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https://www.readbyqxmd.com/read/28052629/pathology-of-non-alcoholic-fatty-liver-disease
#1
REVIEW
Pierre Bedossa
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of lesions ranging from steatosis (Non-alcoholic Fatty Liver or NAFL) to a complex pattern with hepatocellular injury and inflammation (non-alcoholic steatohepatitis; NASH) in the absence of alcohol intake. However, it is increasingly clear that intermediate patterns may exist. The histopathological evaluation of liver biopsy samples is central in the diagnosis of NAFLD and NASH in the absence of sufficiently accurate non-invasive tests because a precise definition of each group is a key issue...
January 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27970630/development-and-content-validity-of-the-advanced-systemic-mastocytosis-symptom-assessment-form-advsm-saf
#2
Mazar, E Evans, F Taylor, A Patki, O Ojo, R E Lamoureux, H Horny, A Reiter, J Gotlib, A Shields
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27941048/the-association-between-skin-autofluorescence-and-mean-deviation-in-patients-with-open-angle-glaucoma
#3
Noriko Himori, Hiroshi Kunikata, Ryo Kawasaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toshio Miyata, Toru Nakazawa
BACKGROUND: It has been suggested that local and systemic oxidative stress levels are causal risk factors for glaucoma. AIM: To evaluate the effect of age on the role of systemic oxidative stress in open-angle glaucoma (OAG). METHODS: This study included 502 eyes of 251 Japanese patients with OAG. Systemic oxidative stress was assessed with skin autofluorescence (SAF), an indicator of advanced glycogen end products. We selected the youngest and oldest patients by quartile (≤58 and ≥74 years old, respectively) and determined the univariate correlation between SAF and mean deviation (MD) of the visual field in both eyes of each group...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27884440/re-infection-with-fasciola-gigantica-6-month-post-treatment-with-triclabendazole-in-cattle-from-mobile-pastoralist-husbandry-systems-at-lake-chad
#4
Helena Greter, Annour A Batil, Idriss O Alfaroukh, Felix Grimm, Bongo N Ngandolo, Jennifer Keiser, Jürg Utzinger, Jakob Zinsstag, Jan Hattendorf
At Lake Chad in central Africa, livestock fascioliasis caused by Fasciola gigantica represents a major veterinary health problem, particularly in cattle reared in mobile pastoralist husbandry systems. We assessed re-infection after a single dose of triclabendazole with fascioliasis in cattle in a mobile pastoralist setting towards the end of the dry season. Within the cattle herds of 14 groups of mobile pastoralists, 375 cattle were randomly selected. A faecal sample was obtained from each animal to determine the prevalence of F...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27872501/synchronization-of-heterogeneous-oscillators-under-network-modifications-perturbation-and-optimization-of-the-synchrony-alignment-function
#5
Dane Taylor, Per Sebastian Skardal, Jie Sun
Synchronization is central to many complex systems in engineering physics (e.g., the power-grid, Josephson junction circuits, and electro-chemical oscillators) and biology (e.g., neuronal, circadian, and cardiac rhythms). Despite these widespread applications-for which proper functionality depends sensitively on the extent of synchronization-there remains a lack of understanding for how systems can best evolve and adapt to enhance or inhibit synchronization. We study how network modifications affect the synchronization properties of network-coupled dynamical systems that have heterogeneous node dynamics (e...
2016: SIAM Journal on Applied Mathematics
https://www.readbyqxmd.com/read/27814579/the-emergence-of-aspergillus-species-in-chronic-respiratory-disease
#6
Anthony Ca Yii, Mariko S Koh, Therese S Lapperre, Gan L Tan, Sanjay H Chotirmall
Chronic lung disease is recognized as an important risk factor for developing pulmonary aspergillosis. The development of specific aspergillus-associated syndromes depends on host immunity and underlying lung disease. In the setting of asthma, hypersensitivity to Aspergillus can lead to allergic bronchopulmonary aspergillosis (ABPA) or severe asthma with fungal sensitization (SAFS). Chronic use of systemic or inhaled corticosteroids coupled with recurrent antibiotic use for exacerbations prevalent in chronic obstructive pulmonary disease (COPD) predisposes to chronic pulmonary aspergillosis (CPA)...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27808450/comparative-analysis-of-saf-protaper-next-and-bt-race-in-eliminating-enterococcus-faecalis-from-long-oval-canals-an-ex-vivo-study
#7
Andreas Krokidis, Carlo Bonfanti, Antonio Cerutti, Nicola Barabanti, Spyros Zinelis, Panos Panopoulos
Comparison of the ability of newly designed rotary files to eliminate viable Enterococcus faecalis populations from long oval root canals of extracted human teeth to that of the self-adjusting file (SAF). One hundred caries-free, single-rooted, long oval teeth were contaminated with E. faecalis. The teeth were randomly distributed into four groups (n = 25) as follows: G.1, manual; G.2, SAF; G.3, ProTaper Next; and G.4, BT-Race. Two microbial samples were obtained from each tooth with sterile paper points, (s1) before and (s2) after instrumentation...
November 3, 2016: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/27788034/hepatic-fibrosis-inflammation-and-steatosis-influence-on-the-mr-viscoelastic-and-diffusion-parameters-in-patients-with-chronic-liver-disease
#8
Helena S Leitão, Sabrina Doblas, Philippe Garteiser, Gaspard d'Assignies, Valérie Paradis, Feryel Mouri, Carlos F G C Geraldes, Maxime Ronot, Bernard E Van Beers
Purpose To determine the relationship of liver fibrosis, inflammation, and steatosis with the magnetic resonance (MR) viscoelastic and diffusion parameters in patients with chronic liver disease and to compare the diagnostic accuracy of the imaging parameters in staging liver fibrosis. Materials and Methods Consecutive patients with chronic liver disease scheduled for liver biopsy were prospectively recruited from November 2010 to October 2012 for this institutional review board-approved study after they provided written informed consent...
October 27, 2016: Radiology
https://www.readbyqxmd.com/read/27662605/post-instrumentation-pain-after-the-use-of-either-mtwo-or-the-saf-system-a-randomized-controlled-clinical-trial
#9
P Saumya-Rajesh, J Krithikadatta, N Velmurugan, C Sooriaprakas
AIM: This randomized controlled trial compared the incidence of post-instrumentation pain associated with Mtwo rotary NiTi files and the self-adjusting file system following canal shaping and cleaning. METHODOLOGY: Following sample size estimation, a total of 130 patients were randomized into two groups based on selection criteria [group Mtwo and group SAF (self-adjusting file)]. Root canal treatment was carried out in two appointments. The teeth were endodontically treated with the appropriate allotted systems following the similar clinical parameters...
September 23, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27623498/supplementary-steps-for-removing-hard-tissue-debris-from-isthmus-containing-canal-systems
#10
Ali Keleş, Hatice Alçin, Manoel D Sousa-Neto, Marco A Versiani
INTRODUCTION: The purpose of this ex vivo study was to evaluate the percentage reduction of accumulated hard tissue debris (AHTD) in the mesial root canal system of mandibular molars under different final irrigation regimens by means of micro-computed tomographic imaging. METHODS: Sixty curved mesial roots of mandibular molars with 2 independent canals joint apically by an isthmus (Vertucci type II) were selected. Specimens were scanned at a resolution of 12.5 μm, anatomically matched, and distributed into 3 groups (n = 20) according to the preparation protocol: Self-Adjusting File (SAF; ReDent Nova, Ra'anana, Israel), Reciproc (VDW GmbH, Munich, Germany), and Revo-S (Micro-Mega, Besançon, France) systems...
November 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27616339/saf-score-and-mortality-in-nafld-after-up-to-41-years-of-follow-up
#11
Hannes Hagström, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Per Stål, Pierre Bedossa, Rolf Hultcrantz
BACKGROUND AND AIMS: A new score for the histological severity of nonalcoholic fatty liver disease (NAFLD), called SAF (Steatosis, Activity and Fibrosis) has been developed. We aimed to evaluate the impact of this score on overall mortality. METHODS: We used data from 139 patients with biopsy-proven NAFLD. All biopsies were graded according to the SAF scoring system and disease severity was classified as mild, moderate or severe. Causes of death were extracted from a national, population-based register...
January 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27598303/fracture-resistance-of-endodontically-retreated-roots-after-retreatment-using-self-adjusting-file-passive-ultrasonic-irrigation-photon-induced-photoacoustic-streaming-or-laser
#12
Aliye Kamalak, Ismail Uzun, Hakan Arslan, Ali Keleş, Ezgi Doğanay, Cangül Keskin, Merve Akçay
OBJECTIVE: Additional cleaning techniques and devices are required to remove maximum amount of residual filling material, which might limit disinfection of root canal system during retreatment. This study aimed to compare fracture resistance of roots when self-adjusting file (SAF), photon-induced photoacoustic streaming (PIPS), passive ultrasonic irrigation (PUI), erbium-doped yttrium aluminum garnet (Er:YAG), or neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers are applied following the use of retreatment files in endodontics...
October 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27549244/diagnostic-performance-of-fibrotest-steatotest-and-actitest-in-patients-with-nafld-using-the-saf-score-as-histological-reference
#13
M Munteanu, D Tiniakos, Q Anstee, F Charlotte, G Marchesini, E Bugianesi, M Trauner, M Romero Gomez, C Oliveira, C Day, J-F Dufour, S Bellentani, Y Ngo, S Traussnig, H Perazzo, O Deckmyn, P Bedossa, V Ratziu, T Poynard
BACKGROUND: Blood tests of liver injury are less well validated in non-alcoholic fatty liver disease (NAFLD) than in patients with chronic viral hepatitis. AIMS: To improve the validation of three blood tests used in NAFLD patients, FibroTest for fibrosis staging, SteatoTest for steatosis grading and ActiTest for inflammation activity grading. METHODS: We pre-included new NAFLD patients with biopsy and blood tests from a single-centre cohort (FibroFrance) and from the multicentre FLIP consortium...
October 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27446675/measuring-membrane-association-and-protein-diffusion-within-membranes-with-supercritical-angle-fluorescence-microscopy
#14
Yuanqing Ma, Aleš Benda, Philip R Nicovich, Katharina Gaus
Supercritical angle fluorescence (SAF) detection combines the axial discrimination and exquisite signal-to-noise ratio of total internal reflection fluorescence (TIRF) with the lateral discrimination and convenience of confocal excitation. This combination makes SAF ideal for fluorescence correlation spectroscopy (FCS) on membranes and other structures in close proximity to the coverslip. Here we report a straightforward modification of a commercial microscope to implement SAF FCS and demonstrate in both model supported lipid bilayers and cellular systems that this approach shows an increase in signal from membrane-bound fluorophores relative to fluorophores in solution, benchmarked against line-scanning FCS...
April 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27400743/influence-of-apical-enlargement-and-complementary-canal-preparation-with-the-self-adjusting-file-on-endotoxin-reduction-in-retreatment-cases
#15
E J N L Silva, V M Ferreira, C C Silva, Herrera, G De-Deus, B P Gomes
AIM: To compare the effectiveness of large apical preparations and complementary canal preparation with the Self Adjusting File (SAF) in removing endotoxins from the root canal of teeth with apical periodontitis. METHODOLOGY: Ten single-rooted and single-canaled teeth with post-treatment apical periodontitis were selected. Endotoxin samples were taken after the removal of the root filling (S1), after chemomechanical preparation (CMP) using 2.5% NaOCl and an R25 file (S2), after CMP using 2...
July 12, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27337981/comparison-of-different-scores-as-predictors-of-mechanical-ventilation-in-drug-overdose-patients
#16
Ghada N El-Sarnagawy, Amal Saf Hafez
The decision of intubation and mechanical ventilation in poisoned patients with impaired consciousness can be a difficult task. The present study aimed to evaluate the power of Glasgow Coma Scale (GCS), acute physiology and chronic health evaluation (APACHE II), rapid acute physiology score (RAPS) and rapid emergency medicine score (REMS) at admission in predicting the need of intubation and mechanical ventilation in drug overdose patients with disturbed consciousness level (DCL). This prospective observational study was conducted on 104 poisoned patients who were admitted to Tanta Toxicological Unit with a DCL...
June 23, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27321320/a-novel-imaging-platform-for-non-invasive-screening-of-abnormal-glucose-tolerance
#17
Bosu Jeong, Chang Hee Jung, Yong-Ho Lee, Il-Hyung Shin, Hansuk Kim, Soo-Jin Bae, Dae-Sic Lee, Eun Seok Kang, Uk Kang, Jong Jin Kim, Joong-Yeol Park
Optical measurement of skin auto-fluorescence (SAF), most likely emanating from accumulated advanced glycation end-products (AGEs), has been proposed for the noninvasive diagnosis of glucose intolerance in clinical settings. Here, we developed a novel imaging system with transmission geometry for SAF measurement and compared its diagnostic performance in a Korean population.
June 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27217636/comparative-evaluation-of-apically-extruded-debris-with-v-taper-protaper-next-and-the-self-adjusting-file-systems
#18
Nishant K Vyavahare, Srinidhi Surya Raghavendra, Niranjan N Desai
BACKGROUND: Complete cleaning of the root canal is the goal for ensuring success in endodontics. Removal of debris plays an important role in achieving this goal. In spite of advancements in instrument design, apical extrusion of debris remains a source of inflammation in the periradicular region. AIM: To comparatively evaluate the amount of apically extruded debris with V-Taper, ProTaper Next, and the self-adjusting File (SAF) system. MATERIALS AND METHODS: Sixty-four extracted human mandibular teeth with straight root canals were taken...
May 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27194509/effect-of-finishing-instrumentation-using-niti-hand-files-on-volume-surface-area-and-uninstrumented-surfaces-in-c-shaped-root-canal-systems
#19
P Amoroso-Silva, M P Alcalde, M A Hungaro Duarte, G de Deus, R Ordinola-Zapata, L G Freire, B C Cavenago, I G de Moraes
AIM: To assess the effect of 90º-oscillatory instrumentation with hand files on the following morphological parameters (volume, surface area and uninstrumented surface) in C-shaped root canals after instrumentation using a single-file reciprocation system (Reciproc; VDW, Munich, Germany) and a Self-Adjusting File System (SAF; ReDent Nova, Ra'anana, Israel). METHODOLOGY: Twenty mandibular second molars with C-shaped canals and C1 canal configurations were divided into two groups (n = 10) and instrumented with Reciproc and SAF instruments...
May 19, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27099416/apical-extrusion-of-debris-by-supplementary-files-used-for-retreatment-an-ex-vivo-comparative-study
#20
Ajinkya M Pawar, Mansing Pawar, Zvi Metzger, Bhagyashree Thakur
AIM: This study evaluated whether using supplementary files for removing root canal filling residues after ProTaper Universal Retreatment files (RFs) increased the debris extrusion apically. MATERIALS AND METHODS: Eighty mandibular premolars with single root and canal were instrumented with ProTaper Universal rotary system (SX-F3) and obturated. The samples were divided randomly into four groups (n = 20). Group 1 served as a control; only ProTaper Universal RFs D1-D3 were used, and the extruded debris was weighed...
March 2016: Journal of Conservative Dentistry: JCD
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