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chronic intermittent hypoxia

Shixiao Zhang, Zan Guo, Shijie Yang, Huijuan Ma, Congrui Fu, Sheng Wang, Yi Zhang, Yixian Liu, Jie Hu
OBJECTIVE: Providing adequate protection against cerebral ischemia remains an unrealized goal. The present study was aimed at testing whether chronic intermittent hypobaric hypoxia (CIHH) would have protective effects against cerebral ischemia and investigating the potential role of mitochondrial membrane ATP-sensitive potassium channel (mitoKATP) in this effect. METHODS: Ischemia was induced in rats by occlusion of bilateral common carotid arteries for 8min on day 2 after bilateral vertebral arteries were permanently electrocauterized and CIHH was simulated in a hypoxic chamber...
October 16, 2016: Neuroscience Letters
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnea (OSA) is characterized by repetitive interruptions of breathing, causing a Chronic Intermittent Hypoxia (CIH) that can be a key step in the development and progression of cardiovascular diseases. Nowadays, in fact, there is scientific evidence showing the close relationship between OSA and atherosclerosis, even in those patients who do not show co-morbidities such as hypertension, diabetes, high levels of low-density lipoprotein (LDL), cigarette smoking and obesity, which normally are able to activate the endothelium...
October 7, 2016: Current Vascular Pharmacology
Nadia Gildeh, Panagis Drakatos, Sean Higgins, Ivana Rosenzweig, Brian D Kent
Obstructive sleep apnea (OSA) causes daytime fatigue and sleepiness, and has an established relationship with cardiovascular and metabolic disease. Recent years have seen the emergence of an evidence base linking OSA with an increased risk of degenerative neurological disease and associated cognitive impairment, an accelerated rate of decline in kidney function with an increased risk of clinically significant chronic kidney disease (CKD), and with a significantly higher rate of cancer incidence and death. This review evaluates the evidence base linking OSA with these seemingly unrelated co-morbidities, and explores potential mechanistic links underpinning their development in patients with OSA, including intermittent hypoxia (IH), sleep fragmentation, sympathetic excitation, and immune dysregulation...
September 2016: Journal of Thoracic Disease
Katrin Gutsche, Elisa Randi, Volker Blank, Daniel Fink, Roland H Wenger, Cornelia Leo, Carsten C Scholz
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Treatment options are limited and the mechanisms underlying its aggressiveness are poorly understood. Intermittent hypoxia (IH) causes oxidative stress and is emerging as important regulator of tumor metastasis. Vessels in IBC tumors have been shown to be immature, which is a primary cause of IH. We therefore investigated the relevance of IH for the modulation of gene expression in IBC cells in order to assess IH as potential regulator of IBC aggressiveness...
October 5, 2016: Free Radical Biology & Medicine
Angela Navarrete-Opazo A, Julio Alcayaga J, Oscar Sepúlveda, Gonzalo Varas
OBJECTIVE: To test the effect of combined intermittent hypoxia (IH) and body weight-supported treadmill training (BWSTT) on standing and dynamic balance in persons with incomplete spinal cord injury (iSCI). DESIGN: Randomized, triple-blind, placebo-controlled study. SETTING: "Instituto Teletón Santiago" and "Hospital Clínico Mutual de seguridad" in Santiago, Chile. PARTICIPANTS: Persons with ASIA C and D chronic iSCI (> 1 year post-injury) were randomly assigned to either IH plus BWSTT (n=18) or continued normoxia (Nx, placebo) plus BWSTT protocol (n=17)...
October 1, 2016: Archives of Physical Medicine and Rehabilitation
Jinrong Fu, Furong Guo, Cheng Chen, Xiaoman Yu, Ke Hu, Mingjiang Li
The optimal treatment for chronic intermittent hypoxia (CIH)-induced cardiovascular injuries has yet to be determined. The aim of the current study was to explore the potential protective effect and mechanism of a C1 inhibitor in CIH in the myocardium. The present study used a rat model of CIH in which complement regulatory protein, known as C1 inhibitor (C1INH), was administered to the rats in the intervention groups. Cardiomyocyte apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling...
October 2016: Experimental and Therapeutic Medicine
Xu Wu, Wenyu Gu, Huan Lu, Chengying Liu, Biyun Yu, Hui Xu, Yaodong Tang, Shanqun Li, Jian Zhou, Chuan Shao
Obstructive sleep apnea (OSA) associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered tissue damage. Receptor for advanced glycation end product (RAGE) and its ligand high mobility group box 1 (HMGB1) are expressed on renal cells and mediate inflammatory responses in OSA-related diseases. To determine their roles in CIH-induced renal injury, soluble RAGE (sRAGE), the RAGE neutralizing antibody, was intravenously administered in a CIH model. We also evaluated the effect of sRAGE on inflammation and apoptosis...
2016: Oxidative Medicine and Cellular Longevity
Petra Micova, Klara Hahnova, Marketa Hlavackova, Barbara Elsnicova, Anna Chytilova, Kristyna Holzerova, Jitka Zurmanova, Jan Neckar, Frantisek Kolar, Olga Novakova, Jiri Novotny
Cardiac resistance against acute ischemia/reperfusion (I/R) injury can be enhanced by adaptation to chronic intermittent hypoxia (CIH), but the changes at the molecular level associated with this adaptation are still not fully explored. Phospholipase A2 (PLA2) plays an important role in phospholipid metabolism and may contribute to membrane destruction under conditions of energy deprivation during I/R. The aim of this study was to determine the effect of CIH (7000 m, 8 h/day, 5 weeks) on the expression of cytosolic PLA2α (cPLA2α) and its phosphorylated form (p-cPLA2α), as well as other related signaling proteins in the left ventricular myocardium of adult male Wistar rats...
September 30, 2016: Molecular and Cellular Biochemistry
Wenxiao Ding, Qiang Zhang, Yanbin Dong, Ning Ding, Hanpeng Huang, Xianji Zhu, Sean Hutchinson, Xingya Gao, Xilong Zhang
This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on the liver, the associated mechanisms and the potential therapeutic roles of adiponectin (Ad). Sixty rats were randomly assigned to four groups: the normal control (NC), NC and Ad supplement (NC + Ad), CIH, and CIH and Ad supplement (CIH + Ad) groups. The rats in the CIH and CIH + Ad groups were exposed to a hypoxic environment for 4 months. Rats in the NC + Ad and CIH + Ad groups were also treated with an intravenous injection of Ad (10 ug), twice a week...
September 28, 2016: Scientific Reports
Marisol Domínguez-Álvarez, Joaquim Gea, Esther Barreiro
We hypothesized that inflammatory events and reactive oxygen species (ROS) production may be differentially expressed in respiratory and limb muscles, and blood of a chronic intermittent hypoxia (CIH) experimental model and that antioxidants and TNF-alpha blockade may influence those events. In blood, diaphragm, and gastrocnemius of rats non-invasively exposed to CIH (10% hypoxia, two hours/day, 14 consecutive days) with/without concomitant treatment with either anti-TNF-alpha antibody (infliximab) or N-acetyl cysteine (NAC), inflammatory cytokines, superoxide anion production, muscle structural abnormalities, and fiber-type composition were assessed...
September 16, 2016: Journal of Cellular Physiology
S Asker, M Asker, M Ozgokce, B Ozbay
Objective: We hypothesized that the effect of intermittent and continuous hypoxia on carotid and brachial artery intima-media thicknesses (IMTs) may be similar. We aimed to assess the carotid and brachial arteries' IMTs in cases with intermittent [obstructive sleep apnea syndrome] (OSAS) and continuous (chronic obstructive pulmonary disease) [COPD] hypoxemia together with other confounding demographic and biochemical factors. Methods: The study was prospectively performed on 197 patients allocated in three groups: 80 patients with severe OSAS, 80 severe COPD patients and 37 healthy controls...
February 12, 2016: West Indian Medical Journal
George Miguel P R Souza, Leni G H Bonagamba, Mateus R Amorim, Davi J A Moraes, Benedito H Machado
What is the central question of the study? There are sex differences in the respiratory network and in the regulation of arterial blood pressure. Female rats develop hypertension after chronic intermittent hypoxia (CIH). In this context, we evaluated the respiratory-related mechanism underlying the development of hypertension in CIH-exposed female rats. What is the main finding and its importance? Female rats exposed to CIH develop changes in the respiratory pattern related to inspiration and sympathetic overactivity phase locked to the inspiratory phase of the respiratory cycle, which is different from CIH-exposed male rats...
September 12, 2016: Experimental Physiology
Anne Briançon-Marjollet, Denis Monneret, Marion Henri, Marie Joyeux-Faure, Perle Totoson, Sandrine Cachot, Patrice Faure, Diane Godin-Ribuot
What is the central question of this study? This study addresses the relative impact of obesity and intermittent hypoxia in the pathophysiological process of obstructive sleep apnoea by investigating the metabolic, inflammatory and cardiovascular consequences of intermittent hypoxia in lean and obese Zucker rats. What is the main finding and its importance? We found that obesity and intermittent hypoxia have mainly distinct consequences on the investigated inflammatory and cardiometabolic parameters in Zucker rats...
October 5, 2016: Experimental Physiology
Jag Sunderram, John Semmlow, Pranav Patel, Harshit Rao, Glen Chun, Priya Agarwala, Mantu Bhaumik, Oanh Le-Hoang, Shou-En Lu, Judith A Neubauer
Chronic intermittent hypoxia (CIH) increases sympathetic tone, and respiratory instability. Our previous work showed that chronic hypoxia induces the oxygen sensing enzyme, heme oxygenase-1 (HO-1) within the C1 sympathoexcitatory region and the pre-Bötzinger complex (pre-BötC). We therefore examined the effect of CIH on time course of induced expression of HO-1 within these regions and determined whether the induction of HO-1 correlated with changes in respiratory, sigh frequency, and sympathetic responses (spectral analysis of heart rate) to acute hypoxia (10%O2) during 10 days of exposure to CIH in chronically instrumented awake wild type (WT) and HO-1 null mice (HO-1(-/-))...
September 8, 2016: Journal of Applied Physiology
Bin Liu, Xiaoli Su, Yan Zhang, Li Huang, Pinhua Pan, Chengping Hu
OBJECTIVE: To explore the effect of chronic intermittent hypoxia (CIH) on liver injury and to examine the expression of liver CXC chemokine ligand-10 (CXCL10) in the rats, and to explore the effect of N-acetylcysteine (NAC).
 METHODS: A total of 21 male SD rats were randomly divided into a control group, a CIH group and a CIH+NAC group (n=7 in each group). The control group exposed to normal gaseous environment, the other 2 groups were exposed to CIH for 5 weeks (8 h/d); the control group and the CIH group were given daily saline lavage, the CIH+NAC group daily received NAC solution...
August 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
W Lu, J Kang, K Hu, S Tang, X Zhou, S Yu, Y Li, L Xu
Obstructive sleep apnea is associated with inflammation and oxidative stress in lung tissues and can lead to metabolic abnormalities. We investigated the effects of angiotensin1-7 [Ang-(1-7)] on lung injury in rats induced by chronic intermittent hypoxia (CIH). We randomly assigned 32 male Sprague-Dawley rats (180-200 g) to normoxia control (NC), CIH-untreated (uCIH), Ang-(1-7)-treated normoxia control (N-A), and Ang-(1-7)-treated CIH (CIH-A) groups. Oxidative stress biomarkers were measured in lung tissues, and expression of NADPH oxidase 4 (Nox4) and Nox subunits (p22phox, and p47phox) was determined by Western blot and reverse transcription-polymerase chain reaction...
September 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Haifeng Jin, Mingcheng Liu, Xin Zhang, Jinjin Pan, Jinzhen Han, Yudong Wang, Haixin Lei, Yanchun Ding, Yuhui Yuan
Hypoxia-induced oxidative stress and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) play important roles in the pathological process of hypoxic pulmonary hypertension (HPH). Grape seed procyanidin extract (GSPE) possesses antioxidant properties and has beneficial effects on the cardiovascular system. However, the effect of GSPE on HPH remains unclear. In this study, adult Sprague-Dawley rats were exposed to intermittent chronic hypoxia for 4 weeks to mimic a severe HPH condition. Hemodynamic and pulmonary pathomorphology data showed that chronic hypoxia significantly increased right ventricular systolic pressures (RVSP), weight of the right ventricle/left ventricle plus septum (RV/LV+S) ratio and median width of pulmonary arteries...
October 2016: Journal of Nutritional Biochemistry
Barbara J Morgan, Melissa L Bates, Rodrigo Del Rio, Zunyi Wang, John M Dopp
Chronic exposure to intermittent hypoxia (CIH) elicits plasticity of the carotid sinus and phrenic nerves via reactive oxygen species (ROS). To determine whether CIH-induced alterations in ventilation, metabolism, and heart rate are also dependent on ROS, we measured responses to acute hypoxia in conscious rats after 14 and 21 d of either CIH or normoxia (NORM), with or without concomitant administration of allopurinol (xanthine oxidase inhibitor), combined allopurinol plus losartan (angiotensin II type 1 receptor antagonist), or apocynin (NADPH oxidase inhibitor)...
September 2, 2016: Respiratory Physiology & Neurobiology
Kun Li, Su-Ge Dong, Hua-Xiang Zhang, Shu Zhou, Li Ma, Qiong-Qiong Yu, Zhi-Yong Jiang, Qiang-Fu Hu, Dan Zhou
OBJECTIVE: To discuss the expression of RUNX2 and MDM21 in rats with periodontitis under the chronic intermittent hypoxia. METHODS: A total of 32 SD healthy rats were randomly divided into four groups, with 8 rats in each group. The molecular biological techniques of immunohistochemistry, RT-PCR and Western blotting were employed to detect the effect of different hypoxia time (0, 6, 12, 24 and 48 h) and different concentrations of hypoxia (0.000, 0.001, 0.010, 0...
August 2016: Asian Pacific Journal of Tropical Medicine
Isaac Almendros, Abdelnaby Khalyfa, Wojciech Trzepizur, Alex Gileles-Hillel, Lei Huang, Mahzad Akbarpour, Jorge Andrade, Ramon Farré, David Gozal
BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased cancer incidence and mortality. Exosomes are vesicles secreted by most cells, are released into the bloodstream, and play a role in tumor progression and metastasis. Here, we evaluated whether the chronic intermittent hypoxia (IH) that characterizes OSA leads to release of tumor-promoting exosomes in circulation. METHODS: C57/B6 male mice were randomized to 6 weeks of IH or room air (RA). A subgroup of the mice was injected with TC1 lung carcinoma cells in the left flank after 2 weeks of IH...
August 25, 2016: Chest
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