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https://www.readbyqxmd.com/read/27888300/analysis-of-local-recurrences-after-transanal-endoscopic-microsurgery-for-low-risk-rectal-carcinoma
#1
Theodor Junginger, Ursula Goenner, Mirjam Hitzler, Tong T Trinh, Achim Heintz, Wilfried Roth, Maria Blettner, Daniel Wollschlaeger
AIM: Rates of local recurrence (LR) after transanal endoscopic microsurgery (TEM) for rectal carcinoma vary; the reasons remain unclear. We analyzed LR after TEM for low-risk pT1 (G1/2/X, L0/X) rectal carcinoma to investigate the influence of completeness of resection and occult lymph node metastasis on risk of LR. METHOD: LR location and stage, completeness of resection of primary carcinoma (minimal distance between tumor and resection line ≤1 mm vs >1 mm), and incidence of involved lymph nodes in resected LR specimens were collected, and tumor characteristics of LR were compared with primary carcinoma...
November 25, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27846173/current-controversies-in-transanal-surgery-for-rectal-cancer
#2
Jose M Ramirez, Manuela Elia, Elena Cordoba, Jose A Gracia, Vicente Aguilella
Local surgery for rectal tumors has been traditionally limited due to technical issues for lower risk lesions. In the 1980s, Buess described the transanal endoscopic microsurgery (TEM) technique that enabled excision of lesions that were larger and in a higher location. TEM in a short time became the gold standard for the excision of large adenomas and early rectal carcinomas. Since the advent of TEM, and due to advances in minimal invasive technology, new devices and procedures have come to the surgical armamentarium, in many cases with only very slight differences between them...
December 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27668073/transanal-endoscopic-microsurgery-as-optimal-option-in-treatment-of-rare-rectal-lesions-a-single-centre-experience
#3
Monica Ortenzi, Roberto Ghiselli, Maria Michela Cappelletti Trombettoni, Luca Cardinali, Mario Guerrieri
AIM: To analyze the outcomes of transanal endoscopic microsurgery (TEM) in the treatment of rare rectal condition like mesenchymal tumors, condylomas, endometriosis and melanoma. METHODS: We retrospectively reviewed a twenty-three years database. Fifty-two patients were enrolled in this study. The lesions were considered suitable for TEM if they were within 20 cm from the anus. All of them underwent an accurate preoperative workup consisting in clinical examination, total colonoscopy with biopsies, endoscopic ultrasonography, and pelvic computerized tomography or pelvic magnetic resonance imaging...
September 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27547025/transanal-minimally-invasive-surgery-for-rectal-lesions
#4
Silvia Quaresima, Andrea Balla, Luana Franceschilli, Marco La Torre, Corrado Iafrate, Mostafa Shalaby, Nicola Di Lorenzo, Pierpaolo Sileri
BACKGROUND AND OBJECTIVES: Transanal minimally invasive surgery (TAMIS) has emerged as an alternative to transanal endoscopic microsurgery (TEM). The authors report their experience with TAMIS for the treatment of mid and high rectal tumors. METHODS: From November 2011 through May 2016, 31 patients (21 females, 68%), with a median age of 65 years who underwent single-port TAMIS were prospectively enrolled. Mean distance from the anal verge of the rectal tumors was 9...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27387173/the-surgical-defect-after-transanal-endoscopic-microsurgery-open-versus-closed-management
#5
Carl Brown, Manoj J Raval, P Terry Phang, Ahmer A Karimuddin
BACKGROUND: To determine whether closure of the defect created during full thickness excision of a rectal lesion with transanal endoscopic microsurgery (TEM) leads to fewer complications when compared to leaving the defect unsutured. METHODS: This is a single-center cohort study using a prospectively maintained database. All patients ≥18 years old treated with full thickness TEM with no compromise of the peritoneal cavity were included. Two cohorts were established: patients with the defect sutured and patients with the defect left open...
July 7, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27000716/transanal-endoscopic-microsurgery-for-large-benign-rectal-tumors-where-are-the-limits
#6
Reem Khoury, Simon D Duek, Nidal Issa, Wisam Khoury
INTRODUCTION: Local excision is the treatment of choice for large benign rectal lesions. Transanal endoscopic microsurgery is recommended. The excision of large lesions >4 cm has been previously described. We report our series of lesions >5 cm that have been excised via the transanal endoscopic microsurgery. METHODS: Patients who underwent transanal endoscopic microsurgery for rectal tumors, between the years 2002-2012, were identified. Patients with tumors greater than 5 cm consisted the study group...
May 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/26908311/laparoscopy-following-peritoneal-entry-during-transanal-endoscopic-microsurgery-may-increase-the-safety-and-maximize-the-benefits-of-the-transanal-excision
#7
N Issa, Y Fenig, M Yasin, H Schmilovitz-Weiss, W Khoury, E Powsner
BACKGROUND: Peritoneal entry (PE) during transanal endoscopic microsurgery (TEM) for tumors of the upper rectum is not an uncommon complication. The suture line of the rectal defect performed for PE is not devoid of leaks. Diagnostic laparoscopy after PE enables visualization and testing of the suture line. Here, we report the outcome of patients undergoing laparoscopy for PE following TEM. METHODS: Data pertaining to patients undergoing laparoscopy for PE following TEM between 2004 and 2013 were retrospectively collected...
April 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/26902614/transanal-endoscopic-microsurgery-for-rectal-cancer-t1-and-beyond-an-evidence-based-review
#8
Marco E Allaix, Alberto Arezzo, Mario Morino
BACKGROUND: The last three decades have witnessed significant improvements in the diagnosis, staging and treatment of rectal cancer leading to a more tailored approach. One of the most clinically relevant advances in this field is represented by transanal endoscopic microsurgery (TEM). Several studies have investigated its role in the treatment of rectal cancer. However, evidence-based recommendations are limited. The aim of this report is to provide an evidence-based review of current indications, controversies and future perspectives of TEM in the management of rectal cancer...
February 22, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26882538/endoluminal-loco-regional-resection-by-tem-after-r1-endoscopic-removal-or-recurrence-of-rectal-tumors
#9
Silvia Quaresima, Andrea Balla, Giancarlo D'Ambrosio, Paolo Bruzzone, Pietro Ursi, Emanuele Lezoche, Alessandro M Paganini
PURPOSE: The aim of this study is to evaluate the safety and efficacy of endoluminal loco-regional resection (ELRR) by transanal endoscopic microsurgery (TEM) after R1 endoscopic resection or local recurrence of early rectal cancer after operative endoscopy. MATERIAL AND METHODS: Twenty patients with early rectal cancer were enrolled, including patients with incomplete endoscopic resection, or complete endoscopic resection of a tumor with unfavorable prognostic factors (group A, ten patients), and local recurrence after endoscopic removal (group B, ten patients)...
2016: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/26865896/removal-of-gallstone-from-mesorectum-after-laparoscopic-cholecystectomy-new-indication-for-transanal-endoscopic-microsurgery-technique
#10
Marek Szczepkowski, Alicja Przywózka, Tomasz Zieliński
Transanal endoscopic microsurgery (TEM) is a minimally invasive technique for local excision of benign and malignant neoplasms in the rectum. Indications for this technique are constantly changing and extending. The aim of this study is to describe a case of a unique and innovative application of this surgical technique. A 72-year-old patient was admitted to the Clinical Department of General and Colorectal Surgery for elective resection of a tumor located in the perianal area using the TEM surgical technique...
January 2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/26861635/postoperative-complications-in-the-treatment-of-rectal-neoplasia-by-transanal-endoscopic-microsurgery-a-prospective-study-of-risk-factors-and-time-course
#11
Carlos Frederico S Marques, Caio Sergio R Nahas, Ulysses Ribeiro, Leonardo A Bustamante, Rodrigo Ambar Pinto, Eduardo Kenzo Mory, Ivan Cecconello, Sergio Carlos Nahas
PURPOSE: Transanal endoscopic microsurgery (TEM) is a safe and efficient minimally invasive treatment for rectal benign and early malignant neoplasia, but postoperative complications may be severe. We aimed to evaluate the risk factors related to the incidence, severity, and time course of postoperative complications of TEM. METHODS: This is a prospective study of postoperative complications in 53 patients (>18 years old) with benign or early rectal neoplasia who underwent TEM with curative intention or, for higher stages, palliation...
April 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/26794664/the-accuracy-of-endorectal-ultrasound-in-staging-rectal-lesions-in-patients-undergoing-transanal-endoscopic-microsurgery
#12
Marisa Leon-Carlyle, Jacqueline A Brown, Jeremy Hamm, P Terry Phang, Manoj J Raval, Carl J Brown
BACKGROUND: Endorectal ultrasound (ERUS) is used to preoperatively assess locoregional stage in patients with rectal neoplasms. This study evaluates the accuracy of ERUS in determining the T stage of rectal neoplasms treated by transanal endoscopic microsurgery (TEM). METHODS: All patients in the St Paul's Hospital TEM database were evaluated and excluded if they had been treated with neoadjuvant therapy. ERUS results were compared with gold-standard postoperative histopathology reports...
September 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/20455665/gastrointestinal-stromal-tumor-an-ultrastructural-investigation-on-regional-differences-with-considerations-on-their-histogenesis
#13
Kyung-Whan Min
Gastrointestinal stromal tumor (GIST) is the most frequent spindle cell tumor in the gastrointestinal tract and may arise from esophagus to rectum. The stomach is the most frequent site, followed by small intestine, rectum, and esophagus. There have been some regional differences reported in their histopathologic and clinical presentations. The purpose of this study is to compare ultrastructural features of GIST, according to its anatomic site, in order to provide additional data to support the current concept of its histogenesis...
May 2010: Ultrastructural Pathology
https://www.readbyqxmd.com/read/19092636/polypoid-pecoma-in-the-rectum-of-a-15-year-old-girl-case-report-and-review-of-pecoma-in-the-gastrointestinal-tract
#14
Paul Ryan, Van-Hung Nguyen, Suad Gholoum, Lucia Carpineta, Sharon Abish, Najma N Ahmed, Jean-Martin Laberge, Robert H Riddell
PEComa of the gastrointestinal tract, composed of perivascular epithelioid cells with myomelanocytic differentiation, is rare with previous literature limited to 16 case reports. There is a marked female preponderance and approximately one-third of the cases occur in the pediatric age group. We report PEComa with lymph node involvement occurring in the rectum of a 15-year-old girl, treated by surgical resection and adjuvant chemotherapy. The patient is well at 9 months follow-up with neither radiologic nor endoscopic evidence of recurrence...
March 2009: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/17786832/primary-small-cell-malignant-melanoma-of-the-rectum-case-report-of-a-very-rare-tumor
#15
Guofeng Wang, Brian Eyden, Li Fang Yao, Shui Zhen Chen, S Sankar Banerjee
Rectal/anorectal malignant melanomas are highly aggressive tumors with a poor prognosis and low 5-year survival rate. They are also very rare. Of the well-known histological variants of malignant melanoma, the small cell subtype is also very uncommon; consequently, small cell anorectal malignant melanoma is an exceedingly rare occurrence. In this article, the authors provide a detailed clinicopathological description of small cell malignant melanoma of the rectum, documenting clinical, histological, immunohistochemical, and ultrastructural features, to add to the sparse references on this tumor in the literature...
July 2007: Ultrastructural Pathology
https://www.readbyqxmd.com/read/17344285/biologic-antigenic-and-full-length-genomic-characterization-of-a-bovine-like-coronavirus-isolated-from-a-giraffe
#16
Mustafa Hasoksuz, Konstantin Alekseev, Anastasia Vlasova, Xinsheng Zhang, David Spiro, Rebecca Halpin, Shiliang Wang, Elodie Ghedin, Linda J Saif
Coronaviruses (CoVs) possess large RNA genomes and exist as quasispecies, which increases the possibility of adaptive mutations and interspecies transmission. Recently, CoVs were recognized as important pathogens in captive wild ruminants. This is the first report of the isolation and detailed genetic, biologic, and antigenic characterization of a bovine-like CoV from a giraffe (Giraffa camelopardalis) in a wild-animal park in the United States. CoV particles were detected by immune electron microscopy in fecal samples from three giraffes with mild-to-severe diarrhea...
May 2007: Journal of Virology
https://www.readbyqxmd.com/read/16586547/morphological-observation-of-tumor-infiltrating-immunocytes-in-human-rectal-cancer
#17
Zun-Jiang Xie, Li-Min Jia, Ye-Chun He, Jiang-Tao Gao
AIM: To investigate the morphological characterization of tumor infiltrating dendritic cells (TIDCs) and tumor infiltrating lymphocytes (TILs) in human rectal cancer. METHODS: Light and electron microscopy as well as immunohistochemistry were used to observe the distributive and morphological changes of TIDCs and TILs. RESULTS: TIDCs were mainly located in tumor-surrounding tissue. The number of TIDCs in the earlier stage was higher than that in the later stage (P<0...
March 21, 2006: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/8609042/paneth-cell-rich-flat-adenoma-of-the-rectum-report-of-a-case
#18
C A Rubio, L Kanter, J Björk, B Poppen, L Bry
A patient having familiar adenomatosis polyposis and an ileo-rectal anastomosis developed a flat mucosal lesion in the rectum. A punch biopsy revealed a villous adenoma with high-grade dysplasia. The subsequent surgical specimen indicated that the flat villous adenoma was rich in Paneth cells. Special stains included lysozyme muramidase (to visualize Paneth cells), MIB1 proliferation monoclonal antibody and single and multilabel immunohistochemistry for Paneth cells. Other methods included transmission electron microscopy and quantification with an image quantifier (Program Optilab 2...
January 1996: Japanese Journal of Cancer Research: Gann
https://www.readbyqxmd.com/read/8586714/isolation-of-coronaviruses-antigenically-indistinguishable-from-bovine-coronavirus-from-wild-ruminants-with-diarrhea
#19
H Tsunemitsu, Z R el-Kanawati, D R Smith, H H Reed, L J Saif
Diarrheal feces from three sambar deer and one waterbuck in a wild animal habitat and one white-tailed deer on a wildlife farm in Ohio contained coronavirus particles which were agglutinated by antiserum to bovine coronavirus (BCV) in immune electron microscopy. Three coronavirus strains were isolated in human rectal tumor cells from the feces of the sambar and white-tailed deer and the waterbuck, respectively. Hemagglutination, receptor-destroying enzyme activity, indirect immunofluorescence, hemagglutination inhibition, virus neutralization, and Western blot (immunoblot) tests showed close biological and antigenic relationships among the isolates and with selected BCV strains...
December 1995: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/7769609/water-pathways-across-a-reconstituted-epithelial-barrier-formed-by-caco-2-cells-effects-of-medium-hypertonicity
#20
M Parisi, M Pisam, G Calamita, R Gobin, R Toriano, J Bourguet
Caco-2 cells, originated in a human colonic cancer, are currently used as model systems to study transepithelial transports. To further characterize their water permeability properties, clone P1 Caco-2 cells were cultured on permeable supports. At confluence, the transepithelial net water movement (Jw), mannitol permeability (Ps), and electrical resistance (R) were simultaneously measured. The observed results were correlated with transmission and freeze-fracture electron microscopy studies and compared with those obtained, in similar experimental conditions, in a typical mammalian epithelial barrier: the rabbit rectum...
February 1995: Journal of Membrane Biology
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