Sarah E Woodfield, Brandon J Mistretta, Roma H Patel, Aryana M Ibarra, Kevin E Fisher, Stephen F Sarabia, Ilavarasi Gandhi, Jacquelyn Reuther, Zbigniew Starosolski, Andrew Badachhape, Jessica Epps, Barry Zorman, Aayushi P Shah, Samuel R Larson, Rohit K Srivastava, Yan Shi, Andres F Espinoza, Saiabhiroop R Govindu, Richard S Whitlock, Kimberly Holloway, Angshumoy Roy, Pavel Sumazin, Ketan B Ghaghada, Dolores Lopez-Terrada, Preethi H Gunaratne, Sanjeev A Vasudevan
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models that show high-risk features including multifocal tumors, vascular invasion, metastasis, and circulating tumor cells (CTCs). HepT1 cells were injected into the livers or tail veins of mice, and tumor growth was monitored with magnetic resonance and bioluminescent imaging...
September 15, 2022: Biology Open