Watcharapong Hongjamrassilp, Jae-Young Jung, Philip A Hastings, Vlado A Lubarda, Joanna McKittrick
Animal propulsion systems are believed to show high energy and mechanical efficiency in assisting movement compared to artificial designs. As an example, batoid fishes have very light cartilaginous skeletons that facilitate their elegant swimming via enlarged wing-like pectoral fins. The aim of this work is to illustrate the hierarchical structure of the pectoral fin of a representative batoid, the Longnose Skate (Raja rhina), and explain the mechanical implications of its structural design. At the macro level, the pectoral fins are comprised of radially oriented fin rays, formed by staggered mineralized skeletal elements stacked end-to-end...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28019071/the-effects-of-atrasentan-on-urinary-metabolites-in-patients-with-type-2-diabetes-and-nephropathy
#2
Michelle J Pena, Dick de Zeeuw, Dennis Andress, John J Brennan, Ricardo Correa-Rotter, Blai Coll, Donald E Kohan, Hirofumi Makino, Vlado Perkovic, Giuseppe Remuzzi, Sheldon W Tobe, Robert Toto, Hans-Henrik Parving, Shoba Sharma, Tom Corringham, Kumar Sharma, Hiddo Jl Heerspink
We assessed the effect of atrasentan therapy on a pre-specified panel of 13 urinary metabolites known to reflect mitochondrial function in patients with diabetic kidney disease. This post-hoc analysis was performed using urine samples collected during the RADAR study which was a randomized, double-blind, placebo-controlled trial that tested the effects of atrasentan on albuminuria reduction in patients with type 2 diabetes and nephropathy. At baseline, four of the 13 metabolites, quantified by gas-chromatography mass spectrometry, were below detectable levels, and six were reduced in patients with eGFR <60 ml/min/1...
December 25, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27998624/warfarin-initiation-atrial-fibrillation-and-kidney-function-%C3%A2-comparative-effectiveness-and-safety-of%C3%A2-warfarin%C3%A2-in%C3%A2-older%C3%A2-adults%C3%A2-with-newly-diagnosed-atrial%C3%A2-fibrillation
#3
Min Jun, Matthew T James, Zhihai Ma, Jianguo Zhang, Marcello Tonelli, Finlay A McAlister, Braden J Manns, Pietro Ravani, Robert R Quinn, Natasha Wiebe, Vlado Perkovic, Stephen B Wilton, Wolfgang C Winkelmayer, Brenda R Hemmelgarn
BACKGROUND: The effectiveness and safety of warfarin use among patients with atrial fibrillation (AF) and reduced kidney function are uncertain. STUDY DESIGN: Community-based retrospective cohort study (May 1, 2003, to March 31, 2012) using province-wide laboratory and administrative data in Alberta, Canada. SETTING & PARTICIPANTS: 14,892 adults 66 years or older with new AF and a measurement of kidney function. Long-term dialysis patients or kidney transplant recipients were excluded...
December 17, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27992927/review-revascularization-and-medical-treatment-may-be-similar-in-atherosclerotic-renal-artery-stenosis
#4
Vlado Perkovic
No abstract text is available yet for this article.
December 20, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27981738/comparison-of-exposure-response-relationship-of-atrasentan-between-north-american-and-asian-populations
#5
Hiddo J L Heerspink, Hirofumi Makino, Dennis Andress, John J Brennan, Ricardo Correa-Rotter, Blai Coll, Justin Wade Davis, Ken Idler, Donald E Kohan, Mohan Liu, Vlado Perkovic, Giuseppe Remuzzi, Sheldon W Tobe, Robert Toto, Hans-Henrik Parving, Dick de Zeeuw
AIMS: The selective endothelin (ET) A receptor antagonist atrasentan has been shown to lower albuminuria in North American and Asian patients with type 2 diabetes and nephropathy. As drug responses for many drugs may differ between North American and Asian populations, we assessed the influence of geographical region on the albuminuria and fluid retention response to atrasentan. MATERIALS AND METHODS: Two 12-week double-blind randomized controlled trials were performed with atrasentan 0...
December 15, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27904416/adsorption-characteristics-of-different-adsorbents-and-iron-iii-salt-for-removing-as-v-from-water
#6
Josip Ćurko, Marin Matošić, Vlado Crnek, Višnja Stulić, Ivan Mijatović
The aim of this study is to determine the adsorption performance of three types of adsorbents for removal of As(V) from water: Bayoxide(®) E33 (granular iron(III) oxide), Titansorb(®) (granular titanium oxide) and a suspension of precipitated iron(III) hydroxide. Results of As(V) adsorption stoichiometry of two commercial adsorbents and precipitated iron(III) hydroxide in tap and demineralized water were fitted to Freundlich and Langmuir adsorption isotherm equations, from which adsorption constants and adsorption capacity were calculated...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27884312/management-of-patients-with-diabetes-and-ckd-%C3%A2-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#7
Vlado Perkovic, Rajiv Agarwal, Paola Fioretto, Brenda R Hemmelgarn, Adeera Levin, Merlin C Thomas, Christoph Wanner, Bertram L Kasiske, David C Wheeler, Per-Henrik Groop
The prevalence of diabetes around the world has reached epidemic proportions and is projected to increase to 642 million people by 2040. Diabetes is already the leading cause of end-stage kidney disease (ESKD) in most developed countries, and the growth in the number of people with ESKD around the world parallels the increase in diabetes. The presence of kidney disease is associated with a markedly elevated risk of cardiovascular disease and death in people with diabetes. Several new therapies and novel investigational agents targeting chronic kidney disease patients with diabetes are now under development...
December 2016: Kidney International
https://www.readbyqxmd.com/read/27883325/solitary-fibrous-tumor-of-the-pancreas-a-case-report-and-review-of-the-literature
#8
Liljana Spasevska, Vesna Janevska, Vlado Janevski, Biljana Noveska, Julija Zhivadinovik
Pancreas is an extremely rare abdominal localization of the solitary fibrous tumor (SFT). It usually grows asymptomatically for a long time before a diagnosis can be made on the basis of symptoms and/or mechanical complications. Due to the rarity and nonspecific clinical presentation, this entity is diagnostically challenging. We present a 47-year-old man with a history of progressive epigastric pain for the last two weeks, and jaundice, who was admitted to hospital for further investigation. Cystadenocarcinoma was suspected based on the radiologic findings, and a pancreatoduodenectomy was performed...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27869132/realisation-of-magnetically-and-atomically-abrupt-half-metal-semiconductor-interface-co2fesi0-5al0-5-ge-111
#9
Zlatko Nedelkoski, Balati Kuerbanjiang, Stephanie E Glover, Ana M Sanchez, Demie Kepaptsoglou, Arsham Ghasemi, Christopher W Burrows, Shinya Yamada, Kohei Hamaya, Quentin M Ramasse, Philip J Hasnip, Thomas Hase, Gavin R Bell, Atsufumi Hirohata, Vlado K Lazarov
Halfmetal-semiconductor interfaces are crucial for hybrid spintronic devices. Atomically sharp interfaces with high spin polarisation are required for efficient spin injection. In this work we show that thin film of half-metallic full Heusler alloy Co2FeSi0.5Al0.5 with uniform thickness and B2 ordering can form structurally abrupt interface with Ge(111). Atomic resolution energy dispersive X-ray spectroscopy reveals that there is a small outdiffusion of Ge into specific atomic planes of the Co2FeSi0.5Al0.5 film, limited to a very narrow 1 nm interface region...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27823905/bioassessment-of-heavy-metals-in-the-surface-soil-layer-of-an-opencast-mine-aimed-for-its-rehabilitation
#10
Vlado Ličina, Milica Fotirić Akšić, Zorica Tomić, Ivana Trajković, Svetlana Antić Mladenović, Milena Marjanović, Jörg Rinklebe
The contemporary reclamation method in an opencast coal mine closure comprises the use of the preserved surface soil layer (SSL) before mining, and can be directly returned to the areas being rehabilitated. The present study emphasizes a risk in the use of such a SSL in mine rehabilitation due to the possible excessive amount of heavy metals which usually derives from a metal-rich sediment or fluvial character of overburden material. This indication was approved by the bioassessment of cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), lead (Pb), nickel (Ni), and zinc (Zn) in root and aerial parts of maize (Zea mays), alfalfa (Medicago sativa), sweet clover (Melilotus officinalis), wheat (Triticum aestivum), barley (Hordeum sativum), white clover (Trifolium repens), pasture (Poales sp...
January 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27821641/effects-of-ischaemic-conditioning-on-major-clinical-outcomes-in-people-undergoing-invasive-procedures-systematic-review-and-meta-analysis
#11
Louisa Sukkar, Daqing Hong, Muh Geot Wong, Sunil V Badve, Kris Rogers, Vlado Perkovic, Michael Walsh, Xueqing Yu, Graham S Hillis, Martin Gallagher, Meg Jardine
OBJECTIVE:  To summarise the benefits and harms of ischaemic conditioning on major clinical outcomes in various settings. DESIGN:  Systematic review and meta-analysis. DATA SOURCES:  Medline, Embase, Cochrane databases, and International Clinical Trials Registry platform from inception through October 2015. STUDY SELECTION:  All randomised controlled comparisons of the effect of ischaemic conditioning on clinical outcomes were included...
November 7, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27751627/a-structural-and-mathematical-modeling-analysis-of-the-likelihood-of-antibody-dependent-enhancement-in-influenza
#12
Boopathy Ramakrishnan, Karthik Viswanathan, Kannan Tharakaraman, Vlado Dančík, Rahul Raman, Gregory J Babcock, Zachary Shriver, Ram Sasisekharan
Broadly neutralizing monoclonal antibodies (bNAbs) for viral infections, such as HIV, respiratory syncytial virus (RSV), and influenza, are increasingly entering clinical development. For influenza, most neutralizing antibodies target influenza virus hemagglutinin. These bNAbs represent an emerging, promising modality for treatment and prophylaxis of influenza due to their multiple mechanisms of antiviral action and generally safe profile. Preclinical work in other viral diseases, such as dengue, has demonstrated the potential for antibody-based therapies to enhance viral uptake, leading to enhanced viremia and worsening of disease...
October 14, 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/27713984/heracleum-orphanidis-chemical-characterisation-and-comparative-evaluation-of-antioxidant-and-antimicrobial-activities-with-specific-interest-in-the-influence-on-pseudomonas-aeruginosa-pao1
#13
Ksenija S Mileski, Ana D Ćirić, Snežana S Trifunović, Mihailo S Ristić, Marina D Soković, Vlado S Matevski, Vele V Tešević, Milka B Jadranin, Petar D Marin, Ana M Džamić
GC-FID and GC-MS were used to determine the chemical composition of the essential oil of the aerial parts of Heracleum orphanidis Boiss. Also, the HPLC-DAD/ESI-ToF-MS profile of the methanol extracts of aerial parts and roots was determined. The main components of the essential oil were n-octanol, octyl hexanoate and n-octyl acetate, while coumarins were the most prevalent compounds in methanol extracts. An evaluation of antioxidant activity showed that the methanol and aqueous extracts of the aerial parts had the highest potential...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27707552/comparative-effectiveness-of-12-treatment-strategies-for-preventing-contrast-induced-acute-kidney-injury-a-systematic-review-and-bayesian-network-meta-analysis
#14
Xiaole Su, Xinfang Xie, Lijun Liu, Jicheng Lv, Fujian Song, Vlado Perkovic, Hong Zhang
BACKGROUND: To simultaneously evaluate the relative efficacy of multiple pharmacologic strategies for preventing contrast-induced acute kidney injury (AKI). STUDY DESIGN: Systematic review containing a Bayesian network meta-analysis of randomized controlled trials. SETTING & POPULATION: Participants undergoing diagnostic and/or interventional procedures with contrast media. SELECTION CRITERIA FOR STUDIES: Randomized controlled trials comparing the active drug treatments with each other or with hydration alone...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27671667/a-call-to-action-and-a-lifecourse-strategy-to-address-the-global-burden-of-raised-blood-pressure-on-current-and-future-generations-the-lancet-commission-on-hypertension
#15
Michael H Olsen, Sonia Y Angell, Samira Asma, Pierre Boutouyrie, Dylan Burger, Julio A Chirinos, Albertino Damasceno, Christian Delles, Anne-Paule Gimenez-Roqueplo, Dagmara Hering, Patricio López-Jaramillo, Fernando Martinez, Vlado Perkovic, Ernst R Rietzschel, Giuseppe Schillaci, Aletta E Schutte, Angelo Scuteri, James E Sharman, Kristian Wachtell, Ji Guang Wang
No abstract text is available yet for this article.
September 22, 2016: Lancet
https://www.readbyqxmd.com/read/27658832/treatment-patterns-of-schizophrenia-based-on-the-data-from-seven-central-and-eastern-european-countries
#16
Monika Szkultecka-Dębek, Katarzyna Miernik, Jarosław Stelmachowski, Miro Jakovljević, Vlado Jukić, Kaire Aadamsoo, Sven Janno, István Bitter, Judit Tolna, Marek Jarema, Slobodan Jankovic, Jan Pecenak, Livia Vavrusova, Rok Tavčar, Jacek Walczak, Darren Talbot, Joanna Augustyńska
OBJECTIVE: The aim is to analyze how schizophrenia is pharmacologically treated in seven CEE countries: Croatia, Estonia, Hungary, Poland, Serbia, Slovakia and Slovenia. METHODS: Psychiatrists from selected centers in each of participating countries were asked to complete a pre-defined questionnaire on their current clinical practice. Information on protocols and resource utilization in schizophrenia treatment was included and derived from randomly selected patient medical records...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27539604/canagliflozin-slows-progression-of-renal-function-decline-independently-of-glycemic-effects
#17
Hiddo J L Heerspink, Mehul Desai, Meg Jardine, Dainius Balis, Gary Meininger, Vlado Perkovic
Sodium-glucose cotransporter 2 inhibition with canagliflozin decreases HbA1c, body weight, BP, and albuminuria, implying that canagliflozin confers renoprotection. We determined whether canagliflozin decreases albuminuria and reduces renal function decline independently of its glycemic effects in a secondary analysis of a clinical trial in 1450 patients with type 2 diabetes receiving metformin and randomly assigned to either once-daily canagliflozin 100 mg, canagliflozin 300 mg, or glimepiride uptitrated to 6-8 mg...
January 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27509006/effects-of-the-mediterranean-diet-on-cardiovascular-outcomes-a-systematic-review-and-meta-analysis
#18
Thaminda Liyanage, Toshiharu Ninomiya, Amanda Wang, Bruce Neal, Min Jun, Muh Geot Wong, Meg Jardine, Graham S Hillis, Vlado Perkovic
BACKGROUND: A Mediterranean dietary pattern is widely recommended for the prevention of chronic disease. We sought to define the most likely effects of the Mediterranean diet on vascular disease and mortality. METHODS: We searched MEDLINE, EMBASE and the Cochrane Central Register without language restriction for randomized controlled trials comparing Mediterranean to control diets. Data on study design, patient characteristics, interventions, follow-up duration, outcomes and adverse events were sought...
2016: PloS One
https://www.readbyqxmd.com/read/27501822/controlling-the-half-metallicity-of-heusler-si-1%C3%A2-1%C3%A2-1-interfaces-by-a-monolayer-of-si-co-si
#19
Zlatko Nedelkoski, Demie Kepaptsoglou, Arsham Ghasemi, Balati Kuerbanjiang, Philip J Hasnip, Shinya Yamada, Kohei Hamaya, Quentin M Ramasse, Atsufumi Hirohata, Vlado K Lazarov
By using first-principles calculations we show that the spin-polarization reverses its sign at atomically abrupt interfaces between the half-metallic Co2(Fe,Mn)(Al,Si) and Si(1 1 1). This unfavourable spin-electronic configuration at the Fermi-level can be completely removed by introducing a Si-Co-Si monolayer at the interface. In addition, this interfacial monolayer shifts the Fermi-level from the valence band edge close to the conduction band edge of Si. We show that such a layer is energetically favourable to exist at the interface...
October 5, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27477772/knowing-what-we-do-not-know-statin-therapy-in-advanced-chronic-kidney-disease
#20
Muh Geot Wong, Vlado Perkovic
No abstract text is available yet for this article.
October 2016: Lancet Diabetes & Endocrinology
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