Kohei Murakami, Saki Miyatake, Jiro Miyamae, Kanna Saeki, Mizutani Shinya, Natsuki Akashi, Ikki Mitsui, Kosuke Kobayashi, Kohei Saeki, Noritaka Maeta, Teppei Kanda, Yasuhiko Okamura, Hiroaki Hemmi
Cancers utilize a variety of molecules to escape host immune responses. Better understanding the immune environment surrounding cancer may facilitate application of innovative cancer immunotherapies, such as immune checkpoint inhibitors, to dogs as well as humans. In this study, we screened the expression of 20 immune regulatory molecules in diverse canine tumors (n = 59). Quantitative RT-PCR (qPCR) analysis revealed that some immune regulatory molecules, such as LGALS9 (coding Galectin-9) and CD48, were expressed in most canine tumors, but other molecules, such as CD274 (coding PD-L1), IL4I1, PVR, TNFSF18, ICOSLG, and TNFSF4, were rarely expressed...
October 26, 2022: Veterinary Immunology and Immunopathology