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https://www.readbyqxmd.com/read/28654772/evidence-for-the-presence-of-cell-surface-bound-and-intracellular-bactericidal-toxins-in-the-dinoflagellate-heterocapsa-circularisquama
#1
Kichul Cho, Li Wencheng, Satoshi Takeshita, Jung-Kil Seo, Young-Ho Chung, Daekyung Kim, Tatsuya Oda
Heterocapsa circularisquama, a harmful dinoflagellate, has multiple haemolytic toxins that are considered to be involved in the toxic mechanism against shellfish and certain species of zooplankton. To evaluate the further nature of the toxins of H. circularisquama, we investigated its effects on several species of bacteria. By colony formation assay, we found that H. circularisquama had antibacterial activity toward the marine bacterium Vibrio alginolyticus in a cell density-dependent manner. When the inoculated bacterial cells were co-cultured with H...
June 19, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28654270/ultralong-hydroxyapatite-nanowires-based-paper-co-loaded-with-silver-nanoparticles-and-antibiotic-for-long-term-antibacterial-benefit
#2
Zhi-Chao Xiong, Zi-Yue Yang, Ying-Jie Zhu, Fei-Fei Chen, Yong-Gang Zhang, Ri-Long Yang
Hydroxyapatite is a kind of biocompatible, environmentally friendly, and versatile inorganic biomaterial. Herein, the preparation of ultralong hydroxyapatite nanowires (HAPNWs)-based antibacterial paper co-loaded with silver nanoparticles (AgNPs) and antibiotic is reported. HAPNWs are used to prepare AgNPs in situ using an aqueous solution containing AgNO3 under the sunlight without added reducing agent at room temperature. Subsequently, ciprofloxacin (CIP) as an antibiotic is loaded on the HAPNWs@AgNPs. The resultant HAPNWs@AgNPs-CIP paper possesses several unique properties, including high flexibility, high Brunauer-Emmett-Teller (BET) specific surface area (47...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28654257/lipophosphonoxins-ii-design-synthesis-and-properties-of-novel-broad-spectrum-antibacterial-agents
#3
Gabriela Seydlová, Radek Pohl, Eva Zborníková, Marcel Ehn, Ondrej Simak, Natalya Panova, Milan Kolar, Katerina Bogdanova, Renata Vecerova, Radovan Fiser, Hana Šanderová, Dragana Vítovská, Petra Sudzinová, Jiří Pospíšil, Oldrich Benada, Tomáš Křížek, David Sedlak, Petr Bartunek, Libor Krasny, Dominik Rejman
The increase in the number of bacterial strains resistant to known antibiotics is alarming. In this study we report the synthesis of novel compounds termed Lipophosphonoxins II (LPPO II). We show that LPPO II display excellent activities against Gram positive and -negative bacteria, including pathogens and multiresistant strains. We describe their mechanism of action - plasmatic membrane pore-forming activity selective for bacteria. Importantly, LPPO II neither damage nor cross the eukaryotic plasmatic membrane at their bactericidal concentrations...
June 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28652728/ti-go-ag-nanocomposite-the-effect-of-content-level-on-the-antimicrobial-activity-and-cytotoxicity
#4
Jianfeng Jin, Li Zhang, Mengqi Shi, Yumei Zhang, Qintao Wang
Surface modification of titanium (Ti) implants are extensively studied in order to obtain prominent biocompatibility and antimicrobial activity, especially preventing implant-associated infection. In this study, Ti substrates surface were modified by graphene oxide (GO) thin film and silver (Ag) nanoparticles via electroplating and ultraviolet reduction methods so as to achieve this purpose. Microstructures, distribution, quantities and spectral peaks of GO and Ag loading on the Ti sheets surface were characterized...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28652330/exploiting-the-synthetic-lethality-between-terminal-respiratory-oxidases-to-kill-mycobacterium-tuberculosis-and-clear-host-infection
#5
Nitin P Kalia, Erik J Hasenoehrl, Nurlilah B Ab Rahman, Vanessa H Koh, Michelle L T Ang, Dannah R Sajorda, Kiel Hards, Gerhard Grüber, Sylvie Alonso, Gregory M Cook, Michael Berney, Kevin Pethe
The recent discovery of small molecules targeting the cytochrome bc1 :aa3 in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome bc1 :aa3 consists of a menaquinone:cytochrome c reductase (bc1 ) and a cytochrome aa3 -type oxidase. The clinical-stage drug candidate Q203 interferes with the function of the subunit b of the menaquinone:cytochrome c reductase. Despite the affinity of Q203 for the bc1 :aa3 complex, the drug is only bacteriostatic and does not kill drug-tolerant persisters...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28651889/a-novel-expression-vector-for-the-secretion-of-abaecin-in-bacillus-subtilis
#6
Li Li, Lan Mu, Xiaojuan Wang, Jingfeng Yu, Ruiping Hu, Zhen Li
This study aimed to describe a Bacillus subtilis expression system based on genetically modified B. subtilis. Abaecin, an antimicrobial peptide obtained from Apis mellifera, can enhance the effect of pore-forming peptides from other species on the inhibition of bacterial growth. For the exogenous expression, the abaecin gene was fused with a tobacco etch virus protease cleavage site, a promoter Pglv, and a mature beta-glucanase signal peptide. Also, a B. subtilis expression system was constructed. The recombinant abaecin gene was expressed and purified as a recombinant protein in the culture supernatant...
June 3, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28651840/the-role-of-anti-nhba-antibody-in-bactericidal-activity-elicited-by-the-meningococcal-serogroup-b-vaccine-menb-4c
#7
Elizabeth Partridge, Eduardo Lujan, Serena Giuntini, David M Vu, Dan M Granoff
BACKGROUND: MenB-4C (Bexsero®) is a multicomponent serogroup B meningococcal vaccine. For vaccine licensure, efficacy was inferred from serum bactericidal antibody (SBA) against three antigen-specific indicator strains. The bactericidal role of antibody to the fourth vaccine antigen, Neisserial Heparin binding antigen (NHba), is incompletely understood. METHODS: We identified nine adults immunized with two or three doses of MenB-4C who had sufficient volumes of sera and >3-fold increases in SBA titer against a strain with high NHba expression, which was mismatched with the other three MenB-4C antigens that elicit SBA...
June 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28651094/in-vitro-susceptibility-of-brachyspira-hyodysenteriae-to-a-commercial-citrus-fruit-extract
#8
Pedro J G de Nova, Ana Carvajal, Miguel Prieto, Pedro Rubio
Brachyspira hyodysenteriae is the main etiological agent of swine dysentery (SD). Nowadays, treatment and control of SD is increasingly difficult due to the emergence of antimicrobial resistance together with the restrictions on the use of antibiotics in veterinary practice. The aim of this study was to evaluate, as an alternative in the control of this disease, the antimicrobial activity and the main mechanism of action of BIOCITRO, a citrus extract commercialized as raw material and used as feed additive, against B...
June 20, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28650661/triaryl-benzimidazoles-as-a-new-class-of-antibacterial-agents-against-resistant-pathogenic-microorganisms
#9
Pietro Picconi, Charlotte Hind, Shirin Jamshidi, Kazi Nahar, Melanie Clifford, Matthew E Wand, J Mark Sutton, K Miraz Rahman
A new class of non-toxic triaryl benzimidazole compounds, derived from existing classes of DNA minor groove binders, were designed, synthesized and evaluated for their antibacterial activity against multi-drug resistant (MDR) Gram-positive and Gram-negative species. Molecular modelling experiments suggest that the newly synthesized class cannot be accommodated within the minor groove of DNA, due to a change in the shape of the molecules. Compounds 8, 13 and 14 were found to be the most active of the series, with MICs in the range of 0...
June 26, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28648647/in-vitro-antibacterial-activity-of-fosfomycin-combined-with-other-antimicrobials-against-kpc-producing-klebsiella-pneumoniae
#10
Wei Yu, Ping Shen, Zhang Bao, Kai Zhou, Beiwen Zheng, Jinru Ji, Lihua Guo, Chen Huang, Yonghong Xiao
The increasing prevalence of KPC-producing Klebsiella pneumoniae (KPC-Kp) strains poses a serious threat to patients. Therapeutic options are limited to colistin, fosfomycin, tigecycline and selected aminoglycosides. Although the combination of fosfomycin with other antimicrobials is recommended, data regarding possible synergistic activity in vitro and in vivo appear inconsistent. Here we report that five drug combinations (fosfomycin combined with imipenem, ertapenem, tigecycline, colistin or amikacin) had a significant additive effect against 136 KPC-Kp strains in an in vitro chequerboard assay...
June 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28647534/molecular-cell-biology-of-complement-membrane-attack
#11
REVIEW
B Paul Morgan, Courtney Boyd, Doryen Bubeck
The membrane attack complex (MAC) is the pore-forming toxin of the complement system, a relatively early evolutionary acquisition that confers upon complement the capacity to directly kill pathogens. The MAC is more than just a bactericidal missile, having the capacity when formed on self-cells to initiate a host of cell activation events that can have profound consequences for tissue homeostasis in the face of infection or injury. Although the capacity of complement to directly kill pathogens has been recognised for over a century, and the pore-forming killing mechanism for at least 50 years, there remains considerable uncertainty regarding precisely how MAC mediates its killing and cell activation activities...
June 21, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28647167/adolescent-meningococcal-serogroup-a-w-and-y-immune-responses-following-immunization-with-quadrivalent-meningococcal-a-c-w-and-y-conjugate-vaccine-optimal-age-for-vaccination
#12
Mariëtte B van Ravenhorst, Fiona R M van der Klis, Debbie M van Rooijen, Elisabeth A M Sanders, Guy A M Berbers
BACKGROUND: Recently the incidence of meningococcal serogroup Y (MenY) and in particular serogroup W (MenW) invasive disease has risen in several European countries, including the Netherlands. Adolescents are a target group for primary prevention through vaccination to protect against disease and reduce carriage and induce herd protection in the population. The present study assessed MenA, MenW and MenY antibody levels in adolescents up to one year following primary vaccination with quadrivalent MenACWY-PS conjugated to tetanus toxoid (MenACWY-TT)...
June 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28646437/cytotoxic-and-genotoxic-effects-of-silver-nanoparticle-carboxymethyl-cellulose-on-allium-cepa
#13
Aline A Becaro, Maria Célia Siqueira, Fernanda C Puti, Marcia Regina de Moura, Daniel S Correa, José Manoel Marconcini, Luiz H C Mattoso, Marcos David Ferreira
Several mutagenic agents may be present in substances released in the environment, which may cause serious environmental impacts. Among these substances, there is a special concern regarding the widespread use of silver nanoparticles (AgNP) in several products due to their widely known bactericidal properties, including in the medical field and the food industry (e.g., active packaging). The assessment of the effects of AgNP released in the environment, having different concentrations, sizes, and being associated or not to other types of materials, including polymers, is therefore essential...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28645650/isolation-identification-and-biocontrol-of-antagonistic-bacterium-against-botrytis-cinerea-after-tomato-harvest
#14
Jun-Feng Shi, Chang-Qing Sun
Tomato is one of the most important vegetables in the world. Decay after harvest is a major issue in the development of tomato industry. Currently, the most effective method for controlling decay after harvest is storage of tomato at low temperature combined with usage of chemical bactericide; however, long-term usage of chemical bactericide not only causes pathogen resistance but also is harmful for human health and environment. Biocontrol method for the management of disease after tomato harvest has great practical significance...
June 3, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28644529/reciprocal-cooperation-of-phytochemicals-and-micronutrients-against-typical-and-atypical-forms-of-borrelia-spp
#15
Anna Goc, Alexandra Niedzwiecki, Matthias Rath
AIMS: Borrelia spp., a causative pathogenic factor of Lyme disease, has become a major public health threat. Current treatments based on antibiotics often lead to relapse after their withdrawal. Naturally derived substances that could work synergistically to display higher efficacy compared to the individual components may serve as a resource for the development of novel approaches to combat both active and latent forms of Borrelia spp. METHODS AND RESULTS: Using checkerboard assay, we investigated the anti-borreliae reciprocal cooperation of phytochemicals and micronutrients against two species of Borrelia selected as prevalent causes of Lyme disease in the US and Europe...
June 23, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28642934/evaluation-of-the-antibacterial-and-antifungal-properties-of-phragmanthera-capitata-sprengel-balle-loranthaceae-a-mistletoe-growing-on-rubber-tree-using-the-dilution-techniques
#16
Franklin Uangbaoje Ohikhena, Olubunmi Abosede Wintola, Anthony Jide Afolayan
The alarming increase in multidrug resistance of pathogenic microorganisms to conventional drugs in recent years has prompted the search for new leads in alternative remedies in natural products. Hence, this study was aimed at evaluating the antimicrobial properties of Phragmanthera capitata, a parasitic mistletoe growing on rubber trees. The in vitro antimicrobial activities of the acetone, methanol, ethanol, and aqueous extracts were investigated using five gram-negative and five gram-positive bacteria and four fungi...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28642751/in-vitro-antimicrobial-activity-of-chlorquinaldol-against-microorganisms-responsible-for-skin-and-soft-tissue-infections-comparative-evaluation-with-gentamicin-and-fusidic-acid
#17
Monica Bortolin, Alessandro Bidossi, Elena De Vecchi, Maura Avveniente, Lorenzo Drago
Skin and soft tissue infections (SSTIs) are a major therapeutic challenge for clinicians. The emergence of pathogens with decreased susceptibility to available therapies has become an emerging problem often associated with treatment failure. Hence, there is an urgent need for novel broad-spectrum antimicrobial agents. The purpose of this study was to assess the feasibility of chlorquinaldol as an alternative approach to currently used topical antibiotics for the treatment of skin and soft tissue infections...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28642571/pharmacokinetic-and-pharmacodynamic-modeling-of-cyadox-against-clostridium-perfringens-in-swine
#18
Lei Yan, Shuyu Xie, Dongmei Chen, Yuanhu Pan, Yanfei Tao, Wei Qu, ZhenLi Liu, Zonghui Yuan, Lingli Huang
The purpose of this study was to evaluate the activity of cyadox against Clostridium perfringens in swine and optimize the dosage regimen using ex vivo pharmacokinetic-pharmacodynamic (PK-PD) modeling. After oral administration, the ileum fluid of pigs containing the free cyadox was collected by implanted ultrafiltration probes. The Tmax, AUC24h, and CL/F of free cyadox in the ileum fluid were 1.96 h, 106.40 μg/h/mL, and 0.27 L/kg/h, respectively. Cyadox displayed a concentration-dependent killing action against C...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642073/synthesis-of-biogenic-ag-pd-core-shell-nanoparticles-having-anti-cancer-anti-microbial-functions
#19
Wafa I Abdel-Fattah, M M Eid, Sh I Abd El-Moez, E Mohamed, Ghareib W Ali
Biogenic Ag@Pd core-shell nanoparticles were greenly synthesized within two plant extracts aiming at enhanced anticancer/bactericidal functions. These functions were verified for the two Pd@Ag biogenic core-shell nanoparticles (BCSnp) with constant Pd to several Ag contents. BCSnp were synthesized within two extracts of Almond nuts and Black Berry fruits, four samples each, through simple, low cost and echo friendly microwave route. The BCSnp Surface Plasmon Resonance (SPR) was detected via UV/visible spectrophotometer...
June 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/28641565/d-amino-acid-analogues-of-the-antimicrobial-peptide-cdt-exhibit-anti-cancer-properties-in-a549-a-human-lung-adenocarcinoma-cell-line
#20
Deborah L Heyl, Hedeel Guy Evans, Jeff Guthrie, Murali Jujjavarapu, Nathan Hendrickson, Anna Eitel, Yeji Park, Jennifer Garvey, Rebecca Newman, Daniel Esckilsen
The importance of the antitumor activity of some antimicrobial peptides is being increasingly recognized. The antimicrobial peptide, tachyplesin, has been shown to exhibit anticancer properties and a linear, cysteine deleted analogue (CDT), was found to retain its antibacterial function. We used sequence reversal and D-amino acids to synthesize four CDT analogues. We found that D-CDT exhibited the best bactericidal properties with the highest selectivity index. While the MIC was found to improve only modestly against S...
June 20, 2017: Protein and Peptide Letters
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