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https://www.readbyqxmd.com/read/29160391/agnps-the-new-allies-against-s-mutans-biofilm-a-pilot-clinical-trial-and-microbiological-assay
#1
Priscila L L Freire, Allan J R Albuquerque, Fabio C Sampaio, André Galembeck, Miguel A P Flores, Thayza C M Stamford, Aronita Rosenblatt
The purpose of this study was to evaluate the antimicrobial properties of a new formulation containing silver nanoparticles, named Nano Silver Fluoride (NSF), to inhibit Streptococcus mutans biofilm formation on children's dental enamel. The variations in dental biofilm pH and in the Simplified-Oral-Hygiene-Index (OHI-S) also were evaluated after the treatment with NSF. This was a randomized, double-blind, crossover and prospective pilot clinical trial study in which 12 schoolchildren, aged between 7-8 years, had their dental enamel treated with two solutions: S1 - Nano Silver Fluoride and S2 - negative control (saline solution), in different experimental moments...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29160117/determination-and-identification-of-antibiotic-resistant-oral-streptococci-isolated-from-active-dental-infections-in-adults
#2
Juan Pablo Loyola-Rodriguez, Maria Elena Ponce-Diaz, Alejandra Loyola-Leyva, Jose O Garcia-Cortes, Carlo E Medina-Solis, Azael A Contreras-Ramire, Eduardo Serena-Gomez
OBJECTIVE: To determine and identify antibiotic-resistant bacteria (ARB) of oral streptococci from active dental infections in adults and its association with age and gender. MATERIAL AND METHODS: This cross-sectional study included 59 subjects from 18 to 62 years old. Ninety-eighth samples obtained from the subjects were cultivated in agar plates containing antibiotics amoxicillin/clavulanic acid (A-CA), clindamycin, and moxifloxacin (concentrations of 16, 32 or 64 µg/ml)...
November 21, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29159979/ultrasound-microbubbles-enhance-the-activity-of-vancomycin-against-staphylococcus-epidermidis-biofilms-in-vivo
#3
Ying Dong, Junshuai Li, Pan Li, Jialin Yu
OBJECTIVES: Staphylococcus epidermidis is the predominant pathogen of device-associated infections. By forming biofilms on the device surface, S epidermidis has substantial resistance to antibiotics and is difficult to eradicate. This study aimed to explore the synergistic effect of ultrasound (US)-mediated microbubbles combined with vancomycin on S epidermidis biofilms in a rabbit model. METHODS: Two polytetrafluoroethene catheters with preformed S epidermidis biofilms were implanted subcutaneously in a rabbit, one on either side of the spine...
November 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29159916/purification-and-characterization-of-ribosomal-proteins-l27-and-l30-having-antimicrobial-activity-produced-by-the-lactobacillus-salivarius-sgl03
#4
Paolo Pidutti, Federica Federici, Jessica Brandi, Laura Manna, Eleonora Rizzi, Umberto Marini, Daniela Cecconi
AIMS: The aim of this study was to investigate the antimicrobial potential of proteins secreted by a new strain of Lactobacillus salivarius. METHODS AND RESULTS: The secretome of L. salivarius SGL03 strain was analyzed by gel-assisted fractionation and MS/MS to identify low-molecular-mass proteins. This strategy allowed us to identify ten secreted proteins. Then a combination of heterologous expression and agar well diffusion was used to characterize them as to their antimicrobial activity, mechanisms of action, and stability...
November 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29158722/synthesis-and-investigation-of-antimicrobial-activities-of-nitrofurazone-analogues-containing-hydrazide-hydrazone-moiety
#5
Łukasz Popiołek, Anna Biernasiuk
In this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of (1)H NMR and (13)C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds 28, 29, 32-43, and 45-48 showed very high bactericidal effect towards Staphylococcus spp. ATTC and Bacillus spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29158280/anti-pseudomonal-activity-of-phage-pev20-in-a-dry-powder-formulation-a-proof-of-principle-study-in-a-murine-lung-infection-model
#6
Rachel Yoon Kyung Chang, Ke Chen, Jiping Wang, Martin Wallin, Warwick Britton, Sandra Morales, Elizabeth Kutter, Jian Li, Hak-Kim Chan
Bacteriophage therapy is a promising alternative treatment to antibiotics as it has been documented to be efficacious against multi-drug resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, phage dry powder administration to the lungs has not yet been explored. Powder formulations provide potential advantages over liquid formulation, including easy storage, transport and administration...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158143/urinary-concentration-and-antimicrobial-activity-of-tobramycin-in-healthy-volunteers-receiving-a-single-oral-dose-of-a-novel-formulation-for-improved-absorption
#7
Maria Loose, Kurt G Naber, Paul Shields, Harald Reinhart, Florian M E Wagenlehner
BACKGROUND: Oral antibiotics for the treatment of UTI are scarce. In this ex vivo phase 1 annex study, clinical safety, urinary concentrations and bactericidal activity of a new formulation for improved oral absorption of tobramycin (Tobrate(TM)) were evaluated. METHODS: The minimal inhibitory and bactericidal concentrations (MIC/MBC) of five test strains, one reference strain and four clinical uropathogenic strains, were determined in cation-adjusted Mueller-Hinton Broth (CAMHB) and in pooled antimicrobial agent-free urine of the subjects at different pH (5...
November 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29157966/antibiotic-killing-through-incomplete-dna-repair
#8
Benno H Ter Kuile, Marloes Hoeksema
Two recent studies show that incomplete repair of DNA damage due to oxidized nucleotides is crucial for reactive oxygen species (ROS)-related antimicrobial lethality. Using widely different experimental approaches they both reach the same conclusions on the role of downstream ROS production in cell killing upon exposure to bactericidal antimicrobials.
November 17, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29156617/optimum-thermal-processing-for-extended-shelf-life-esl-milk
#9
REVIEW
Hilton Deeth
Extended shelf-life (ESL) or ultra-pasteurized milk is produced by thermal processing using conditions between those used for traditional high-temperature, short-time (HTST) pasteurization and those used for ultra-high-temperature (UHT) sterilization. It should have a refrigerated shelf-life of more than 30 days. To achieve this, the thermal processing has to be quite intense. The challenge is to produce a product that has high bacteriological quality and safety but also very good organoleptic characteristics...
November 20, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29155393/enhanced-antibacterial-effect-of-azlocillin-in-conjugation-with-silver-nanoparticles-against-pseudomonas-aeruginosa
#10
Aram Alizadeh, Mojtaba Salouti, Hamed Alizadeh, Ali Reza Kazemizadeh, Ali Asghar Safari, Sanaz Mahmazi
In recent years, the problems associated with bacterial resistance to antibiotics caused nanodrugs to be considered as a new way for infectious diseases treatment. The main purpose of this study was to develop a new agent against Pseudomonas aeruginosa, a very difficult bacterium to treat, based on azlocillin antibiotic and silver nanoparticles (AgNPs). Azlocillin was conjugated with AgNPs by chemical methods and its antimicrobial activity was studied against P. aeruginosa using well diffusion agar method. Then, minimum inhibitory concentration and minimum bactericidal concentration of the new conjugate was specified with macro-dilution method...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29155361/silver-nanoparticles-increase-bactericidal-activity-and-radical-oxygen-responses-against-bacterial-pathogens-in-human-osteoclasts
#11
Valerie Aurore, Fabienne Caldana, Marianne Blanchard, Solange Kharoubi Hess, Nils Lannes, Pierre-Yves Mantel, Luis Filgueira, Michael Walch
Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its bactericidal activity. Here, we investigated the bactericidal effects of nano-silver particles in bacteria infected human osteoclasts...
November 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29155126/treatment-strategy-by-lactoperoxidase-and-lactoferrin-combination-immunomodulatory-and-antibacterial-activity-against-multidrug-resistant-acinetobacter-baumannii
#12
Likaa Mahdi, Nada Mahdi, Sana'a Al-Kakei, Hadeel Musafer, Ikbal Al-Joofy, Rajwa Essa, Luma Zwain, Istabreq Salman, Haifa Mater, Shaymaa Al-Alak, Rasha Al-Oqaili
Lactoperoxidase (Lpo) and Lactoferrin (Lf) were extracted from camel colostrum milk and purified. The antibacterial activity of the two purified proteins was estimated against 14 isolates of multidrug resistance Acinetobacter baumannii. A combination of Lpo and Lf exhibited bactericidal action against A. baumannii in vitro. A mouse model of acute A. baumannii pneumonia was improved. The injection of combined Lpo and Lf after infection leads to significant clearance of A. baumannii rates in lung as well as blood culture P < 0...
November 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29154899/combining-diagnostic-methods-for-antimicrobial-susceptibility-testing-a-comparative-approach
#13
Sylvia Natalie Kłodzińska, Petra Alexandra Priemel, Thomas Rades, Hanne Mørck Nielsen
BACKGROUND: The minimum inhibitory concentration (MIC) is a measure of antimicrobial susceptibility testing (AST) of a given antibiotic, but provides insufficient information when bacterial killing is crucial, e.g. when treating immunocompromised patients. In these cases, the minimum bactericidal concentration (MBC) is a more reliable measure of antibiotic activity. Here, we aim to demonstrate and recommend combinations of methods for MIC and MBC measurements. We also aim to emphasize the importance of uniform protocols for these procedures including the time point for reading MIC results, which the authors suggest to be 20h...
November 14, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29154746/in-vitro-and-in-vivo-activity-of-fosfomycin-alone-and-in-combination-with-rifampin-and-tigecycline-against-gram-positive-cocci-isolated-from-surgical-wound-infections
#14
Oriana Simonetti, Gianluca Morroni, Roberto Ghiselli, Fiorenza Orlando, Andrea Brenciani, Ledia Xhuvelaj, Mauro Provinciali, Annamaria Offidani, Mario Guerrieri, Andrea Giacometti, Oscar Cirioni
Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders, with surgical site infections being the most common hospital-acquired ones. The aim of our study was to investigate the synergistic and bactericidal activities of antimicrobial combinations of fosfomycin with rifampicin and tigecycline against Enterococcus faecalis, Enterococcus faecium and methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, and also to evaluate their in vivo effects in a mouse wound infection model...
November 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29154480/in-vitro-activity-and-time-kill-curve-analysis-of-sitafloxacin-against-a-global-panel-of-antimicrobial-resistant-and-multidrug-resistant-neisseria-gonorrhoeae-isolates
#15
Agnez Jönsson, Sunniva Foerster, Daniel Golparian, Ryoichi Hamasuna, Susanne Jacobsson, Magnus Lindberg, Jörgen Skov Jensen, Makoto Ohnishi, Magnus Unemo
Treatment of gonorrhoea is a challenge worldwide because of emergence of resistance in N. gonorrhoeae to all therapeutic antimicrobials available and novel antimicrobials are imperative. The newer-generation fluoroquinolone sitafloxacin, mostly used for respiratory tract infections in Japan, can have a high in vitro activity against gonococci. However, only a limited number of recent antimicrobial-resistant isolates from Japan have been examined. We investigated the sitafloxacin activity against a global gonococcal panel (250 isolates cultured in 1991-2013), including multidrug-resistant geographically, temporally and genetically diverse isolates, and performed time-kill curve analysis for sitafloxacin...
November 20, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29152974/biocompatible-copper-oxide-nanoparticle-composites-from-cellulose-and-chitosan-facile-synthesis-unique-structure-and-antimicrobial-activity
#16
Chieu D Tran, James Makuvaza, Erik Munson, Brian Bennett
Copper in various forms has been known to have bactericidal activity. Challenges to its application include preventing mobilization of the copper, to both extend activity and avoid toxicity, and bioincompatibility of many candidate substrates for copper-immobilization. Using a simple ionic liquid, butylmethylimmidazolium chloride as the solvent, we developed a facile and green method to synthesize biocompatible composites containing copper oxide nanoparticles (CuONPs) from cellulose (CEL) and chitosan (CS) or CEL and keratin (KER)...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29152576/meningococcal-antigen-typing-system-mats-based-neisseria-meningitidis-serogroup-b-coverage-prediction-for-the-menb-4c-vaccine-in-the-united-states
#17
Gowrisankar Rajam, Maria Stella, Ellie Kim, Simon Paulos, Giuseppe Boccadifuoco, Laura Serino, George Carlone, Duccio Medini
Neisseria meningitidis is the most common cause of bacterial meningitis in children and young adults worldwide. A 4-component vaccine against N. meningitidis serogroup B (MenB) disease (MenB-4C [Bexsero]; GSK) combining factor H binding protein (fHBP), neisserial heparin binding protein (NHBA), neisserial adhesin A (NadA), and PorA-containing outer membrane vesicles was recently approved for use in the United States and other countries worldwide. Because the public health impact of MenB-4C in the United States is unclear, we used the meningococcal antigen typing system (MATS) to assess the strain coverage in a panel of strains representative of serogroup B (NmB) disease in the United States...
November 2017: MSphere
https://www.readbyqxmd.com/read/29152049/indolylalkyltriphenylphosphonium-analogues-are-membrane-depolarizing-mycobactericidal-agents
#18
Ming Li, Samuel A Nyantakyi, Pooja Gopal, Dinah Binte Aziz, Thomas Dick, Mei-Lin Go
Agents that selectively target the mycobacterial membrane could potentially shorten treatment time for tuberculosis, reduce relapse, and curtail emergence of resistant strains. The lipophilicity and extensive charge-delocalized state of the triphenylphosphonium cation strongly favor accumulation within bacterial membranes. Here, we explored the antimycobacterial activities and membrane-targeting properties of indolylalkyltriphenylphosphonium analogues. The most active analogues preferentially inhibited growth of Mycobacterium tuberculosis H37Rv (MIC50 2-4 μM) and were bactericidal against Mycobacterium bovis BCG (MBC99 3 μM)...
November 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29151353/challenges-in-application-of-langmuir-monolayer-studies-to-determine-the-mechanisms-of-bactericide-activity-of-ruthenium-complexes
#19
Bianca Sandrino, Jessica Fernanda Affonso de Oliveira, Thatyane M Nobre, Patricia Appelt, Akash Gupta, Marcio Peres de Araujo, Vincent M Rotello, Osvaldo Novais Oliveira
The effects induced by antibiotics on the bacteria membrane may be correlated with their bactericidal activity, and such molecular-level interactions can be probed with Langmuir monolayers representing the cell membrane. In this study, we investigated the interaction between [Ru(mcbtz)2(PPh3)2] (RuBTZ, mcbtz= 2-mercaptobenzothiazoline) and [Ru(mctz)2(PPh3)2] (RuCTZ, mctz= 2-mercaptothiazoline) with Langmuir monolayers of a lipid extract of Escherichia coli, an extract of lipopolysaccharides (LPS) and a zwitterionic phospholipid, dioleoylphosphatidyl choline (DOPC)...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29151250/mudskipper-boleophthalmus-pectinirostris-hepcidin-1-and-hepcidin-2-present-different-gene-expression-profile-and-antibacterial-activity-and-possess-distinct-protective-effect-against-edwardsiella-tarda-infection
#20
Jie Chen, Li Nie, Jiong Chen
Hepcidins are small cysteine-rich antimicrobial peptides that play an important role in fish immunity against pathogens. Most fish species have two or more hepcidin homologs that have distinct functions. This study investigated the immune functions of mudskipper (Boleophthalmus pectinirostris) hepcidin-1 (BpHep-1) and hepcidin-2 (BpHep-2) in vitro and in vivo. Upon infection with Edwardsiella tarda, the expression of BpHep-1 and BpHep-2 mRNA in immune tissues was significantly upregulated, but the expression profiles were different...
November 18, 2017: Probiotics and Antimicrobial Proteins
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