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https://www.readbyqxmd.com/read/28218276/natural-and-laboratory-mutations-in-kuzbanian-are-associated-with-zinc-stress-phenotypes-in-drosophila-melanogaster
#1
Hung Le Manh, Lain Guio, Miriam Merenciano, Quirze Rovira, Maite G Barrón, Josefa González
Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which is conserved from Drosophila to humans. MTF-1 binds to metal response elements (MREs) and changes the expression of target genes. kuzbanian (kuz), a metalloendopeptidase that activates the evolutionary conserved Notch signaling pathway, has been identified as an MTF-1 target gene. We have previously identified a putatively adaptive transposable element in the Drosophila melanogaster genome, named FBti0019170, inserted in a kuz intron...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28214247/radiation-exposure-to-the-pregnant-interventional-cardiologist-does-it-really-pose-a-risk-to-the-fetus
#2
Maite Velázquez, Marta Pombo, Leire Unzué, Teresa Bastante, Elena Mejía, Agustín Albarrán
No abstract text is available yet for this article.
February 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28213996/three-dimensional-computed-tomography-for-preoperative-assessment-of-the-pulmonary-artery-in-patients-undergoing-endoscopic-lobectomy-or-segmentectomy
#3
Amaia Ojanguren, José Luis Recuero, Marina Pardina, Lucía Milla, Maite Santamaría
BACKGROUND: The interest for endoscopic pulmonary anatomic resections has grown exponentially during the last decade. During thoracoscopic procedures surgeons cannot rely on digital handling and operative field is viewed on a two-dimensional video monitor, thus frequently encountering anatomical difficulties. The hypothesis is that foreknowledge of the anatomy of each patient would greatly contribute to the safety and accuracy of the operation. The aim of the study was to evaluate the effectiveness of 3dimensional multidetector computed tomography (3D-MDCT) software to identify the pulmonary artery branching pattern during the preoperative study of endoscopic lobectomies and segmentectomies...
February 14, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28213561/primary-care-requests-for-anaemia-chemistry-tests-in-spain-potential-iron-transferrin-and-folate-over-requesting
#4
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
AIM: To study the regional variability of requests for anaemia chemistry tests in primary care in Spain and the associated economic costs of potential over-requesting. METHODS: Requests for anaemia tests were examined in a cross-sectional study. Clinical laboratories from different autonomous communities (AACCs) were invited to report on primary care anaemia chemistry tests requested during 2014. Demand for iron, ferritin, vitamin B12 and folate tests per 1000 inhabitants and the ratios of the folate/vitamin B12 and transferrin/ferritin requests were compared between AACCs...
February 17, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28204900/cadmium-bioaccumulation-in-aquatic-oligochaetes-using-a-biodynamic-model-a-review-of-values-of-physiological-parameters-and-model-validation-using-laboratory-and-field-bioaccumulation-data
#5
REVIEW
Leire Méndez-Fernández, Pilar Rodriguez, Maite Martínez-Madrid
This study reviews certain physiological digestive parameters in the literature that could be used to predict tissue residues in aquatic oligochaetes using the biodynamic model. Predictions were evaluated with independently measured Cd bioaccumulation data in sediment bioassays and field oligochaetes. The parameter review focused on three species commonly used in ecotoxicity testing and bioaccumulation studies: Tubifex tubifex (Tt), Limnodrilus hoffmeisteri (Lh) and Lumbriculus variegatus (Lv). Median Ingestion rates (g g(-1) d(-1), dw) at unpolluted conditions were 7...
February 16, 2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28200111/real-time-assessment-of-health-care-requirements-during-the-zika-virus-epidemic-in-martinique
#6
Alessio Andronico, Frédérique Dorléans, Jean-Louis Fergé, Henrik Salje, Frédéric Ghawché, Aissatou Signate, Elise Daudens-Vaysse, Laure Baudouin, Timothée Dub, Maite Aubry, Van-Mai Cao-Lormeau, Martine Ledrans, Harold Noel, Henri-Pierre Mallet, Arnaud Fontanet, André Cabié, Simon Cauchemez
No abstract text is available yet for this article.
February 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28199445/plant-arginyltransferases-ates
#7
Tatiana Domitrovic, Anna K Fausto, Tatiane da F Silva, Elisson Romanel, Maite F S Vaslin
Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One important enzyme involved in this process is arginyl-t-RNA transferase, known as ATE. This enzyme acts post-translationally by introducing an arginine residue at the N-terminus of specific protein targets to signal degradation via the UPS...
February 13, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28197680/effect-of-a-condolence-letter-on-grief-symptoms-among-relatives-of-patients-who-died-in-the-icu-a-randomized-clinical-trial
#8
Nancy Kentish-Barnes, Sylvie Chevret, Benoît Champigneulle, Marina Thirion, Virginie Souppart, Marion Gilbert, Olivier Lesieur, Anne Renault, Maïté Garrouste-Orgeas, Laurent Argaud, Marion Venot, Alexandre Demoule, Olivier Guisset, Isabelle Vinatier, Gilles Troché, Julien Massot, Samir Jaber, Caroline Bornstain, Véronique Gaday, René Robert, Jean-Philippe Rigaud, Raphaël Cinotti, Mélanie Adda, François Thomas, Laure Calvet, Marion Galon, Zoé Cohen-Solal, Alain Cariou, Elie Azoulay
PURPOSE: Family members of patients who die in the intensive care unit (ICU) may experience symptoms of stress, anxiety, depression, posttraumatic stress disorder (PTSD), and/or prolonged grief. We evaluated whether grief symptoms were alleviated if the physician and the nurse in charge at the time of death sent the closest relative a handwritten condolence letter. METHODS: Multicenter randomized trial conducted among 242 relatives of patients who died at 22 ICUs in France between December 2014 and October 2015...
February 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28196752/efficiency-of-prescribe-vida-saludable-a-health-promotion-innovation-pilot-phase
#9
Aitor Sanz-Guinea, Maite Espinosa, Gonzalo Grandes, Alvaro Sanchez, Catalina Martinez, Haizea Pombo, Paola Bully, Josep Cortada
OBJECTIVE: "Prescribe Vida Saludable" (PVS) is an organisational innovation designed to optimise the promotion of multiple healthy habits in primary healthcare. It aims to estimate the cost effectiveness and cost-utility of prescribing physical activity in the pilot phase of the PVS programme, compared to the routine clinical practice of promoting physical activity in primary healthcare. METHODS: An economic evaluation of the quasi-experimental pilot phase of PVS was carried out...
February 10, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28188934/new-evidence-for-endemic-circulation-of-ross-river-virus-in-the-pacific-islands-and-the-potential-for-emergence
#10
Colleen Lau, Maite Aubry, Didier Musso, Anita Teissier, Sylvie Paulous, Philippe Desprès, Xavier de-Lamballerie, Boris Pastorino, Van-Mai Cao-Lormeau, Philip Weinstein
OBJECTIVES: An epidemic of Ross River Virus (RRV) occurred in the South Pacific in 1979-1980, but it was not believed to occur endemically outside Australia and Papua New Guinea. We conducted a seroprevalence study to determine whether RRV has circulated in American Samoa after 1980. METHODS: RRV ELISA IgG were performed on 200 serum samples collected in American Samoa in 2010, and seroneutralisation tests on 60 representative samples. RESULTS: Of 196 results available for ELISA IgG, 145 (74%, 95% CI 67-80%) were seropositive...
February 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28185157/continuous-measurement-of-atmospheric-reduced-sulphur-compounds-as-key-tracers-between-odour-complaints-and-source-apportionment
#11
Maite de Blas, Marino Navazo, Lucio Alonso, Gotzon Gangoiti, José Antonio García, Estíbaliz Sáez de Cámara, Verónica Valdenebro, Estíbaliz García-Ruiz, Nicolás García-Borreguero
Odour complaints are frequent nowadays, particularly nearby industrial facilities emitting odorous compounds. Among all compounds susceptible of causing odour annoyance, reduced sulphur compounds (RSC) were studied, due to their unpleasant odour and low odour threshold. RSC ambient air mixing ratios, meteorological conditions and population complaints were analysed in an area of complex topography in order to identify their potential sources. Mixing ratios of three compounds, dimethyl sulphide (DMS), carbon disulphide (CDS) and dimethyl disulphide (DMDS), were continuously monitored using an online gas chromatograph coupled with a mass spectrometer detector (GC-MSD), which was placed in a mobile air quality monitoring unit...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28182671/screen-based-sedentary-time-association-with-soft-drink-consumption-and-the-moderating-effect-of-parental-education-in-european-children-the-energy-study
#12
Mekdes K Gebremariam, Mai J Chinapaw, Bettina Bringolf-Isler, Elling Bere, Eva Kovacs, Maïté Verloigne, F Marijn Stok, Yannis Manios, Johannes Brug, Nanna Lien
AIM: The aim of the present study was to explore if children who spend more time on screen-based sedentary behaviors (i.e.TV viewing and computer use) drink more sugar-sweetened soft drinks. The study also assessed whether these associations were independent of individual and home environmental correlates of soft drink consumption and whether they were moderated by parental education. METHODS: Data were collected from 7886 children participating in the EuropeaN Energy balance Research to prevent excessive weight Gain among Youth (ENERGY) survey conducted in eight European countries...
2017: PloS One
https://www.readbyqxmd.com/read/28179539/smoking-reduces-circulating-cd26-hi-cd161-hi-mait-cells-in-healthy-individuals-and-patients-with-multiple-sclerosis
#13
Cecilie Ammitzbøll, Lars Börnsen, Jeppe Romme Christensen, Rikke Ratzer, Birgitte Romme Nielsen, Helle B Søndergaard, Marina R von Essen, Finn Sellebjerg
Upon chronic cigarette smoke exposure, inhaled antigens and irritants cause altered lung immune homeostasis. Circulating immune cells are affected, and smoking is associated with an increased risk of developing various disorders, including multiple sclerosis (MS). This study was conducted to determine the impact of smoking on circulating immune cell subsets. Furthermore, we determined whether any smoking-associated changes were related to MS. With the use of flow cytometry, CFSE assays, and ELISpot assays, we analyzed circulating immune cell phenotypes and quantified antigen-induced proliferation and cytokine secretion in smokers and nonsmokers in a cohort of 100 healthy individuals (HI)...
February 8, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28178926/framework-for-the-establishment-of-a-feasible-tailored-and-effective-perinatal-education-programme
#14
Isabel Artieta-Pinedo, Carmen Paz-Pascual, Gonzalo Grandes, Maite Espinosa
BACKGROUND: Antenatal education needs to be renewed and adapted to the needs of women. OBJECTIVES: to assess women needs, identify factors that influence the desired outcomes, and propose a framework for developing new perinatal education based on the guidance published by the UK Medical Research Council for the development and evaluation of complex interventions in primary care. METHODS: For this study: (a) four focus group sessions were held from October to November 2010 in Bizkaia (Spain) with 30 women exploring their needs during pregnancy and postpartum; (b) two literature reviews were conducted on women's needs at these times and theoretical models of healthcare education; and (c) seven discussion and consensus sessions were run with a group of experts composed of midwifes, gynaecologists, paediatricians, and paediatric and postpartum nurses...
February 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28177458/the-influence-of-parental-modelling-on-children-s-physical-activity-and-screen-time-does-it-differ-by-gender
#15
Stephanie Schoeppe, Corneel Vandelanotte, Elling Bere, Nanna Lien, Maïté Verloigne, Éva Kovács, Yannis Manios, Mona Bjelland, Frøydis Nordgård Vik, Wendy Van Lippevelde
No abstract text is available yet for this article.
February 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28169072/baseline-tissue-concentrations-of-metal-in-aquatic-oligochaetes-field-and-laboratory-approaches
#16
Leire Méndez-Fernández, Maite Martinez-Madrid, Isabel Pardo, Pilar Rodriguez
Metal tissue residue evaluation in benthic macroinvertebrates is an important component of an integrated approach to ecological risk assessment of metals and metalloids in the Nalón River basin (North Spain), where historic mining activities took place. The purpose of this study was to know the baseline tissue concentration of 7 metals (Cd, Cu, Cr, Hg, Ni, Pb, and Zn) and one metalloid (As) in aquatic oligochaetes, sediment burrower organisms, representative of the collector-gatherer functional feeding group in the macroinvertebrate community...
February 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28166248/characterization-of-three-dimensional-cancer-cell-migration-in-mixed-collagen-matrigel-scaffolds-using-microfluidics-and-image-analysis
#17
María Anguiano, Carlos Castilla, Martin Maška, Cristina Ederra, Rafael Peláez, Xabier Morales, Gorka Muñoz-Arrieta, Maite Mujika, Michal Kozubek, Arrate Muñoz-Barrutia, Ana Rouzaut, Sergio Arana, José Manuel Garcia-Aznar, Carlos Ortiz-de-Solorzano
Microfluidic devices are becoming mainstream tools to recapitulate in vitro the behavior of cells and tissues. In this study, we use microfluidic devices filled with hydrogels of mixed collagen-Matrigel composition to study the migration of lung cancer cells under different cancer invasion microenvironments. We present the design of the microfluidic device, characterize the hydrogels morphologically and mechanically and use quantitative image analysis to measure the migration of H1299 lung adenocarcinoma cancer cells in different experimental conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28166217/drugs-and-drug-like-molecules-can-modulate-the-function-of-mucosal-associated-invariant-t-cells
#18
Andrew N Keller, Sidonia B G Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes, Jeffrey Y W Mak, Bronwyn S Meehan, Troi Pediongco, Richard W Birkinshaw, Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Lars Kjer-Nielsen, Nicholas A Gherardin, Dale I Godfrey, Lyudmila Kostenko, Alexandra J Corbett, Anthony W Purcell, David P Fairlie, James McCluskey, Jamie Rossjohn
The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified a range of small organic molecules, drugs, drug metabolites and drug-like molecules, including salicylates and diclofenac, as MR1-binding ligands. Some of these ligands inhibited MAIT cells ex vivo and in vivo, while others, including diclofenac metabolites, were agonists...
February 6, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28164306/amustaline-s-303-treatment-inactivates-high-levels-of-zika-virus-in-red-blood-cell-components
#19
Andrew Laughhunn, Felicia Santa Maria, Julien Broult, Marion C Lanteri, Adonis Stassinopoulos, Didier Musso, Maite Aubry
BACKGROUND: The potential for Zika virus (ZIKV) transmission by blood transfusion (TT) has been demonstrated in French Polynesia and Brazil. Pathogen inactivation (PI) of blood products is a proactive strategy to inactivate TT pathogens including arboviruses. Inactivation of West Nile, dengue, Zika, and chikungunya viruses was previously demonstrated by photochemical treatment with amotosalen and ultraviolet A (UVA) illumination. In this study, we evaluated ZIKV inactivation in red blood cell (RBC) components by a chemical approach that uses amustaline (S-303) and glutathione (GSH)...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28158203/silymarin-suppresses-basal-and-stimulus-induced-activation-exhaustion-differentiation-and-inflammatory-markers-in-primary-human-immune-cells
#20
Erica S Lovelace, Nicholas J Maurice, Hannah W Miller, Chloe K Slichter, Robert Harrington, Amalia Magaret, Martin Prlic, Stephen De Rosa, Stephen J Polyak
Silymarin (SM), and its flavonolignan components, alter cellular metabolism and inhibit inflammatory status in human liver and T cell lines. In this study, we hypothesized that SM suppresses both acute and chronic immune activation (CIA), including in the context of HIV infection. SM treatment suppressed the expression of T cell activation and exhaustion markers on CD4+ and CD8+ T cells from chronically-infected, HIV-positive subjects. SM also showed a trend towards modifying CD4+ T cell memory subsets from HIV+ subjects...
2017: PloS One
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