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Dysplasia in inflammatory bowel disease

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https://www.readbyqxmd.com/read/28078646/mucosal-healing-in-ulcerative-colitis-a-comprehensive-review
#1
REVIEW
Pedro Boal Carvalho, José Cotter
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by periods of remission and periods of relapse. Patients often present with symptoms such as rectal bleeding, diarrhea and weight loss, and may require hospitalization and even colectomy. Long-term complications of UC include decreased quality of life and productivity and an increased risk of colorectal cancer. Mucosal healing (MH) has gained progressive importance in the management of UC patients. In this article, we review the endoscopic findings that define both mucosal injury and MH, and the strengths and limitations of the scoring systems currently available in clinical practice...
January 11, 2017: Drugs
https://www.readbyqxmd.com/read/28077799/kras-and-tp53-mutations-in-inflammatory-bowel-disease-associated-colorectal-cancer-a-meta-analysis
#2
Lijun Du, John J Kim, Jinhua Shen, Binrui Chen, Ning Dai
Although KRAS and TP53 mutations are common in both inflammatory bowel disease-associated colorectal cancer (IBD-CRC) and sporadic colorectal cancer (S-CRC), molecular events leading to carcinogenesis may be different. Previous studies comparing the frequency of KRAS and TP53 mutations in IBD-CRC and S-CRC were inconsistent. We performed a meta-analysis to compare the presence of KRAS and TP53 mutations among patients with IBD-CRC, S-CRC, and IBD without dysplasia. A total of 19 publications (482 patients with IBD-CRC, 4,222 with S-CRC, 281 with IBD without dysplasia) met the study inclusion criteria...
January 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28066941/surveillance-for-dysplasia-in-patients-with-ulcerative-colitis-discrepancy-between-guidelines-and-practice
#3
Masaru Shinozaki, Kiyonori Kobayashi, Reiko Kunisaki, Tadakazu Hisamatsu, Makoto Naganuma, Kenichi Takahashi, Yasushi Iwao, Yasuo Suzuki, Mamoru Watanabe, Michio Itabashi, Akira Torii, Masakazu Takazoe, Akira Sugita
BACKGROUND AND AIM: The risk of developing colorectal cancer is higher in patients with ulcerative colitis (UC) than in the general population. Guidelines recommend surveillance colonoscopy (SCS) to reduce mortality; however, few studies have assessed physicians' adherence to guidelines. This study was aimed to clarify the current status of SCS and adherence to guidelines through the characteristics of cancer/dysplasia surveillance for UC patients in Japan. METHODS: A questionnaire was mailed to 541 physicians who attended meetings on inflammatory bowel disease...
January 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28024986/the-natural-history-of-diminutive-and-small-colorectal-polyps-a-systematic-literature-review
#4
REVIEW
Jasper L A Vleugels, Yark Hazewinkel, Paul Fockens, Evelien Dekker
BACKGROUND: Diminutive (1-5 mm) and small (6-9 mm) polyps comprise 90% of detected lesions during colonoscopy and rarely contain advanced histology or colorectal cancer (CRC). Routine removal of these lesions results in a significant burden to colonoscopy programs. At the same time, the risk for progression of these polyps to CRC is unclear. We performed a systematic review to explore the natural history of diminutive and small colorectal polyps. METHODS: We searched MEDLINE and EMBASE for studies investigating the natural history of colorectal polyps...
December 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27951611/clinical-implications-of-low-grade-dysplasia-found-during-inflammatory-bowel-disease-surveillance-a-retrospective-study-comparing-chromoendoscopy-and-white-light-endoscopy
#5
Joren R Ten Hove, Erik Mooiweer, Andrea E van der Meulen de Jong, Evelien Dekker, Cyriel Y Ponsioen, Peter D Siersema, Bas Oldenburg
Background and study aims: Current guidelines recommend the use of pancolonic chromoendoscopy for surveillance of patients with inflammatory bowel disease (IBD). It is currently unknown whether low grade dysplasia (LGD) found using chromoendoscopy carries a similar risk of high grade dysplasia (HGD) or colorectal cancer (CRC) compared with LGD detected using white-light endoscopy (WLE). The aim of this study was to compare the risk of advanced neoplasia, a combined endpoint of HGD and CRC, during follow-up after detection of lesions containing LGD identified with either chromoendoscopy or WLE...
December 12, 2016: Endoscopy
https://www.readbyqxmd.com/read/27938789/surveillance-of-patients-with-inflammatory-bowel-disease
#6
REVIEW
Jessica X Yu, James E East, Tonya Kaltenbach
Patients with inflammatory bowel disease involving the colon are at increased risk for developing colorectal cancer. Colonoscopy surveillance is important to identify and treat IBD associated dysplasia. The SCENIC consensus provides evidence-based recommendations for optimal surveillance and management of dysplasia in IBD. Chromoendoscopy, with the surface application of dyes to enhance mucosal visualization, is the superior endoscopic surveillance strategy to detect dysplasia. Most dysplasia is visible, and can be endoscopically resected...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27935768/hypertrophic-osteoarthropathy-clinical-and-imaging-features
#7
Felix Y Yap, Matthew R Skalski, Dakshesh B Patel, Aaron J Schein, Eric A White, Anderanik Tomasian, Sulabha Masih, George R Matcuk
Hypertrophic osteoarthropathy (HOA) is a medical condition characterized by abnormal proliferation of skin and periosteal tissues involving the extremities and characterized by three clinical features: digital clubbing (also termed Hippocratic fingers), periostosis of tubular bones, and synovial effusions. HOA can be a primary entity, known as pachydermoperiostosis, or can be secondary to extraskeletal conditions, with different prognoses and management implications for each. There is a high association between secondary HOA and malignancy, especially non-small cell lung cancer...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27927720/restorative-proctocolectomy-in-elderly-ibd-patients-a-multicentre-comparative-study-on-safety-and-efficacy
#8
Francesco Colombo, Saloomeh Sahami, Antony de Buck Van Overstraeten, Hagit Tulchinsky, Diane Mege, Iris Dotan, Diego Foschi, Cosimo Alex Leo, Janindra Warusavitarne, André D'Hoore, Yves Panis, Willem Bemelman, Gianluca M Sampietro
BACKGROUND AND AIMS: Restorative proctocolectomy in elderly inflammatory bowel disease [ IBD] patients is controversial and limited data are available on the outcomes of surgery. The aim of this study was to evaluate the safety, efficacy, and long-term results of ileal-pouch-anal anastomosis in elderly patients, in a multicentre survey from European referral centres. METHODS: The International Pouch Database [IPD] combined 101 variables. Patients aged ≥ 65 years were matched on the basis of open versus laparoscopic surgery with a control group of consecutive younger unselected patients with a ratio of 1:2...
December 7, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27906680/chemopreventive-effects-of-5-aminosalicylic-acid-on-inflammatory-bowel-disease-associated-colorectal-cancer-and-dysplasia-a-systematic-review-with-meta-analysis
#9
Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang
BACKGROUND AND AIMS: The chemopreventive effect of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) has been widely studied; however, the results remain conflicting. The aim of this study was to systematically review the literature and update evidence concerning effects of 5-ASA on the risk of colorectal cancer (CRC) and dysplasia (Dys) in patients with ulcerative colitis (UC) or Crohn's disease (CD). RESULTS: 5-ASA showed a chemopreventive effect against CRC/Dys in IBD patients (OR = 0...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27890853/chromoendoscopy-for-surveillance-in-ulcerative-colitis-and-crohn-s-disease-a-systematic-review-of-randomized-trials
#10
REVIEW
Andrea Iannone, Marinella Ruospo, Germaine Wong, Mariabeatrice Principi, Michele Barone, Giovanni Fm Strippoli, Alfredo Di Leo
BACKGROUND & AIMS: Key international guideline agencies recommend dysplasia surveillance in inflammatory bowel diseases with chromoendoscopy. We performed a systematic review of randomized trials comparing chromoendoscopy versus other endoscopic techniques for dysplasia surveillance in inflammatory bowel diseases. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials for relevant studies published through September 2016. We estimated risk ratios (RR) for dichotomous outcomes (all-cause/colorectal cancer-related mortality, time to interval cancer, patients with dysplasia, total/subtypes of dysplastic lesions, dysplasia detected by targeted biopsies, adverse events), mean differences (MD) for continuous outcomes (procedural time, costs, total/targeted biopsies) and their 95% confidence intervals (CI) using a random-effects model...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27888861/inflammatory-bowel-disease-in-digestive-disease-week-2016-advances-in-epidemiology-follow-up-treatment-monitoring-optimisation-and-individual-tailoring-and-colon-cancer-prevention
#11
Santiago García-López
In Digestive Disease Week 2016, interesting data were presented on the eventual role of certain foods in inflammatory bowel disease, although the value of these data is relative. Also of interest were epidemiological studies, of which several analysed the natural history of the disease. Some presentations dealt with the search for individual predictive factors, a pressing need in clinical practice. Unfortunately, some of the findings presented were of dubious value. A study suggesting that a simple parameter as increased blood monocytes could be a clear predictive factor of poor outcome could perhaps be highlighted (the results were striking but had multiple limitations)...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27765687/changing-paradigms-in-detection-of-dysplasia-and-management-of-patients-with-inflammatory-bowel-disease-is-colectomy-still%C3%A2-necessary
#12
Fernando Velayos, Priya Kathpalia, Emily Finlayson
This review chronicles the evolution of dysplasia detection and management in inflammatory bowel disease since 1925, the year the first case report of colitis-related colorectal cancer was published. We conclude that colorectal cancer prevention and dysplasia management for patients with inflammatory bowel disease has changed since this first case report, from somewhat hopeless to hopeful.
February 2017: Gastroenterology
https://www.readbyqxmd.com/read/27679553/colorectal-cancer-and-dysplasia-in-inflammatory-bowel-disease-a-review-of-disease-epidemiology-pathophysiology-and-management
#13
REVIEW
Parambir S Dulai, William J Sandborn, Samir Gupta
Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) characterized by recurrent episodes of mucosal inflammation. This chronic mucosal inflammation has several potential consequences, one of which is the occurrence of colitis-associated colorectal cancer. Over the past decade, our understanding of the epidemiology, pathophysiology, and overall approach to diagnosing and managing colitis-associated colorectal cancer has grown considerably. In the current review article, we outline these advancements and highlight areas in need of further research...
December 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27622232/a-gp-primer-to-understanding-biopsy-reports-of-the-lower-gastrointestinal-tract
#14
Marjorie M Walker, Angela K Harris, Georgia C Edwards, Nicholas J Talley
BACKGROUND: Colonoscopic biopsies are taken to make a diagnosis of inflammation, dysplasia or malignancy, to assess treatment success and to monitor patients' progression. OBJECTIVE: This aim of this article is to provide a guide to understanding histology reports sent to the general practitioner (GP) from the colonoscopy and anatomical pathology departments for the diagnosis of increasingly prevalent gastrointestinal (GI) diseases. DISCUSSION: Many diseases in the lower GI tract are increasing in prevalence and new diseases are emerging that require biopsy for diagnosis...
June 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27613257/low-rate-of-dysplasia-detection-in-mucosa-surrounding-dysplastic-lesions-in-patients-undergoing-surveillance-for-inflammatory-bowel-diseases
#15
Joren R Ten Hove, Erik Mooiweer, Evelien Dekker, Andrea E van der Meulen-de Jong, G Johan A Offerhaus, Cyriel Y Ponsioen, Peter D Siersema, Bas Oldenburg
BACKGROUND & AIMS: When dysplastic lesions are encountered during surveillance colonoscopy of patients with inflammatory bowel disease (IBD), guidelines recommend collection of additional biopsies from the surrounding mucosa to ensure the lesion has been adequately circumscribed. We aimed to determine the rate of dysplasia in mucosa biopsies collected from tissues surrounding dysplastic lesions during IBD surveillance. METHODS: In a retrospective study, we collected endoscopy and pathology reports from 1065 patients undergoing colonoscopic surveillance for IBD from 2000 through 2015 at 3 centers in the Netherlands...
September 6, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27578918/expression-profile-of-p53-and-p21-in-large-bowel-mucosa-as-biomarkers-of-inflammatory-related-carcinogenesis-in-ulcerative-colitis
#16
Cristiana Popp, Luciana Nichita, Theodor Voiosu, Alexandra Bastian, Mirela Cioplea, Gianina Micu, Gabriel Pop, Liana Sticlaru, Andreea Bengus, Andrei Voiosu, Radu Bogdan Mateescu
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease that slightly increases the risk of colorectal cancer in patients with long-standing extended disease. Overexpression of p53 and p21 in colonic epithelia is usually detected in UC patients when no dysplasia is histologically seen and it is used by pathologists as a discriminator between regenerative changes and intraepithelial neoplasia, as well as a tissue biomarker useful to predict the risk of evolution toward malignancy. We present a one-year prospective observational study including a cohort of 45 patients with UC; p53 and p21 were evaluated in epithelial cells...
2016: Disease Markers
https://www.readbyqxmd.com/read/27567189/immunohistochemistry-in-the-diagnosis-of-dysplasia-in-chronic-inflammatory-bowel-disease-colorectal-polyps
#17
Ehsen B Brahim, Ali Mrabet, Raja Jouini, Wafa Koubaa, Rimel B Sidhom, Hela Elloumi, Aschraf Chadli
BACKGROUND AND STUDY AIMS: Development of cancer is the most significant complication in inflammatory bowel disease (IBD). Distinguishing true dysplasia from reactive atypia in polyps is difficult, leading sometimes to the unsatisfactory diagnosis of "indefinite for dysplasia". Therefore, there is a need for the development of markers that can help improve diagnosis. We evaluated the diagnostic value of the expression of AMACR, Ki67 and p53 by immunohistochemistry in the diagnosis of dysplasia in polyps developed on IBD...
September 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27540581/diagnostic-yield-of-endomicroscopy-for-dysplasia-in-primary-sclerosing-cholangitis-associated-inflammatory-bowel-disease-a-feasibility-study
#18
Aldona Dlugosz, Ammar Mohkles Barakat, Niklas K Björkström, Åke Öst, Annika Bergquist
BACKGROUND AND STUDY AIMS: Primary sclerosing cholangitis associated inflammatory bowel disease (PSC-IBD) is characterized by a high risk of colorectal dysplasia. Surveillance colonoscopies with random biopsies have doubtful power for dysplasia detection. Our aim was to prospectively investigate the feasibility and efficacy of pCLE in surveillance colonoscopies in patients with PSC-IBD. PATIENTS AND METHODS: Sixty-nine patients with PSC-IBD underwent colonoscopy in 2 steps...
August 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27508509/the-significance-of-sessile-serrated-polyps-in-inflammatory-bowel-disease
#19
Whitney E Jackson, Jean-Paul Achkar, Carole Macaron, Lili Lee, Xiuli Liu, Rish K Pai, Rocio Lopez, Carol A Burke, Daniela S Allende
BACKGROUND: The significance of serrated lesions in inflammatory bowel disease (IBD) remains unclear. We aim to characterize synchronous and metachronous lesions in IBD patients with an index serrated polyp and compare them to sporadic subjects with SSP. METHODS: Serrated lesions in patients with IBD were identified from a pathology database and, after review, were reclassified as hyperplastic (HP), sessile serrated (SSPs), or serrated polyps unclassifiable (SPU)...
September 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27440581/in-vivo-19-f-mr-imaging-cell-tracking-of-inflammatory-macrophages-and-site-specific-development-of-colitis-associated-dysplasia
#20
Soo Hyun Shin, Deepak K Kadayakkara, Jeff W M Bulte
Purpose To investigate whether the magnitude of in vivo fluorine 19 ((19)F) magnetic resonance (MR) imaging signal is associated with subsequent development of colitis-associated dysplasia after in situ fluorination of inflammatory macrophages in a mouse model of inflammatory bowel disease (IBD). Materials and Methods Experiments were approved by the institutional animal care and use committee. Mice in the experimental group (n = 10) were administered azoxymethane and dextran sulfate sodium to induce colitis-associated dysplasia...
January 2017: Radiology
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