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https://www.readbyqxmd.com/read/29779025/differential-determinants-of-tubular-phosphate-reabsorption-insights-on-renal-excretion-of-phosphates-in-kidney-disease
#1
Nahid Tabibzadeh, Romuald Mentaverri, Maïté Daroux, Rafik Mesbah, Alexia Delpierre, Jean-Gabriel Paul, Valérie Deken, Ziad A Massy, Pierre Bataille
We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29775806/case-report-cd103-cd8-lymphocytes-characterize-the-immune-infiltration-in-a-case-with-pseudoprogression-in-sqnsclc
#2
Pedro Rocha, Max Hardy-Werbin, Dolores Naranjo, Álvaro Taus, Maite Rodrigo, Flavio Zuccarino, René Roth, Oliver Wood, Christian H Ottensmeier, Edurne Arriola
No abstract text is available yet for this article.
May 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29773261/perioperative-transfusion-management-in-gastric-cancer-surgery-analysis-of-the-spanish-subset-of-the-eurecca-oesophago-gastric-cancer-registry
#3
Javier Osorio, Carlos Jericó, Coro Miranda, Elisenda Garsot, Alexis Luna, Mónica Miró, Maite Santamaría, Eva Artigau, Joaquín Rodríguez-Santiago, Sandra Castro, Josep Feliu, Aurora Aldeano, Carles Olona, Dulce Momblan, David Ruiz, Gonzalo Galofré, Inmaculada Pros, Xabier García-Albéniz, Miguel Lozano, Manuel Pera
INTRODUCTION: This study evaluated allogenic packed red blood cell (aPRBC) transfusion rates in patients undergoing resection for gastric cancer and the implementation of blood-saving protocols (BSP). METHODS: Retrospective study of all gastric cancer patients operated on with curative intent in Catalonia and Navarra (2011-2013) and included in the Spanish subset of the EURECCA Oesophago-Gastric Cancer Registry. Hospitals with BSP were defined as those with a preoperative haemoglobin (Hb) optimisation circuit associated with restrictive transfusion strategies...
May 14, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29766731/-current-and-prospective-biologics-and-small-molecules-in-the-treatment-of-inflammatory-bowel-diseases
#4
Milan Buc
Crohns disease (CD) and ulcerative colitis (UC) belong to chronic inflammatory bowel diseases, which are induced by autoimmune processes. While CD is characterized by over-activity of Th1, ILC1, and MAIT cells, UC is mediated by exaggerated activities of Th2 and ILC2 cells and cytokines they produce. Knowledge of the pathogenesis enabled a rational therapy based mostly on biologics and small molecules. TNF is the principal proinflammatory cytokine in both diseases. Anti-TNF monoclonal antibodies, mostly infliximab or adalimumab were therefore introduced to their treatment...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29765367/detection-of-bacteriophage-particles-containing-antibiotic-resistance-genes-in-the-sputum-of-cystic-fibrosis-patients
#5
Maryury Brown-Jaque, Lirain Rodriguez Oyarzun, Thais Cornejo-Sánchez, Maria T Martín-Gómez, Silvia Gartner, Javier de Gracia, Sandra Rovira, Antonio Alvarez, Joan Jofre, Juan J González-López, Maite Muniesa
Cystic fibrosis (CF) is a chronic disease in which the bacterial colonization of the lung is linked to an excessive inflammatory response that leads to respiratory failure. The microbiology of CF is complex. Staphylococcus aureus is the first bacterium to colonize the lungs in 30% of pediatric CF patients, and 80% of adult patients develop a chronic Pseudomonas aeruginosa infection, but other microorganisms can also be found. The use of antibiotics is essential to treat the disease, but antibiotic performance is compromised by resistance mechanisms...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29765117/risk-of-poisoning-in-children-and-adolescents-with-adhd-a-systematic-review-and-meta-analysis
#6
Maite Ruiz-Goikoetxea, Samuele Cortese, Sara Magallón, Maite Aznárez-Sanado, Noelia Álvarez Zallo, Elkin O Luis, Pilar de Castro-Manglano, Cesar Soutullo, Gonzalo Arrondo
Poisoning, a subtype of physical injury, is an important hazard in children and youth. Individuals with ADHD may be at higher risk of poisoning. Here, we conducted a systematic review and meta-analysis to quantify this risk. Furthermore, since physical injuries, likely share causal mechanisms with those of poisoning, we compared the relative risk of poisoning and injuries pooling studies reporting both. As per our pre-registered protocol (PROSPERO ID CRD42017079911), we searched 114 databases through November 2017...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29759110/effects-of-a-multi-component-nutritional-telemonitoring-intervention-on-nutritional-status-diet-quality-physical-functioning-and-quality-of-life-of-community-dwelling-older-adults
#7
Marije N van Doorn-van Atten, Annemien Haveman-Nies, Marit M van Bakel, Monique Ferry, Maite Franco, Lisette C P G M de Groot, Jeanne H M de Vries
This study aimed to evaluate the effects of an intervention including nutritional telemonitoring, nutrition education, and follow-up by a nurse on nutritional status, diet quality, appetite, physical functioning and quality of life of Dutch community-dwelling elderly. We used a parallel arm pre-test post-test design with 214 older adults (average age 80 years) who were allocated to the intervention group (n 97) or control group (n 107), based on the municipality. The intervention group received a 6-month intervention including telemonitoring measurements, nutrition education and follow-up by a nurse...
May 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29754112/mr1-antigen-presentation-to-mait-cells-new-ligands-diverse-pathways
#8
REVIEW
Hamish Eg McWilliam, Jose A Villadangos
The major histocompatibility complex class I-related molecule MR1 is the only antigen (Ag) presenting molecule that captures and displays vitamin B-derived metabolites that are unique to a wide array of microbes. Presentation of these metabolite Ag at the cell surface activates mucosal-associated invariant T (MAIT) cells, a highly abundant innate-like T cell population, and represents a recently-described mechanism used by the mammalian immune system to sense pathogenic or commensal microbes. Our understanding of the cell biology of how MR1 accomplishes this unique task is still evolving, but recent advances are allowing a general picture to emerge...
May 10, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29754028/frequency-and-factors-associated-with-providing-injection-initiation-assistance-in-tallinn-estonia
#9
Anneli Uusküla, David M Barnes, Mait Raag, Ave Talu, Susan Tross, Don C Des Jarlais
Injection drug use is expanding in numerous regions in the world. Persons who inject drugs (PWID) play an important role encouraging new persons into injecting, by providing injection initiation assistance ("assisting" behaviors) and stimulating interest in injection ("promoting" behaviors). OBJECTIVES: To describe the prevalence of assisting and promoting behaviors, and to identify factors associated with assisting, among PWID in Tallinn, Estonia. METHODS: In 2016, PWID were recruited through respondent-driven sampling (RDS), interviewed, and HIV tested...
May 8, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29749611/proteomic-definition-of-human-mucosal-associated-invariant-t-cells-determines-their-unique-molecular-effector-phenotype
#10
Björn Bulitta, Werner Zuschratter, Isabel Bernal, Dunja Bruder, Frank Klawonn, Martin von Bergen, Henrikus Stephanus Paulus Garritsen, Lothar Jänsch
Mucosal-associated invariant T cells (MAIT) constitute the most abundant anti-bacterial CD8+ T cell population in humans. MR1/TCR-activated MAIT cells were reported to organize cytotoxic and innate-like responses but knowledge about their molecular effector phenotype is still fragmentary. Here, we have examined the functional inventory of human MAIT cells (CD3+Vα7.2+CD161+) in comparison with those from conventional non-MAIT CD8+ T cells (cCD8+ ) and NK cells. Quantitative mass spectrometry characterized 5500 proteins of primary MAIT cells and identified 160 and 135 proteins that discriminate them from cCD8+ T cells and NK cells donor-independently...
May 11, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29748460/experiences-and-opinions-of-adults-with-type-2-diabetes-regarding-a-self-regulation-based-ehealth-intervention-targeting-physical-activity-and-sedentary-behaviour
#11
Louise Poppe, Geert Crombez, Ilse De Bourdeaudhuij, Celien Van der Mispel, Samyah Shadid, Maïté Verloigne
Background: Online interventions targeting a healthy lifestyle in adults with type 2 diabetes are more effective when informed by behaviour change theories. Although these theories provide guidance in developing the content of an intervention, information regarding how to present this content in an engaging way is often lacking. Consequently, incorporating users’ views in the creation of eHealth interventions has become an important target. Methods: Via a qualitative interview study with 21 adults with type 2 diabetes who had completed an online self-regulation-based intervention (‘MyPlan 2...
May 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29743663/drp-1-mediated-apoptosis-induces-muscle-degeneration-in-dystrophin-mutants
#12
Charlotte Scholtes, Stéphanie Bellemin, Edwige Martin, Maïté Carre-Pierrat, Bertrand Mollereau, Kathrin Gieseler, Ludivine Walter
Mitochondria are double-membrane subcellular organelles with highly conserved metabolic functions including ATP production. Mitochondria shapes change continually through the combined actions of fission and fusion events rendering mitochondrial network very dynamic. Mitochondria are largely implicated in pathologies and mitochondrial dynamics is often disrupted upon muscle degeneration in various models. Currently, the exact roles of mitochondria in the molecular mechanisms that lead to muscle degeneration remain poorly understood...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743612/modulation-of-bacterial-metabolism-by-the-microenvironment-controls-mait-cell-stimulation
#13
Mathias Schmaler, Alessia Colone, Julian Spagnuolo, Michael Zimmermann, Marco Lepore, Artem Kalinichenko, Sumedha Bhatia, Fabien Cottier, Tobias Rutishauser, Norman Pavelka, Adrian Egli, Elisa Azzali, Marco Pieroni, Gabriele Costantino, Petr Hruz, Uwe Sauer, Lucia Mori, Gennaro De Libero
Mucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in mucosal tissues and recognize a variety of riboflavin-related metabolites produced by the microbial flora. Relevant issues are whether MAIT cells are heterogeneous in the colon, and whether the local environment influences microbial metabolism thereby shaping MAIT cell phenotypes and responses. We found discrete MAIT cell populations in human colon, characterized by the diverse expression of transcription factors, cytokines and surface markers, indicative of activated and precisely controlled lymphocyte populations...
May 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29740432/unique-and-common-features-of-innate-like-human-v%C3%AE-2-%C3%AE-%C3%AE-t-cells-and-mucosal-associated-invariant-t-cells
#14
Nicholas M Provine, Benedikt Binder, Michael E B FitzPatrick, Anita Schuch, Lucy C Garner, Kate D Williamson, Bonnie van Wilgenburg, Robert Thimme, Paul Klenerman, Maike Hofmann
Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally linked to a transcriptional program that can be identified by the expression of the C-type lectin receptor, CD161. In addition to MAIT cells, it has been demonstrated that a subset of γδT cells expresses CD161 and can be activated by TCR-independent cytokine stimulation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29739318/safety-of-cilostazol-in-peripheral-artery-disease-a-cohort-from-a-primary-healthcare-electronic-database
#15
Jordi Real, M Catalina Serna, Maria Giner-Soriano, Rosa Forés, Guillem Pera, Esther Ribes, Maite Alzamora, Josep Ramon Marsal, Antonio Heras, Rosa Morros
BACKGROUND: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users. METHODS: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009-2011 in SIDIAP database...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29736594/a-decision-support-tool-facilitating-medicine-design-for-optimal-acceptability-in-the-older-population
#16
Thibault Vallet, Emilie Belissa, Sandra Laribe-Caget, Alain Chevallier, François-Xavier Chedhomme, Patrick Leglise, Matthieu Piccoli, Hugues Michelon, Vanessa Bloch, Sylvie Meaume, Anne-Sophie Grancher, Nathalie Bachalat, Imad Boulaich, Fattima Abdallah, Maite Rabus, Jean-Paul Rwabihama, Annie-Claude Ribemont, Celia Lachuer, Ines Perquy, Laurent Lechowski, Anne Delahaye, Mathieu Depoisson, Yann Orven, Caroline Guinot, Stephane Gibaud, Corinne Michel, Abdel Mahiou, Sid-Ahmed Belbachir, Jean-Hugues Trouvin, Amelie Dufaÿ-Wojcicki, Vincent Boudy, Fabrice Ruiz
PURPOSE: Medicine acceptability, which is of the utmost importance for vulnerable patients' adherence, is driven by both user and product characteristics. Herein, a novel multivariate approach integrating the many aspects of acceptability is used to discriminate positively and negatively accepted medicines in the older population. METHODS: An observational study was carried out in eight hospitals and eight nursing homes to collect a large set of real-life data on medicines uses in older patients (≥65 years)...
May 7, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29731053/severely-impaired-control-of-bacterial-infections-in-a-patient-with-cystic-fibrosis-defective-in-mucosal-associated-invariant-t-cells
#17
Terezia Pincikova, Dominic Paquin-Proulx, Markus Moll, Malin Flodström-Tullberg, Lena Hjelte, Johan K Sandberg
Here we report a unique case of a patient with cystic fibrosis characterized by severely impaired control of bacterial respiratory infections. This patient's susceptibility to such infections was much worse than expected from a cystic fibrosis clinical perspective, and he died at age 22 years despite extensive efforts and massive use of antibiotics. We found that this severe condition was associated with a near-complete deficiency in circulating mucosal-associated invariant T (MAIT) cells as measured at several time points...
May 2018: Chest
https://www.readbyqxmd.com/read/29722299/the-adjustment-of-%C3%AE-aminobutyric-acid-a-tonic-subunits-in-huntington-s-disease-from-transcription-to-translation-to-synaptic-levels-into-the-neostriatum
#18
REVIEW
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Carola A Mantellero, Carlos Tejeda-Guzmán, Maite A Castro
γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of membrane receptors known as GABAA and GABAB , the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6, β3, δ, or ρ1-3 subunits, they are located at perisynaptic and/or in extrasynaptic regions. The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29715174/computer-assisted-interventions-in-the-clinical-laboratory-process-improve-the-diagnosis-and-treatment-of-severe-vitamin-b12-deficiency
#19
Maria Salinas, Emilio Flores, Maite López-Garrigós, Maria Leiva-Salinas, Alberto Asencio, Javier Lugo, Carlos Leiva-Salinas
BACKGROUND: Severe vitamin B12 deficiency can result in serious complications if undiagnosed or untreated. Our aim was to test the efficacy of interventions in the laboratory process to improve the detection and the treatment of severe vitamin B12 deficiency. METHODS: Quasi-experimental investigation with a retrospective 7-year pre-intervention period and 29-month post-intervention follow-up in a university hospital. Two interventions were designed to improve the detection and treatment of subjects with vitamin B12 deficiency: the laboratory information system (LIS) automatically added seru vitamin B12 (s-vitamin B12) based on certain conditions; and created a comment in the report and scheduled an appointment with the general practitioner (GP)...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29702250/type-2-diabetes-impairs-angiogenesis-and-osteogenesis-in-calvarial-defects-microct-study-in-zdf-rats
#20
Guavri Caliaperoumal, Maite Souyet, Morad Bensidhoum, Herve Petite, Fani Anagnostou
OBJECTIVES: The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potential of calvarial bone, was evaluated in Zucker diabetic fatty (ZDF) rats, an established rat model for obese T2DM. MATERIALS AND METHODS: The study used 16-week-old ZDF rats and their age-matched controls, Zucker Lean (ZL)...
April 24, 2018: Bone
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