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Dysplasia in ulcerative colitis

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https://www.readbyqxmd.com/read/29780594/role-of-endoscopy-in-inflammatory-bowel-disease
#1
REVIEW
Shishira Bharadwaj, Neeraj Narula, Parul Tandon, Mohammad Yaghoobi
Crohn's disease (CD) and ulcerative colitis (UC) constitute the two most common phenotypes of inflammatory bowel disease (IBD). Ileocolonoscopy with biopsy has been considered the gold standard for the diagnosis of IBD. Differential diagnosis of CD and UC is important, as their medical and surgical treatment modalities and prognoses can be different. However, approximately 15% of patients with IBD are misdiagnosed as IBD unclassified due to the lack of diagnostic certainty of CD or UC. Recently, there has been increased recognition of the role of the therapeutic endoscopist in the field of IBD...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29775793/analysis-of-dna-methylation-at-specific-loci-in-stool-samples-detects-colorectal-cancer-and-high-grade-dysplasia-in-patients-with-inflammatory-bowel-disease
#2
John B Kisiel, Pasquale Klepp, Hatim T Allawi, William R Taylor, Maria Giakoumopoulos, Tamara Sander, Tracy C Yab, Bjorn A Moum, Graham P Lidgard, Stephan Brackmann, Douglas W Mahoney, Arne Roseth, David A Ahlquist
BACKGROUND & AIMS: Patients with inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are at increased risk for colorectal cancer (CRC). Analyses of DNA methylation patterns in stool samples have been reported to detect CRC in patients with IBD. We sought to validate these findings in larger cohorts and assess the accuracy of analysis of DNA methylation patterns in stool for detection of CRC and high-grade dysplasia (HGD) normalized to methylation level at ZDHHC1...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29771698/updates-in-colorectal-cancer-screening-in-inflammatory-bowel-disease
#3
William T Clarke, Joseph D Feuerstein
PURPOSE OF REVIEW: This review article will discuss the risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD), as well as the current recommendations for CRC screening and surveillance in patients with ulcerative colitis or Crohn's colitis involving one-third of the colon. RECENT FINDINGS: Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...
May 15, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29762666/discovery-and-validation-of-methylation-biomarkers-for-ulcerative-colitis-associated-neoplasia
#4
Andrew D Beggs, Jonathan James, Germaine Caldwell, Toby Prout, Mark P Dilworth, Phillipe Taniere, Tariq Iqbal, Dion G Morton, Glenn Matthews
Background and aims: Ulcerative colitis (UC) is associated with a higher background risk of dysplasia and/or neoplasia due to chronic inflammation. There exist few biomarkers for identification of patients with dysplasia, and targeted biopsies in this group of patients are inaccurate in reliably identifying dysplasia. We aimed to examine the epigenome of UC dysplasia and to identify and validate potential biomarkers. Methods: Colonic samples from patients with UC-associated dysplasia or neoplasia underwent epigenome-wide analysis on the Illumina 450K methylation array...
May 14, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29743830/predicting-outcomes-to-optimize-disease-management-in-inflammatory-bowel-disease-in-japan-their-differences-and-similarities-to-western-countries
#5
REVIEW
Taku Kobayashi, Tadakazu Hisamatsu, Yasuo Suzuki, Haruhiko Ogata, Akira Andoh, Toshimitsu Araki, Ryota Hokari, Hideki Iijima, Hiroki Ikeuchi, Yoh Ishiguro, Shingo Kato, Reiko Kunisaki, Takayuki Matsumoto, Satoshi Motoya, Masakazu Nagahori, Shiro Nakamura, Hiroshi Nakase, Tomoyuki Tsujikawa, Makoto Sasaki, Kaoru Yokoyama, Naoki Yoshimura, Kenji Watanabe, Miiko Katafuchi, Mamoru Watanabe, Toshifumi Hibi
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the gastrointestinal tract, with increasing prevalence worldwide. IBD Ahead is an international educational program that aims to explore questions commonly raised by clinicians about various areas of IBD care and to consolidate available published evidence and expert opinion into a consensus for the optimization of IBD management. Given differences in the epidemiology, clinical and genetic characteristics, management, and prognosis of IBD between patients in Japan and the rest of the world, this statement was formulated as the result of literature reviews and discussions among Japanese experts as part of the IBD Ahead program to consolidate statements of factors for disease prognosis in IBD...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29724427/acr-appropriateness-criteria-%C3%A2-colorectal-cancer-screening
#6
Courtney Moreno, David H Kim, Twyla B Bartel, Brooks D Cash, Kevin J Chang, Barry W Feig, Kathryn J Fowler, Evelyn M Garcia, Avinash R Kambadakone, Drew L Lambert, Angela D Levy, Daniele Marin, Christine M Peterson, Christopher D Scheirey, Martin P Smith, Stefanie Weinstein, Laura R Carucci
This review summarizes the relevant literature regarding colorectal screening with imaging. For individuals at average or moderate risk for colorectal cancer, CT colonography is usually appropriate for colorectal cancer screening. After positive results on a fecal occult blood test or immunohistochemical test, CT colonography is usually appropriate for colorectal cancer detection. For individuals at high risk for colorectal cancer (eg, hereditary nonpolyposis colorectal cancer, ulcerative colitis, or Crohn colitis), optical colonoscopy is preferred because of its ability to obtain biopsies to detect dysplasia...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29718243/the-impact-of-age-at-time-of-ileal-pouch-anal-anastomosis-on-short-and-long-term-outcomes-in-adults
#7
Nicholas P McKenna, Kellie L Mathis, John H Pemberton, Amy L Lightner
Background: There is limited knowledge on ileal pouch anal anastomosis (IPAA) function when performed on patients older than age 50 years. The aim of this study was to determine if surgery on those older than age 50 years impacts short-term complications or long-term function. Methods: A retrospective review of all patients undergoing IPAA for chronic ulcerative colitis at a single tertiary referral center between 2002 and 2013 was conducted. Short-term postoperative complications and long-term function and quality of life were analyzed according to age at pouch formation (age >50 vs age ≤50 years)...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688465/low-incidence-of-dysplasia-and-colorectal-cancer-observed-among-inflammatory-bowel-disease-patients-with-prolonged-colonic-diversion
#8
Weston Bettner, Anthony Rizzo, Steven Brant, Sharon Dudley-Brown, Jonathan Efron, Sandy Fang, Susan Gearhart, Michael Marohn, Alyssa Parian, Maryam Kherad Pezhouh, Joanna Melia, Bashar Safar, Brindusa Truta, Elizabeth Wick, Mark Lazarev
Background: In inflammatory bowel disease (IBD), many scenarios call for fecal diversion, leaving behind defunctionalized bowel. The theoretical risk of colorectal cancer (CRC) in this segment is frequently cited as a reason for resection. To date, no studies have characterized the incidence of neoplasia in the diverted colorectal segments of IBD patients. Methods: A retrospective cohort analysis was conducted for IBD patients identified through a tertiary care center pathology database...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29673364/colorectal-dysplasia-and-adenocarcinoma-in-patients-with-ulcerative-colitis-an-experience-from-a-tertiary-care-hospital
#9
Naila Younus, Mariam Abid, Atif Ali Hashmi, Saher Aijaz, Muhammad Muzzammil Edhi, Ahmareen Khalid Sheikh, Amir Khan
BACKGROUND: The rationale behind this study was to find out the frequency of dysplasia and colorectal cancer (CRC) in young patients with ulcerative colitis (UC) using histopathological examination. This facilitated early detection of dysplasia and CRC by regular endoscopic biopsies and also guided physicians on appropriate surveillance and management, thus improved outcome. METHODS: It was a prospective cross-sectional study conducted at the Department of Pathology, PIMS, Islamabad...
April 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29668968/outcomes-of-endoscopic-resections-of-large-laterally-spreading-colorectal-lesions-in-inflammatory-bowel-disease-a-single-united-kingdom-center-experience
#10
Shraddha Gulati, Andrew Emmanuel, Margaret Burt, Patrick Dubois, Bu'Hussain Hayee, Amyn Haji
Background: The SCENIC consensus statement recommends endoscopic resection of all visible dysplasia in inflammatory bowel disease, but patients with large or complex lesions may still be advised to have colectomy. This article presents outcomes for large nonpolypoid resections associated with colitis at our institution. Methods: Data including demographics, clinical history, lesion characteristics, method of resection, and postresection surveillance were collected prospectively in patients with visible lesions within colitic mucosa from January 2011 to November 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668929/chromoendoscopy-for-dysplasia-surveillance-in-inflammatory-bowel-disease
#11
Ann D Flynn, John F Valentine
Long-standing ulcerative colitis (UC) and extensive Crohn's colitis confer increased risk for development of colorectal cancer. Screening and surveillance colonoscopy programs aim to identify, resect, or detect dysplasia or colorectal cancer. Dysplastic lesions can be removed by endoscopic resection and patients with unresectable lesions can be referred for colectomy at an earlier stage, with the goal of reducing overall morbidity and mortality from colorectal cancer. Surveillance colonoscopy for patients with inflammatory bowel disease (IBD) is endorsed by multiple specialty societies...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29617680/the-role-of-crush-cytology-in-the-diagnosis-of-large-intestine-lesions-with-correlation-on-histopathology
#12
Chaithra Gv, Debarshi Saha, Richa Yadav, Deepa S Adiga, Flore D Lobo, Apurv Ghosh, Jyoti Kini
OBJECTIVE: To study the efficacy of colonoscopic crush cytology as a convenient and near-accurate method to evaluate colonic neoplasms. STUDY DESIGN: Retrospective and cross-sectional. The original cytologic diagnoses were correlated with a histology report on 100 cases sent to the cytology laboratory over 2 years. RESULTS: Of the 100 cases, 25 were nonmalignant. Of the 75 malignant lesions, 72 could be identified as positive for malignancy on cytology...
April 4, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29599347/morphological-classification-of-corrupted-colonic-crypts-in-ulcerative-colitis
#13
Carlos A Rubio, Peter T Schmidt
BACKGROUND/AIM: In ulcerative colitis (UC) the colonic mucosa shows, in addition to a high number of inflammatory cells, crypts with architectural distortions, called corrupted colonic crypts (CCC). Here we classify the histologic repertoire and assess the frequency of CCC in UC. PATIENTS AND METHODS: Five-hundred and sixteen histologic sections from 29 colectomy specimens with UC (24 having adenocarcinoma and five, high-grade dysplasia, HGD) were reviewed. RESULTS: The vast majority of the colonic mucosa portrayed countless crypts with normal shapes (CNS) lined with normal epithelium, except for 45 CNS: 28 showed inconclusive-suspected cellular changes (ISCC), and 17, high-grade dysplasia (HGD)...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29594739/the-ibd-and-psc-phenotypes-of-psc-ibd
#14
REVIEW
Amanda Ricciuto, Binita M Kamath, Anne M Griffiths
PURPOSE OF REVIEW: To review the characteristics of IBD and PSC that occur in association, as well as their reciprocal influences on disease evolution, in adult and pediatric populations. RECENT FINDINGS: IBD co-existing with PSC is genetically and clinically distinct from IBD alone. It is frequently characterized by pancolitis, rectal sparing, and possibly backwash ileitis, as well as a threefold increased risk of colorectal dysplasia. Adults and children with colitis and PSC appear to be at increased risk of active endoscopic and histologic disease in the absence of symptoms compared to individuals without PSC...
March 28, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29567006/chromoendoscopy-versus-autofluorescence-imaging-for-neoplasia-detection-in-patients-with-longstanding-ulcerative-colitis-find-uc-an-international-multicentre-randomised-controlled-trial
#15
Jasper L A Vleugels, Matt D Rutter, Krish Ragunath, Colin J Rees, Cyriel Y Ponsioen, Conor Lahiff, Shara N Ket, Linda K Wanders, Sunil Samuel, Faheem Butt, Teaco Kuiper, Simon P L Travis, Geert D'Haens, Lai M Wang, Susanne van Eeden, James E East, Evelien Dekker
BACKGROUND: Patients with longstanding ulcerative colitis undergo regular dysplasia surveillance because they have an increased colorectal cancer risk. Autofluorescence imaging and chromoendoscopy improve dysplasia detection. The aim of this study was to determine whether autofluorescence imaging should be further studied as an alternative method for dysplasia surveillance in patients with longstanding ulcerative colitis. METHODS: This prospective, international, randomised controlled trial included patients from an ulcerative colitis-dysplasia surveillance cohort from five centres in the Netherlands and the UK...
May 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29567005/is-autofluorescence-inferior-to-chromoendoscopy-for-dysplasia-detection-in-ulcerative-colitis
#16
Michael F Picco
No abstract text is available yet for this article.
March 19, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29560697/dysplasia-in-inflammatory-bowel-disease
#17
REVIEW
A Driessen, E Macken, T Moreels, A Jouret-Mourin
Ulcerative colitis and Crohn's diseases are relapsing longstanding inflammatory bowel diseases, associated with an increased risk of developing colorectal cancer. Continuous surveillance is necessary to detect the preneoplastic lesions in an early stage. New endoscopic techniques have improved the diagnostic accuracy and have resulted in a new and more simplified classification system of the dysplastic lesions in the bowel. Histopathologically these lesions are very heterogenous, consisting of adenomatous, villous and the more recently discovered serrated dysplasia...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29516293/an-update-on-surveillance-in-ulcerative-colitis
#18
REVIEW
Jimmy K Limdi, Francis A Farraye
PURPOSE OF REVIEW: Patients with long-standing ulcerative colitis have an increased risk for the development of colorectal cancer (CRC). Colitis-related dysplasia appears to confer the greatest risk. Colonoscopic surveillance to detect dysplasia has been advocated by gastrointestinal societies. The aim of surveillance is the reduction of mortality and morbidity of CRC through detection and resection of dysplasia or detecting CRC at an earlier and potentially curable stage. Traditional surveillance has relied on mucosal assessment with targeted biopsy of visible lesions and random biopsy sampling on the premise that dysplasia was not visible at endoscopy...
March 7, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29462738/detecting-dysplasia-using-white-light-endoscopy-or-chromoendoscopy-in-ulcerative-colitis-patients-without-primary-sclerosing-cholangitis-a-systematic-review-and-meta-analysis
#19
REVIEW
Saeed Azizi, Hussein Al-Rubaye, Mohammed Adil A Turki, Muhammad R Sameem Siddiqui, Arun P Shanmuganandan, Bushra Ehsanullah, Ranjeet Brar, Al-Mutaz Abulafi
BACKGROUND: Endoscopic examinations are a vital diagnostic tool for dysplasia. Establishing the precision of different modes of examination is essential due to the disparate pick-up rates of dysplasia. OBJECTIVE: The aim of this article was to establish the pick-up rates of dysplastic or cancerous lesions using white light endoscopy (WLE) and random/targeted biopsies, or chromoendoscopy (CE), in patients with ulcerative colitis (UC) without primary sclerosing (PSC) or Crohn's disease (CD)...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29462394/nondysplastic-ulcerative-colitis-has-high-levels-of-the-homologous-recombination-repair-protein-nucks1-and-low-levels-of-the-dna-damage-marker-gamma-h2ax
#20
Paula M De Angelis, Aasa R Schjølberg, Juliana B Hughes, Henrik S Huitfeldt, Solveig Norheim Andersen, Anne Carine Østvold
Background: The colon and rectum are continuously exposed to oxidative stress that generates reactive oxygen species, which are a major cause of DNA double-strand breaks (DSB). Furthermore, chronic inflammatory diseases such as ulcerative colitis (UC) are characterized by an excess of reactive nitrogen species that can also lead to DNA double-strand breakage and genomic instability. We investigated the expression of the nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) protein in UC and sporadic colorectal cancer (CRC) due to its involvement in both DNA double-strand break repair and inflammatory signaling...
February 15, 2018: Inflammatory Bowel Diseases
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