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https://www.readbyqxmd.com/read/28816107/fishing-anti-inflammatories-from-known-drugs-in-silico-repurposing-design-synthesis-and-biological-evaluation-of-bisacodyl-analogues
#1
Maité Sylla-Iyarreta Veitía, Dany Siverio Mota, Vanessa Lerari, Marta Marín, Rosa M Giner, Liliana Vicet Muro, Yankier Rivero Guerra, Françoise Dumas, Clotilde Ferroud, Peter A M de Witte, Alexander D Crawford, Vicente J Arán, Yovani Marrero Ponce
Herein is described in silico repositioning, design, synthesis, biological evaluation and structure-activity relationship (SAR) of an original class of anti-inflammatory agents based on a polyaromatic pharmacophore structurally related to bisacodyl (BSL) drug used in therapeutic as laxative. We describe the potential of TOMOCOMD-CARDD methods to find out new anti-inflammatory drug-like agents from a diverse series of compounds using the total and local atom based bilinear indices as molecular descriptors. The models obtained were validated by biological studies, identifying BSL as the first anti-inflammatory lead-like using in silico repurposing from commercially available drugs...
August 17, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28815300/holaphyllamine-a-steroid-is-able-to-induce-defense-responses-in-arabidopsis-thaliana-and-increases-resistance-against-bacterial-infection
#2
Abderrakib Zahid, Rim Jaber, Ferdousse Laggoun, Arnaud Lehner, Isabelle Remy-Jouet, Olivier Pamlard, Sandra Beaupierre, Jérome Leprince, Marie-Laure Follet-Gueye, Maïté Vicré-Gibouin, Xavier Latour, Vincent Richard, Catherine Guillou, Patrice Lerouge, Azeddine Driouich, Jean-Claude Mollet
A chemical screen of plant-derived compounds identified holaphyllamine, a steroid, able to trigger defense responses in Arabidopsis thaliana and improve resistance against the pathogenic bacterium Pseudomonas syringae pv tomato DC3000. A chemical screen of 1600 plant-derived compounds was conducted and allowed the identification of a steroid able to activate defense responses in A. thaliana at a concentration of 1 µM without altering growth. The identified compound is holaphyllamine (HPA) whose chemical structure is similar to steroid pregnanes of mammals...
August 16, 2017: Planta
https://www.readbyqxmd.com/read/28807929/human-mucosal-associated-invariant-t-mait-cells-possess-capacity-for-b-cell-help
#3
Michael S Bennett, Shubhanshi Trivedi, Anita S Iyer, J Scott Hale, Daniel T Leung
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell subset, restricted by the nonclassic MHC class I-related protein MR1 and enriched at mucosal sites. Human studies have shown an association between MAIT cells and pathogen-specific antibody responses. In this study, we investigate the effect of human MAIT cells on B cells ex vivo. We found that supernatants from microbe- or cytokine-stimulated MAIT cells, when added to purified autologous B cells, increase frequencies of plasmablasts and promote IgA, IgG, and IgM production...
August 14, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28804935/confirming-the-mechanisms-behind-cognitive-behavioural-therapy-effectiveness-in-chronic-pain-using-structural-equation-modeling-in-a-sample-of-patients-with-temporomandibular-disorders
#4
Estrella Durá-Ferrandis, Maite Ferrando-García, Mª José Galdón-Garrido, Yolanda Andreu-Vaillo
OBJECTIVE: To evaluate whether therapeutic mechanisms assumed to explain the effect of cognitive behavioural therapy (CBT) concerning temporomandibular symptoms are confirmed by structural equation modelling. METHOD: Patients were randomly assigned to either an experimental group receiving CBT (N = 41) or a standard therapy control group (N = 31). Subjects were assessed before and after intervention using mediator variables hypothesized according to the CBT model, as well as outcome variables and other socio-demographic and clinical measures...
August 14, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28798979/mucosa-associated-invariant-t-cells-infiltrate-hepatic-metastases-in-patients-with-colorectal-carcinoma-but-are-rendered-dysfunctional-within-and-adjacent-to-tumor-microenvironment
#5
Christopher R Shaler, Mauro E Tun-Abraham, Anton I Skaro, Khashayarsha Khazaie, Alexandra J Corbett, Tina Mele, Roberto Hernandez-Alejandro, S M Mansour Haeryfar
Mucosa-associated invariant T (MAIT) cells are innate-like T lymphocytes that are unusually abundant in the human liver, a common site of colorectal carcinoma (CRC) metastasis. However, whether they contribute to immune surveillance against colorectal liver metastasis (CRLM) is essentially unexplored. In addition, whether MAIT cell functions can be impacted by chemotherapy is unclear. These are important questions given MAIT cells' potent immunomodulatory and inflammatory properties. Herein, we examined the frequencies and functions of peripheral blood, healthy liver tissue, tumor-margin and tumor-infiltrating MAIT cells in 21 CRLM patients who received no chemotherapy, FOLFOX, or a combination of FOLFOX and Avastin before they underwent liver resection...
August 10, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28798380/contribution-of-cropland-to-the-spread-of-shiga-toxin-phages-and-the-emergence-of-new-shiga-toxin-producing-strains
#6
Pablo Quirós, Maite Muniesa
A growing interest in healthy eating has lead to an increase in the consumption of vegetables, associated with a rising number of bacterial outbreaks related to fresh produce. This is the case of the outbreak in Germany, caused by a O104:H4 enteroaggregative E. coli strain lysogenic for a Stx phage. Temperate Stx phages released from their hosts occur as free particles in various environments. This study reports the occurrence of Stx phages in vegetables (lettuce, cucumber, and spinach) and cropland soil samples...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28792688/uncritical-request-of-thyroid-laboratory-tests-may-result-in-a-major-societal-economic-burden-results-from-a-large-population-study-in-spain
#7
Maria Salinas, Maite Lopez-Garrigos, Emilio Flores, Carlos Leiva-Salinas
BACKGROUND: Our aim is to study the regional variability in the request of thyroid laboratory tests from primary care facilities in Spain and to investigate a potential inappropriate request and its economic societal impact. METHODS: Spain is divided into 17 autonomous communities (AACCs) which are in turn divided in Health Departments that cover a geographic area and its population and a laboratory that attends the needs of every inhabitant. Each participating laboratory was required to report the number of thyroid tests requested from primary care during year 2014 and to provide organizational data...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792648/mait-cell-frequency-and-function-in-blood-and-liver-of-hcv-mono-and-hcv-hiv-co-infected-patients-with-advanced-fibrosis
#8
Boris J B Beudeker, Gertine W van Oord, Joop E Arends, Julian Schulze Zur Wiesch, Marieke S van der Heide, Robert J de Knegt, Annelies Verbon, Andre Boonstra, Mark A A Claassen
BACKGROUND & AIMS: Mucosal-associated invariant T (MAIT) cells are important innate T-cells with anti-microbial and immunoregulatory activity, recently found to be depleted in blood of patients with HIV and HCV mono-infections. In this study, we assessed the impact of HIV, HCV and HCV/HIV co-infection on circulating and intrahepatic MAIT-cells and correlations with liver fibrosis. METHODS: In this cross-sectional study, 9 healthy subjects, 9 HIV, 20 HCV and 22 HCV/HIV co-infected patients were included...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28789524/glucuronidated-flavonoids-in-neurological-protection-structural-analysis-and-approaches-for-chemical-and-biological-synthesis
#9
Maite Docampo, Adiji Olubu, Xiaoqiang Wang, Giulio M Pasinetti, Richard Arthur Dixon
Both plant and mammalian cells express glucuronosyltransferases that catalyze glucuronidation of polyphenols such as flavonoids and other small molecules. Oral administration of select polyphenolic compounds leads to the accumulation of the corresponding glucuronidated metabolites at µM and sub-µM concentrations in the brain, associated with amelioration of a range of neurological symptoms. Determining the mechanisms whereby botanical extracts impact cognitive wellbeing and psychological resiliency will require investigation of the modes of action of the brain-targeted metabolites...
August 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28780074/intra-hepatic-depletion-of-mucosal-associated-invariant-t-cells-in-hepatitis-c-virus-induced-liver-inflammation
#10
Fabian J Bolte, Ashley C O'Keefe, Lauren M Webb, Elisavet Serti, Elenita Rivera, T Jake Liang, Marc Ghany, Barbara Rehermann
BACKGROUND & AIMS: Chronic hepatitis affects phenotypes of innate and adaptive immune cells. Mucosal associated invariant T (MAIT) cells are enriched in the liver as compared to the blood, respond to intra-hepatic cytokines, and (via the semi-invariant T-cell receptor) to bacteria translocated from the gut. Little is known about the role of MAIT cells in livers of patients with chronic hepatitis C virus (HCV) infection and their fate after antiviral therapy. METHODS: We collected blood samples from 42 patients with chronic HCV infection who achieved a sustained virologic response after 12 weeks of treatment with sofosbuvir and velpatasvir...
August 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28777565/synthesis-and-characterization-of-pegylated-and-fluorinated-chitosans-application-to-the-synthesis-of-targeted-nanoparticles-for-drug-delivery
#11
Yamina Belabassi, Juliette Moreau, Virginia Gheran, Céline Henoumont, Anthony Robert, Maité Callewaert, Guillaume Rigaux, Cyril Cadiou, Luce Vander Elst, Sophie Laurent, Robert N Muller, Anca Dinischiotu, Sorina Nicoleta Voicu, Francoise Chuburu
To synthesize chitosan nanoparticles (CS NPs), ionic gelation is a very attractive method. It relies on the spontaneous supramolecular assembly of cationic CS with anionic compounds, which leads to nanohydrogels. To extend ionic gelation to functionalized CS, the assessment of CS degree of substitution (DSCS) is a key step. In this paper, we have developed a hyphenated strategy for functionalized CS characterization, based upon 1H, DOSY and when relevant, 1D diffusion-filtered 19F NMR spectroscopies. For that, we have synthesized two series of water-soluble CS via amidation of CS amino groups with mPEG2000-COOH or fluorinated synthons (TFB-COOH)...
August 4, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28765153/erratum-for-martinez-castillo-et-al-shiga-toxin-2-encoding-bacteriophages-in-human-fecal-samples-from-healthy-individuals
#12
Alexandre Martinez-Castillo, Pablo Quirós, Ferran Navarro, Elisenda Miró, Maite Muniesa
No abstract text is available yet for this article.
August 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28765152/erratum-for-quir%C3%A3-s-et-al-improving-detection-of-shiga-toxin-producing-escherichia-coli-by-molecular-methods-by-reducing-the-interference-of-free-shiga-toxin-encoding-bacteriophages
#13
Pablo Quirós, Alexandre Martínez-Castillo, Maite Muniesa
No abstract text is available yet for this article.
August 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28763041/using-a-co-creational-approach-to-develop-implement-and-evaluate-an-intervention-to-promote-physical-activity-in-adolescent-girls-from-vocational-and-technical-schools-a-case-control-study
#14
Maïté Verloigne, Teatske Maria Altenburg, Mai Jeanette Maidy Chinapaw, Sebastien Chastin, Greet Cardon, Ilse De Bourdeaudhuij
Background: As physical inactivity is particularly prevalent amongst lower-educated adolescent girls, interventions are needed. Using a co-creational approach increases their engagement and might be effective. This study aimed to: (1) describe the co-creation process, (2) evaluate how girls experienced co-creation, and (3) evaluate the effect of the co-creational interventions on physical activity, individual, sociocultural and school-based factors. Methods: Three intervention schools (n = 91) and three control schools (n = 105) across Flanders participated...
August 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28761175/rock1-is-a-novel-rac1-effector-to-regulate-tubular-endocytic-membrane-formation-during-clathrin-independent-endocytosis
#15
David Soriano-Castell, Albert Chavero, Carles Rentero, Marta Bosch, Maite Vidal-Quadras, Albert Pol, Carlos Enrich, Francesc Tebar
Clathrin-dependent and -independent pathways contribute for β1-integrin endocytosis. This study defines a tubular membrane clathrin-independent endocytic network, induced with the calmodulin inhibitor W13, for β1-integrin internalization. This pathway is dependent on increased phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) levels and dynamin activity at the plasma membrane. Exogenous addition of PI(4,5)P2 or phosphatidylinositol-4-phosphate 5-kinase (PIP5K) expression mimicked W13-generated-tubules which are inhibited by active Rac1...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28760800/protocol-for-a-prospective-longitudinal-study-of-risk-factors-for-hypertension-incidence-in-a-mexico-city-population-the-tlalpan-2020-cohort
#16
Eloisa Colín-Ramírez, Susana Rivera-Mancía, Oscar Infante-Vázquez, Raúl Cartas-Rosado, Jesús Vargas-Barrón, Magdalena Madero, Maite Vallejo
INTRODUCTION: Systemic hypertension (HTN) is a common risk factor for cardiovascular disease. In Mexico, HTN prevalence has increased over time and is currently 31%. Nonetheless, information about the country's HTN incidence and its associated risk factors is scarce. Understanding this condition is a priority for identifying the scope of primary prevention. The main objective of this study is to evaluate the effect of traditional and non-traditional risk factors on the incidence of HTN in a cohort of healthy Mexico City residents under biannual follow-up for 10 years...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28760799/rationale-and-study-design-for-an-individualised-perioperative-open-lung-ventilatory-strategy-with-a-high-versus-conventional-inspiratory-oxygen-fraction-iprove-o2-and-its-effects-on-surgical-site-infection-study-protocol-for-a-randomised-controlled-trial
#17
Carlos Ferrando, Marina Soro, Carmen Unzueta, Jaume Canet, Gerardo Tusman, Fernando Suarez-Sipmann, Julian Librero, Salvador Peiró, Natividad Pozo, Carlos Delgado, Maite Ibáñez, César Aldecoa, Ignacio Garutti, David Pestaña, Aurelio Rodríguez, Santiago García Del Valle, Oscar Diaz-Cambronero, Jaume Balust, Francisco Javier Redondo, Manuel De La Matta, Lucía Gallego, Manuel Granell, Pascual Martínez, Ana Pérez, Sonsoles Leal, Kike Alday, Pablo García, Pablo Monedero, Rafael Gonzalez, Guido Mazzinari, Gerardo Aguilar, Jesús Villar, Francisco Javier Belda
INTRODUCTION: Surgical site infection (SSI) is a serious postoperative complication that increases morbidity and healthcare costs. SSIs tend to increase as the partial pressure of tissue oxygen decreases: previous trials have focused on trying to reduce them by comparing high versus conventional inspiratory oxygen fractions (FIO2) in the perioperative period but did not use a protocolised ventilatory strategy. The open-lung ventilatory approach restores functional lung volume and improves gas exchange, and therefore it may increase the partial pressure of tissue oxygen for a given FIO2...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28759268/relationship-between-neuropsychological-tests-and-driver-s-licence-renewal-tests-in-parkinson-s-disease
#18
Dolors Badenes, Maite Garolera, Laura Casas, Juan Carlos Cejudo, Silvia Zaragoza, Noemi Calzado, Miquel Aguilar
Objective To determine whether the standard Spanish driving test (ASDE test) was able to identify patients with Parkinson's disease (PD) at risk of unsafe driving, and to examine the relationship between the ASDE test and the UFOV as well as with a battery of neuropsychological tests in PD drivers. Methods Thirty-seven PD patients and 33 controls matched by age and education level were included in an observational study. All participants were active drivers and PD patients underwent study procedures after taking the medication in the "on" period...
July 31, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28757236/fiber-based-modeling-of-in-situ-ankle-ligaments-with-consideration-of-progressive-failure
#19
Bingbing Nie, Jason L Forman, Matthew B Panzer, Alexander R Mait, John-Paul Donlon, Richard W Kent
Ligament sprains account for a majority of injuries to the foot and ankle complex among athletic populations. The infeasibility of measuring the in situ response and load paths of individual ligaments has precluded a complete characterization of their mechanical behavior via experiment. In the present study a fiber-based modeling approach of in situ ankle ligaments was developed and validated for determining the heterogeneous force-elongation characteristics and the consequent injury patterns. Nine major ankle ligaments were modeled as bundles of discrete elements, corresponding functionally to the structure of collagen fibers...
July 18, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28756686/beyond-diagnosis-the-core-sets-for-persons-with-schizophrenia-based-on-the-world-health-organization-s-international-classification-of-functioning-disability-and-health
#20
Juana Gómez-Benito, Georgina Guilera, Maite Barrios, Emilio Rojo, Oscar Pino, Arantxa Gorostiaga, Nekane Balluerka, María Dolores Hidalgo, José Luis Padilla, Isabel Benítez, Melissa Selb
PURPOSE: Based on the International Classification of Functioning, Disability and Health (ICF), this paper presents the results of the process to develop the Comprehensive and Brief Core Sets for schizophrenia that allow to comprehensively describe functioning in persons with schizophrenia. METHODS: Twenty health professionals from diverse backgrounds participated in a formal and iterative decision-making process during an international consensus conference to develop these Core Sets...
July 30, 2017: Disability and Rehabilitation
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