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https://www.readbyqxmd.com/read/29166754/advances-in-oncological-treatment-limitations-of-recist-1-1-criteria
#1
Serena Grimaldi, Marie Terroir, Caroline Caramella
INTRODUCTION: RECIST 1.1 criteria are the standard for the response assessment of most solid tumors on computed tomography (CT). Nevertheless, the emergence of new classes of treatment in the lasts decades has brought new challenges in the response evaluation. EVIDENCE ACQUISITION: A PubMed online database literature search was performed in order to identify papers in English with full text available published up to September 2017. EVIDENCE SYNTHESIS: Some oncologic treatments, such as anti-angiogenic agents, immunotherapy and local treatments, have proven to be effective despite atypical patterns of responses...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166724/-beneficial-effects-of-schisandrin-b-on-the-cardiac-structure-and-function-in-a-mice-model-of-myocardial-infarction
#2
P S Chen, J Liu, H Y Meng, P Wu, Z J Yang
Objective: To investigate whether Schisandrin B (Sch B) could improve cardiac structure and function in myocardial infarction (MI) mice and related mechanisms. Methods: Male C57BL/6J mice were randomized into sham (n=8), MI+ Sch B (n=24, 80 mg·kg(-1)·d(-1) per gavage) or MI+ vehicle (n=24, equal volume). After treatment for 3 weeks, cardiac function was detected by echocardiography measurement.Infarction size was measured by Evans blue and TTC staining.HE and Masson trichrome staining were used to observe the myocardial inflammation, structure and fibrosis...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166691/-emil-kraepelin-s-time-in-dorpat-did-this-stay-made-marks-in-russian-and-soviet-psychiatry
#3
Birk Engmann, Holger Steinberg
In Russia, German psychiatrist Emil Kraepelin (1856-1926) is regarded as an influential and famous personality in the history of the field. This study discusses whether it was his period in the Russian Empire in the years 1886 to 1891 when he worked at Dorpat University (today Tartu, Estonia) that raised his popularity in Russia. Our research shows that all of his writings which had been translated into Russian language derive from a period much later than Dorpat. Moreover, none of his students has ever reached a scientific position which would have enabled him to become a proponent of Kraepelin's ideas in Russia...
November 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29166658/episodic-future-thinking-reduces-temporal-discounting-in-healthy-adolescents
#4
Uli Bromberg, Maria Lobatcheva, Jan Peters
Episodic Future Thinking has proven efficient in reducing impulsive behavior in several adult populations. Whether it also has a beneficial impact on decision making in adolescents is not known. Here the impact of episodic future thinking on discounting behavior was investigated in a sample of healthy adolescents (n = 44, age range 13-16 years). Discounting behavior in trials including episodic future thinking was significantly less impulsive than in control trials (t = 2.74, p = .009, dz = .44). In a subsample we controlled for executive function, alcohol use and developmental measures...
2017: PloS One
https://www.readbyqxmd.com/read/29166650/feeding-induced-changes-in-allatostatin-a-and-short-neuropeptide-f-in-the-antennal-lobes-affect-odor-mediated-host-seeking-in-the-yellow-fever-mosquito-aedes-aegypti
#5
Peter Christ, Anna Reifenrath, Jörg Kahnt, Frank Hauser, Sharon Rose Hill, Joachim Schachtner, Rickard Ignell
Aedes aegypti is a model species in which the endogenous regulation of odor-mediated host seeking behavior has received some attention. Sugar feeding and host seeking in female A. aegypti are transiently inhibited following a blood meal. This inhibition is partially mediated by short neuropeptide F (sNPF). The paired antennal lobes (ALs), as the first processing centers for olfactory information, has been shown to play a significant role in the neuropeptidergic regulation of odor-mediated behaviors in insects...
2017: PloS One
https://www.readbyqxmd.com/read/29166648/different-response-to-hypoxia-of-adipose-derived-multipotent-cells-from-obese-subjects-with-and-without-metabolic-syndrome
#6
Wilfredo Oliva-Olivera, Isabel Moreno-Indias, Leticia Coín-Aragüez, Said Lhamyani, Juan Alcaide Torres, Sonia Fernández-Veledo, Joan Vendrell, Antonio Camargo, Rajaa El Bekay, Francisco José Tinahones
BACKGROUND/OBJECTIVES: Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related insulin resistance. In addition, dysfunction of adipose tissue in obese subjects with metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. The aim of the current study was to examine the neovascular properties of visceral adipose tissue-derived multipotent mesenchymal cells subjected to hypoxia (hypox-visASCs) from normal-weight subjects (Nw) and obese patients with metabolic syndrome (MS) and without metabolic syndrome (NonMS)...
2017: PloS One
https://www.readbyqxmd.com/read/29166593/neural-correlates-of-improvements-in-personality-and-behavior-following-a-neurological-event
#7
Marcie L King, Kenneth Manzel, Joel Bruss, Daniel Tranel
Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurological event (e.g., stroke, benign tumor resection)...
November 19, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29166579/the-tcr-takes-some-immune-responsibility
#8
Ashley A Viehmann Milam, Paul M Allen
In this issue of Immunity, Van Braeckel-Budimmir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infection is dominated by a Vβ8.1 T cell response. Mice lacking Vβ8.1 T cells fail to mount a pathogenic response, thus showing that the TCR locus can be an Immune response (Ir) gene.
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166575/chemical-characterization-and-pharmacological-assessment-of-cashew-gum-extract-anacardium-occidentale-l-polysaccharide-free
#9
Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, Lorrane Kelle da Silva Moreira, Adriane Ferreira Brito, Verônica Vale Carvalho, Géssica Adriana Vasconcelos, Boniek Gontijo Vaz, Marcus Antônio Pereira-Junior, Kátia Flávia Fernandes, Elson Alves Costa
ETHNOPHARMACOLOGICAL RELEVANCE: The cashew gum (Anacardium occidentale L.) is used in Brazilian traditional medicine in the treatment of inflammatory conditions, asthma, diabetes, and gastrointestinal disturbs. AIM OF THE STUDY: The present study was aimed the chemical characterization and the investigation of the antinociceptive and anti-inflammatory activities of cashew gum aqueous extract without the presence of polysaccharides in its composition (CGE). MATERIALS AND METHODS: The CGE was obtained after precipitation and removal of polysaccharides using acetone...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29166533/potential-effects-of-fungicide-and-algaecide-extracts-of-annona-glabra-l-annonaceae-on-the-microalgae-raphidocelis-subcapitata-and-on-the-oomycete-pythium
#10
Giseli S Rocha, Reginaldo S Matsumoto, Ana Teresa Lombardi, Maria Inês S Lima
Annona glabra L. is a semi-deciduous tree that contains several active substances, including secondary metabolites, with antifungal activity. Phytopathogenic strains of the genus Pythium cause billion dollar losses all over the world on natural and crop species. Searching for eco-friendly algaecides and fungicides, we analyzed the effects of acetone extracts of A. glabra leaves on the algae Rhaphidocelis subcapitata (Korshikov) and on the oomycete Pythium aphanidermatum (Edson). We evaluated ten extract concentrations for each organism - 0 to 400 mg L-1 for algae and 0-1000 µg disc1 for oomycete...
2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29166511/primary-cutaneous-follicle-center-lymphoma
#11
Eline Pinheiro Weba Costa, Bethänia Dias de Lucena, Gabriela Athayde Amin, Maraya de Jesus Semblano Bittencourt, Leonidas Braga Dias, Carla Andréa Avelar Pires
Cutaneous lymphomas are classified according to their cellular origin into T-cell lymphoma and B-cell lymphoma. The annual incidence rate is 0.3 per 100,000 population. We report a case of a 56-year-old male patient who presented with a two-month history of nodules of varying sizes, some ulcerated, on the face, abdomen, and upper limbs. Histopathological examination and immunohistochemical study confirmed the diagnosis of primary cutaneous centrofollicular lymphoma. Studies have shown an increased incidence of non-Hodgkin lymphomas in the last decade...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166509/granulomatous-slack-skin-a-rare-subtype-of-mycosis-fungoides
#12
Letícia Marra da Motta, Cleverson Teixeira Soares, Sadamitsu Nakandakari, Gardênia Viana da Silva, Maria Helena Mazzi Freire Nigro, Leticia Stella Gardini Brandão
We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and sometimes the subcutaneous tissue) associated with histiocytic and multinucleated giant cells containing lymphocytes and elastic fibers (lymphophagocytosis and elastophagocytosis, respectively)...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166504/moderate-to-severe-psoriasis-treatment-challenges-through-the-era-of-biological-drugs
#13
Júlia Vide, Sofia Magina
Biological therapy has revolutionized moderate to severe psoriasis treatment. However, despite being more effective than conventional systemic treatments, some patients do not respond or lose response to biotechnological treatments or develop drug-antibodies, interfering with its safety and efficacy. There are also clinical forms of the disease and patient profiles for which is pending further scientific evidence for more sustained therapeutic interventions. The continuous and more detailed knowledge of psoriasis pathophysiology has allowed identifying new therapeutic targets, which is expected to help overcome the challenges of individualized psoriasis treatment...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#14
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166486/-narratives-of-users-of-mental-health-services-in-an-experiment-with-autonomous-management-of-medication
#15
Laura Lamas Martins Gonçalves, Rosana Teresa Onocko Campos
Numerous studies have highlighted the tendency to chronicity of treatments centered on the use of medications. This study was conducted in a large Brazilian city with users of Centers for Psychosocial Care (CAPS), with the aim of evaluating the effects of experimenting with the personal Guide for Autonomous Management of Medication (GAM) and the users' relationship to their treatments and participation. The instrument, created in Canada and translated and adapted to Brazil, was tested in intervention groups with users of CAPS with severe mental disorders and a history of political participation in the field of health...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166464/implementing-an-epilepsy-surgery-center-initial-experience-at-a-university-hospital-in-brazil
#16
Gabriel Pereira Escudeiro, Rafael Teixeira Magalhães Leal, Heros Henrique Melo de Almeida, Marcus Andre Aciolly, José Alberto Landeiro, Bruno Lima Pessoa
OBJECTIVE: Epilepsy is a serious neurological condition, often without a full and effective treatment. In some cases, surgery is beneficial, despite being underused. Our aim herein is to describe the implementation of an epilepsy surgery center in a federal university hospital, sharing the initial experience gained, as well as describing the main challenges and first results. METHODS: Experience report of an epilepsy surgery center implementation. Retrospective review of 13 drug-resistant patients who underwent surgical treatment...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166444/patterns-of-tobacco-consumption-among-residents-of-a-rural-settlement-a-cross-sectional-study
#17
Andrécia Cósmem da Silva, Lorena Silva Vargas, Roselma Lucchese, Bruno de Souza Calixto, Rafael Alves Guimarães, Ivania Vera, Paulo Alexandre de Castro, Valéria Pagotto, Inaina Lara Fernandes
OBJECTIVE: Investigate patterns and factors associated with tobacco consumption among residents of a rural settlement. METHODS: A cross-sectional study conducted between September and November 2014, with 172 residents of a rural settlement in the Midwest region of Brazil. We analyzed as dependent variables tobacco consumption at some point in life; current tobacco consumption; tobacco abuse; and the high risk of nicotine dependence, with sociodemographic variables associated with tobacco use, and we applied the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) and Self-Reporting Questionnaire (SRQ-20)...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166406/revised-geochronology-correlation-and-dinosaur-stratigraphic-ranges-of-the-santonian-maastrichtian-late-cretaceous-formations-of-the-western-interior-of-north-america
#18
Denver Warwick Fowler
Interbasinal stratigraphic correlation provides the foundation for all consequent continental-scale geological and paleontological analyses. Correlation requires synthesis of lithostratigraphic, biostratigraphic and geochronologic data, and must be periodically updated to accord with advances in dating techniques, changing standards for radiometric dates, new stratigraphic concepts, hypotheses, fossil specimens, and field data. Outdated or incorrect correlation exposes geological and paleontological analyses to potential error...
2017: PloS One
https://www.readbyqxmd.com/read/29166404/species-specific-signatures-of-the-microbiome-from-camponotus-and-colobopsis-ants-across-developmental-stages
#19
Manuela Oliveira Ramalho, Odair Correa Bueno, Corrie Saux Moreau
Symbiotic relationships between hosts and bacteria are common in nature, and these may be responsible for the evolutionary success of various groups of animals. Among ants, these associations have been well studied in some genera of the Camponotini, but several questions remain regarding the generality of the previous findings across all the members of this ant tribe and if bacterial communities change across development in these hosts. This study is the first to characterize the bacterial community associated with a colony of the recently recognized genus Colobopsis and three colonies of Camponotus (two distinct species) and show how different the composition of the bacterial community is when compared across the different genera...
2017: PloS One
https://www.readbyqxmd.com/read/29166394/maternity-care-for-trafficked-women-survivor-experiences-and-clinicians-perspectives-in-the-united-kingdom-s-national-health-service
#20
Debra Bick, Louise M Howard, Sian Oram, Cathy Zimmerman
BACKGROUND: Although trafficked women and adolescents are at risk of unprotected or forced sex, there is little research on maternity care among trafficking survivors. We explored health care needs, service use and challenges among women who became pregnant while in the trafficking situation in the United Kingdom (UK) and clinicians' perspectives of maternity care for trafficked persons. METHODS: Cross-sectional survey and qualitative interviews with trafficking survivors recruited from statutory and voluntary sector organisations in England and qualitative interviews with maternity clinicians and family doctors undertaken to offer further insight into experiences reported by these women...
2017: PloS One
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