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I Papachatzakis, L Velentza, P Zarogoulidis, A Kallianos, G Trakada
OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are separately associated with several comorbidities. The coexistence of the two diseases, referred to as overlap syndrome, may act as a predisposing factor for a higher prevalence of comorbidities compared to those associated with each disease separately. The objective of the study was to evaluate the relative prevalence of cardiovascular as well as other comorbidities, in patients with the overlap syndrome, as compared to patients that are diagnosed solely with OSA...
July 2018: European Review for Medical and Pharmacological Sciences
J Song, Q-H Wang, S-C Zhou
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by inflammatory cell activation and the release of inflammatory mediators. By measuring microRNA expression in the plasma of COPD subjects, we aimed to identify the clinical relevance of plasma miRNA levels in these patients. PATIENTS AND METHODS: A total of 40 COPD patients and 40 healthy controls were enrolled in the study. The COPD model of C57BL/6 mice was also developed by exposing them to cigarette smoke (CS)...
July 2018: European Review for Medical and Pharmacological Sciences
Srinivas Annavarapu, Seth Goldfarb, Melissa Gelb, Chad Moretz, Andrew Renda, Shuchita Kaila
Background: Patients with COPD often experience severe exacerbations involving hospitalization, which accelerate lung function decline and reduce quality of life. This study aimed to develop and validate a predictive model to identify patients at risk of developing severe COPD exacerbations using administrative claims data, to facilitate appropriate disease management programs. Methods: A predictive model was developed using a retrospective cohort of COPD patients aged 55-89 years identified between July 1, 2010 and June 30, 2013 using Humana's claims data...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Alan S Bell, Philip J Lawrence, Dave Singh, Alexander Horsley
Background: Lung clearance index (LCI), derived from multiple-breath washout (MBW), is a well-established assessment of ventilation inhomogeneity in cystic fibrosis but has not been widely applied in other conditions characterized by heterogeneous airways disease, such as COPD. The aim of this study was to evaluate the sensitivity, repeatability, and practicality of LCI in patients with COPD. Methods: Fifty-four COPD patients completed MBW using nitrogen as the washout tracer gas (MBWN2 , measured using an Exhalyzer™ device), spirometry, and plethysmography...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Chung-Yu Chen, Kuang-Ming Liao
Background: Atrial fibrillation (AF) occurs frequently in patients with COPD. There are limited data about the impact of AF in hospitalized COPD patients on other serious health outcomes, such as acute organ dysfunction, severe sepsis, and respiratory failure. The aim of our study was to delineate the impact of AF in hospitalized COPD patients. Methods: We defined COPD populations with and without AF from the National Health Insurance database in Taiwan. The control subjects (patients with COPD without AF) were selected from the population of COPD patients who had no history of AF and were matched to the COPD patients with AF by age (±1 year), gender, and the year of COPD diagnosis (±1 year)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Massimo Nabissi, Oliviero Marinelli, Maria Beatrice Morelli, Giovanna Nicotra, Romilde Iannarelli, Consuelo Amantini, Giorgio Santoni, Filippo Maggi
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by a progressive and irreversible airflow limitation. COPD is associated to a chronic inflammatory response with infiltration of inflammatory cells in the surface epithelium of large airways and abnormalities in structure and functions of cilia. Thyme (Thymus vulgaris L.) is a traditional medicinal plant of the Mediterranean area used to treat respiratory disorders. We previously evidenced that thyme extract reduce IL-1beta and IL-8, by downregulating the activated NF-κB levels, suggesting its potential therapeutically use in COPD...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Karen E Joynt Maddox, E John Orav, Jie Zheng, Arnold M Epstein
BACKGROUND: The Center for Medicare and Medicaid Innovation (CMMI) launched the Bundled Payments for Care Improvement (BPCI) initiative in 2013. A subsequent study showed that the initiative was associated with reductions in Medicare payments for total joint replacement, but little is known about the effect of BPCI on medical conditions. METHODS: We used Medicare claims from 2013 through 2015 to identify admissions for the five most commonly selected medical conditions in BPCI: congestive heart failure (CHF), pneumonia, chronic obstructive pulmonary disease (COPD), sepsis, and acute myocardial infarction (AMI)...
July 19, 2018: New England Journal of Medicine
Lindsay R Kosinski, Joseph A Gil, Wesley M Durand, Steven F DeFroda, Brett D Owens, Alan H Daniels
OBJECTIVES: The purpose of this study is to identify patient characteristics that increase risk for unplanned readmission within 30 days of an initial hospital stay after outpatient rotator cuff repair (RCR). METHODS: A retrospective cohort study was performed utilizing the National Surgical Quality Improvement Program (ACS NSQIP) datasets from 2012-2015. Patients were preliminarily included in the study based on the presence of a primary Common Procedural Terminology (CPT) code for rotator cuff repair (23410, 23412, 23420, and 29827)...
July 18, 2018: Physician and Sportsmedicine
Alvar Agusti, Rosa Faner
No abstract text is available yet for this article.
July 18, 2018: American Journal of Respiratory and Critical Care Medicine
Subhabrata Moitra
No abstract text is available yet for this article.
July 18, 2018: QJM: Monthly Journal of the Association of Physicians
Cardine Martins Dos Reis, Manuela Karloh, Fernanda Rodrigues Fonseca, Roberta Rodolfo Mazzali Biscaro, Giovana Zarpellon Mazo, Anamaria Fleig Mayer
OBJECTIVE: To develop reference equations for the Glittre Activities of Daily Living test (Glittre ADL-test) on the basis of anthropometric and demographic variables in apparently healthy individuals. A secondary objective was to determine the reliability of the equations in a sample of COPD patients. METHODS: This was a cross-sectional study including 190 apparently healthy individuals (95 males; median age, 54.5 years [range, 42-65]; median FEV1 = 97% [range, 91-105...
July 16, 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
İnsu Yılmaz
No abstract text is available yet for this article.
March 2018: Tüberküloz Ve Toraks
Dorina Esendağlı, Sevinç Sarınç Ulaşlı, Antonio Esquinas
Humidification therapy is widely used in patients during invasive ventilation and the importance of heating and humidifying the inhaled air is well defined in both the acute and long term setting. On the other hand the continuous usage of humidification in noninvasive ventilation is controversial and the long term effects are still not well defined. The usage of noninvasive ventilation is especially important in hypercapnic Chronic obstructive pulmonary disease (COPD) and also the obstructive sleep apnea syndrome (OSAS) patients and compliance to this treatment is essential in long term...
March 2018: Tüberküloz Ve Toraks
Zeynep Çelebi Sözener, Fatma Çiftçi, Şadan Soyyiğit, Ömür Aydın, Elif Şen, Dilşad Mungan, Gülfem Çelik
Introduction: Despite the well documented relationship between lower airway diseases and smoking, there are limited data about smoking and allergic rhinitis (AR). In this study, we aimed to document the smoking behaviour and environmental tobacco smoke (ETS) exposure of the patients with AR in comparison with patients with asthma, chronic obstructive pulmonary diseases (COPD) and healthy controls (HC). Materials and Methods: Demographics and disease characteristics were recorded from case files whereas smoking history, childhood and current exposures to ETS, as well as the smoking behaviors were investigated by a self reported questionnaire...
March 2018: Tüberküloz Ve Toraks
İpek Candemir, Pınar Ergün, Dicle Kaymaz, Filiz Taşdemir, Fatma Şengül, Nurcan Egesel
Introduction: Oral nutritional supplement (ONS), an important part of multidisciplinary pulmonary rehabilitation (PR) program, is indicated according to body composition abnormalities in the patients with chronic obtructive pulmonary disease (COPD). We evaluated efficacy of oral nutritional supplement (ONS) during 5-8 months in patients with COPD who completed PR program. Materials and Methods: The data of 41 patients with stable COPD were recorded after the approval had been taken...
March 2018: Tüberküloz Ve Toraks
Stefan M Frent, Kenneth R Chapman, Michael Larbig, Alexander Mackay, Robert Fogel, Florian S Gutzwiller, Steven Shen, Francesco Patalano, Donald Banerji, Konstantinos Kostikas, Jadwiga A Wedzicha
RATIONALE: Chronic obstructive pulmonary disease (COPD) exacerbations accelerate lung function decline, reduce quality of life, and increase mortality. A subset of patients (n=457) from the FLAME study used the EXAcerbations of COPD Tool (EXACT®) to capture symptom-defined exacerbations. OBJECTIVES: To evaluate the effect of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) on symptom-defined exacerbations measured using EXACT, and to assess differences between these events and exacerbations requiring healthcare resource use (HCRU)...
July 18, 2018: American Journal of Respiratory and Critical Care Medicine
Maaike de Vries, Diana A van der Plaat, Judith M Vonk, H Marike Boezen
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with cigarette smoke as the main risk factor for its development. Since not every smoker develops COPD, other factors likely underlie differences in susceptibility to develop COPD. Here, we tested if DNA methylation may be such a factor by assessing the association between DNA methylation levels and COPD in never and current smokers from the general population. Methods: For the current study, 1561 subjects were non-randomly selected from the LifeLines cohort study...
2018: BMJ Open Respiratory Research
Brooks W Morgan, Matthew R Grigsby, Trishul Siddharthan, Robert Kalyesubula, Robert A Wise, John R Hurst, Bruce Kirenga, William Checkley
Introduction: Chronic obstructive pulmonary disease (COPD) will soon be the third leading global cause of death and is increasing rapidly in low/middle-income countries. There is a need for local validation of the Saint George's Respiratory Questionnaire (SGRQ), which can be used to identify those experiencing lifestyle impairment due to their breathing. Methods: The SGRQ was professionally translated into Luganda and reviewed by our field staff and a local pulmonologist...
2018: BMJ Open Respiratory Research
Judith J M Ceelen, Annemie M W J Schols, Anita E M Kneppers, Roger P H A Rosenbrand, Magda M Drożdż, Stefan J van Hoof, Chiel C de Theije, Marco C J M Kelders, Frank Verhaegen, Ramon C J Langen
Exacerbations in Chronic obstructive pulmonary disease (COPD) are often accompanied by pulmonary and systemic inflammation, and are associated with an increased susceptibility to weight loss and muscle wasting. As the emphysematous phenotype in COPD appears prone to skeletal muscle wasting, the aims of this study were to evaluate in emphysematous compared to control mice following repetitive exacerbations (1) changes in muscle mass and strength and, (2) whether muscle mass recovery and its underlying processes are impaired...
July 17, 2018: Scientific Reports
Andreas Kuemmel, Astrid Alflen, Lars Henning Schmidt, Martin Sebastian, Rainer Wiewrodt, Arik Bernard Schulze, Roland Buhl, Markus Radsak
Soluble Triggering Receptor Expressed on Myeloid Cells 1 (sTREM-1) can be found in the sera of patients with infectious, autoimmune and malignant diseases. The primary objective of this study was to investigate the prognostic significance of sTREM-1 in lung cancer patients. We analyzed the sera of 164 patients with lung cancer of all histologies and all stages at the time of diagnosis. We employed an ELISA using the anti-TREM-1 clone 6B1.1G12 mAb and recombinant human TREM-1. Patient data was collected retrospectively by chart review...
July 17, 2018: Scientific Reports
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