Hiroki Imaoka, Hideharu Ieki, Shinji Yamashita, Takashi Ichikawa, Ryo Uratani, Tadanobu Shimura, Takahito Kitajima, Mikio Kawamura, Hiromi Yasuda, Yoshinaga Okugawa, Yuki Morimoto, Yoshiki Okita, Shigeyuki Yoshiyama, Masaki Ohi, Yuji Toiyama
In our department, total neoadjuvant therapy(TNT), which is a combination of preoperative chemotherapy and preoperative chemoradiotherapy(nCRT), has been introduced for the purpose of local and systemic disease control for lower rectal cancer. For patients in whom a clinical complete response(cCR)was obtained by TNT, we avoid the surgery and preserve organs, and follow-up strictly under the informed consent(watch and wait). In addition, for patients with remarkably reduced primary lesions(near cCR)without lymphadenopathy after TNT, the option of omitting total mesorectal excision (TME)and performing organ preservation by local excision can be introduced...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy