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https://www.readbyqxmd.com/read/28318767/immunogenicity-and-safety-of-concomitant-administration-of-meningococcal-serogroup-b-4cmenb-and-serogroup-c-menc-crm-vaccines-in-infants-a-phase-3b-randomized-controlled-trial
#1
Marco Aurelio P Safadi, Federico Martinon-Torres, Lily Yin Weckx, Edson Duarte Moreira, Eduardo Jorge da Fonseca Lima, Ilhem Mensi, Marco Calabresi, Daniela Toneatto
BACKGROUND: After implementation of routine infant MenC vaccination, MenB remains a serious cause of meningococcal disease, yet to be targeted by vaccination programs in several countries. This study (NCT01339923) investigated the immunogenicity and safety of MenC CRM-conjugated vaccine (MenC-CRM) concomitantly administered with MenB vaccine (4CMenB). METHODS: Infants (N=251) were randomised 1:1 to receive 4CMenB and MenC-CRM (Group 1) or MenC-CRM alone (Group 2) at 3 and 5months (M3, M5) and a booster at 12months of age (M12), and pneumococcal vaccine at M3, M5, M7, M12...
March 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28317521/quality-of-life-burden-of-disease-co-morbidities-and-systemic-effects-in-vitiligo%C3%A2-patients
#2
REVIEW
Nada Elbuluk, Khaled Ezzedine
Vitiligo is a complex, systemic disease associated with many autoimmune and autoinflammatory conditions. Additionally, the cutaneous changes of vitiligo have significant effects on quality of life and self-esteem. Further efforts are needed to increase our understanding of vitiligo comorbidities as well as to increase awareness of the psychological effects of vitiligo.
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28315501/mechanical-properties-and-biocompatibility-of-in-situ-enzymatically-cross-linked-gelatin-hydrogels
#3
Nada Z Alarake, Patrick Frohberg, Thomas Groth, Markus Pietzsch
OBJECTIVES: Gelatin, a degraded collagen, has been widely used as a scaffolding material in tissue engineering applications. In this work, we aimed at the development of in situ, cross-linking, cytocompatible hydrogels by the use of transglutaminase as a cross-linker for potential application in the regeneration of tissues. METHODS: Hydrogels were prepared from gelatin of different concentrations and bloom degree (175 (G175) or 300 (G300) bloom gelatin) and cross-linked with various amounts of microbial transglutaminase (mTG) at 37°C...
March 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28314149/cytokinin-response-in-pepper-plants-capsicum-annuum-l-exposed-to-silver-nanoparticles
#4
Tomislav Vinković, Ondrej Novák, Miroslav Strnad, Walter Goessler, Darija Domazet Jurašin, Nada Parađiković, Ivana Vinković Vrček
The increasing development of different nanomaterials, such as silver nanoparticles (AgNPs), and their practical use in agriculture and biotechnology has created a strong need for elucidations of biological effects and risk assessments of AgNPs in plants. This study was aimed to investigate AgNPs effects on metal uptake and their biodistribution in pepper plants as well as on morphological parameters and hormonal responses of the isoprenoid cytokinin (CK) family. In addition, the comparison of effects silver form, nanoparticles vs...
March 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28299498/evaluation-of-vitreoretinal-interface-changes-in-patients-receiving-intravitreal-anti-vegf-therapy
#5
Vartika Kinra, Satvir Singh, Sumeet Khanduja, Manisha Nada
PURPOSE: To study the effects of repeated intravitreal injection of anti-VEGF drug bevacizumab on the vitreoretinal interface (VRI). METHODS: Patients undergoing intravitreal injection of bevacizumab were enrolled. Eyes with media haze, uveitis, high myopia, history of cataract surgery or laser capsulotomy in last 6 months and complicated pseudophakia were excluded. VRI evaluation was done monthly for a minimum of 6 months. The nature and timing of the change(s) event was recorded...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28297631/an-examination-of-suicide-research-and-funding-in-new-zealand-2006-16-implications-for-new-research-and-policies
#6
Daniel D L Coppersmith, Shyamala Nada-Raja, Annette L Beautrais
Objective Suicide is a significant public health problem in New Zealand, with the youth suicide rate being one of the highest among developed countries. Increased suicide rates in recent years suggest that the evidence base and research priorities for New Zealand suicide prevention need to be reassessed. To inform policy development, the aim of the present study was to evaluate all peer-reviewed New Zealand published suicide research and major grant allocations from 2006 to 2016.Methods The methodology duplicated a recent Australian review of suicide prevention research and funding...
March 16, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28293406/%C3%AE-thalassemia-distribution-in-the-old-world-an-ancient-disease-seen-from-a-historical-standpoint
#7
REVIEW
Vincenzo De Sanctis, Christos Kattamis, Duran Canatan, Ashraf T Soliman, Heba Elsedfy, Mehran Karimi, Shahina Daar, Yasser Wali, Mohamed Yassin, Nada Soliman, Praveen Sobti, Soad Al Jaouni, Mohamed El Kholy, Bernadette Fiscina, Michael Angastiniotis
BACKGROUND: Haemoglobinopathies constitute the commonest recessive monogenic disorders worldwide, and the treatment of affected individuals presents a substantial global disease burden. β-thalassaemia is characterised by the reduced synthesis (β(+)) or absence (β(o)) of the β-globin chains in the HbA molecule, resulting in accumulation of excess unbound α-globin chains that precipitate in erythroid precursors in the bone marrow and in the mature erythrocytes, leading to ineffective erythropoiesis and peripheral haemolysis...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28292183/n-docosahexaenoyl-dopamine-an-endocannabinoid-like-conjugate-of-dopamine-and-the-n-3-fatty-acid-docosahexaenoic-acid-attenuates-lipopolysaccharide-induced-activation-of-microglia-and-macrophages-via-cox-2
#8
Ya Wang, Pierluigi Plastina, Jean-Paul Vincken, Renate Jansen, Michiel Balvers, Jean Paul Ten Klooster, Harry Gruppen, Renger Witkamp, Jocelijn Meijerink
Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. To explain these effects, different mechanisms are being proposed, including those involving endocannabinoids and related signaling molecules. Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ethanolamine or serotonin have previously been shown to possess anti-inflammatory and potentially neuroprotective properties...
March 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28285286/necrotizing-polyarteritis-nodosa-like-vasculitis-in-a-child-with-systemic-lupus-erythematosus
#9
Ritambhra Nada, Joseph L Matthews, Sagar Bhattad, Anju Gupta, Surjit Singh
A 10-year-old child presented with prolonged fever, lymphadenopathy, weight loss, oral ulcers, alopecia and parotitis. She later developed arterial thrombosis, poly-serositis, nephritis, myocarditis, sacro-ilitis, autoimmune hemolytic anemia and refractory thrombocytopenia. Though anti-dsDNA was negative, she was diagnosed to have systemic lupus erythematosus (SLE). Terminally, she had pulmonary symptoms and succumbed to her illness. The autopsy showed lupus nephritis-Class II, polyserositis, myocarditis, inflammatory myositis, immune mediated vasculitis involving renal, coronary, pancreatic, adrenal, dermal and intramuscular arteries, and pulmonary hemorrhages and edema...
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28285274/feasibility-and-acceptability-of-text-messaging-to-support-antenatal-healthcare-in-iraqi-pregnant-women-a-pilot-study
#10
Taghreed Alhaidari, Nazar Amso, Taqi Mohammed Jawad, Ulfat Alnakkash, Faris Khazaal, Ahmed Alnaaimi, Timothy Pickles, Rebecca Playle, Robert Istepanian, Nada Philip, John W Gregory, Thamer Al Hilfi
OBJECTIVE: To determine the feasibility and acceptability of mobile health technology and its potential to improve antenatal care (ANC) services in Iraq. METHODS: This was a controlled experimental study conducted at primary health care centers. One hundred pregnant women who attended those centres for ANC were exposed to weekly text messages varying in content, depending on the week of gestation, while 150 women were recruited for the unexposed group. The number of ANC visits in the intervention and control groups, was the main outcome measure...
March 13, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28284470/virtual-fracture-clinic-management-of-fifth-metatarsal-including-jones-fractures-is-safe-and-cost-effective
#11
Kit Brogan, Simon Bellringer, Harold Akehurst, Christopher Gee, Nada Ibrahim, Lucy Cassidy, Ben Rogers, James Gibbs
Virtual clinics have been shown to be safe and cost-effective in many specialties, yet barriers exist to their implementation in orthopaedics. The aims of this study were to look at whether the management of 5th metatarsal fractures using a virtual fracture clinic model is safe, cost effective and avoids adverse outcomes whilst being acceptable to patients using the service. All patients with a fifth metatarsal fracture between September 2013 and September 2015 had a standardised management plan initiated (blackboot, full weightbearing) in the emergency department (ED)...
February 12, 2017: Injury
https://www.readbyqxmd.com/read/28283149/erratum-to-fistula-experience-in-niger-how-we-overcame-an-ethical-dilemma-mount-sinai-journal-of-medicine-76-2009-71-74
#12
Cedric K Olivera, Charles J Ascher-Walsh, Nada Gligorov
No abstract text is available yet for this article.
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28282874/serum-cystatin-c-as-a-biomarker-in-diffuse-large-b-cell-lymphoma
#13
Nada E Hammouda, Manal A Salah El-Din, Mamdouh M El-Shishtawy, Amal M El-Gayar
Elevated serum levels of cystatin C are found to be related to poor outcome and metastatic potential of some malignant disorders. To evaluate the clinical prominence of serum cystatin C in diffuse large B-cell lymphoma (DLBCL), blood samples were obtained from 58 patients at the time of diagnosis and paired blood samples were obtained from 22 patients at the time of remission. Also, serum cystatin C level was measured in matched healthy controls. Serum cystatin C levels were significantly more elevated in DLBCL patients than in controls (p < 0...
March 8, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28282548/attenuated-in-vitro-effects-of-ifn-%C3%AE-il-2-and-il-12-on-functional-and-receptor-characteristics-of-peripheral-blood-lymphocytes-in-metastatic-melanoma-patients
#14
Katarina M Mirjačić Martinović, Ana M Vuletić, Nada Lj Babović, Radan R Džodić, Gordana M Konjević, Vladimir B Jurišić
Considering tumor-induced suppression of lymphocytes the aim of this study was to investigate in vitro effects of IFN-α, IL-2, IL-12 and IL-18 as immunomodulating agents on the functional and receptor characteristics of peripheral blood lymphocytes (PBL) in metastatic melanoma (MM) patients compared to healthy controls (HC). In HC IFN-α, IL-2 and IL-12 enhanced mRNA level of perforin by inducing pSTAT-1 and pSTAT-5 signaling molecules. Additionally, the expression of NKG2D activating receptor and its DAP10 signaling molecule was upregulated by IL-2...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28278431/parenting-and-youth-sexual-risk-in-context-the-role-of-community-factors
#15
Nada M Goodrum, Lisa P Armistead, Erin C Tully, Sarah L Cook, Donald Skinner
Black South African youth are disproportionately affected by HIV, and risky sexual behaviors increase youths' vulnerability to infection. U.S.-based research has highlighted several contextual influences on sexual risk, but these processes have not been examined in a South African context. In a convenience sample of Black South African caregivers and their 10-14-year-old youth (Mage = 11.7, SD = 1.4; 52.5% female), we examined the relation between parenting and youth sexual risk within the context of community-level processes, including neighborhood quality and maternal social support...
March 6, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28275277/attitudes-of-students-of-differenet-schools-of-university-of-zagreb-on-tooth-bleaching
#16
Dinka Diklić, Eva Klarić Sever, Nada Galić, Jelena Spajić, Katica Prskalo
OBJECTIVE: To compare the awareness that students from four different faculties within the University of Zagreb have of oral health and tooth bleaching procedure. MATERIALS AND METHODS: The study included 158 subjects (both male and female) - 38 students from the School of Dental Medicine and 40 students from each of the following faculties: the School of Medicine, the Faculty of Economics and the Faculty of Civil Engineering. The respondents were asked to fill out the survey with multiple choices by marking the answers they considered correct...
December 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28274197/sparse-proteomics-analysis-a-compressed-sensing-based-approach-for-feature-selection-and-classification-of-high-dimensional-proteomics-mass-spectrometry-data
#17
Tim O F Conrad, Martin Genzel, Nada Cvetkovic, Niklas Wulkow, Alexander Leichtle, Jan Vybiral, Gitta Kutyniok, Christof Schütte
BACKGROUND: High-throughput proteomics techniques, such as mass spectrometry (MS)-based approaches, produce very high-dimensional data-sets. In a clinical setting one is often interested in how mass spectra differ between patients of different classes, for example spectra from healthy patients vs. spectra from patients having a particular disease. Machine learning algorithms are needed to (a) identify these discriminating features and (b) classify unknown spectra based on this feature set...
March 9, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28272018/genetic-polymorphisms-of-cytochrome-p450-enzymes-cyp2c9-cyp2c19-cyp2d6-cyp3a4-and-cyp3a5-in-the-croatian-population
#18
Lana Ganoci, Tamara Božina, Nikica Mirošević Skvrce, Mila Lovrić, Petar Mas, Nada Božina
BACKGROUND: Data on the frequency of pharmacogenetic polymorphisms in the Croatian population are limited. We determined and analyzed frequencies for the most important CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 genetic variants in the Croatian population. METHODS: 2637 subjects were included. Genotyping was performed by real-time polymerase chain reaction (PCR) using TaqMan® DME or TaqMan® SNP Genotyping Assays, and by PCR, and PCR-RFLP analysis. RESULTS: For CYP2C9, allele frequencies of *2 and *3 variant were 14...
March 1, 2017: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/28269748/e2f3-transcription-factor-a-promising-biomarker-in-lung-cancer
#19
Hala Abdel Al, Ola Nada
BACKGROUND: Many researches aiming to explore the pathogenesis of lung cancer have extensively studied the molecular alteration in such disease. OBJECTIVE: In the present study we measured the blood E2F3 mRNA using real-time RT-PCR technique in order to evaluate its clinical significance in early diagnosis and monitoring of lung cancer. METHODS: This case-control study included 50 lung cancer patients, 20 patients with benign lung diseases and 20 healthy controls...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28263596/inactivation-of-a-virulent-wastewater-escherichia-coli-and-non-virulent-commensal-escherichia-coli-dsm1103-strains-and-their-gene-expression-upon-solar-irradiation
#20
Nada Al-Jassim, David Mantilla-Calderon, Tiannyu Wang, Peiying Hong
This study examined the decay kinetics and molecular responses of two E. coli strains upon solar irradiation. The first is E. coli PI-7, a virulent and antibiotic-resistant strain that was isolated from wastewater and carries the emerging NDM-1 antibiotic resistance gene. The other strain, E. coli DSM1103, displayed lower virulence and antibiotic resistance than E. coli PI-7. In a buffer solution, E. coli PI-7 displayed a longer lag phase prior to decay and a longer half-life compared with E. coli DSM1103 (6...
March 6, 2017: Environmental Science & Technology
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