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Dysplasia in ulcerative colitis

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https://www.readbyqxmd.com/read/27906680/chemopreventive-effects-of-5-aminosalicylic-acid-on-inflammatory-bowel-disease-associated-colorectal-cancer-and-dysplasia-a-systematic-review-with-meta-analysis
#1
Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang
BACKGROUND AND AIMS: The chemopreventive effect of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) has been widely studied; however, the results remain conflicting. The aim of this study was to systematically review the literature and update evidence concerning effects of 5-ASA on the risk of colorectal cancer (CRC) and dysplasia (Dys) in patients with ulcerative colitis (UC) or Crohn's disease (CD). RESULTS: 5-ASA showed a chemopreventive effect against CRC/Dys in IBD patients (OR = 0...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27890853/chromoendoscopy-for-surveillance-in-ulcerative-colitis-and-crohn-s-disease-a-systematic-review-of-randomized-trials
#2
REVIEW
Andrea Iannone, Marinella Ruospo, Germaine Wong, Mariabeatrice Principi, Michele Barone, Giovanni Fm Strippoli, Alfredo Di Leo
BACKGROUND & AIMS: Key international guideline agencies recommend dysplasia surveillance in inflammatory bowel diseases with chromoendoscopy. We performed a systematic review of randomized trials comparing chromoendoscopy versus other endoscopic techniques for dysplasia surveillance in inflammatory bowel diseases. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials for relevant studies published through September 2016. We estimated risk ratios (RR) for dichotomous outcomes (all-cause/colorectal cancer-related mortality, time to interval cancer, patients with dysplasia, total/subtypes of dysplastic lesions, dysplasia detected by targeted biopsies, adverse events), mean differences (MD) for continuous outcomes (procedural time, costs, total/targeted biopsies) and their 95% confidence intervals (CI) using a random-effects model...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27884517/endoscopic-morphological-features-of-ulcerative-colitis-associated-dysplasia-classified-according-to-the-scenic-consensus-statement
#3
Shinya Sugimoto, Makoto Naganuma, Yasushi Iwao, Katsuyoshi Matsuoka, Masayuki Shimoda, Shuji Mikami, Shinta Mizuno, Yoshihiro Nakazato, Kosaku Nanki, Nagamu Inoue, Haruhiko Ogata, Takanori Kanai
BACKGROUND AND AIMS: Recent advances in endoscopic equipment and diagnostic techniques have made possible the detection of early dysplasia in the inflamed mucosa of ulcerative colitis (UC). The SCENIC consensus statement recommends the use of unified terminology for the morphology of dysplasia. In this study, we investigated the endoscopic features of high-grade dysplasia (HGD) in a clinical setting. METHODS: We retrospectively identified 62 patients with UC who were diagnosed with colitis-associated cancer or HGD between 1997 and 2015...
November 21, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27878770/a-low-cost-method-for-chromoendoscopy-for-surveillance-in-ulcerative-colitis
#4
Sawan Bopanna, Saurabh Kedia, Vineet Ahuja
The risk of colorectal cancer in Indian patients with long-standing ulcerative colitis is high and similar to that in the West. Surveillance for dysplasia in these patients is therefore important. Recent studies and guidelines suggest an increasing role for chromoendoscopy-guided biopsy in surveillance for dysplasia. We report our experience with the technique of chromoendoscopy and an economical method of performing it. Reconstituting indigo carmine from a powder form rather than the dyes available commercially is a better economical alternative and should help make chromoendoscopy the standard of care for dysplasia surveillance across the country...
November 23, 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27853744/clinical-usefulness-of-narrow-band-imaging-magnifying-colonoscopy-for-assessing-ulcerative-colitis-associated-cancer-dysplasia
#5
Soki Nishiyama, Shiro Oka, Shinji Tanaka, Shintaro Sagami, Ryohei Hayashi, Yoshitaka Ueno, Koji Arihiro, Kazuaki Chayama
Background and study aims: Colitis-associated cancer/dysplasia (CC/D) can affect the life expectancy of patients with ulcerative colitis (UC). Although the utility of magnifying chromocolonoscopy has been shown, the use of optical magnification with narrow band imaging (NBI) for distinguishing CC/D from non-neoplastic lesions in patients with UC has not been reported. We evaluated whether endoscopic findings are distinguishing and thus assessed the clinical usefulness of NBI magnification for differentiating UC-associated lesions...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27843448/could-total-colectomy-with-ileorectal-anastomosis-be-an-alternative-to-total-proctocolectomy-with-ileal-pouch-anal-anastomosis-in-selected-ulcerative-colitis-patients
#6
Francesco Tonelli, Carmela Di Martino, Francesco Giudici
Purpose. To evaluate ileorectal anastomosis (IRA) in selected ulcerative colitis patients. Methods. Early and late complications after IRA and IPAA were investigated. Bowel function and quality of life were assessed. Functional and QoL studies were performed as a matched pair analysis, comparing 98 patients who underwent IRA versus 98 patients who underwent IPAA. Results. In IRA group, 2 patients (1.6%) developed anastomotic l dysplasia (HGD) developed in 3 patients dysplasia (HGD) developed in 3 patients eakage, 1 patient (0...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27766414/combining-aneuploidy-and-dysplasia-for-colitis-cancer-risk-assessment-outperforms-current-surveillance-efficiency-a-meta-analysis
#7
Rüdiger Meyer, Sandra Freitag-Wolf, Silke Blindow, Jürgen Büning, Jens K Habermann
PURPOSE: Cancer risk assessment for ulcerative colitis patients by evaluating histological changes through colonoscopy surveillance is still challenging. Thus, additional parameters of high prognostic impact for the development of colitis-associated carcinoma are necessary. This meta-analysis was conducted to clarify the value of aneuploidy as predictor for individual cancer risk compared with current surveillance parameters. METHODS: A systematic web-based search identified studies published in English that addressed the relevance of the ploidy status for individual cancer risk during surveillance in comparison to neoplastic mucosal changes...
October 20, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27679553/colorectal-cancer-and-dysplasia-in-inflammatory-bowel-disease-a-review-of-disease-epidemiology-pathophysiology-and-management
#8
REVIEW
Parambir S Dulai, William J Sandborn, Samir Gupta
Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) characterized by recurrent episodes of mucosal inflammation. This chronic mucosal inflammation has several potential consequences, one of which is the occurrence of colitis-associated colorectal cancer. Over the past decade, our understanding of the epidemiology, pathophysiology, and overall approach to diagnosing and managing colitis-associated colorectal cancer has grown considerably. In the current review article, we outline these advancements and highlight areas in need of further research...
December 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27672285/biomarkers-for-colitis-associated-colorectal-cancer
#9
REVIEW
Ru Chen, Lisa A Lai, Teresa A Brentnall, Sheng Pan
Patients with extensive ulcerative colitis (UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. Using a wide range of molecular techniques - including cutting-edge OMICS technologies - recent studies have identified clinically relevant biomarker candidates from a variety of biosamples, including colonic biopsies, blood, stool, and urine. While the challenge remains to validate these candidate biomarkers in multi-center studies and with larger patient cohorts, it is certain that accurate biomarkers of colitis-associated neoplasia would improve clinical management of neoplastic risk in UC patients...
September 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27664423/phip-dss-induced-colon-carcinogenesis-in-cyp1a-humanized-mice-and-the-possible-role-of-lgr5-stem-cells
#10
Jayson X Chen, Hong Wang, Anna Liu, Lanjing Zhang, Kenneth Reuhl, Chung S Yang
In the past decades, experimental rodent models developed to study the pathogenesis of human colorectal cancer (CRC) generally employed synthetic chemical carcinogens or genetic manipulation. Our lab, in order to establish a more physiologically relevant CRC model, recently developed a colon carcinogenesis model induced by the meat-derived dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and promoted by dextran sodium sulfate (DSS)-induced colitis in the cytochrome P450 1A-humanized (hCYP1A) mice...
September 23, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27613257/low-rate-of-dysplasia-detection-in-mucosa-surrounding-dysplastic-lesions-in-patients-undergoing-surveillance-for-inflammatory-bowel-diseases
#11
Joren R Ten Hove, Erik Mooiweer, Evelien Dekker, Andrea E van der Meulen-de Jong, G Johan A Offerhaus, Cyriel Y Ponsioen, Peter D Siersema, Bas Oldenburg
BACKGROUND & AIMS: When dysplastic lesions are encountered during surveillance colonoscopy of patients with inflammatory bowel disease (IBD), guidelines recommend collection of additional biopsies from the surrounding mucosa to ensure the lesion has been adequately circumscribed. We aimed to determine the rate of dysplasia in mucosa biopsies collected from tissues surrounding dysplastic lesions during IBD surveillance. METHODS: In a retrospective study, we collected endoscopy and pathology reports from 1065 patients undergoing colonoscopic surveillance for IBD from 2000 through 2015 at 3 centers in the Netherlands...
September 6, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27578918/expression-profile-of-p53-and-p21-in-large-bowel-mucosa-as-biomarkers-of-inflammatory-related-carcinogenesis-in-ulcerative-colitis
#12
Cristiana Popp, Luciana Nichita, Theodor Voiosu, Alexandra Bastian, Mirela Cioplea, Gianina Micu, Gabriel Pop, Liana Sticlaru, Andreea Bengus, Andrei Voiosu, Radu Bogdan Mateescu
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease that slightly increases the risk of colorectal cancer in patients with long-standing extended disease. Overexpression of p53 and p21 in colonic epithelia is usually detected in UC patients when no dysplasia is histologically seen and it is used by pathologists as a discriminator between regenerative changes and intraepithelial neoplasia, as well as a tissue biomarker useful to predict the risk of evolution toward malignancy. We present a one-year prospective observational study including a cohort of 45 patients with UC; p53 and p21 were evaluated in epithelial cells...
2016: Disease Markers
https://www.readbyqxmd.com/read/27500367/effect-of-appendicectomy-on-colonic-inflammation-and-neoplasia-in-experimental-ulcerative-colitis
#13
Y Harnoy, Y Bouhnik, N Gault, L Maggiori, L Sulpice, D Cazals-Hatem, K Boudjema, Y Panis, E Ogier-Denis, X Treton
BACKGROUND: Ulcerative colitis (UC) promotes cancer, and can be ameliorated by early appendicectomy for appendicitis. The aim of the study was to explore the effect of appendicectomy on colitis and colonic neoplasia in an animal model of colitis and a cohort of patients with UC. METHODS: Five-week old IL10/Nox1(DKO) mice with nascent colitis and 8-week-old IL10/Nox1(DKO) mice with established colitis underwent appendicectomy (for experimental appendicitis or no appendicitis) or sham laparotomy...
October 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27464589/stool-dna-analysis-is-cost-effective-for-colorectal-cancer-surveillance-in-patients-with-ulcerative-colitis
#14
John B Kisiel, Gauree G Konijeti, Andrew J Piscitello, Tarun Chandra, Thomas F Goss, David A Ahlquist, Francis A Farraye, Ashwin N Ananthakrishnan
BACKGROUND & AIMS: Patients with chronic ulcerative colitis are at increased risk for colorectal neoplasia (CRN). Surveillance by white-light endoscopy (WLE) or chromoendoscopy may reduce risk of CRN, but these strategies are underused. Analysis of DNA from stool samples (sDNA) can detect CRN with high levels of sensitivity, but it is not clear if this approach is cost-effective. We simulated these strategies for CRN detection to determine which approach is most cost-effective. METHODS: We adapted a previously published Markov model to simulate the clinical course of chronic ulcerative colitis, the incidence of cancer or dysplasia, and costs and benefits of care with 4 surveillance strategies: (1) analysis of sDNA and diagnostic chromoendoscopy for patients with positive results, (2) analysis of sDNA with diagnostic WLE for patients with positive results, (3) chromoendoscopy with targeted collection of biopsies, or (4) WLE with random collection of biopsies...
December 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27450459/ulcerative-colitis-associated-with-nephrotic-syndrome-after-treatment-with-mesalazine-developed-into-rectal-carcinoma-a-case-study
#15
Shinichi Sameshima, Shinichiro Koketsu, Takashi Okuyama, Yawara Kubota, Yuko Ono, Tamaki Noie, Masatoshi Oya
BACKGROUND: Previous studies reported that nephrotic syndrome is associated with ulcerative colitis (UC) patients treated with mesalazine. Dysplasia associated with UC often develops into colorectal carcinoma. CASE PRESENTATION: A 17-year-old man was referred to our hospital, complaining of diarrhea and bloody stool. Total colonoscopy (TC) was performed and total-type UC was diagnosed. After treatment with mesalazine for 5 years, a low-grade dysplasia (LGD) was detected in the rectum by histological analysis of a biopsy sample...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27433149/role-of-random-biopsies-in-surveillance-of-dysplasia-in-ulcerative-colitis-patients-with-high-risk-of-colorectal-cancer
#16
Sawan Bopanna, Maitreyee Roy, Prasenjit Das, S Dattagupta, V Sreenivas, V Pratap Mouli, Saurabh Kedia, Rajan Dhingra, Rajesh Pradhan, N Suraj Kumar, Dawesh P Yadav, Govind Makharia, Vineet Ahuja
BACKGROUND/AIMS: Recent data suggest that the incidence of ulcerative colitis (UC) related colorectal cancer (CRC) in India is similar to that of West. The optimum method for surveillance is still a debate. Surveillance with random biopsies has been the standard of care, but is a tedious process. We therefore undertook this study to assess the yield of random biopsy in dysplasia surveillance. METHODS: Between March 2014 and July 2015, patients of UC attending the Inflammatory Bowel Disease clinic at the All India Institute of Medical Sciences with high risk factors for CRC like duration of disease >15 years and pancolitis, family history of CRC, primary sclerosing cholangitis underwent surveillance colonoscopy for dysplasia...
July 2016: Intestinal Research
https://www.readbyqxmd.com/read/27431978/efficiency-of-colorectal-cancer-surveillance-in-patients-with-ulcerative-colitis-38-years-experience-in-a-patient-cohort-from-a-defined-population-area
#17
M Rutegård, R Palmqvist, R Stenling, J Lindberg, J Rutegård
BACKGROUND AND AIMS: Ulcerative colitis increases the risk of developing colorectal cancer. Colonoscopic surveillance is recommended although there are no randomized trials evaluating the efficacy of such a strategy. This study is an update of earlier studies from an ongoing colonoscopic surveillance program. MATERIAL AND METHODS: All patients with ulcerative colitis were invited to the surveillance program that started in 1977 at Örnsköldsvik Hospital, located in the northern part of Sweden...
July 18, 2016: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/27379390/altered-plasma-levels-of-decanoic-acid-in-colorectal-cancer-as-a-new-diagnostic-biomarker
#18
Sara Crotti, Elisa Agnoletto, Gabriella Cancemi, Valerio Di Marco, Pietro Traldi, Salvatore Pucciarelli, Donato Nitti, Marco Agostini
Colorectal cancer (CRC) is one of the most common tumors in developed countries. The five-year survival rate decreases depending on how advanced the CRC is when first diagnosed. Screening has been proven to greatly reduce mortality from colorectal cancer, but an ideal screening tool is far from being established. Here, we aimed to discover and validate early CRC biomarkers by means of an untargeted/targeted metabolomic approach. A preliminary untargeted analysis of plasma lipids performed on a small patient cohort (30 plasma samples) revealed some alterations that occurred in the presence of this tumor...
September 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27280713/downregulation-of-the-deiminase-padi2-is-an-early-event-in-colorectal-carcinogenesis-and-indicates-poor-prognosis
#19
Neus Cantariño, Eva Musulén, Vanesa Valero, Miquel Angel Peinado, Manuel Perucho, Victor Moreno, Sònia-Vanina Forcales, Julien Douet, Marcus Buschbeck
UNLABELLED: Peptidyl arginine deiminases (PADI) are a family of enzymes that catalyze the poorly understood posttranslational modification converting arginine residues into citrullines. In this study, the role of PADIs in the pathogenesis of colorectal cancer was investigated. Specifically, RNA expression was analyzed and its association with survival in a cohort of 98 colorectal cancer patient specimens with matched adjacent mucosa and 50 controls from donors without cancer. Key results were validated in an independent collection of tumors with matched adjacent mucosa and by mining of a publicly available expression data set...
September 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27245408/helicobacter-saguini-a-novel-helicobacter-isolated-from-cotton-top-tamarins-with-ulcerative-colitis-has-proinflammatory-properties-and-induces-typhlocolitis-and-dysplasia-in-gnotobiotic-il-10-mice
#20
Z Shen, A Mannion, M T Whary, S Muthupalani, A Sheh, Y Feng, G Gong, P Vandamme, H R Holcombe, B J Paster, J G Fox
A urease-negative, fusiform, novel bacterium named Helicobacter saguini was isolated from the intestines and feces of cotton-top tamarins (CTTs) with chronic colitis. Helicobacter sp. was detected in 69% of feces or intestinal samples from 116 CTTs. The draft genome sequence, obtained by Illumina MiSeq sequencing, for H. saguini isolate MIT 97-6194-5, consisting of ∼2.9 Mb with a G+C content of 35% and 2,704 genes, was annotated using the NCBI Prokaryotic Genomes Automatic Annotation Pipeline. H. saguini contains homologous genes of known virulence factors found in other enterohepatic helicobacter species (EHS) and H...
August 2016: Infection and Immunity
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