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gastric cancer peritoneal metastasis

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https://www.readbyqxmd.com/read/28428517/-a-hematogenous-metastasis-from-scirrhous-gastric-cancer-to-the-uterus
#1
Masatake Taniguchi, Masanobu Hyodo, Munetoshi Tsukahara, Takashi Watanabe, Shoichi Shinohara, Hirofumi Hayashi, Yasuhiro Inoue, Hirotake Satoh, Masaki Okada, Yoshikazu Yasuda, Alan Kawarai Lefor
A 46-year-old woman was referred to our hospital because of nausea. Endoscopy revealed scirrhous gastric cancer, and abdominalcomputed tomography revealed peritonealdissemination. She was diagnosed with Stage IV gastric cancer and treated with S-1 plus CDDP combination chemotherapy. After 4 courses of chemotherapy, the primary tumor and peritoneal dissemination were considered clinically stable, but the uterus grew rapidly. She was diagnosed as having uterine metastasis based on cervicaland endometrialsmear class V cytology...
April 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28384215/use-of-the-combination-of-the-preoperative-platelet-to-lymphocyte-ratio-and-tumor-characteristics-to-predict-peritoneal-metastasis-in-patients-with-gastric-cancer
#2
Xiao-Dong Chen, Chen-Chen Mao, Rui-Sen Wu, Wei-Teng Zhang, Ji Lin, Xiang-Wei Sun, Chu-Huai Chi, Neng Lou, Peng-Fei Wang, Xian Shen, Guan-Bao Zhu, Shu-Rong Shen
The aims of the present study were to evaluate the predictive value of the platelet-to-lymphocyte ratio for peritoneal metastasis in patients with gastric cancer and to construct an available preoperative prediction system for peritoneal metastasis. A total of 1080 patients with gastric cancer were enrolled in our study. The preoperative platelet-to-lymphocyte ratio and other serum markers and objective clinical tumor characteristics were evaluated by receiver operating characteristic curves. A logistic analysis was performed to determine the independent predictive indicators of peritoneal metastasis...
2017: PloS One
https://www.readbyqxmd.com/read/28365892/conversion-surgery-after-combination-chemotherapy-of-docetaxel-cisplatin-and-s-1-dcs-for-far-advanced-gastric-cancer
#3
Hiroaki Mieno, Keishi Yamashita, Kei Hosoda, Hiromitsu Moriya, Katsuhiko Higuchi, Mizutomo Azuma, Shouko Komori, Tsutomu Yoshida, Satoshi Tanabe, Wasaburo Koizumi, Natsuya Katada, Masahiko Watanabe
PURPOSE: A triplet regimen of docetaxel, cisplatin, and S-1(DCS) is highly effective against metastatic gastric cancer. We performed this study to clarify the safety and efficacy of surgical resection in patients with initially unresectable gastric cancer, after down-staging or disease control was achieved by DCS chemotherapy. METHODS: The subjects of this retrospective study were 31 consecutive patients with initially unresectable gastric cancer, who underwent surgical resection between October, 2006 and December, 2012, after down-staging or disease control was achieved by DCS chemotherapy...
April 1, 2017: Surgery Today
https://www.readbyqxmd.com/read/28344747/gastric-peritoneal-carcinomatosis-a-retrospective-review
#4
Hwee Leong Tan, Claramae Shulyn Chia, Grace Hwei Ching Tan, Su Pin Choo, David Wai-Meng Tai, Clarinda Wei Ling Chua, Matthew Chau Hsien Ng, Khee Chee Soo, Melissa Ching Ching Teo
AIM: To characterize patients with gastric peritoneal carcinomatosis (PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care. METHODS: We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre. RESULTS: We studied a total of 271 patients with a median age of 63...
March 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28315004/alex1-a-novel-tumor-suppressor-gene-inhibits-gastric-cancer-metastasis-via-the-par-1-rho-gtpase-signaling-pathway
#5
Li Pang, Jian-Fang Li, Liping Su, Mingde Zang, Zhiyuan Fan, Beiqin Yu, Xiongyan Wu, Chen Li, Min Yan, Zheng-Gang Zhu, Bingya Liu
BACKGROUND: The ALEX is a novel member of the armadillo family and ALEX1 was reported to be reduced or even lost in multiple solid tumors. However, its expression profile and oncogenic role in gastric cancer (GC) remains largely unknown. METHODS: ALEX1 expression was detected in 161 GC samples by immunohistochemistry staining. NCI-N87 cells transfected by ALEX1 lentivirus vectors and MKN28 cells transfected by ALEX1 shRNA were used for biological function investigation...
March 17, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28303362/phase-i-ii-study-of-a-combination-of-capecitabine-cisplatin-and-intraperitoneal-docetaxel-xp-id-in-advanced-gastric-cancer-patients-with-peritoneal-metastasis
#6
Hyungwoo Cho, Min-Hee Ryu, Kyu-Pyo Kim, Baek-Yeol Ryoo, Sook Ryun Park, Bum Soo Kim, In-Seob Lee, Hee-Sung Kim, Moon-Won Yoo, Jeong Hwan Yook, Seong Tae Oh, Byung Sik Kim, Yoon-Koo Kang
BACKGROUND: This study was conducted to determine the recommended dose (RD) of intraperitoneal docetaxel (ID) in combination with systemic capecitabine and cisplatin (XP) and to evaluate its efficacy and safety at the RD in advanced gastric cancer (AGC) patients with peritoneal metastasis. METHODS: AGC patients with peritoneal metastasis received XP ID, which consists of 937.5 mg/m(2) of capecitabine twice daily on days 1-14, 60 mg/m(2) of intravenous cisplatin on day 1, and intraperitoneal docetaxel at 3 different dose levels (60, 80, or 100 mg/m(2)) on day 1, every 3 weeks...
March 16, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28276310/basic-transcription-factor-3-is-required-for-proliferation-and-epithelial-mesenchymal-transition-via-regulation-of-foxm1-and-jak2-stat3-signaling-in-gastric-cancer
#7
De-Zhong Zhang, Bing-He Chen, Lan-Fang Zhang, Ming-Kun Cheng, Xiang-Jie Fang, Xin-Jun Wu
Gastric cancer (GC) is the most common epithelial malignancy worldwide. Basic transcription factor 3 (BTF3) plays a crucial role in the regulation of various biological processes. We designed experiments to investigate the molecular mechanism underlying the role of BTF3 in GC cell proliferation and metastasis. We confirmed that BTF3 expression was decreased in GC tissues and several GC cell lines. Lentivirus-mediated downregualtion of BTF3 reduced cell proliferation, induced S and G2/M cell cycle arrest, and increased apoptosis...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28269747/microrna-203-suppresses-invasion-of-gastric-cancer-cells-by-targeting-erk1-2-slug-e-cadherin-signaling
#8
Jiangdong Du, Shijie Wang, Fuchun Jing, Jiang Zhan, Yunhui Wang
BACKGROUND AND AIMS: Growing evidence suggests that microRNA plays an essential role in the development and metastasis of many tumors, including gastric cancer (GC). Expression of microRNA-203 (miR-203) has been reported to decrease in GC. In addition, overexpression of miR-203 inhibits grow of GC cells in vitro and in vivo. However, whether miR-203 affects cell migration and invasion of GC remains unclear. This study aimed to reveal the role of miR-203 on migration and invasion of GC, and its potential mechanisms...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28256061/intraoperative-peritoneal-lavage-cytology-offers-prognostic-significance-for-gastric-cancer-patients-with-curative-resection
#9
Eiji Higaki, Shinya Yanagi, Naoto Gotohda, Takahiro Kinoshita, Takeshi Kuwata, Masato Nagino, Atsushi Ochiai, Satoshi Fujii
Outcomes of patients with gastric cancer who exhibit positive peritoneal lavage cytology findings (CY(+) ) vary by diagnostic methods because of quantitative and qualitative cancer cell diversity. This study sought to establish practical diagnostic criteria for performing curative resections, based on peritoneal lavage cytology findings in gastric cancer patients. We enrolled 1028 patients with gastric cancer who underwent R0/1 (n=911) or R2 (n=117) resections and analyzed relationships between cancer cell findings in peritoneal lavage fluid and clinicopathological factors in the R0/1 group...
March 3, 2017: Cancer Science
https://www.readbyqxmd.com/read/28256037/novel-small-molecule-inhibiting-cdcp1-pkc%C3%AE-pathway-reduces-tumor-metastasis-and-proliferation
#10
Katsuhiko Nakashima, Takamasa Uekita, Shigenobu Yano, Jun-Ichi Kikuchi, Ruri Nakanishi, Nozomi Sakamoto, Keisuke Fukumoto, Akihiro Nomoto, Keisuke Kawamoto, Takashi Shibahara, Hideki Yamaguchi, Ryuichi Sakai
CUB domain-containing protein-1 (CDCP1) is a trans-membrane protein predominantly expressed in various cancer cells and involved in tumor progression. CDCP1 is phosphorylated at tyrosine residues in the intracellular domain by Src family kinases and recruits PKCδ to the plasma membrane through tyrosine phosphorylation-dependent association with the C2 domain of PKCδ, which in turn induces a survival signal in an anchorage-independent condithion. In this study, we utilized our cell-free screening system to identify a small compound, glycoconjugated palladium complex (Pd-Oqn), which significantly inhibited the interaction between the C2 domain of PKCδ and phosphorylated CDCP1...
March 3, 2017: Cancer Science
https://www.readbyqxmd.com/read/28197204/effects-of-combined-simultaneous-and-sequential-endostar-and-cisplatin-treatment-in-a-mice-model-of-gastric-cancer-peritoneal-metastases
#11
Lin Jia, Shuguang Ren, Tao Li, Jianing Wu, Xinliang Zhou, Yan Zhang, Jianhua Wu, Wei Liu
Objective. Aimed to study the effects of endostar and cisplatin using an in vivo imaging system (IVIS) in a model of peritoneal metastasis of gastric cancer. Methods. NUGC-4 gastric cancer cells transfected with luciferase gene (NUGC-4-Luc) were injected i.p. into nude mice. One week later, mice were randomly injected i.p.: group 1, cisplatin (d1-3) + endostar (d4-7); group 2, endostar (d1-4) + cisplatin (d5-7); group 3, endostar + cisplatin d1, 4, and 7; group 4, saline for two weeks. One week after the final administration, mice were sacrificed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28186964/il-6-secreted-by-cancer-associated-fibroblasts-promotes-epithelial-mesenchymal-transition-and-metastasis-of-gastric-cancer-via-jak2-stat3-signaling-pathway
#12
Xiongyan Wu, Pan Tao, Quan Zhou, Jie Li, Zhenjia Yu, Xiaofeng Wang, Jiaanfang Li, Chen Li, Min Yan, Zhenggang Zhu, Bingya Liu, Liping Su
Cancer-associated fibroblasts (CAFs), as the activated fibroblasts in tumor stroma, are important modifiers of tumor progression. However, the molecular mechanisms underlying the tumor-promoting properties of CAFs in gastric cancer remain unclear. Here, we show that CAFs isolated from gastric cancer produce significant amounts of interleukin-6 (IL-6). CAFs enhances the migration and EMT of gastric cancer cells through the secretion of IL-6 that activates Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT3) pathway in gastric cancer cells, while deprivation of IL-6 using a neutralizing antibody or inhibition of JAK/STAT3 pathway with specific inhibitor AG490 markedly attenuates these phenotypes in gastric cancer cells induced by CAFs...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185236/regulation-of-osmolality-for-cancer-treatment
#13
REVIEW
Atsushi Shiozaki, Daisuke Ichikawa, Toshiyuki Kosuga, Yoshinori Marunaka, Eigo Otsuji
Disseminated metastasis is associated with a poor prognosis, and its management in the peritoneal or pleural cavity is crucial in the treatment of cancer. Recent studies show that ion and water transporters play important roles in fundamental cellular functions, including the regulation of cell volume that would be involved in the cancer process. Here, we review the evidence for hypotonic treatments of cancer and evaluate the potential of the cellular physiological approach in clinical management. The regulation of extracellular osmolality is a promising method, with several studies demonstrating the cytocidal effects of hypotonic solution on cancer cells...
February 10, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28174485/prognostic-nutritional-index-is-an-independent-prognostic-factor-for-gastric-cancer-patients-with-peritoneal-dissemination
#14
Runcong Nie, Shuqiang Yuan, Shi Chen, Xiaojiang Chen, Yongming Chen, Baoyan Zhu, Haibo Qiu, Zhiwei Zhou, Junsheng Peng, Yingbo Chen
OBJECTIVE: The predictive and prognostic role of prognostic nutritional index (PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination. METHODS: A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28165032/gpr155-serves-as-a-predictive-biomarker-for-hematogenous-metastasis-in-patients-with-gastric-cancer
#15
Dai Shimizu, Mitsuro Kanda, Haruyoshi Tanaka, Daisuke Kobayashi, Chie Tanaka, Masamichi Hayashi, Naoki Iwata, Yukiko Niwa, Hideki Takami, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
The prognosis of patients with gastric cancer (GC) with hematogenous metastasis is dismal. Identification of biomarkers specific for hematogenous metastasis is required to develop personalized treatments that improve patients' outcomes. Global expression profiling of GC tissues with synchronous hepatic metastasis without metastasis to the peritoneal cavity or distant lymph nodes was conducted using next-generation sequencing and identified the G protein-coupled receptor 155 (GPR155) as a candidate biomarker...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28133336/-a-case-of-an-elderly-patient-with-unresectable-gastric-cancer-treated-by-paclitaxel-and-ramucirumab
#16
Yutaka Kimura, Yoichi Makari, Johta Mikami, Junpei Yoshimura, Toshiya Inoue, Genta Sawada, Shin Nakahira, Jun Yamamura, Shunji Kamigaki, Ken Nakata, Tameyoshi Yamamoto, Naoki Ikeda, Masaki Tsujie, Junya Fujita, Hiroki Ohzato
An 80-year-old man was admitted to our hospital with appetite loss in December 2014. Gastroduodenal scope, abdominal computed tomography(CT), and laparoscopy revealed type 4 advanced gastric cancer(poorly differentiated adenocarcinoma) with multiple lymph node(LN)involvement and multiple peritoneal metastasis. S-1(80mg/body)was administrated between January 2015 and September 2015 in the outpatient clinic. A partial response was obtained, but a gastric tumor, ascites, and LN re-growth were observed. Since October 2015, paclitaxel(PTX)(70mg/m2; day 1, 8, and 15)and ramucir- umab(RAM)(8mg/kg; day 1 and 15)have been administered...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133335/-a-case-of-rectal-metastasis-of-gastric-cancer-associated-with-dermatomyositis
#17
Kazuhiro Nishikawa, Chu Matsuda, Junji Kawada, Kazumasa Fujitani, Shunji Endo, Motohiro Hirao, Kazuyoshi Yamamoto, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto
We report a case of rectal metastasis of gastric cancer associated with dermatomyositis showing paraneoplastic syndrome. The patient was a 70-year-old man who had undergone curative total gastrectomy for Stage III Agastric cancer in March 2005. He was diagnosed with dermatomyositis and treated with prednisolone after gastrectomy. In April 2006, erythema of his face relapsed, and his serum CPK level was abnormally elevated. He experienced muscle weakness and dysphagia, and was treated with increased doses of prednisolone and gamma-globulin...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133187/-stage-iv-gastric-cancer-with-positive-peritoneal-washing-cytology-or-peritoneal-dissemination-was-successfully-treated-with-gastrectomy-and-hyperthermic-intraperitoneal-chemotherapy-hipec-followed-by-systemic-chemotherapy-a-report-of-two-cases
#18
Tsuyoshi Yamaguchi, Satoshi Murata, Sachiko Kaida, Reiko Ohtake, Katsushi Takebayashi, Hiroshi Yamamoto, Toru Miyake, Hiroya Akabori, Hiromichi Sonoda, Tsuyoshi Mori, Tomoharu Shimizu, Shigeyuki Naka, Suzuko Moritani, Ryoji Kushima, Masaji Tani
Survival of Stage IV gastric cancer is poor. We report 2 cases of Stage IV gastric cancer with positive peritoneal washing cytology or peritoneal dissemination that were successfully treated with gastrectomy and hyperthermic intraperitoneal chemotherapy( HIPEC)followed by systemic chemotherapy. Case 1: A 59-year-old woman. She was diagnosed with advanced gastric cancer and underwent gastrectomy with HIPEC. Her peritoneal washing cytology was positive during the gastrectomy. After the surgery, she underwent chemotherapy consisting of 8 courses of combination S-1 plus CPT-11 and 19 courses of PTX...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133178/-a-long-surviving-patient-with-unresectable-gastric-cancer-treated-with-multiple-rounds-of-chemotherapyafter-gastrojejunostomyand-ileocolonostomy
#19
Kazuhiro Nishikawa, Tsuyoshi Takahashi, Junji Kawada, Kazumasa Fujitani, Shunji Endo, Motohiro Hirao, Kazuyoshi Yamamoto, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto
We report a long-surviving patient with unresectable gastric cancer treated with multiple rounds of chemotherapy after gastrojejunostomy and ileocolonostomy. The patient was a 79-year-old man. Endoscopic examination revealed a type 3 gastric cancer in the antrum and showed pyloric stenosis. We observed that the gastric tumor had invaded the transverse colon, pancreas, and duodenum, and was associated with peritoneal metastasis on the surface of the hepatoduodenal ligament and the posterior leaf of the transverse mesocolon...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133171/-gastric-cancer-diagnosed-with-metastasis-of-the-navel-sister-mary-joseph-s-nodule-a-case-report
#20
Tomohiro Katayama, Takaaki Ishii, Takeshi Tono, Yusuke Okubo, Koji Shinozaki, Yasuhito Kawasaki, Shuho Senba, Seiji Yasuda, Minoru Otsuru
A woman in her 60s was admitted to our hospital with pain and induration of the navel. She was diagnosed with gastric cancer with metastasis to the navel and underwent total gastrectomy and navel extraction. Because disseminated nodules were detected in the Douglas pouch and sigmoid colon, sigmoidectomy was performed to prevent bowel obstruction. The navel tumor was histologically diagnosed as a metastasis of the gastric cancer. One month after surgery, a chest skin tumor, which was also a skin metastasis of the gastric cancer[T4aN3M1(SKI, OTH)H0P1, fStage IV ], was detected, and tumor enucleation was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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