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https://www.readbyqxmd.com/read/29604389/effects-of-sodium-glucose-cotransporter-2-inhibitors-on-cardiovascular-disease-death-and-safety-outcomes-in-type-2-diabetes-a-systematic-review
#1
REVIEW
Karin Rådholm, Jason Hy Wu, Muh Geot Wong, Celine Foote, Gregory Fulcher, Kenneth W Mahaffey, Vlado Perkovic, Bruce Neal
AIM: Sodium glucose co-transporter 2 (SGLT2) inhibitors appear to protect against increased risks of cardiovascular and kidney disease in patients with type 2 diabetes but also cause some harms. Whether effects are comparable across drug class or specific to individual compounds is unclear. This meta-analysis assessed the class and individual compound effects of SGLT2 inhibition versus control on cardiovascular events, death, kidney disease and safety outcomes in patients with type 2 diabetes...
March 28, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29604160/baseline-characteristics-and-enrichment-results-of-the-study-of-diabetic-nephropathy-with-atrasentan-sonar-trial
#2
Hiddo J L Heerspink, Dennis L Andress, George Bakris, John J Brennan, Ricardo Correa-Rotter, Fan Fan Hou, Dalane W Kitzman, Donald Kohan, Hirofumi Makino, John McMurray, Vlado Perkovic, Sheldon Tobe, Melissa Wigderson, Tingting Yi, Hans-Henrik Parving, Dick de Zeeuw
INTRODUCTION: The SONAR trial uses an enrichment design based on the individual response to the selective endothelin receptor antagonist atrasentan on efficacy (the degree of the individual response in urinary albumin:creatinine ratio, UACR), and safety/tolerability (signs of sodium retention and acute increases in serum creatinine) to assess the effects of this agent on major renal outcomes. The patient population and enrichment results are described here. METHODS: Patients with type 2 diabetes with estimated Glomerular Filtration Rate (eGFR) between 25 and 75 ml/min/1...
March 31, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29563507/in-situ-measurements-of-rare-earth-elements-in-deep-sea-sediments-using-nuclear-methods
#3
Jasmina Obhođaš, Davorin Sudac, Ilker Meric, Helge E S Pettersen, Milivoj Uroić, Karlo Nađ, Vlado Valković
The prospecting activities for finding new rare earth elements (REE) sources have increased greatly in recent years. One of the main discoveries was announced in 2011 by Japanese researchers who found large quantities of REE on the ocean seafloor at the sea depths greater than 4,000 m. The classic approach to investigate REE in deep sea sediments is to obtain sediment samples by drilling that is followed by laborious laboratory analysis. This is very expensive, time consuming and not appropriate for exploring vast areas...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29540217/rationale-design-and-baseline-characteristics-of-the-cardiovascular-safety-and-renal-microvascular-outcome-study-with-linagliptin-carmelina-%C3%A2-a-randomized-double-blind-placebo-controlled-clinical-trial-in-patients-with-type-2-diabetes-and-high-cardio-renal
#4
Julio Rosenstock, Vlado Perkovic, John H Alexander, Mark E Cooper, Nikolaus Marx, Michael J Pencina, Robert D Toto, Christoph Wanner, Bernard Zinman, David Baanstra, Egon Pfarr, Michaela Mattheus, Uli C Broedl, Hans-Juergen Woerle, Jyothis T George, Maximilian von Eynatten, Darren K McGuire
BACKGROUND: Cardiovascular (CV) outcome trials in type 2 diabetes (T2D) have underrepresented patients with chronic kidney disease (CKD), leading to uncertainty regarding their kidney efficacy and safety. The CARMELINA® trial aims to evaluate the effects of linagliptin, a DPP-4 inhibitor, on both CV and kidney outcomes in a study population enriched for cardio-renal risk. METHODS: CARMELINA® is a randomized, double-blind, placebo-controlled clinical trial conducted in 27 countries in T2D patients at high risk of CV and/or kidney events...
March 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29526832/canagliflozin-and-heart-failure-in-type-2-diabetes-mellitus-results-from-the-canvas-program-canagliflozin-cardiovascular-assessment-study
#5
Karin Rådholm, Gemma Figtree, Vlado Perkovic, Scott D Solomon, Kenneth W Mahaffey, Dick de Zeeuw, Greg Fulcher, Terrance D Barrett, Wayne Shaw, Mehul Desai, David R Matthews, Bruce Neal
BACKGROUND : Canagliflozin is a sodium glucose cotransporter 2 inhibitor that reduces the risk of cardiovascular events. We report the effects on heart failure and cardiovascular death overall, in those with and without a baseline history of heart failure, and in other participant subgroups. METHODS : The CANVAS Program (Canagliflozin Cardiovascular Assessment Study) enrolled 10 142 participants with type 2 diabetes mellitus and high cardiovascular risk. Participants were randomly assigned to canagliflozin or placebo and followed for a mean of 188 weeks...
March 11, 2018: Circulation
https://www.readbyqxmd.com/read/29467424/spin-canting-across-core-shell-fe-3-o-4-mn-x-fe-3-x-o-4-nanoparticles
#6
Samuel D Oberdick, Ahmed Abdelgawad, Carlos Moya, Samaneh Mesbahi-Vasey, Demie Kepaptsoglou, Vlado K Lazarov, Richard F L Evans, Daniel Meilak, Elizabeth Skoropata, Johan van Lierop, Ian Hunt-Isaak, Hillary Pan, Yumi Ijiri, Kathryn L Krycka, Julie A Borchers, Sara A Majetich
Magnetic nanoparticles (MNPs) have become increasingly important in biomedical applications like magnetic imaging and hyperthermia based cancer treatment. Understanding their magnetic spin configurations is important for optimizing these applications. The measured magnetization of MNPs can be significantly lower than bulk counterparts, often due to canted spins. This has previously been presumed to be a surface effect, where reduced exchange allows spins closest to the nanoparticle surface to deviate locally from collinear structures...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29424935/the-effect-of-extended-hours-dialysis-on-sleep-quality-in-a-randomised-trial
#7
Jin-Lan Liao, Oliver van den Broek-Best, Brendan Smyth, Daqing Hong, Kha Vo, Li Zuo, Nicholas A Gray, Christopher T Chan, Janak de Zoysa, Vlado Perkovic, Lei Jiang, Meg Jardine
BACKGROUND: Poor sleep quality is common in haemodialysis patients and associated with worse outcomes. In this pre-specified analysis, we examined the impact of extended hours haemodialysis on sleep quality. METHODS: The ACTIVE Dialysis trial randomized 200 participants to extended (≥24 hours/week) or standard (target 12-15 hours) hours haemodialysis over 12 months. Sleep quality was measured in the Kidney Disease Quality of Life Short Form 1.3 (KDQOL-SF) by overall sleep quality score (0-10, 10 = "very good") and the sleep subscale (0-100, 100 = 'best possible sleep') every three months via blinded telephone interviewer...
February 9, 2018: Nephrology
https://www.readbyqxmd.com/read/29405626/rationale-and-protocol-of-the-study-of-diabetic-nephropathy-with-atrasentan-sonar-trial-a-clinical-trial-design-novel-to-diabetic-nephropathy
#8
Hiddo J L Heerspink, Dennis L Andress, George Bakris, John J Brennan, Ricardo Correa-Rotter, Jyotirmoy Dey, Fan Fan Hou, Dalane W Kitzman, Donald Kohan, Hirofumi Makino, John McMurray, Vlado Perkovic, Sheldon Tobe, Melissa Wigderson, Hans-Henrik Parving, Dick de Zeeuw
AIMS: Individuals with diabetes and chronic kidney disease (CKD) are at high risk for renal events. Recent trials of novel treatments have been negative, possibly because of variability in response to treatment of the target risk factor. Atrasentan is a selective endothelin A receptor antagonist that reduces urinary albumin-to-creatinine ratio (UACR), with a large variability between patients. We are assessing its effect on renal outcomes in the Study Of diabetic Nephropathy with AtRasentan (SONAR; NCT01858532) with an enrichment design (>30% lowering of albuminuria) to select patients most likely to benefit...
February 6, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29343817/associations-between-body-mass-index-and-the-risk-of-renal-events-in-patients-with-type-2-diabetes
#9
Kamel Mohammedi, John Chalmers, William Herrington, Qiang Li, Giuseppe Mancia, Michel Marre, Neil Poulter, Anthony Rodgers, Bryan Williams, Vlado Perkovic, Josef Coresh, Mark Woodward
BACKGROUND/OBJECTIVES: We aimed to evaluate the relationship between BMI and the risk of renal disease in patients with type 2 diabetes in the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. SUBJECTS/METHODS: Participants were divided into six baseline BMI categories: <18.5 (underweight, n = 58); ≥18.5 to <25 (normal, n = 2894); ≥25 to <30 (overweight, n = 4340); ≥30 to <35 (obesity grade 1, n = 2265); ≥35 to <40 (obesity grade 2, n = 744); and ≥40 kg/m2 (obesity grade 3, n = 294); those underweight were excluded...
January 17, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29337694/magnetic-and-structural-depth-profiles-of-heusler-alloy-co-2-feal-0-5-si-0-5-epitaxial-films-on-si-1-1-1
#10
Stephanie E Glover, Thomas Saerbeck, Balati Kuerbanjiang, Arsham Ghasemi, Demie Kepaptsoglou, Quentin M Ramasse, Shinya Yamada, Kohei Hamaya, Thomas P A Hase, Vlado K Lazarov, Gavin R Bell
The depth-resolved chemical structure and magnetic moment of [Formula: see text], thin films grown on Si(1 1 1) have been determined using x-ray and polarized neutron reflectometry. Bulk-like magnetization is retained across the majority of the film, but reduced moments are observed within 45[Formula: see text] of the surface and in a 25[Formula: see text] substrate-interface region. The reduced moment is related to compositional changes due to oxidation and diffusion, which are further quantified by elemental profiling using electron microscopy with electron energy loss spectroscopy...
January 16, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29327905/canagliflozin-and-cardiovascular-and-renal-events-in-type-2-diabetes
#11
Bruce Neal, Vlado Perkovic, David R Matthews
No abstract text is available yet for this article.
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29297471/magnetic-and-structural-depth-profiles-of-heusler-alloy-co-sub-2-sub-feal-sub-0-5-sub-si-sub-0-5-sub-epitaxial-films-on-si-111
#12
Stephanie Elizabeth Glover, Thomas Saerbeck, Balati Kuerbanjiang, Arsham Ghasemi, Despoina Kepaptsoglou, Quentin Ramasse, Shinya Yamada, Kohei Hamaya, Thomas P A Hase, Vlado Lazarov, Gavin R Bell
The depth-resolved chemical structure and magnetic moment of Co&lt;sub&gt;2&lt;/sub&gt;FeAl&lt;sub&gt;0.5&lt;/sub&gt;Si&lt;sub&gt;0.5&lt;/sub&gt; thin films grown on Si(111) have been determined using x-ray and polarized neutron reflectometry. Bulk-like magnetization is retained across the majority of the film, but reduced moments are observed within 45 Å of the surface and in a 25 Å substrate interface region. The reduced moment is related to with compositional changes due to oxidation and diffusion, which are further quantified by elemental profiling using electron microscopy with electron energy loss spectroscopy...
January 3, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29225940/chronic-kidney-disease-and-the-global-ncds-agenda
#13
EDITORIAL
Brendon Lange Neuen, Steven James Chadban, Alessandro Rhyl Demaio, David Wayne Johnson, Vlado Perkovic
No abstract text is available yet for this article.
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29220450/ctd2-dashboard-a-searchable-web-interface-to-connect-validated-results-from-the-cancer-target-discovery-and-development-network
#14
Bülent Arman Aksoy, Vlado Dancík, Kenneth Smith, Jessica N Mazerik, Zhou Ji, Benjamin Gross, Olga Nikolova, Nadia Jaber, Andrea Califano, Stuart L Schreiber, Daniela S Gerhard, Leandro C Hermida, Subhashini Jagu, Chris Sander, Aris Floratos, Paul A Clemons
https://ctd2-dashboard.nci.nih.gov/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29201044/ischaemic-preconditioning-suppresses-necrosis-of-adipocutaneous-flaps-in-a-diabetic-rat-model-regardless-of-the-manner-of-preischaemia-induction
#15
Christian Ottomann, Markus Küntscher, Bernd Hartmann, Vlado Antonic
Ischaemic insult in the skin flaps is a major problem in reconstructive surgery particularly in patients with diabetes mellitus. Here, we sought to investigate the effectiveness of ischaemic preconditioning (IP) on diabetic skin flaps in rat animal model. Hundred Wistar rats (90 streptozotocin treated animals and 10 nondiabetic controls) were used. Diabetes mellitus was confirmed by measuring glucose level in blood, HbA1c, and ketonuria. We used blood vessel clamping, hind limb tourniquet, and NO donors (Spermine/NO complex) to induce short-term ischaemia of tissues that will be excised for skin flaps...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29156017/early-and-late-outcomes-after-surgical-repair-of-congenital-supravalvular-aortic-stenosis-a-european-congenital-heart-surgeons-association-multicentric-study
#16
Massimo A Padalino, Anna Chiara Frigo, Marina Comisso, Martin Kostolny, Ikenna Omeje, Christian Schreiber, Jelena Pabst von Ohain, Julie Cleuziou, David J Barron, Bart Meyns, Viktor Hraska, Bohdan Maruszewski, Michal Kozlowski, Luca A Vricella, Narutoshi Hibino, Sarah Collica, Hakan Berggren, Mats Synnergren, Stojan Lazarov, David Kalfa, Emile Bacha, Christian Pizarro, Mark Hazekamp, Vlado Sojak, Jeffrey P Jacobs, Matej Nosal, Jose Fragata, Sertac Cicek, George E Sarris, Panayotis Zografos, Vladimiro L Vida, Giovanni Stellin
OBJECTIVES: Our goal was to evaluate the early and late results of the surgical management of congenital supravalvular aortic stenosis (SVAS). METHODS: We performed a retrospective, multicentre study using data from the European Congenital Heart Surgeons Association. Exclusion criteria were age >18 years, operation before 1990 and redo supravalvular aortic stenosis operations. Multivariate Cox regression analysis was performed to detect independent predictors of adverse events...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29149664/copper-phospholipid-interaction-at-cell-membrane-model-hydrophobic-surfaces
#17
Marina Mlakar, Vlado Cuculić, Sanja Frka, Blaženka Gašparović
Detailed investigation of Cu (II) binding with natural lipid phosphatidylglycerol (PG) in aqueous solution was carried out by voltammetric measurements at the mercury drop electrode, complemented by monolayer studies in a Langmuir trough and electrophoretic measurements, all used as models for hydrophobic cell membranes. Penetration of copper ions into the PG layer was facilitated by the formation of hydrophilic Cu-Phenanthroline (Phen) complex in the subphase, followed by the mixed ligand Cu-Phen-PG complex formation at the hydrophobic interface...
November 11, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29133604/canagliflozin-for-primary-and-secondary-prevention-of-cardiovascular-events-results-from-the-canvas-program-canagliflozin-cardiovascular-assessment-study
#18
Kenneth W Mahaffey, Bruce Neal, Vlado Perkovic, Dick de Zeeuw, Greg Fulcher, Ngozi Erondu, Wayne Shaw, Elisa Fabbrini, Tao Sun, Qiang Li, Mehul Desai, David R Matthews
BACKGROUND: Canagliflozin is a sodium glucose cotransporter 2 inhibitor that significantly reduces the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and elevated cardiovascular risk. The comparative effects among participants with and without a history of cardiovascular disease (secondary versus primary prevention) were prespecified for evaluation. METHODS: The CANVAS Program (Canagliflozin Cardiovascular Assessment Study) randomly assigned 10 142 participants with type 2 diabetes mellitus to canagliflozin or placebo...
January 23, 2018: Circulation
https://www.readbyqxmd.com/read/29129053/research-on-chemical-composition-and-biological-properties-including-antiquorum-sensing-activity-of-angelica-pancicii-vandas-aerial-parts-and-roots
#19
Ksenija S Mileski, Snežana S Trifunović, Ana D Ćirić, Željana M Šakić, Mihailo S Ristić, Nina M Todorović, Vlado S Matevski, Petar D Marin, Vele V Tešević, Ana M Džamić
The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and β-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents...
December 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29090363/calcium-axonemal-microtubuli-interactions-underlie-mechanism-s-of-primary-cilia-morphological-changes
#20
Vlado A Buljan, Manuel B Graeber, R M Damian Holsinger, Daniel Brown, Brett D Hambly, Edward J Delikatny, Vladimira R Vuletic, Xavier N Krebs, Ilijan B Tomas, John J Bohorquez-Florez, Guo Jun Liu, Richard B Banati
We have used cell culture of astrocytes aligned within microchannels to investigate calcium effects on primary cilia morphology. In the absence of calcium and in the presence of flow of media (10 μL.s(-1)) the majority (90%) of primary cilia showed reversible bending with an average curvature of 2.1 ± 0.9 × 10(-4) nm(-1). When 1.0 mM calcium was present, 90% of cilia underwent bending. Forty percent of these cilia demonstrated strong irreversible bending, resulting in a final average curvature of 3...
October 31, 2017: Journal of Biological Physics
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