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Dysplasia in inflammatory bowel disease

Stella Arelaki, Athanasios Arampatzioglou, Konstantinos Kambas, Efthimios Sivridis, Alexandra Giatromanolaki, Konstantinos Ritis
Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils to release NETs, we examined surgical specimens from CRC to investigate the presence of polyP, as a possible NET inducer. Biopsies with adenomas, hyperplastic polyps, inflammatory bowel disease and healthy colon tissues were used as controls...
2018: PloS One
Jimmy K Limdi, Francis A Farraye
PURPOSE OF REVIEW: Patients with long-standing ulcerative colitis have an increased risk for the development of colorectal cancer (CRC). Colitis-related dysplasia appears to confer the greatest risk. Colonoscopic surveillance to detect dysplasia has been advocated by gastrointestinal societies. The aim of surveillance is the reduction of mortality and morbidity of CRC through detection and resection of dysplasia or detecting CRC at an earlier and potentially curable stage. Traditional surveillance has relied on mucosal assessment with targeted biopsy of visible lesions and random biopsy sampling on the premise that dysplasia was not visible at endoscopy...
March 7, 2018: Current Gastroenterology Reports
Mohamad A Mouchli, Lidia Ouk, Marianne R Scheitel, Alisha P Chaudhry, Donna Felmlee-Devine, Diane E Grill, Shahrooz Rashtak, Panwen Wang, Junwen Wang, Rajeev Chaudhry, Thomas C Smyrk, Ann L Oberg, Brooke R Druliner, Lisa A Boardman
AIM: To determine the frequency and risk factors for colorectal cancer (CRC) development among individuals with resected advanced adenoma (AA)/traditional serrated adenoma (TSA)/advanced sessile serrated adenoma (ASSA). METHODS: Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study...
February 28, 2018: World Journal of Gastroenterology: WJG
Carlo Arévalo, Natalia Chunga, Steven Alarcón, Omar Rodríguez, Fernando Arévalo, Pedro Montes, Eduardo Monge
OBJECTIVE: To determine whether localization and size are related to the presence of high-grade dysplasia of colon adenomas in patients of a Peruvian hospital. MATERIALS AND METHODS: This is a descriptive transversal study. We checked colonoscopyreports of 2014-2015 years of Hospital Daniel Alcides Carrion, we included the polyps found in patients older than 18 years old, and excluded reports from patients with colorectal cancer, an antecedent of oncological surgery, inflammatory bowel disease and polyposis (6 or more)...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Vivek Pandrangi, Daniel Mandel, Norman Gellada, Dionisio Mieses, Cindy Kallman, Karen Zaghiyan, Phillip Fleshner
Chronic pouchitis (CP) after ileal pouch-anal anastomosis is a significant clinical problem. Adipose tissues produce antiinflammatory cytokines and chemokines. We evaluated the association between abdominal visceral fat area (VFA) and CP. Patients with a preoperative CT evaluation were included. The diagnosis of CP was confirmed in all cases by endoscopy with afferent ileal limb intubation. Patients were allocated into groups of high VFA and low VFA. The study cohort of 52 patients had a median body mass index of 22 (range, 14-32)...
October 1, 2017: American Surgeon
Conor Lahiff, Lai Mun Wang, Simon P L Travis, James E East
Introduction: Patients with inflammatory bowel disease (IBD) undergoing polypectomy are recommended by current guidelines to have biopsies taken from adjacent mucosa to determine whether there is dysplasia present. With improvements in endoscopic imaging it is now possible to characterise colonic lesions with higher levels of confidence than previously. We reviewed the diagnostic yield of polyp-adjacent biopsies in IBD. Materials and Methods: A systematic search of our histopathology database revealed cases where polyps had been endoscopically resected or biopsied in patients with IBD...
January 27, 2018: Journal of Crohn's & Colitis
Adrian Frick, Vineeta Khare, Gregor Paul, Michaela Lang, Franziska Ferk, Siegfried Knasmueller, Andrea Beer, Georg Oberhuber, Christoph Gasche
Patients with inflammatory bowel disease (IBD) have a higher risk of developing colitis-associated-cancer (CAC), however, the underlying processes of disease progression are not completely understood. Here, the molecular processes of inflammation-driven colon carcinogenesis were investigated using IL-10 deficient mice (IL-10- KO). IL-10- KO mice were euthanized after development of colitis and dysplasia. Immunohistochemistry (IHC) was performed for markers of colitis-induced DNA damage (CIDD): oxidative-DNA-lesions (8-oxoG), double-strand breaks (DSB; γH2AX) and DSB-repair...
January 29, 2018: Molecular Cancer Research: MCR
Shailja C Shah, Joren R Ten Hove, Daniel Castaneda, Carolina Palmela, Erik Mooiweer, Jean-Frédéric Colombel, Noam Harpaz, Thomas A Ullman, Ad A van Bodegraven, Jeroen M Jansen, Nofel Mahmmod, Andrea E van der Meulen-de Jong, Cyriel Y Ponsioen, Christine J van der Woude, Bas Oldenburg, Steven H Itzkowitz, Joana Torres
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC, termed PSC-IBD) are at increased risk for colorectal cancer (CRC), but their risk following a diagnosis of low-grade dysplasia (LGD) is not well described. We aimed to determine the rate of advanced colorectal neoplasia (aCRN), defined as high-grade dysplasia and/or colorectal cancer, following a diagnosis of indefinite dysplasia or LGD in this population. METHODS: We performed a retrospective, longitudinal study of 1911 patients with colonic IBD (293 with PSC and 1618 without PSC) who underwent more than 2 surveillance colonoscopies from 2000 through 2015 in the Netherlands or the United States (9265 patient-years of follow up)...
January 25, 2018: Clinical Gastroenterology and Hepatology
Zhehui Zhu, Zubing Mei, Yuegui Guo, Guanghui Wang, Tingyu Wu, Ximao Cui, Zhenyu Huang, Yilian Zhu, Dongpeng Wen, Jinlve Song, Hailan He, Weimin Xu, Long Cui, Chenying Liu
Background & Aims: The association between thiopurines and colorectal neoplasia risk remains controversial in inflammatory bowel disease (IBD) patients. We performed a systematic review and meta-analysis examining this association. Methods: A comprehensive search of the PubMed, EMBASE and Cochrane Library databases was performed to identify relevant literature. Random-effects models were applied to calculate the pooled odds ratio (OR) and relative risk (RR) with corresponding 95% confidence intervals (CIs) among case-control and cohort studies, respectively...
January 23, 2018: Journal of Crohn's & Colitis
Elena Bolzacchini, Claudio Chini, Claudio Camillo Cortelezzi, Ilaria Vallini, Graziella Pinotti, Stefano La Rosa, Silvia Uccella
A 37-year-old male with long-standing and extensive ulcerative pancolitis developed a rapidly lethal poorly differentiated neuroendocrine carcinoma (NEC) in the sigmoid colon. Prior biopsies obtained from multiple sites of the colon during endoscopic surveillance showed minimal inflammatory changes and no sign of dysplasia. Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal malignancies, and adenocarcinoma is the most common type of colorectal neoplasm associated with ulcerative colitis and Crohn's disease, but other types of epithelial and nonepithelial tumors have also been described in IBD...
January 1, 2018: International Journal of Surgical Pathology
Mikihiro Fujiya
Inflammatory bowel disease (IBD) is a major risk factor for colorectal cancer. Surveillance colonoscopy is presumably important for the early detection of colitis-associated cancer/dysplasia (CC/Ds). However, it is not easy to detect certain lesions in the inflamed mucosa using white-light endoscopy (WLE), even during the remission phase. Therefore, WLE with random biopsies has been the traditional approach for dysplasia detection. Recent advances in endoscopic technologies, including high-definition endoscopy and image-enhanced endoscopy, have improved the visibility of dysplastic lesions, suggesting that novel endoscopic procedures with a target biopsy are suitable for the surveillance of CC/Ds[1]...
January 23, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Pasquale Klepp, John B Kisiel, Milada Cvancarova Småstuen, Arne Røseth, Solveig N Andersen, Morten H Vatn, David A Ahlquist, Bjørn A Moum, Stephan Brackmann
BACKGROUND AND AIM: Colonoscopic surveillance is recommended in patients with longstanding inflammatory bowel disease (IBD) as they are at increased risk of colorectal cancer (CRC). Non-invasive surveillance may improve compliance and access. Multi-target stool DNA (MT-sDNA) has been validated for screening of sporadic CRC but has not been assessed in IBD. Our aim was to assess the performance of a MT-sDNA test in a real-life surveillance setting of patients with longstanding IBD. MATERIAL AND METHODS: A total of 192 IBD patients enrolled from two prospective cohorts submitted an EDTA buffered stool sample and underwent chromo- or white light colonoscopy...
January 9, 2018: Scandinavian Journal of Gastroenterology
M J Lu, X Y Qiu, X Q Mao, X T Li, H J Zhang
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a high risk of developing colorectal neoplasia. AIM: To investigate whether thiopurines can decrease the risk of developing colorectal neoplasia in patients with ulcerative colitis (UC) or Crohn's disease (CD). METHODS: We conducted a meta-analysis of 24 observational studies involving 76,999 participants to evaluate the risks of developing colorectal neoplasia in IBD patients receiving thiopurine treatment...
February 2018: Alimentary Pharmacology & Therapeutics
Marietta Iacucci, Gilaad G Kaplan, Remo Panaccione, Oluseyi Akinola, Brendan Cord Lethebe, Mark Lowerison, Yvette Leung, Kerri L Novak, Cynthia H Seow, Stefan Urbanski, Parham Minoo, Xianyong Gui, Subrata Ghosh
OBJECTIVES: Dye spraying chromoendoscopy (DCE) is recommended for the detection of colonic neoplastic lesions in inflammatory bowel disease (IBD). The majority of neoplastic lesions are visible endoscopically and therefore targeted biopsies are appropriate for surveillance colonoscopy. To compare three different techniques for surveillance colonoscopy to detect colonic neoplastic lesions in IBD patients: high definition (HD), (DCE), or virtual chromoendoscopy (VCE) using iSCAN image enhanced colonoscopy...
November 14, 2017: American Journal of Gastroenterology
Toufic Saber, Khalil Bedran, Fatima Ghandour, Mansour El Khoury, Roula Bou Khalil, Said Farhat
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) and colorectal cancer have an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of IBD and colorectal cancer at a tertiary hospital centre in Lebanon. METHODS: 1007 patients underwent colonoscopy over a period of 12 months by qualified physicians. 91 patients were excluded from the study. Biopsy results were divided into normal versus abnormal colonic tissue...
2017: BMJ Open Gastroenterology
Sung Noh Hong
Long-standing intestinal inflammation in patients with inflammatory bowel disease (IBD) induces dysplastic change in the intestinal mucosa and increases the risk of subsequent colorectal cancer. The evolving endoscopic techniques and technologies, including dye spraying methods and high-definition images, have been replacing random biopsies and have been revealed as more practical and efficient for detection of dysplasia in IBD patients. In addition, they have potential usefulness in detailed characterization of lesions and in the assessment of endoscopic resectability...
September 2017: Clinical Endoscopy
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
Daisuke Nagakubo, Jeremy B Swann, Stefanie Birmelin, Thomas Boehm
Autoimmune and inflammatory conditions are a frequent complication in patients with reduced numbers of T cells. Here, we describe a mouse model of thymic stromal dysplasia resulting in peripheral T cell lymphopenia. In Foxn1:CFP-NTR transgenic mice, the bacterial nitroreductase enzyme is expressed in thymic epithelial cells and converts the prodrug CB1954 into a cytotoxic agent. This strategy enables titratable and durable destruction of thymopoietic tissue in early embryogenesis. Our results indicate that the resulting low levels of thymic capacity for T cell production create a predisposition for the development of a complex autoimmune syndrome, chiefly characterized by inflammatory bowel disease and lymphocytic organ infiltrations...
September 12, 2017: International Immunology
Tonya Kaltenbach, William J Sandborn
No abstract text is available yet for this article.
December 2017: Gastrointestinal Endoscopy
Zane R Gallinger, Amir Rumman, Sanjay K Murthy, Geoffrey C Nguyen
BACKGROUND AND STUDY AIMS:  Dye-based chromoendoscopy (DBC) is the preferred method for endoscopic dysplasia surveillance in patients with inflammatory bowel disease (IBD). We sought to examine the uptake of, and perception toward DBC among academic gastroenterologists. METHODS:  We conducted an online survey of academic members of the Canadian Association of Gastroenterology to assess their current dysplasia surveillance practice, uptake of DBC, and perceived barriers to adoption of DBC...
October 2017: Endoscopy International Open
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