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https://www.readbyqxmd.com/read/27906500/phylogenetic-studies-gene-cluster-analysis-and-enzymatic-reaction-support-anthrahydroquinone-reduction-as-the-physiological-function-of-fungal-17%C3%AE-hydroxysteroid-dehydrogenase
#1
Leon Fürtges, David Conradt, Michael A Schätzle, Shailesh Kumar Singh, Nada Kraševec, Tea Lanišnik Rižner, Michael Müller, Syed Masood Husain
17β-Hydroxysteroid dehydrogenase (17β-HSDcl) from the filamentous fungus Curvularia lunata (teleomorph Cochliobolus lunatus) catalyzes NADP(H)-dependent oxidoreductions of androgens and estrogens. Despite detailed biochemical and structural characterization of 17β-HSDcl, its physiological function remains unknown. On the basis of amino acid sequence alignment, phylogenetic studies, and the recent identification of the physiological substrates of the homologous MdpC from Aspergillus nidulans and AflM from Aspergillus parasiticus, we propose an anthrahydroquinone as the physiological substrate of 17β-HSDcl...
December 1, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27904446/somatic-mutations-of-isocitrate-dehydrogenases-1-and-2-are-prognostic-and-follow-up-markers-in-patients-with-acute-myeloid-leukaemia-with-normal-karyotype
#2
Marijana Virijevic, Teodora Karan-Djurasevic, Irena Marjanovic, Natasa Tosic, Mirjana Mitrovic, Irena Djunic, Natasa Colovic, Ana Vidovic, Nada Suvajdzic-Vukovic, Dragica Tomin, Sonja Pavlovic
BACKGROUND: Mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes are frequent molecular lesions in acute myeloid leukaemia with normal karyotype (AML-NK). The effects of IDH mutations on clinical features and treatment outcome in AML-NK have been widely investigated, but only a few studies monitored these mutations during follow-up. PATIENTS AND METHODS: In our study samples from 110 adult de novo AML-NK were studied for the presence of IDH1 and IDH2 mutations, their associations with other prognostic markers and disease outcome...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27904409/morphological-characterization-and-chemical-composition%C3%A2-of-fruits-of-the-traditional-croatian-chestnut-variety%C3%A2-lovran-marron
#3
Igor Poljak, Nada Vahčić, Milica Gačić, Marilena Idžojtić
'Lovran Marron' is the only known traditional Croatian variety of the sweet chestnut. The objective of this study is to specify qualitative and quantitative morphological characteristics and to analyze the chemical composition of the 'Lovran Marron' fruits as well as to compare them to Marušnjak fruits (trees from the 'Lovran Marron' seed) and fruits from the local natural sweet chestnut population. Seven morphological characteristics were measured: fruit mass, height, width and thickness, scar length and width, and the length of the longest intrusion of the seed coat into the kernel...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27903998/survival-benefit-of-hemodiafiltration-compared-with-prolonged-high-flux-hemodialysis
#4
Petar S Djuric, Aleksandar Jankovic, Jovan Popovic, Jelena Tosic Dragovic, Ana Bulatovic, Zivka Djuric, Milos Mitrovic, Nada Dimkovic
INTRODUCTION:  Patients on dialysis have a high rate of death, mainly of cardiovascular cause. Nephrologists are actively looking for ways to improve patients' outcomes, and alternative dialysis strategies, such as long conventional hemodialysis and hemodiafiltration, are currently being investigated. The aim of this study was to compare anemia, nutrition, inflammation, mineral metabolism, and 3-year survival rates between patients treated with hemodiafiltration and prolonged high-flux hemodialysis (HFH)...
November 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/27895047/innovative-approaches-to-establish-and-characterize-primary-cultures-an-ex-vivo-3d-system-and-the-zebrafish-model
#5
Chiara Liverani, Federico La Manna, Arwin Groenewoud, Laura Mercatali, Gabri Van Der Pluijm, Federica Pieri, Davide Cavaliere, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Alberto Bongiovanni, Federica Recine, Nada Riva, Dino Amadori, Ennio Tasciotti, Ewa Snaar-Jagalska, Toni Ibrahim
Patient-derived specimens are an invaluable resource to investigate tumor biology. However, in vivo studies on primary cultures are often limited by the small amount of material available, while conventional in vitro systems might alter the features and behavior that characterize cancer cells. We present our data obtained on primary dedifferentiated liposarcoma cells cultured in a 3D scaffold-based system and injected into a zebrafish model. Primary cells were characterized in vitro for their morphological features, sensitivity to drugs and biomarker expression, and in vivo for their engraftment and invasiveness abilities...
November 28, 2016: Biology Open
https://www.readbyqxmd.com/read/27894351/characterizing-the-morbid-genome-of-ciliopathies
#6
Ranad Shaheen, Katarzyna Szymanska, Basudha Basu, Nisha Patel, Nour Ewida, Eissa Faqeih, Amal Al Hashem, Nada Derar, Hadeel Alsharif, Mohammed A Aldahmesh, Anas M Alazami, Mais Hashem, Niema Ibrahim, Firdous M Abdulwahab, Rawda Sonbul, Hisham Alkuraya, Maha Alnemer, Saeed Al Tala, Muneera Al-Husain, Heba Morsy, Mohammed Zain Seidahmed, Neama Meriki, Mohammed Al-Owain, Saad AlShahwan, Brahim Tabarki, Mustafa A Salih, Tariq Faquih, Mohamed El-Kalioby, Marius Ueffing, Karsten Boldt, Clare V Logan, David A Parry, Nada Al Tassan, Dorota Monies, Andre Megarbane, Mohamed Abouelhoda, Anason Halees, Colin A Johnson, Fowzan S Alkuraya
BACKGROUND: Ciliopathies are clinically diverse disorders of the primary cilium. Remarkable progress has been made in understanding the molecular basis of these genetically heterogeneous conditions; however, our knowledge of their morbid genome, pleiotropy, and variable expressivity remains incomplete. RESULTS: We applied genomic approaches on a large patient cohort of 371 affected individuals from 265 families, with phenotypes that span the entire ciliopathy spectrum...
November 28, 2016: Genome Biology
https://www.readbyqxmd.com/read/27889303/pgla-h-tandem-repeat-peptides-active-against-multidrug-resistant-clinical-bacterial-isolates
#7
Tomislav Rončević, Goran Gajski, Nada Ilić, Ivana Goić-Barišić, Marija Tonkić, Larisa Zoranić, Juraj Simunić, Monica Benincasa, Marijana Mijaković, Alessandro Tossi, Davor Juretić
Antimicrobial peptides (AMPs) are promising candidates for new antibiotic classes but often display an unacceptably high toxicity towards human cells. A naturally produced C-terminal fragment of PGLa, named PGLa-H, has been reported to have a very low haemolytic activity while maintaining a moderate antibacterial activity. A sequential tandem repeat of this fragment, diPGLa-H, was designed, as well as an analogue with a Val to Gly substitution at a key position. These peptides showed markedly improved in vitro bacteriostatic and bactericidal activity against both reference strains and multidrug resistant clinical isolates of Gram-negative and Gram-positive pathogens, with generally low toxicity for human cells as assessed by haemolysis, cell viability, and DNA damage assays...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27888169/impact-of-information-technology-based-interventions-for-type-2-diabetes-mellitus-on-glycemic-control-a-systematic-review-and-meta-analysis
#8
Nouf Sahal Alharbi, Nada Alsubki, Simon Jones, Kamlesh Khunti, Neil Munro, Simon de Lusignan
BACKGROUND: Information technology-based interventions are increasingly being used to manage health care. However, there is conflicting evidence regarding whether these interventions improve outcomes in people with type 2 diabetes. OBJECTIVE: The objective of this study was to conduct a systematic review and meta-analysis of clinical trials, assessing the impact of information technology on changes in the levels of hemoglobin A1c (HbA1c) and mapping the interventions with chronic care model (CCM) elements...
November 25, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27884676/protein-interactions-with-silver-nanoparticles-green-synthesis-and-biophysical-approach
#9
Nada Shaeel Al-Thabaiti, Maqsood Ahmad Malik, Zaheer Khan
Silver nanoparticles (AgNPs) with an average particle size of 20nm were synthesized by using aromatic amino acid fluorescence active, tryptophan as a reducing agent. This study aims to investigate the interaction between Bovine Serum Albumin (BSA) and AgNPs as a function of particle size and shape. UV-vis analysis implies the formation of the ground state complex between BSA and AgNPs through electrostatic interactions. The fluorescence spectra indicated that the AgNPs have a potent ability to quench the intrinsic fluorescence of BSA by static quenching mechanisms...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27883329/how-to-recognize-and-avoid-potential-possible-or-probable-predatory-open-access-publishers-standalone-and-hijacked-journals
#10
Lenche Danevska, Mirko Spiroski, Doncho Donev, Nada Pop-Jordanova, Momir Polenakovic
INTRODUCTION AND AIM: The Internet has enabled an easy method to search through the vast majority of publications and has improved the impact of scholarly journals. However, it can also pose threats to the quality of published articles. New publishers and journals have emerged so-called open-access potential, possible, or probable predatory publishers and journals, and so-called hijacked journals. It was our aim to increase the awareness and warn scholars, especially young researchers, how to recognize these journals and how to avoid submission of their papers to these journals...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27883317/somatoform-disorders-a-pediatric-experience
#11
Nada Pop-Jordanova, Tatjana Zorcec
Somatization in children consists of the persistent experience and complaints of somatic distress that cannot be fully explained by a medical diagnosis. Working at the Psychophysiological Department at the University Clinic we are dealing with more than 100 children per year manifesting this kind of disorders. The aim of this article is to summarize some specific characteristics of the somatoform disorder in a group of 243 children, mean age 10.31 (± 2.75) years for both genders, selected randomly. The used psychometric instruments are: CBCL, EPQ for children, and MMPI-201 for mothers...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27881915/copd-care-delivery-pathways-in-five-european-union-countries-mapping-and-health-care-professionals-perceptions
#12
Reem Kayyali, Bassel Odeh, Inéz Frerichs, Nikki Davies, Eleni Perantoni, Shona D'arcy, Anouk W Vaes, John Chang, Martijn A Spruit, Brenda Deering, Nada Philip, Roshan Siva, Evangelos Kaimakamis, Ioanna Chouvarda, Barbara Pierscionek, Norbert Weiler, Emiel Fm Wouters, Andreas Raptopoulos, Shereen Nabhani-Gebara
BACKGROUND: COPD is among the leading causes of chronic morbidity and mortality in the European Union with an estimated annual economic burden of €25.1 billion. Various care pathways for COPD exist across Europe leading to different responses to similar problems. Determining these differences and the similarities may improve health and the functioning of health services. OBJECTIVE: The aim of this study was to compare COPD patients' care pathway in five European Union countries including England, Ireland, the Netherlands, Greece, and Germany and to explore health care professionals' (HCPs) perceptions about the current pathways...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27876599/self-emulsifying-drug-delivery-systems-sedds-proof-of-concept-how-to-make-them-mucoadhesive
#13
Gintare Leonaviciute, Nada Trivic Adamovic, Hung Thanh Lam, Julia Rohrer, Alexandra Partenhauser, Andreas Bernkop-Schnürch
AIM: The objective of this study was to provide a proof-of-concept that self-emulsifying drug delivery systems can be made mucoadhesive by the incorporation of hydrophobic mucoadhesive polymers. METHODS: In order to obtain such a hydrophobic mucoadhesive polymer, Eudragit® S100 was thiolated by covalent attachment of cysteamine. After determination of the thiol group content, in vitro mucoadhesion studies (rotating cylinder and rheological measurements) were performed...
November 19, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27872570/influence-of-premolar-extraction-or-non-extraction-orthodontic-therapy-on-the-angular-changes-of-mandibular-third-molars
#14
Bangalore H Durgesh, Kiran H Komari Gowda, Obaid A AlShahrani, Ahmad D Almalki, Waleed D Almalki, Manea Mohammed S Balharith, Nada Yahya H Motashesh, Abdulaziz A Alkheraif, Mohamed I Hashem
AIM: To compare the angular changes of the third molars relative to the occlusal plane and to the second molar long axis in extraction group and compare these changes with a non extraction group. MATERIALS AND METHODS: The study included pre and post treatment panoramic radiograph records of 90 subjects treated by first premolar extractions and 90 subjects who had been treated with non extraction orthodontic therapy (n = 90). Two angular variables were measured...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27871261/quantitative-characterization-of-t-cell-repertoire-and-biomarkers-in-kidney-transplant-rejection
#15
Houda Alachkar, Martin Mutonga, Taigo Kato, Sowjanya Kalluri, Yoichi Kakuta, Motohide Uemura, Ryoichi Imamura, Norio Nonomura, Vikas Vujjini, Sami Alasfar, Hamid Rabb, Yusuke Nakamura, Nada Alachkar
BACKGROUND: T-cell-mediated rejection (TCMR) remains a major cause of kidney allograft failure. The characterization of T-cell repertoire in different immunological disorders has emerged recently as a novel tool with significant implications. We herein sought to characterize T-cell repertoire using next generation sequencing to diagnose TCMR. METHODS: In this prospective study, we analyzed samples from 50 kidney transplant recipients. We collected blood and kidney transplant biopsy samples at sequential time points before and post transplant...
November 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27870772/strawberry-gingivitis-first-manifestation-of-a-vasculitic-disorder-in-a-young-child
#16
Vignesh Pandiarajan, Abdul Kk Rauf, Neeraj Kumar, Anju Gupta, Ashima Goyal, Ritambhra Nada
No abstract text is available yet for this article.
December 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27865777/making-health-systems-research-work-time-to-shift-funding-to-locally-led-research-in-the-south
#17
Amalia Hasnida, Robert A Borst, Anneke M Johnson, Nada R Rahmani, Sabine van Esland, Maarten O Kok
No abstract text is available yet for this article.
November 16, 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27864607/computed-tomography-versus-invasive-coronary-angiography-design-and-methods-of-the-pragmatic-randomised-multicentre-discharge-trial
#18
Adriane E Napp, Robert Haase, Michael Laule, Georg M Schuetz, Matthias Rief, Henryk Dreger, Gudrun Feuchtner, Guy Friedrich, Miloslav Špaček, Vojtěch Suchánek, Klaus Fuglsang Kofoed, Thomas Engstroem, Stephen Schroeder, Tanja Drosch, Matthias Gutberlet, Michael Woinke, Pál Maurovich-Horvat, Béla Merkely, Patrick Donnelly, Peter Ball, Jonathan D Dodd, Martin Quinn, Luca Saba, Maurizio Porcu, Marco Francone, Massimo Mancone, Andrejs Erglis, Ligita Zvaigzne, Antanas Jankauskas, Gintare Sakalyte, Tomasz Harań, Malgorzata Ilnicka-Suckiel, Nuno Bettencourt, Vasco Gama-Ribeiro, Sebastian Condrea, Imre Benedek, Nada Čemerlić Adjić, Oto Adjić, José Rodriguez-Palomares, Bruno Garcia Del Blanco, Giles Roditi, Colin Berry, Gershan Davis, Erica Thwaite, Juhani Knuuti, Mikko Pietilä, Cezary Kępka, Mariusz Kruk, Radosav Vidakovic, Aleksandar N Neskovic, Ignacio Díez, Iñigo Lecumberri, Jacob Geleijns, Christine Kubiak, Anke Strenge-Hesse, The-Hoang Do, Felix Frömel, Iñaki Gutiérrez-Ibarluzea, Gaizka Benguria-Arrate, Hans Keiding, Christoph Katzer, Jacqueline Müller-Nordhorn, Nina Rieckmann, Mario Walther, Peter Schlattmann, Marc Dewey
OBJECTIVES: More than 3.5 million invasive coronary angiographies (ICA) are performed in Europe annually. Approximately 2 million of these invasive procedures might be reduced by noninvasive tests because no coronary intervention is performed. Computed tomography (CT) is the most accurate noninvasive test for detection and exclusion of coronary artery disease (CAD). To investigate the comparative effectiveness of CT and ICA, we designed the European pragmatic multicentre DISCHARGE trial funded by the 7th Framework Programme of the European Union (EC-GA 603266)...
November 18, 2016: European Radiology
https://www.readbyqxmd.com/read/27857488/porosity-of-bleb-capsule-declines-rapidly-with-fluid-challenge
#19
Surinder S Pandav, Craig M Ross, Faisal Thattaruthody, Ritambhra Nada, Nirbhai Singh, Natasha Gautam, Stephen Beirne, Gordon G Wallace, Mark B Sherwood, Jonathan G Crowston, Michael Coote
INTRODUCTION: The porosity of the fibrous capsule around a glaucoma drainage device (GDD) may be the most important functional attribute. The factors that determine capsular porosity are not well understood. Failed GDD surgeries are usually associated with thick impervious capsules and components of aqueous have been implicated in this process. PURPOSE: In this study, we interrogated the effect of passage of nonaqueous fluid on capsular porosity in mature (but aqueous naïve) blebs in a previously reported GDD model (the "Center for Eye Research Australia Implant")...
September 2016: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/27850494/856-qtc-interval-prolongation-with-low-dose-iv-haloperidol-post-hoc-analysis-of-a-placebo-control-trial
#20
Matthew Duprey, Nada Al-Qadheeb, Russel Roberts, Yoanna Skrobik, Greg Schumaker, John Devlin
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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