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https://www.readbyqxmd.com/read/28917937/pyrazole-based-compounds-in-chitosan-liposomal-emulsion-for-antimicrobial-cotton-fabrics
#1
Ahmed Nada, Marwa Al-Moghazy, Ahmed A F Soliman, Gehan M T Rashwan, Taghreed Hosny Ahmed Eldawy, Ashraf Abd Elhakim Hasan, Galal Hosni Sayed
The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. 1-phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] and 1H- pyrazole-3 (1), 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (2) were synthesized, characterized and encapsulated into liposomal chitosan emulsions for textile finishing. The chemical modifications of cotton fabrics were demonstrated by infrared analysis...
September 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28917063/accuracy-of-preoperative-fine-needle-aspiration-in-diagnosis-of-malignant-parotid-tumors
#2
Hani Z Marzouki, Mohammed A Altabsh, Mohammed O Albakrei, Talal A Al-Khatib, Mazin A Merdad, Nada J Farsi
To determine the diagnostic accuracy of fine needle aspiration (FNA) for detecting malignant parotid tumors. Methods: We conducted a retrospective study of all patients diagnosed with benign or malignant parotid gland tumors in King Abdulaziz University Hospital,  Jeddah, Saudi Arabia, between January 2004 and May 2015. The records of 65 subjects were obtained. Histopathological findings and data from FNA examinations were obtained from medical records. Twenty-three subjects were excluded due to missing FNA, histopathology results or both...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28914783/smoothed-temporal-atlases-of-age-gender-all-cause-mortality-in-south-africa
#3
Samuel O M Manda, Nada Abdelatif
Most mortality maps in South Africa and most contried of the sub-Saharan region are static, showing aggregated count data over years or at specific years. Lack of space and temporral dynamanics in these maps may adversely impact on their use and application for vigorous public health policy decisions and interventions. This study aims at describing and modeling sub-national distributions of age-gender specific all-cause mortality and their temporal evolutions from 1997 to 2013 in South Africa. Mortality information that included year, age, gender, and municipality administrative division were obtained from Statistics South Africa for the period...
September 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28904263/concerning-increase-in-antimicrobial-resistance-in-shiga-toxin-producing-escherichia-coli-isolated-from-young-animals-during-1980-2016
#4
Flore Chirila, Alexandra Tabaran, Nicodim Fit, George Nadas, Marian Mihaiu, Flaviu Tabaran, Cornel Cătoi, Oana Lucia Reget, Sorin Daniel Dan
This study was conducted in order to assess the antimicrobial resistance patterns of E. coli isolated from young animals affected between 1980 and 2016. The selected isolates for this study (n=175) carried stx1/stx2 genes and the most prevalent type of pathogenic E. coli found belonged to serogroup O101, antigen (K99)-F41 positive. All STEC-positive isolates were tested for susceptibility to 11 antimicrobials. Multidrug resistance (MDR) increased from 11% during the 1980s to 40% between 2000 and 2016. Resistance to tetracycline and streptomycin was the most frequent co-resistance phenotype (37%)...
September 12, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28895235/infrared-assisted-extraction-and-hplc-analysis-of-prunus-armeniaca-l-pomace-and-detoxified-kernel-and-their-antidiabetic-effects
#5
Karim Raafat, Nada El-Darra, Fatima A Saleh, Hiba N Rajha, Richard G Maroun, Nicolas Louka
INTRODUCTION: Prunus armeniaca L. (P. armeniaca) is one of the medicinal plants with a high safety-profile. OBJECTIVES: The aim of this work was to make an infrared-assisted extraction (IR-AE) of P. armeniaca fruit (pomace) and kernel, and analyse them using reverse phase high-performance liquid chromatography (RP-HPLC) aided method. METHODS: IR-AE is a novel-technique aimed at increasing the extraction-efficiency. The antidiabetic-potentials of the P...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28892641/independent-assortment-of-gc-gene-polymorphism-rs2282679-and-25-hydroxyvitamin-d-levels-in-coronary-artery-disease
#6
Nada Sedky, Sally Hassanein, Mohamed Gad
BACKGROUND: Coronary artery disease (CAD) remains a major public health burden. Emerging research has suggested an association between vitamin D insufficiency and CAD. Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn, might affect its serum levels and CAD incidence. SUBJECTS/METHODS: 112 male patients, aged between 35 and 50, with verified CAD and 109 age- and sex-matched controls were recruited...
September 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28891393/improving-ambulatory-care-resident-training-preparing-for-opportunities-to-treat-mental-illness-in-the-primary-care-setting
#7
Nada M Farhat, Jolene R Bostwick, Stuart D Rockafellow
PURPOSE: The development of an outpatient psychiatry clinical practice learning experience for PGY2 ambulatory care pharmacy residents in preparation for the treatment of psychiatric disorders in the primary care setting is described. SUMMARY: With the increased prevalence of psychiatric disorders, significant mortality, and limited access to care, integration of mental health treatment into the primary care setting is necessary to improve patient outcomes. Given the majority of mental health treatment occurs in the primary care setting, pharmacists in patient-centered medical homes (PCMHs) are in a unique position with direct access to patients to effectively manage these illnesses...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28889149/patterns-knowledge-and-barriers-of-mammography-use-among-women-in-saudi-arabia
#8
Rolina K Al-Wassia, Nada J Farsi, Leena A Merdad, Sara K Hagi
To assess mammography utilization and knowledge, and to determine barriers associated with mammography utilization among Saudi women. Methods: We conducted a cross-sectional survey in 5 main geographic regions of Saudi Arabia from February 2015 to May 2015. The sample comprised women aged ≥40 years. Associations between socio-demographic factors and mammography use were tested using chi-square test. Predictors of mammography use were assessed by logistic regression. Results: A total of 3,245 women were surveyed, with 40% reporting ever having a mammogram...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28888420/transition-to-residency-the-successful-development-and-implementation-of-a-nonclinical-elective-in-perioperative-management
#9
Heather McDonald, Nada Gawad, Isabelle Raîche, Fraser D Rubens
OBJECTIVE: Few medical school programs in Canada address challenges related to the significant increase in responsibility for patient care between medical school and residency. This is particularly important in surgery and anesthesia due to the high-acuity care required during the perioperative period. The purpose of this study was to develop and assess a program that would help students transition to surgical and anesthesia residencies, in terms of knowledge acquisition, clinical decision-making skills, and subjective preparedness...
September 6, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28887642/evaluation-of-the-functional-capacity-of-nk-cells-of-melanoma-patients-in-an-in-vitro-model-of-nk-cell-contact-with-k562-and-femx-tumor-cell-lines
#10
Gordana Konjevic, Ana Vuletic, Katarina Mirjacic Martinovic, Ana Krivokuca, Radmila Jankovic, Nada Babovic
NK cells of metastatic melanoma (MM) patients display impaired function, making them incapable to mount an effective antitumor response. In this study, we evaluated immunophenotypic characteristics and functional capacity of CD3(-)CD16(+) NK cells of MM patients in an in vitro model based on NK cell contact with an NK sensitive, K562, and a tumor-specific, melanoma FemX tumor cell line. Although our results indicate similar NK cell antitumor cytotoxic potential of MM patients in contact with both cell lines based on the expression of CD107a degranulation marker, there is a discrepancy in NK cell IFNγ production, as it is not significantly induced by FemX tumor cells, found to be, contrary to K562, HLA class I positive...
September 8, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28882950/cytocompatibility-of-direct-laser-interference-patterned-titanium-surfaces-for-implants
#11
Philip Hartjen, Ola Nada, Thiago Gundelwein Silva, Clarissa Precht, Anders Henningsen, Marzellus GROßE Holthaus, Nikolai Gulow, Reinhard E Friedrich, Henning Hanken, Max Heiland, Christoph Zwahr, Ralf Smeets, Ole Jung
In an effort to generate titanium surfaces for implants with improved osseointegration, we used direct laser interference patterning (DLIP) to modify the surface of pure titanium grade 4 of four different structures. We assessed in vitro cytoxicity and cell attachment, as well as the viability and proliferation of cells cultured directly on the surfaces. Attachment of the cells to the modified surfaces was comparably good compared to that of cells on grit-blasted and acid-etched reference titanium surfaces...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28880361/a-randomized-multicenter-study-safety-and-efficacy-of-mini-pool-intravenous-immunoglobulin-versus-standard-immunoglobulin-in-children-aged-1-18-years-with-immune-thrombocytopenia
#12
Mohsen Elalfy, Marwa Reda, Islam Elghamry, Omar Elalfy, Mohamed Meabed, Nada El-Ekiaby, Mahmoud A El-Hawy, Hadi Goubran, Magdy El-Ekiaby
BACKGROUND: Because there is a global shortage of intravenous immunoglobulin, there is a need for new products to fill the gap. STUDY DESIGN AND METHODS: This was a multicenter, open-label study investigating the safety and efficacy of a newly developed mini-pool intravenous immunoglobulin G for children with immune thrombocytopenia. Seventy-two patients ages 1 to 18 years with newly diagnosed (<1 month) immune thrombocytopenia who had platelet counts from 5 to 20 × 10(9) /L with no serious bleeding were recruited from four centers in Egypt...
September 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28877451/the-liver-as-a-hub-in-thermogenesis
#13
Nada A Abumrad
Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al. (2017) demonstrate in cold-exposed mice that liver-generated acylcarnitines are required to fuel thermogenesis.
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28876960/trpm2-shredding-the-mitochondrial-network
#14
Fangfang Li, Nada Abuarab, Asipu Sivaprasadarao
No abstract text is available yet for this article.
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28869855/reactivity-of-12-tungstophosphoric-acid-and-its-inhibitor-potency-toward-na-k-atpase-a-combined-31-p-nmr-study-ab-initio-calculations-and-crystallographic-analysis
#15
Nada Bošnjaković-Pavlović, Danica Bajuk-Bogdanović, Joanna Zakrzewska, Zeyin Yan, Ivanka Holclajtner-Antunović, Jean-Michel Gillet, Anne Spasojević-de Biré
Influence of 12-tungstophosphoric acid (WPA) on conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) in the presence of Na(+)/K(+)-ATPase was monitored by (31)P NMR spectroscopy. It was shown that WPA exhibits inhibitory effect on Na(+)/K(+)-ATPase activity. In order to study WPA reactivity and intermolecular interactions between WPA oxygen atoms and different proton donor types (D=O, N, C), we have considered data for WPA based compounds from the Cambridge Structural Database (CSD), the Crystallographic Open Database (COD) and the Inorganic Crystal Structure Database (ICSD)...
August 26, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28858729/effect-of-zinc-gluconate-sage-oil-on-inflammatory-patterns-and-hyperglycemia-in-zinc-deficient-diabetic-rats
#16
Mohamed M Elseweidy, Abdel-Moniem A Ali, Nabila Zein Elabidine, Nada M Mursey
BACKGROUND: The relationship between zinc homeostasis and pancreatic function had been established. In this study we aimed firstly to configure the inflammatory pattern and hyperglycemia in zinc deficient diabetic rats. Secondly to illustrate the effect of two selected agents namely Zinc gluconate and sage oil (Salvia Officinalis, family Lamiaceae). METHODS: Rats were fed on Zinc deficient diet, deionized water for 28days along with Zinc level check up at intervals to achieve zinc deficient state then rats were rendered diabetic through receiving one dose of alloxan monohydrate (120mg/kg) body weight, classified later into 5 subgroups...
August 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28851578/moving-towards-precision-urologic-oncology-targeting-enzalutamide-resistant-prostate-cancer-and-mutated-forms-of-the-androgen-receptor-using-the-novel-inhibitor-darolutamide-odm-201
#17
Hendrik Borgmann, Nada Lallous, Deniz Ozistanbullu, Eliana Beraldi, Naman Paul, Kush Dalal, Ladan Fazli, Axel Haferkamp, Pascale Lejeune, Artem Cherkasov, Martin E Gleave
Darolutamide (ODM-201) is a novel androgen receptor (AR) antagonist with a chemical structure distinctly different from currently approved AR antagonists that targets both wild-type and mutated ligand binding domain variants to inhibit AR nuclear translocation. Here, we evaluate the activity of darolutamide in enzalutamide-resistant castration resistant prostate cancer (CRPC) as well as in AR mutants detected in patients after treatment with enzalutamide, abiraterone, or bicalutamide. Darolutamide significantly inhibited cell growth and AR transcriptional activity in enzalutamide-resistant MR49F cells in vitro, and led to decreased tumor volume and serum prostate-specific antigen levels in vivo, prolonging survival in mice bearing enzalutamide-resistant MR49F xenografts...
August 26, 2017: European Urology
https://www.readbyqxmd.com/read/28845842/an-adolescent-with-an-asymptomatic-adnexal-cyst-to-worry-or-not-to-worry-medical-versus-surgical-management-options
#18
Vincenzo De Sanctis, Ashraf T Soliman, Heba Elsedfy, Nada A Soliman, Rania Elalaily, Salvatore Di Maio, Alaa Y Ahmed, Giuseppe Millimaggi
Paraovarian cysts or paratubal cysts (PTCs) arise from either the mesothelium or from paramesonephric remnants. These present as either adnexal mass or as an incidental finding. Diagnosis is usually established on ultrasound and it is important to differentiate these from ovarian cysts. Typically PCTs appear as simple cysts by ultrasound and are indistinguishable from ovarian cysts if one does not recognize the extraovarian location. Occasionally, PTCs have internal echoes due to hemorrhage. PTCs are usually asymptomatic and benign...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28845841/caffeinated-energy-drink-consumption-among-adolescents-and-potential-health-consequences-associated-with-their-use-a-significant-public-health-hazard
#19
Vincenzo De Sanctis, Nada Soliman, Ashraf T Soliman, Heba Elsedfy, Salvatore Di Maio, Mohamed El Kholy, Bernadette Fiscina
Caffeinated energy drinks (EDs) are increasingly popular among adolescents despite growing evidence of their negative health effects. The consumption of EDs has seen a substantial increase during the past few decades, especially in the Western and Asian countries. EDs contain high levels of caffeine, sugar, and novel ingredients, and are often marketed through youth-oriented media and venues. The known and unknown pharmacology of the constituents of EDs poses a risk of caffeine toxicity and other ill effects when consumed by young people...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28838926/a-comprehensive-functional-assessment-of-carboxylesterase-1-nonsynonymous-polymorphisms
#20
Xinwen Wang, Nada Rida, Jian Shi, Audrey Wu, Barry Bleske, Hao-Jie Zhu
Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the metabolism of many clinically important medications. CES1 expression and activity vary markedly among individuals; and genetic variation is a major contributing factor to CES1 interindividual variability. In the present study, we comprehensively examined the functions of CES1 nonsynonymous single nucleotide polymorphisms (nsSNPs) and haplotypes using transfected cell lines and individual human liver tissues. The 20 candidate variants include CES1 nsSNPs with a minor allele frequency (MAF) > 0...
August 24, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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