Louis de Mestier, Rémy Nicolle, Nicolas Poté, Vinciane Rebours, François Cauchy, Olivia Hentic, Frédérique Maire, Maxime Ronot, Rachida Lebtahi, Alain Sauvanet, Valérie Paradis, Philippe Ruszniewski, Anne Couvelard, Jérôme Cros
Isolated hepatic localizations of neuroendocrine tumors (NETs) are generally considered as metastatic NETs of unknown primary but could correspond to primary hepatic NETs (PHNETs), a poorly explored entity. We aimed to describe the clinicopathological and molecular features of PHNETs and compare them with other primary NETs. We assembled a retrospective cohort of patients managed for hepatic localization of NET without extra-hepatic primary tumor after exhaustive clinical, imaging, and immunohistochemical characterization...
September 2022: Journal of Pathology