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https://www.readbyqxmd.com/read/28934516/large-scale-analysis-evaluating-regional-variability-in-the-request-of-laboratory-tests-in-primary-care-and-its-potential-economic-impact
#1
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
Objective: To compare the ratios of requests of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) and urea to creatinine (Crea); to investigate the variability among regions and to calculate the potential savings if a target is reached. Methods: Laboratories were invited to fill out a registration form on the number of AST, ALT, Urea and Crea requested in 2014, and to provide the reagent price of urea and AST. AST:ALT and Urea:Crea were calculated and compared; also compared were potential savings if each laboratory would have reached the target...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28930020/ross-river-virus-seroprevalence-french-polynesia-2014-2015
#2
Maite Aubry, Anita Teissier, Michael Huart, Sébastien Merceron, Jessica Vanhomwegen, Claudine Roche, Anne-Laure Vial, Sylvianne Teururai, Sébastien Sicard, Sylvie Paulous, Philippe Desprès, Jean-Claude Manuguerra, Henri-Pierre Mallet, Didier Musso, Xavier Deparis, Van-Mai Cao-Lormeau
Ross River virus (RRV), spread by Aedes and Culex mosquitoes, is the most commonly transmitted arbovirus in Australia. A serosurvey of blood donors in French Polynesia during 2011-2013 suggested that RRV circulated without being detected. We report RRV circulation in French Polynesia based on further screening of blood samples collected during 2014-2015.
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28928056/-vaccine-hesitancy-discourse-analysis-of-parents-who-have-not-fully-or-partially-vaccinated-their-children
#3
Maite Cruz Piqueras, Ainhoa Rodríguez García de Cortazar, Joaquín Hortal Carmona, Javier Padilla Bernáldez
OBJECTIVE: To analyse and understand vaccination hesitancy discourses, particularly those of people who have decided not to vaccinate their sons and daughters. METHODS: Qualitative study of five individual interviews and two focus groups with people who chose not to vaccinate their children in the province of Granada (Spain). RESULTS: Mothers and fathers manifest a system of health beliefs different to the biomedical paradigm. From an ethical point of view, they justify their position based on the right to autonomy and responsibility for their decisions...
September 16, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28926962/anti-nkg2d-mab-a-new-treatment-for-crohn-s-disease
#4
REVIEW
Kasper Vadstrup, Flemming Bendtsen
Crohn's disease (CD) and ulcerative colitis (UC) are immunologically-mediated, debilitating conditions resulting from destructive inflammation of the gastrointestinal tract. The pathogenesis of IBD is incompletely understood, but is considered to be the result of an abnormal immune response with a wide range of cell types and proteins involved. Natural Killer Group 2D (NKG2D) is an activating receptor constitutively expressed on human Natural Killer (NK), γδ T, mucosal-associated invariant T (MAIT), CD56⁺ T, and CD8⁺ T cells...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28925595/determination-of-crassphage-in-water-samples-and-applicability-for-tracking-human-faecal-pollution
#5
Cristina García-Aljaro, Elisenda Ballesté, Maite Muniesa, Juan Jofre
In recent decades, considerable effort has been devoted to finding microbial source-tracking (MST) markers that are suitable to assess the health risks of faecally polluted waters, with no universal marker reported so far. In this study, the abundance and prevalence of a crAssphage-derived DNA marker in wastewaters of human and animal origins were studied by a new qPCR assay with the ultimate aim of assessing its potential as an MST marker. crAssphage showed up to 10(6) GC/ml in the sewage samples of human origin, in both the total DNA and the viral DNA fraction...
September 19, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28922898/brewer-s-yeast-saccharomyces-cerevisiae-enhances-attraction-of-two-invasive-yellowjackets-hymenoptera-vespidae-to-dried-fruit-and-fruit-powder
#6
Tamara Babcock, Regine Gries, John Borden, Luis Palmero, Analía Mattiacci, Maité Masciocchi, Juan Corley, Gerhard Gries
The German yellowjacket, Vespula germanica F., and common yellowjacket, Vespula vulgaris L. (Hymenoptera: Vespidae), are pests of significant economic, environmental, and medical importance in many countries. There is a need for the development and improvement of attractive baits that can be deployed in traps to capture and kill these wasps in areas where they are a problem. Yellowjackets are known to feed on fermenting fruit, but this resource is seldom considered as a bait due to its ephemeral nature and its potential attractiveness to nontarget species...
September 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28922750/identification-of-iridoid-glucoside-transporters-in-catharanthus-roseus
#7
Bo Larsen, Victoria L Fuller, Jacob Pollier, Alex Van Moerkercke, Fabian Schweizer, Richard Payne, Maite Colinas, Sarah E O'Connor, Alain Goossens, Barbara A Halkier
Monoterpenoid indole alkaloids (MIAs) are plant defense compounds and high-value pharmaceuticals. Biosynthesis of the universal MIA precursor, secologanin, is organized between internal phloem-associated parenchyma (IPAP) and epidermis cells. Transporters for intercellular transport of proposed mobile pathway intermediates have remained elusive. Screening of an Arabidopsis thaliana transporter library expressed in Xenopus oocytes identified AtNPF2.9 as a putative iridoid glucoside importer. Eight orthologs were identified in Catharanthus roseus, of which three, CrNPF2...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28922472/mirna-506-promotes-primary-biliary-cholangitis-like-features-in-cholangiocytes-and-immune-activation
#8
Oihane Erice, Patricia Munoz-Garrido, Javier Vaquero, Maria J Perugorria, Maite G Fernandez-Barrena, Elena Saez, Alvaro Santos-Laso, Ander Arbelaiz, Raul Jimenez-Agüero, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Verónica Torrano, Arkaitz Carracedo, Meenakshisundaram Ananthanarayanan, Marco Marzioni, Jesus Prieto, Ulrich Beuers, Ronald P Oude Elferink, Nicholas F LaRusso, Luis Bujanda, Jose J G Marin, Jesus M Banales
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells (cholangiocytes). Although PBC etiopathogenesis still remains obscure, development of anti-mitochondrial auto-antibodies against pyruvate dehydrogenase complex-E2 (PDC-E2) is a common feature. MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but their functional relevance is largely unknown. We previously reported that miR-506 is overexpressed in PBC cholangiocytes and directly targets both Cl(-) /HCO3(-) anion exchanger 2 (AE2) and type III inositol 1,4,5-trisphosphate receptor (InsP3R3), leading to cholestasis...
September 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28922408/the-role-of-the-pi3k-akt-signaling-pathway-in-the-developmental-competence-of-bovine-oocytes
#9
Gabriella Mamede Andrade, Juliano Coelho da Silveira, Claudia Perrini, Maite Del Collado, Samuel Gebremedhn, Dawit Tesfaye, Flávio Vieira Meirelles, Felipe Perecin
The ovarian follicle encloses oocytes in a microenvironment throughout their growth and acquisition of competence. Evidence suggests a dynamic interplay among follicular cells and oocytes, since they are constantly exchanging "messages". We dissected bovine ovarian follicles and recovered follicular cells (FCs-granulosa and cumulus cells) and cumulus-oocyte complexes (COCs) to investigate whether the PI3K-Akt signaling pathway impacted oocyte quality. Following follicle rupture, COCs were individually selected for in vitro cultures to track the follicular cells based on oocyte competence to reach the blastocyst stage after parthenogenetic activation...
2017: PloS One
https://www.readbyqxmd.com/read/28921542/pathogen-inactivation-of-dengue-virus-in-red-blood-cells-using-amustaline-and-glutathione
#10
Maite Aubry, Andrew Laughhunn, Felicia Santa Maria, Marion C Lanteri, Adonis Stassinopoulos, Didier Musso
BACKGROUND: Dengue virus (DENV) is an arbovirus primarily transmitted through mosquito bite; however, DENV transfusion-transmitted infections (TTIs) have been reported and asymptomatic DENV RNA-positive blood donors have been identified in endemic countries. DENV is considered a high-risk pathogen for blood safety. One of the mitigation strategies to prevent arbovirus TTIs is pathogen inactivation. In this study we demonstrate that the amustaline and glutathione (S-303/GSH) treatment previously found effective against Zika virus in red blood cells (RBCs) is also effective in inactivating DENV...
September 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28915877/vole-abundance-and-reindeer-carcasses-determine-breeding-activity-of-arctic-foxes-in-low-arctic-yamal-russia
#11
Dorothee Ehrich, Maite Cerezo, Anna Y Rodnikova, Natalya A Sokolova, Eva Fuglei, Victor G Shtro, Aleksandr A Sokolov
BACKGROUND: High latitude ecosystems are at present changing rapidly under the influence of climate warming, and specialized Arctic species at the southern margin of the Arctic may be particularly affected. The Arctic fox (Vulpes lagopus), a small mammalian predator endemic to northern tundra areas, is able to exploit different resources in the context of varying tundra ecosystems. Although generally widespread, it is critically endangered in subarctic Fennoscandia, where a fading out of the characteristic lemming cycles and competition with abundant red foxes have been identified as main threats...
September 16, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28912775/shared-and-distinct-phenotypes-and-functions-of-human-cd161-v%C3%AE-7-2-t-cell-subsets
#12
Ayako Kurioka, Aminu S Jahun, Rachel F Hannaway, Lucy J Walker, Joannah R Fergusson, Eva Sverremark-Ekström, Alexandra J Corbett, James E Ussher, Christian B Willberg, Paul Klenerman
Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically such cells are marked by their expression of Vα7.2-Jα33/Jα20/Jα12 T cell receptors, and functionally they are major histocompatibility complex class I-related protein 1 (MR1)-restricted, responding to bacterially derived riboflavin synthesis intermediates. MAIT cells are contained within the CD161++ Vα7.2+ T cell population, the majority of which express the CD8 receptor (CD8+), while a smaller fraction expresses neither CD8 or CD4 coreceptor (double negative; DN) and a further minority are CD4+...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28906284/effect-of-transfusion-on-mortality-and-other-adverse-events-among-critically-ill-septic-patients-an-observational-study-using-a-marginal-structural-cox-model
#13
Claire Dupuis, Maité Garrouste-Orgeas, Sébastien Bailly, Christophe Adrie, Dany Goldgran-Toledano, Elie Azoulay, Stéphane Ruckly, Guillaume Marcotte, Bertrand Souweine, Michael Darmon, Yves Cohen, Carole Schwebel, Guillaume Lacave, Lila Bouadma, Jean-Francois Timsit
OBJECTIVES: RBC transfusion is often required in patients with sepsis. However, adverse events have been associated with RBC transfusion, raising safety concerns. A randomized controlled trial validated the 7 g/dL threshold, but previously transfused patients were excluded. Cohort studies led to conflicting results and did not handle time-dependent covariates and history of treatment. Additional data are thus warranted to guide patient's management. DESIGN: To estimate the effect of one or more RBC within 1 day on three major outcomes (mortality, ICU-acquired infections, and severe hypoxemia) at day 30, we used marginal structural models...
September 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28903626/light-dominates-peripheral-circadian-oscillations-in-drosophila-melanogaster-during-sensory-conflict
#14
Ross E F Harper, Maite Ogueta, Peter Dayan, Ralf Stanewsky, Joerg T Albert
In Drosophila, as in other animals, the circadian clock is a singular entity in name and concept only. In reality, clock functions emerge from multiple processes and anatomical substrates. One distinction has conventionally been made between a central clock (in the brain) and peripheral clocks (e.g., in the gut and the eyes). Both types of clock generate robust circadian oscillations, which do not require external input. Furthermore, the phases of these oscillations remain exquisitely sensitive to specific environmental cues, such as the daily changes of light and temperature...
September 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28889862/genetic-dna-profile-in-urine-and-hair-follicles-from-patients-who-have-undergone-allogeneic-hematopoietic-stem-cell-transplantation
#15
Ana Santurtún, José A Riancho, Maite Santurtún, Carlos Richard, M Mercedes Colorado, Mayte García Unzueta, María T Zarrabeitia
Biological samples from patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT) constitute a challenge for individual identification. In this study we analyzed the genetic profiles (by the amplification of 15 autosomic STRs) of HSCT patients found in different types of samples (blood, hair and urine) that may be the source of DNA in civil or criminal forensic cases. Our results show that while in hair follicles the donor component was not detected in any patient, thus being a reliable source of biological material for forensic identification, mixed chimerism was detected in urine samples from all patient, and no correlation was found between the time elapsed from the transplant and the percentage of chimerism...
September 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28877992/activation-of-human-mucosal-associated-invariant-t-cells-induces-cd40l-dependent-maturation-of-monocyte-derived-and-primary-dendritic-cells
#16
Mariolina Salio, Olivier Gasser, Claudia Gonzalez-Lopez, Anne Martens, Natacha Veerapen, Uzi Gileadi, Jacob G Verter, Giorgio Napolitani, Regan Anderson, Gavin Painter, Gurdyal S Besra, Ian F Hermans, Vincenzo Cerundolo
Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It remains unclear whether, in addition to their cytolytic activity that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (DC) maturation. In this study, we investigated the molecular mechanisms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an MR1- and CD40L-dependent manner...
September 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28877474/long-noncoding-rna-purpl-suppresses-basal-p53-levels-and-promotes-tumorigenicity-in-colorectal-cancer
#17
Xiao Ling Li, Murugan Subramanian, Matthew F Jones, Ritu Chaudhary, Deepak K Singh, Xinying Zong, Berkley Gryder, Sivasish Sindri, Min Mo, Aaron Schetter, Xinyu Wen, Swetha Parvathaneni, Dickran Kazandjian, Lisa M Jenkins, Wei Tang, Fathi Elloumi, Jennifer L Martindale, Maite Huarte, Yuelin Zhu, Ana I Robles, Susan M Frier, Frank Rigo, Maggie Cam, Stefan Ambs, Sudha Sharma, Curtis C Harris, Mary Dasso, Kannanganattu V Prasanth, Ashish Lal
Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed PURPL (p53 upregulated regulator of p53 levels). Targeted depletion of PURPL in colorectal cancer cells results in elevated basal p53 levels and induces growth defects in cell culture and in mouse xenografts. PURPL associates with MYBBP1A, a protein that binds to and stabilizes p53, and inhibits the formation of the p53-MYBBP1A complex...
September 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28870466/il-12-and-il-7-synergise-to-control-mait-cell-cytotoxic-responses-to-bacterial-infection
#18
Joshua C Wallington, Anthony P Williams, Karl J Staples, Tom M A Wilkinson
BACKGROUND: Bacterial respiratory tract infections and exacerbations of chronic lung diseases are commonly caused by nontypeable Haemophilus influenzae (NTHi). Cell-mediated cytotoxicity may be key to controlling infection, but the responses of NTHi-specific T cell populations are not well understood. Mucosal-associated invariant T (MAIT) cells are a recently-discovered, innate-like subset of T cells with cytotoxic function, whose role in lung immunity is unclear. OBJECTIVE: The aim of this study was to determine the mechanisms behind conventional T and MAIT cell cytotoxic responses to NTHi...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28868514/cd161-expression-on-mucosa-associated-invariant-t-cells-is-reduced-in-hiv-infected-subjects-undergoing-antiretroviral-therapy-who-do-not-recover-cd4-t-cells
#19
Michael L Freeman, Stephen R Morris, Michael M Lederman
BACKGROUND: Mucosa-associated invariant T (MAIT) cells are a recently identified class of innate-like T cells that are involved in the mucosal immune response. MAIT cells are characterized by expression of TCR Vα7.2 and CD161. In HIV infection, there is a profound early loss of MAIT cells from the circulation that never fully recovers, even after prolonged viral control with antiretroviral therapy (ART). METHODS: We analyzed PBMCs from fresh whole blood from HIV-negative or ART-treated HIV-positive donors with full (Immune Success) or impaired (Immune Failure) CD4(+) T- cell recovery by flow cytometry for T-cell markers, TCR Vα7...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28866832/increased-levels-of-brain-adrenomedullin-in-the-neuropathology-of-alzheimer-s-disease
#20
Hilda Ferrero, Ignacio M Larrayoz, Eva Martisova, Maite Solas, David R Howlett, Paul T Francis, Francisco J Gil-Bea, Alfredo Martínez, María J Ramírez
Alzheimer's disease (AD) is characterized by the loss of synaptic contacts caused in part by cytoskeleton disruption. Adrenomedullin (AM) is involved in physiological functions such as vasodilation, hormone secretion, antimicrobial activity, cellular growth, and angiogenesis. In neurons, AM and related peptides are associated with some structural and functional cytoskeletal proteins, causing microtubule destabilization. Here, we describe the relationships between AM and other signs of AD in clinical specimens...
September 2, 2017: Molecular Neurobiology
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