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Dysplasia in ulcerative colitis

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https://www.readbyqxmd.com/read/29122603/the-role-of-colorectal-endoscopic-submucosal-dissection-in-patients-with-ulcerative-colitis
#1
Satoshi Kinoshita, Toshio Uraoka, Toshihiro Nishizawa, Makoto Naganuma, Yasushi Iwao, Yasutoshi Ochiai, Ai Fujimoto, Osamu Goto, Masayuki Shimoda, Haruhiko Ogata, Takanori Kanai, Naohisa Yahagi
BACKGROUND AND AIM: Patients with ulcerative colitis have an increased risk of colorectal dysplasia. Endoscopic submucosal dissection (ESD) for the neoplastic lesions in ulcerative colitis remains controversial. The aim of this study was to clarify the role of ESD in treatment strategy for ulcerative colitis. METHODS: We retrospectively investigated 25 patients with ulcerative colitis in clinical remission who underwent colorectal ESD at two referral centers. We analyzed short-term and long-term outcomes...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29112567/a-pilot-study-of-the-prevalence-of-anal-human-papillomavirus-and-dysplasia-in-a-cohort-of-patients-with-ibd
#2
Ross D Cranston, Miguel Regueiro, Jana Hashash, Jonathan R Baker, Nicola Richardson-Harman, Laura Janocko, Ian McGowan
BACKGROUND: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD. OBJECTIVE: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. DESIGN: Patients had an anal examination before routine colonoscopy. SETTINGS: The study was conducted at a tertiary IBD referral center...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29070013/p53-expression-in-patients-with-ulcerative-colitis-associated-with-dysplasia-and-carcinoma-a-systematic-meta-analysis
#3
Xiaohong Lu, Yuanjie Yu, Shiyun Tan
BACKGROUND: Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC. METHODS: Publications were searched in the PubMed, Embase, EBSCO, Wangfang, and CNKI databases. The overall odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were summarized in this study...
October 25, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29018541/results-from-a-retrospective-analysis-of-colonoscopies-for-inflammatory-bowel-disease-and-colorectal-cancer-in-a-lebanese-tertiary-care-centre
#4
Toufic Saber, Khalil Bedran, Fatima Ghandour, Mansour El Khoury, Roula Bou Khalil, Said Farhat
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) and colorectal cancer have an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of IBD and colorectal cancer at a tertiary hospital centre in Lebanon. METHODS: 1007 patients underwent colonoscopy over a period of 12 months by qualified physicians. 91 patients were excluded from the study. Biopsy results were divided into normal versus abnormal colonic tissue...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28986266/pit-pattern-analysis-with-high-definition-chromoendoscopy-and-narrow-band-imaging-for-optical-diagnosis-of-dysplasia-in-patients-with-ulcerative-colitis
#5
Raf Bisschops, Talat Bessissow, Evelien Dekker, James E East, Adolfo Parra-Blanco, Krish Ragunath, Pradeep Bhandari, Matt Rutter, Erik Schoon, Ana Wilson, Jestinah Mahachie John, Kristel Van Steen, Filip Baert, Marc Ferrante
BACKGROUND AND AIMS: Patients with longstanding ulcerative colitis (UC) are at increased risk of developing colorectal neoplasia. Chromoendoscopy (CE) increases detection of lesions, and Kudo pit pattern classification I and II have been suggested to be predictive of benign polyps in UC. Little is known on the use of this classification in non-magnified high-definition (HD) (virtual) CE and narrow-band Imaging (NBI), or on the interobserver agreement. The aim of this pilot study was to assess the diagnostic accuracy and the interobserver agreement of the Kudo pit pattern classification in UC patients undergoing surveillance with methylene blue CE or NBI in a multicenter study...
October 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28965228/chromoendoscopy-narrow-band-imaging-or-white-light-endoscopy-for-neoplasia-detection-in-inflammatory-bowel-diseases
#6
REVIEW
Ofir Har-Noy, Lior Katz, Tomer Avni, Robert Battat, Talat Bessissow, Diana E Yung, Tal Engel, Anastasios Koulaouzidis, Rami Eliakim, Shomron Ben-Horin, Uri Kopylov
BACKGROUND: Studies have confirmed an increased risk of colorectal cancer in patients with ulcerative colitis; hence, surveillance is recommended. Optional modalities include white light endoscopy (WLE) or dye-spray chromoendoscopy. However, narrow-band imaging (NBI) is still not considered comparable to chromoendoscopy. AIM: The aim of this study was to compare the diagnostic yield (DY) of WLE, chromoendoscopy, NBI for detection of neoplasia in patients with inflammatory bowel disease (IBD) by performing a meta-analysis of the existing literature...
November 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28958412/acute-histological-inflammatory-activity-is-associated-with-clinical-relapse-in-patients-with-ulcerative-colitis-in-clinical-and-endoscopic-remission
#7
Margalida Calafat, Triana Lobatón, Alba Hernández-Gallego, Míriam Mañosa, Paola Torres, Fiorella Cañete, Eduard Cabré, Isabel Ojanguren, Eugeni Domènech
BACKGROUND: It has been suggested that acute histological activity has a prognostic value in the outcome of ulcerative colitis (UC) patients in clinical and endoscopic remission. Our aim was to assess the role of histology as a risk factor for clinical relapse (CR) in patients in both clinical and endoscopic remission. METHODS: Patients with left-sided or extensive UC in clinical and endoscopic remission (Mayo endoscopic subscore ≤1) undergoing colonoscopy for dysplasia surveillance with random colonic biopsies between 2005-2015 were included...
September 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28927130/stereomicroscopic-features-of-colitis-associated-tumors-in-mice-evaluation-of-pit-pattern
#8
Ryosuke Yamauchi, Ken Kominato, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Hiroshi Yamasaki, Shuhei Fukunaga, Atsushi Mori, Jun Akiba, Osamu Tsuruta, Takuji Torimura
Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present study examined whether stereomicroscopic observations with dye-application were able to detect and discriminate tumors in a colitis-associated tumor model in mice. Colonic tumors were induced in C57BL/6 mice by 15 cycles of treatment with dextran sulfate sodium (DSS) in drinking water...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28922695/strategies-for-detecting-colon-cancer-in-patients-with-inflammatory-bowel-disease
#9
REVIEW
William A Bye, Tran M Nguyen, Claire E Parker, Vipul Jairath, James E East
BACKGROUND: Patients with longstanding ulcerative colitis and colonic Crohn's disease have an increased risk of colorectal cancer (CRC) compared with the general population. This review assessed the evidence that endoscopic surveillance may prolong life by allowing earlier detection of CRC or its pre-cursor lesion, dysplasia, in patients with inflammatory bowel disease (IBD). OBJECTIVES: To assess the effectiveness of cancer surveillance programs for diagnosis of IBD-associated colorectal cancer and in reducing the mortality rate from colorectal cancer in patients with IBD...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28884228/expression-of-atf6-as-a-marker-of-pre-cancerous-atypical-change-in-ulcerative-colitis-associated-colorectal-cancer-a-potential-role-in-the-management-of-dysplasia
#10
Marie Hanaoka, Toshiaki Ishikawa, Megumi Ishiguro, Michiyo Tokura, Shinichi Yamauchi, Akifumi Kikuchi, Hiroyuki Uetake, Masamichi Yasuno, Tatsuyuki Kawano
BACKGROUND: Diagnosis of low-grade dysplasia (LGD) is important in the management of ulcerative colitis (UC), but it is often difficult to distinguish LGD from inflammatory regenerative epithelium. The unfolded protein response (UPR) is activated in inflammatory bowel disease and malignancies. We aimed to identify a UPR-related gene that is involved in the development of non-UC and UC-associated colorectal cancer (CRC), and to investigate whether the target gene is useful for the diagnosis of LGD...
September 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28882578/surgery-versus-surveillance-in-ulcerative-colitis-patients%C3%A2-with%C3%A2-endoscopically-invisible-low-grade-dysplasia-a-cost-effectiveness-analysis
#11
Ben Parker, James Buchanan, Sarah Wordsworth, Satish Keshav, Bruce George, James E East
BACKGROUND AND AIMS: There is uncertainty regarding the optimal management of endoscopically invisible (flat) low-grade dysplasia in ulcerative colitis. Such a finding does not currently provide an automatic indication for colectomy; however, a recommendation of surveillance instead of surgery is controversial. The aim of this study was to determine the clinical and cost-effectiveness of colonoscopic surveillance versus colectomy for endoscopically invisible low-grade dysplasia of the colon in ulcerative colitis...
December 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28843232/colorectal-cancer-and-precancerous-lesions-associated-with-ulcerative-colitis-in-thailand
#12
Peranart Chotivitayatarakorn, Ratha-Korn Vilaichone
Background: Ulcerative colitis(UC) is important risk factor of colorectal cancer. Many evidences from western countries confirmed this relationship but limited studies were reported in ASEAN. This study was aimed to investigate prevalence, clinical presentations, endoscopic findings, histopathology, disease progression and risk for colorectal cancer(CRC) of UC patients in Thailand. Methods: We conducted a retrospective cohort study using computer data base from Thammasat University Hospital, Pathumthani, Thailand between September 2011 and December 2015, follow-up through May 2016...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28839872/advanced-imaging-in-colonoscopy-contemporary-approach-to-dysplasia-surveillance-in-inflammatory-bowel-disease
#13
Iosif Beintaris, Matt Rutter
Inflammatory bowel disease (IBD) (ulcerative colitis (UC) and Crohn's disease (CD)) is a chronic relapsing/remitting condition characterised by intestinal inflammation. One of the main concerns in patients with longstanding ulcerative and Crohn's colitis is development of colonic dysplasia and colorectal cancer (CRC), a risk higher than that of the general population. Colonoscopy surveillance programmes have been developed by major societies worldwide to improve early dysplasia detection and treatment, thus preventing progression to colorectal cancer...
October 2016: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28836702/results-of-a-36-year-surveillance-program-for-ulcerative-colitis-associated-neoplasia-in-the-japanese-population
#14
Junko Kishikawa, Hata Keisuke, Shinsuke Kazama, Hiroyuki Anzai, Takahide Shinagawa, Koji Murono, Manabu Kaneko, Kazuhito Sasaki, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Teppei Morikawa, Masashi Fukayama, Toshiaki Watanabe
BACKGROUND: Surveillance colonoscopy has been performed for patients with long-standing ulcerative colitis, who have an increased risk for colorectal cancer. The aim of this study was to determine the incidence of and the risk factors for neoplasia. METHODS: We evaluated 289 ulcerative colitis patients who underwent surveillance colonoscopy between January1979 and December 2014. The cumulative incidence of neoplasia and its risk factors were investigated. The clinical stage and overall survival were compared between the surveillance and non-surveillance groups...
August 24, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28826742/a-comprehensive-review-and-update-on-crohn-s-disease
#15
Mahesh Gajendran, Priyadarshini Loganathan, Anthony P Catinella, Jana G Hashash
The term inflammatory bowel disease (IBD) refers principally to two major categories of chronic relapsing inflammatory intestinal disorders: Crohn's disease (CD) and ulcerative colitis (UC). In the United States, it is currently estimated that about 1.5 million people suffer from IBD, causing considerable suffering, mortality and economic loss every year. Yet the cause of IBD is unknown, and until we understand more, prevention or cure will not be possible. There is a lot of variation in the incidence and prevalence of CD based on geographic region, environment, immigrant population, and ethnic groups...
August 18, 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/28818507/optimizing-quality-of-endoscopy-in-inflammatory-bowel-disease-focus-on-surveillance-and-management-of-colorectal-dysplasia-using-interactive-image-and-video-based-teaching
#16
Tonya R Kaltenbach, Roy M Soetikno, Rebecca DeVivo, Loren A Laine, Alan Barkun, Kenneth R McQuaid
BACKGROUND & AIMS: Varying recommendations regarding the detection and management of dysplasia can lead to uncertainty and may have impeded the uptake of strategies that could improve surveillance in patients with inflammatory bowel disease (IBD). As such, an educational event was held to assist in disseminating the recently published Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations (SCENIC)...
August 14, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28814670/mtg16-is-a-tumor-suppressor-in-colitis-associated-carcinoma
#17
Elizabeth M McDonough, Caitlyn W Barrett, Bobak Parang, Mukul K Mittal, J Joshua Smith, Amber M Bradley, Yash A Choksi, Lori A Coburn, Sarah P Short, Joshua J Thompson, Baolin Zhang, Shenika V Poindexter, Melissa A Fischer, Xi Chen, Jiang Li, Frank L Revetta, Rishi Naik, M Kay Washington, Michael J Rosen, Scott W Hiebert, Keith T Wilson, Christopher S Williams
MTG16 is a member of the myeloid translocation gene (MTG) family of transcriptional corepressors. While MTGs were originally identified in chromosomal translocations in acute myeloid leukemia, recent studies have uncovered a role in intestinal biology. For example, Mtg16-/- mice have increased intestinal proliferation and are more sensitive to intestinal injury in colitis models. MTG16 is also underexpressed in patients with moderate/severe ulcerative colitis. Based on these findings, we postulated that MTG16 might protect against colitis-associated carcinogenesis...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28811707/myo-inositol-reduces-%C3%AE-catenin-activation-in-colitis
#18
Emily M Bradford, Corey A Thompson, Tatiana Goretsky, Guang-Yu Yang, Luz M Rodriguez, Linheng Li, Terrence A Barrett
AIM: To assess dietary myo-inositol in reducing stem cell activation in colitis, and validate pβ-catenin(S552) as a biomarker of recurrent dysplasia. METHODS: We examined the effects of dietary myo-inositol treatment on inflammation, pβ-catenin(S552) and pAkt levels by histology and western blot in IL-10(-/-) and dextran sodium sulfate-treated colitic mice. Additionally, we assessed nuclear pβ-catenin(S552) in patients treated with myo-inositol in a clinical trial, and in patients with and without a history of colitis-induced dysplasia...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28806821/endoscopic-submucosal-dissection-of-colitis-related-dysplasia
#19
Noriko Suzuki, Takashi Toyonaga, James E East
Background and study aims Endoscopic submucosal dissection (ESD) offers en bloc resection of lesions, allowing precise pathological assessment. Although possible in ulcerative colitis (UC) patients, the chronic inflammation may increase the procedural risks and reduce the complete resection rate. The aim of this study was to assess the feasibility of ESD for UC and to consider the factors contributing to its technical difficulty. Patients and methods Multicenter experiences of ESD for UC were retrospectively analyzed by reviewing endoscopic videos, pictures, reports, and clinical notes...
August 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/28790093/aggressive-large-cell-neuroendocrine-carcinoma-of-the-sigmoid-colon-in-a-patient-with-ulcerative-colitis
#20
Patrick Stoner, Taban Ghaffaripour, David Cohen
Colonic inflammation seen in inflammatory bowel disease (IBD) predisposes to the development of colorectal adenocarcinoma. In contrast, colorectal neuroendocrine carcinomas (NECs) have rarely been reported in the setting of IBD, and no definitive relationship between these tumours and IBD has been established. Dysplasia from chronic inflammation leading to neuroendocrine cell differentiation may be responsible for NEC development, though this finding has not been seen consistently. We present a case of large-cell neuroendocrine carcinoma of the sigmoid colon in a 65-year-old woman with long-standing ulcerative colitis...
August 7, 2017: BMJ Case Reports
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