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https://www.readbyqxmd.com/read/29445610/monitored-transoral-endoscopic-thyroidectomy-via-long-monopolar-stimulation-probe
#1
Gianlorenzo Dionigi, Che-Wei Wu, Ralph P Tufano, Antonio Giacomo Rizzo, Angkoon Anuwong, Hui Sun, Paolo Carcoforo, Cancellieri Antonino, Mattia Portinari, Hoon Yub Kim
This video aimed to describe the role of intraoperative neuromonitoring (IONM) during transoral endoscopic thyroidectomy vestibular approach (TOETVA) with emphasis given to IONM technical and technological notes, the identification of recurrent laryngeal nerve (RLN). Standardized technique of IONM consist in identifying and monitoring both the vagus nerve and the RLNs before and after resection (V1, V2, R1, R2). According to this report, IONM during TOETVA is feasible and safe in providing identification and function of laryngeal nerves...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29443448/an-intraneural-electrode-for-bioelectronic-medicines-for-treatment-of-hypertension
#2
Cristian Sevcencu, Thomas N Nielsen, Johannes J Struijk
OBJECTIVES: As the left vagus nerve (LVN) mediates a baroreflex blood pressure (BP) decrease, LVN stimulation (LVNS) could be a therapy for hypertension. Moreover, LVNS could elegantly be adjusted to the patient's actual BP and physical activity by using the neural information about BP and respiration extractable from LVN. However, unselective LVNS will trigger undesirable side-effects and therefore we here investigated the feasibility of using an intraneural electrode for extracting BP and respiration markers from the LVN and for selective LVNS...
February 14, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29430580/devices-and-interventions-for-the-prevention-of-adverse-outcomes-of-tachycardia-on-heart-failure
#3
REVIEW
Jasneet Devgun, Yash B Jobanputra, Michael Arustamyan, Robert Chait, Waqas Ghumman
Heart failure (HF) is the leading cause of hospitalization in the USA. Despite advances in pharmacologic management, the incidence of HF is on the rise and survivability is persistently reduced. Sympathetic overdrive is implicated in the pathophysiology of HF, particularly HF with reduced ejection fraction (HFrEF). Tachycardia can be particularly deleterious and thus has spurred significant investigation to mitigate its effects. Various modalities including vagus nerve stimulation, baroreceptor activation therapy, spinal cord stimulation, renal sympathetic nerve denervation, left cardiac sympathetic denervation, and carotid body removal will be discussed...
February 12, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29428900/the-provision-of-care-to-adults-with-an-intellectual-disability-in-the-uk-a-special-report-from-the-intellectual-disability-uk-chapter-ilae
#4
M P Kerr, L V Watkins, H Angus-Leppan, A Corp, M Goodwin, C Hanson, A Roy, R Shankar
PURPOSE: This article reflects the report by the British Branch of the International League Against Epilepsy (ILAE) Working Group on services for adults with epilepsy and intellectual disability (ID). Its terms of reference was to explore the current status of aspects of the care of people with an ID and epilepsy. METHODS: Survey content was developed from key themes identified by consensus of the working group. An electronic survey was distributed via email. The sample population was the membership of the ILAE UK, Royal College of Psychiatrists (RCPsych) Faculty of ID, Epilepsy Nurses Association (ESNA), and the Association of British Neurologists (ABN)...
February 8, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29427206/neuromodulation-in-inflammatory-skin-disease
#5
Eric J Yang, Sahil Sekhon, Kristen M Beck, Tina Bhutani, John Koo
Inflammatory skin diseases are difficult to treat because of a lack of available treatment options for severe disease. However, recent advances have shown that vagus nerve stimulation can be used to decrease inflammation and reduce disease severity in rheumatoid arthritis and inflammatory bowel disease. Changes in cytokine profiles observed in these studies are similar to those seen with use of biologics in inflammatory skin disease, suggesting that they act along similar pathways to disrupt chronic inflammation and treat inflammatory disease...
February 9, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29425906/effects-of-vagal-neuromodulation-on-feeding-behavior
#6
Nicole A Pelot, Warren M Grill
Implanted vagus nerve stimulation (VNS) for obesity was recently approved by the FDA. However, its efficacy and mechanisms of action remain unclear. Herein, we synthesize clinical and preclinical effects of VNS on feeding behavior and energy balance and discuss engineering considerations for understanding and improving the therapy. Clinical cervical VNS (≤30 Hz) to treat epilepsy or depression has produced mixed effects on weight loss as a side effect, albeit in uncontrolled, retrospective studies. Conversely, preclinical studies (cervical and subdiaphragmatic VNS) mostly report decreased food intake and either decreased weight gain or weight loss...
February 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29424758/a-6-year-follow-up-study-of-vagus-nerve-stimulation-effect-on-quality-of-life-in-treatment-resistant-depression-a-pilot-study
#7
François Trottier-Duclos, Véronique Desbeaumes Jodoin, Marie-Pierre Fournier-Gosselin, François Richer, Nathalie Desjardins, Sylvie Tieu, Paul Lespérance
OBJECTIVES: Treatment-resistant depression (TRD) carries a major burden on those affected by this disease and significantly impacts their quality of life (QOL). Vagus nerve stimulation (VNS) has showed promising results on symptoms, but its impact on QOL remains underresearched. This study aims to evaluate the long-term effects of VNS on both QOL and clinical symptoms for TRD patients, through a naturalistic 6-year follow-up. METHOD: Outpatients with confirmed TRD were enrolled to receive VNS...
February 7, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29414594/changes-in-sleep-patterns-after-vagus-nerve-stimulation-deep-brain-stimulation-or-epilepsy-surgery-systematic-review-of-the-literature
#8
REVIEW
Óscar Romero-Osorio, Sebastián Gil-Tamayo, Daniel Nariño, Diego Rosselli
PURPOSE: Perform a systematic review of the literature on the effects of vagus nerve stimulation (VNS), deep brain stimulation (DBS) and epilepsy surgery in subjective and objective sleep parameters. METHODS: We performed a literature search in the main medical databases: Medline, Embase, Cochrane, DARE and LILACS, looking for studies that evaluated the effects of VNS, DBS or epilepsy surgery on sleep parameters. In all, 36 studies, coming from 11 countries, including reviews, cohort studies, case series and case reports were included...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29414137/the-effect-of-vagus-nerve-stimulator-in-controlling-status-epilepticus-in-children
#9
Satyanarayana Gedela, Bilal Sitwat, William P Welch, Robert T Krafty, Yoshimi Sogawa
PURPOSE: This study explores the effect of Vagus Nerve Stimulator (VNS) on Status Epilepticus (SE) in children with medically intractable epilepsy. METHODS: Retrospective review was conducted in children with a history of at least two SE, who had VNS implantation and had at least one year follow up after the procedure. RESULTS: Sixteen patients met inclusion/exclusion criteria. The median age of seizure onset and surgery was 1.3 years and 9...
January 23, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29410385/functional-magnetic-resonance-imaging-evaluation-of-auricular-percutaneous-electrical-neural-field-stimulation-for-fibromyalgia-protocol-for-a-feasibility-study
#10
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Roman Sniecinski, Bruce Crosson
BACKGROUND: Fibromyalgia is a chronic pain state that includes widespread musculoskeletal pain, fatigue, psychiatric symptoms, cognitive and sleep disturbances, and multiple somatic symptoms. Current therapies are often insufficient or come with significant risks, and while there is an increasing demand for non-pharmacologic and especially non-opioid pain management such as that offered through complementary and alternative medicine therapies, there is currently insufficient evidence to recommend these therapies...
February 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29408217/autonomic-conflict-exacerbates-long-qt-associated-ventricular-arrhythmia
#11
James Winter, Michael Tipton, Michael J Shattock
This study tested the hypothesis that concomitant sympathetic and parasympathetic stimulation ("autonomic conflict") may act as a trigger for arrhythmia in long QT syndrome (LQTS). Studies were performed in isolated innervated rabbit hearts treated with clofilium (100 nmol/L); a potassium channel blocker. The influence of vagus nerve stimulation (VNS) on spontaneous ventricular arrhythmia was assessed in the absence/presence of sustained noradrenaline perfusion (100 nmol/L) and with sudden adrenergic stress (injections of noradrenaline into the perfusion line)...
February 2, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29399541/cholinergic-anti-inflammatory-pathway-and-the-liver
#12
REVIEW
Khalil Hajiasgharzadeh, Behzad Baradaran
The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers. This activation and subsequent acetylcholine releases from vagus nerve terminals leads to inhibition of inflammatory cytokines through α7 nicotinic acetylcholine receptors (α7nAChRs) which located on the surface of different cell types such as liver Kupffer cells. This protective role of vagus-α7nAChR axis in liver diseases has been shown in several experimental studies...
December 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29398576/a-distinct-biomarker-of-continuous-transcutaneous-vagus-nerve-stimulation-treatment-in-major-depressive-disorder
#13
Yiheng Tu, Jiliang Fang, Jin Cao, Zengjian Wang, Joel Park, Kristen Jorgenson, Courtney Lang, Jun Liu, Guolei Zhang, Yanping Zhao, Bing Zhu, Peijing Rong, Jian Kong
BACKGROUND: Major depression is the fourth leading cause of disability worldwide and poses a socioeconomic burden worldwide. Transcutaneous vagus nerve stimulation (tVNS) is a promising noninvasive clinical device that may reduce the severity of major depression. However, the neural mechanism underlying continuous tVNS has not yet been elucidated. OBJECTIVE: We aimed to explore the effect of hypothalamic subregion functional connectivity (FC) changes during continuous tVNS treatment on major depressive disorder (MDD) patients and to identify the potential biomarkers for treatment outcomes...
January 31, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29397282/non-invasive-brain-stimulation-for-negative-symptoms-in-schizophrenia-an-updated-systematic-review-and-meta-analysis
#14
REVIEW
Caio Osoegawa, July Silveira Gomes, Ruth Bartelli Grigolon, Elisa Brietzke, Ary Gadelha, Acioly L T Lacerda, Álvaro Machado Dias, Quirino Cordeiro, Ronaldo Laranjeira, Danilo de Jesus, Zafiris Jeff Daskalakis, Jerome Brunelin, Joachim Cordes, Alisson Paulino Trevizol
BACKGROUND: Schizophrenia is a mental disorder with significant socioeconomic burden. Although current pharmacological treatments are effective for treating positive symptoms, medications have little-to-no effect in the treatment of negative symptoms. OBJECTIVE: To assess the efficacy of non-invasive brain stimulation (NIBS) for negative symptoms in schizophrenia in randomized clinical trials (RCTs). METHODS: A systematic review in Medline and Cochrane Library databases was performed up to May 31, 2017...
January 31, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29392854/ghrelin-secretion-in-humans-a-role-for-the-vagus-nerve
#15
S Veedfald, A Plamboeck, B Hartmann, T Vilsbøll, F K Knop, C F Deacon, L B Svendsen, J J Holst
BACKGROUND: Ghrelin, an orexigenic peptide, is secreted from endocrine cells in the gastric mucosa. Circulating levels rise in the preprandial phase, suggesting an anticipatory or cephalic phase of release, and decline in the postprandial phase, suggesting either the loss of a stimulatory factor or inhibition by factors released when nutrients enter the intestine. We hypothesized that vagal signals are not required for the (i) preprandial increase or (ii) postprandial suppression of ghrelin levels...
February 2, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29392242/vagus-nerve-stimulation-inhibits-trigeminal-nociception-in-a-rodent-model-of-episodic-migraine
#16
Jordan L Hawkins, Lauren E Cornelison, Brian A Blankenship, Paul L Durham
Introduction: Although neck muscle tension is considered a risk factor for migraine, pungent odors can act as a trigger to initiate an attack in sensitized individuals. Although noninvasive vagus nerve stimulation (nVNS) is now an approved treatment for chronic migraine, how it functions to inhibit trigeminal nociception in an episodic migraine model is not known. Objectives: The objectives of this study were to determine if nVNS could inhibit trigeminal nociception in a novel model of episodic migraine and investigate changes in the expression of proteins implicated in peripheral and central sensitization...
November 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29389905/ablation-of-the-right-cardiac-vagus-nerve-reduces-acetylcholine-content-without-changing-the-inflammatory-response-during-endotoxemia
#17
Konstanze Plaschke, Thuc Quyen Monica Do, Florian Uhle, Thorsten Brenner, Markus A Weigand, Jürgen Kopitz
Acetylcholine is the main transmitter of the parasympathetic vagus nerve. According to the cholinergic anti-inflammatory pathway (CAP) concept, acetylcholine has been shown to be important for signal transmission within the immune system and also for a variety of other functions throughout the organism. The spleen is thought to play an important role in regulating the CAP. In contrast, the existence of a "non-neuronal cardiac cholinergic system" that influences cardiac innervation during inflammation has been hypothesized, with recent publications introducing the heart instead of the spleen as a possible interface between the immune and nervous systems...
February 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29385305/intraoperative-cardiac-arrest-etiologies-in-head-and-neck-surgery-a-comprehensive-review
#18
Constantine Tarabanis, Nicholas B Abt, Heather A Osborn
BACKGROUND: The etiologies of intraoperative cardiac arrest within otolaryngology are not well understood as they are rare events. METHODS: A comprehensive review of the etiologies and corresponding pathophysiologic neural mechanisms of intraoperative cardiac arrest in otolaryngologic surgery are examined. RESULTS: The occurrence of this rare complication has been described in a range of head and neck procedures, including but not limited to suspension laryngoscopy and oncologic resections in the neck, maxilla and thyroid...
January 31, 2018: Head & Neck
https://www.readbyqxmd.com/read/29371435/vagus-nerve-stimulation-enhances-stable-plasticity-and-generalization-of-stroke-recovery
#19
Eric C Meyers, Bleyda R Solorzano, Justin James, Patrick D Ganzer, Elaine S Lai, Robert L Rennaker, Michael P Kilgard, Seth A Hays
BACKGROUND AND PURPOSE: Chronic impairment of the arm and hand is a common consequence of stroke. Animal and human studies indicate that brief bursts of vagus nerve stimulation (VNS) in conjunction with rehabilitative training improve recovery of motor function after stroke. In this study, we tested whether VNS could promote generalization, long-lasting recovery, and structural plasticity in motor networks. METHODS: Rats were trained on a fully automated, quantitative task that measures forelimb supination...
January 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29369741/reflex-bronchoconstriction-evoked-by-inhaled-nicotine-aerosol-in-guinea-pigs-role-of-the-nicotinic-acetylcholine-receptor
#20
Lu-Yuan Lee, Ruei-Lung Lin, Mehdi Khosravi, Fadi Xu
Inhaled cigarette smoke stimulated vagal bronchopulmonary C-fibers via an action of nicotine on neuronal nicotinic acetylcholine receptor (nAChR). Recent studies have reported that nicotine at high concentrations can also activate the transient receptor potential ankyrin 1 receptor (TRPA1) expressed in these sensory nerves. This study was carried out to characterize the airway response to inhaled nicotine aerosol and to investigate the relative roles of nAChR and TRPA1 in this response. Guinea pigs were anesthetized and mechanically ventilated; one tidal volume of nicotine aerosol (2% solution) was diluted by equal volume of air and delivered directly into the lung via a tracheal cannula in a single breath...
January 25, 2018: Journal of Applied Physiology
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