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https://www.readbyqxmd.com/read/29679014/the-association-between-skin-auto-fluorescence-of-palmoplantar-sites-and-microvascular-complications-in-asian-patients-with-type-2-diabetes-mellitus
#1
Jong Jin Kim, Bosu Jeong, Yongin Cho, Mi-Hyang Kwon, Yong-Ho Lee, Uk Kang, Eun Seok Kang
Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar sites in non-Caucasian subjects with dark skin type is still controversial. Here, we tested the diabetic complication screening performance of a novel SAF measuring system in Asian type 2 diabetes mellitus (T2DM) subjects...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29569448/apical-extrusion-of-debris-in-primary-molar-root-canals-using-mechanical-and-manual-systems
#2
B Buldur, C Hascizmeci, S Aksoy, M Nur Aydin, O N Guvendi
AIM: Apical extrusion of debris in primary root canal treatment has not been well elucidated. The purpose of this study is to compare the amount of apically extruded debris during the preparation of primary molar root canals using ProTaper, ProTaper Next, Self-adjusting File (SAF) and hand files. MATERIALS AND METHODS: One hundred sixty extracted primary mandibular molar teeth were assigned to 2 groups: Group 1: Resorbed (n=80) and Group 2: Non-resorbed (n=80) and randomly to four subgroups (n=20 teeth for each subgroup) according to the instruments used, ProTaper, ProTaper Next, SAF, and hand file...
March 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29556726/new-treatment-options-for-inflammatory-bowel-diseases
#3
REVIEW
Bram Verstockt, Marc Ferrante, Séverine Vermeire, Gert Van Assche
The advent of anti-TNF agents has dramatically changed the treatment algorithms for IBD in the last 15 years, but primarily and more importantly secondary loss of response is often observed. Fortunately , new treatment options have been actively explored and some have already entered our clinical practice. In the class of anti-cytokine agents, the anti-IL12/IL23 monoclonal antibodies (mAbs) have entered clinical practice with the anti-p40 mAb ustekinumab in Crohn's disease (CD). Also, more selective anti-IL23 agents (anti-p19) have shown efficacy and are being further developed, in contrast to agents inhibiting IL-17 downstream which have failed in clinical trials despite their clear efficacy in psoriasis (Verstockt et al...
March 19, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29527194/a-glycine-riboswitch-in-streptococcus-pyogenes-controls-expression-of-a-sodium-alanine-symporter-family-protein-gene
#4
Afsaneh Khani, Nicole Popp, Bernd Kreikemeyer, Nadja Patenge
Regulatory RNAs play important roles in the control of bacterial gene expression. In this study, we investigated gene expression regulation by a putative glycine riboswitch located in the 5'-untranslated region of a sodium:alanine symporter family (SAF) protein gene in the group A Streptococcus pyogenes serotype M49 strain 591. Glycine-dependent gene expression mediated by riboswitch activity was studied using a luciferase reporter gene system. Maximal reporter gene expression was observed in the absence of glycine and in the presence of low glycine concentrations...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29473020/functional-analysis-of-the-chaperone-usher-fimbrial-gene-clusters-of-salmonella-enterica-serovar-typhi
#5
Karine Dufresne, Julie Saulnier-Bellemare, France Daigle
The human-specific pathogen Salmonella enterica serovar Typhi causes typhoid, a major public health issue in developing countries. Several aspects of its pathogenesis are still poorly understood. S . Typhi possesses 14 fimbrial gene clusters including 12 chaperone-usher fimbriae ( stg, sth, bcf , fim, saf , sef , sta, stb, stc, std, ste , and tcf ). These fimbriae are weakly expressed in laboratory conditions and only a few are actually characterized. In this study, expression of all S . Typhi chaperone-usher fimbriae and their potential roles in pathogenesis such as interaction with host cells, motility, or biofilm formation were assessed...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29430100/comparison-and-evaluation-of-two-reciprocating-root-canal-instruments-on-removal-of-smear-layer-by-using-two-irrigants-at-apical-one-third-of-the-root-canal-an-ex-vivo-scanning-electron-microscopic-study
#6
M M Jimna, T S Ashwini, H K Sowmya
Aim: To compare and evaluate the cleaning ability of two reciprocating systems, that is, WaveOne (WO) and self-adjusting files (SAF) in terms of removal of smear layer using sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHX) at apical one-third of the root canal. Materials and Methods: Forty-three human maxillary anterior teeth were selected. The canal was instrumented manually up to a number 25 K-file size. WO and SAF were used to prepare the root canals...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29409523/prevalence-survey-on-lungworm-angiostrongylus-vasorum-crenosoma-vulpis-eucoleus-aerophilus-infections-of-wild-red-foxes-vulpes-vulpes-in-central-germany
#7
Kathrin Schug, Friederike Krämer, Roland Schaper, Jörg Hirzmann, Klaus Failing, Carlos Hermosilla, Anja Taubert
BACKGROUND: Angiostrongylus vasorum, Crenosoma vulpis and Eucoleus aerophilus are a source of increasing concern, potentially causing significant pulmonary and severe cardiac/systemic diseases in domestic dogs and wild canids, especially red foxes (Vulpes vulpes). To investigate the prevalence and geographical distribution of these parasites in central Germany, a total of 569 foxes were examined by dissection. METHODS: Pluck (heart and lung) and faecal samples of red foxes were collected from three regions of Germany...
February 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29378986/evaluation-of-apically-extruded-debris-and-irrigant-using-different-file-systems
#8
B Kütük, K E Akpınar, D Altunbaş
OBJECTIVE: The aim of this study was to evaluate the amount of apically extruded debris and irrigant during cleaning and shaping with different file systems. MATERIALS AND METHODS: Seventy-five extracted mandibular premolar and canine teeth were randomly divided into five groups (n = 15). The root canals were instrumented by using Mtwo (VDW, Munich, Germany), Twisted File (TF; Sybron Endo, Orange, California, USA), Reciproc (VDW), Self-Adjusting File (SAF; Re Dent-Nova, Ra'anana, Israel) systems, and K-type stainless steel hand file (Mani Inc...
December 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29277364/identification-of-an-interferon-stimulated-gene-isg15-involved-in-host-immune-defense-against-viral-infections-in-gilthead-seabream-sparus-aurata-l
#9
Daniel Álvarez-Torres, Victoria Gómez-Abellán, Marta Arizcun, Esther García-Rosado, Julia Béjar, María P Sepulcre
Interferons (IFNs) play a key role in the innate immunity of vertebrates against viral infections by inducing hundreds of IFN-stimulated genes (ISGs), such as isg15. Isg15 is an ubiquitin-like protein, which can conjugate cellular and viral proteins in a process called ISGylation, although it can also act as a cytokine-like protein. Gilthead seabream (Sparus aurata L.) is an important asymptomatic carrier of viral haemorrhagic septicaemia virus (VHSV) and nodavirus, representing a threat to other co-cultivated susceptible species...
February 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29245857/interband-cascade-laser-based-mid-infrared-methane-sensor-system-using-a-novel-electrical-domain-self-adaptive-direct-laser-absorption-spectroscopy-sa-dlas
#10
Fang Song, Chuantao Zheng, Wanhong Yan, Weilin Ye, Yiding Wang, Frank K Tittel
To suppress sensor noise with unknown statistical properties, a novel self-adaptive direct laser absorption spectroscopy (SA-DLAS) technique was proposed by incorporating a recursive, least square (RLS) self-adaptive denoising (SAD) algorithm and a 3291 nm interband cascade laser (ICL) for methane (CH4 ) detection. Background noise was suppressed by introducing an electrical-domain noise-channel and an expectation-known-based RLS SAD algorithm. Numerical simulations and measurements were carried out to validate the function of the SA-DLAS technique by imposing low-frequency, high-frequency, White-Gaussian and hybrid noise on the ICL scan signal...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29224471/clinical-relevance-of-liver-histopathology-and-different-histological-classifications-of-nash-in-adults
#11
Fabio Nascimbeni, Stefano Ballestri, Mariana Verdelho Machado, Alessandro Mantovani, Helena Cortez-Pinto, Giovanni Targher, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) encompasses simple steatosis and steatohepatitis (NASH) with or without fibrosis/cirrhosis and hepatocellular carcinoma. NAFLD occurs epidemically in most areas of the world, contributes to cardiovascular events and liver-related mortality and therefore exacts a major economic toll. Areas covered: Here we summarize what clinicians should know about NAFLD histopathology in adults. We report on the individual histological features and scoring systems of NAFLD: the NAFLD activity score (NAS) introduced by the NASH-Clinical Research Network, the 'Fatty Liver Inhibition of Progression' algorithm and Steatosis, Activity, and Fibrosis (SAF) score...
April 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29160396/effect-of-intermediate-flush-using-different-devices-to-prevent-chemical-smear-layer-formation
#12
Camilla Corrêa Silva, Vivian Maria Durange Ferreira, Gustavo De-Deus, Daniel Rodrigo Herrera, Maíra do Prado, Emmanuel João Nogueira Leal da Silva
This study compared the effect of intermediate flush with distilled water delivered by conventional irrigation, EndoVac microcannula or Self-Adjusting File (SAF) system in the prevention of chemical smear layer (CSL) formation. Thirty human premolars were used. Canals were prepared with Reciproc system and 5.25% NaOCl. After chemomechanical preparation, samples were divided in 3 groups (n=10) according to the intermediate irrigation protocol with distilled water using: conventional irrigation, EndoVac microcannula or SAF...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29109318/extrusion-of-debris-from-primary-molar-root-canals-following-instrumentation-with-traditional-and-new-file-systems
#13
Bhagyashree Thakur, Ajinkya M Pawar, Anda Kfir, Prasanna Neelakantan
INTRODUCTION: To assess the amount of debris extruded apically during instrumentation of distal canals of extracted primary molars by three instrument systems [ProTaper Universal (PTU), ProTaper NEXT (PTN), and self-adjusting file (SAF)] compared with conventional stainless steel hand K-files (HF, control). MATERIALS AND METHODS: Primary mandibular molars (n = 120) with a single distal canal were selected and randomly divided into four groups (n = 30) for root canal instrumentation using group I, HF (to size 0...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29076589/non-alcoholic-fatty-liver-disease-histological-scoring-systems-a-large-cohort-single-center-evaluation-study
#14
Archana Rastogi, Saggere Muralikrishna Shasthry, Ayushi Agarwal, Chhagan Bihari, Priyanka Jain, Ankur Jindal, Shiv Sarin
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common cause of chronic liver disease. Till date, liver biopsy remains the gold standard for identification and quantification of the wide histological spectra of NAFLD. Histological scorings are very useful and widely applied for the diagnosis and management in clinical trials and follow-up studies of non-alcoholic steatohepatitis (NASH). However, in view of scarce published literature, there is a need to evaluate them in large cohort of NAFLD. This study was aimed to evaluate the two histological scoring systems (NAS-CRN, SAF) in the diagnosis of NAFLD and to assess the role of histological characteristics as injury markers in NAFLD...
November 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29058218/ontology-based-vaccine-adverse-event-representation-and-analysis
#15
REVIEW
Jiangan Xie, Yongqun He
Vaccine is the one of the greatest inventions of modern medicine that has contributed most to the relief of human misery and the exciting increase in life expectancy. In 1796, an English country physician, Edward Jenner, discovered that inoculating mankind with cowpox can protect them from smallpox (Riedel S, Edward Jenner and the history of smallpox and vaccination. Proceedings (Baylor University. Medical Center) 18(1):21, 2005). Based on the vaccination worldwide, we finally succeeded in the eradication of smallpox in 1977 (Henderson, Vaccine 29:D7-D9, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28951035/cleaning-and-shaping-oval-canals-with-3%C3%A2-instrumentation-systems-a-correlative-micro-computed-tomographic-and-histologic-study
#16
Mariane F L S Lacerda, Marília F Marceliano-Alves, Alejandro R Pérez, José C Provenzano, Mônica A S Neves, Fábio R Pires, Lucio S Gonçalves, Isabela N Rôças, José F Siqueira
INTRODUCTION: The present study evaluated the cleaning and shaping ability of 3 instrumentation systems in oval canals of extracted vital teeth using a correlative analytic approach. METHODS: Oval distal canals from 33 freshly extracted mandibular molars with pulp vitality were scanned by micro-computed tomographic (micro-CT) imaging for sample selection. Specimens matched by anatomic similarities were distributed into 3 experimental groups according to the instrument system to be evaluated: the Self-Adjusting File (SAF; ReDentNOVA, Ra'anana, Israel), TRUShape (Dentsply Sirona, Tulsa, OK), and XP-endo Shaper (FKG Dentaire, La Chaux-de-Fonds, Switzerland)...
November 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28948754/histopathology-grading-and-staging-of-nonalcoholic-fatty-liver-disease
#17
David E Kleiner
Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes and the metabolic syndrome. Although steatosis is a key histological feature, liver biopsies of patients with NAFLD can show a wide range of other findings, including portal and lobular inflammation, ballooning and apoptotic hepatocellular injury, Mallory-Denk bodies, megamitochondria and fibrosis. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD first defined by analogy to alcoholic hepatitis...
March 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28893051/permanent-maxillary-central-incisor-with-dilacerated-crown-and-root-and-c-shaped-root-canal
#18
Vikas Allwani, Mansing Pawar, Ajinkya Pawar, Sayed Abrar, Sangeeta Ambhore
Dilaceration is a rare disturbance in traumatised permanent teeth, which constitutes about 3% of the injuries to developing teeth. It usually occurs as a result of trauma to the deciduous predecessors and results in non axial displacement of the already formed hard tissue portion of the developing crown. Endodontic treatment of such teeth presents a challenge to clinicians, and careful management is required to successfully address the root canal anatomy and other possible variations. The C-shaped canal configuration is most frequently seen in mandibular second molars, but this variation may also occur in mandibular first molars, mandibular third molars, maxillary molars, mandibular first premolars, and even in maxillary lateral incisors, with rare reports of such variations occurring in the maxillary central incisors...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28855758/effect-of-glide-path-preparation-on-apical-extrusion-of-debris-in-root-canals-instrumented-with-three-single-file-systems-an-ex-vivo-comparative-study
#19
Ajinkya M Pawar, Mansing Pawar, Anda Kfir, Bhagyashree Thakur, Pooja Mutha, Kulwinder Singh Banga
AIM: The aim of this study was to test the effect of new protocol of glide path preparation by 20/0.04 rotary file on apical extrusion of debris when instrumenting fine curved mesial canals in mandibular molars with Self-adjusting File (SAF) and compare it to a glide path prepared by 20/0.02 hand K-file and rotary OneShape (OS) and reciprocating WaveOne (WO) file instrumentation. MATERIALS AND METHODS: Sixty mandibular molars with curved mesial roots were selected and randomly divided into three groups (n = 20) for instrumentation...
March 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28855757/canal-transportation-and-centering-ability-of-protaper-and-self-adjusting-file-system-in-long-oval-canals-an-ex-vivo-cone-beam-computed-tomography-analysis
#20
Dipali Yogesh Shah, Swati Ishwara Wadekar, Ashwini Manish Dadpe, Ganesh Ranganath Jadhav, Lalit Jayant Choudhary, Dheeraj Deepak Kalra
CONTEXT AND AIMS: The purpose of this study was to compare and evaluate the shaping ability of ProTaper (PT) and Self-Adjusting File (SAF) system using cone-beam computed tomography (CBCT) to assess their performance in oval-shaped root canals. MATERIALS AND METHODS: Sixty-two mandibular premolars with single oval canals were divided into two experimental groups (n = 31) according to the systems used: Group I - PT and Group II - SAF. Canals were evaluated before and after instrumentation using CBCT to assess centering ratio and canal transportation at three levels...
March 2017: Journal of Conservative Dentistry: JCD
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