keyword
https://read.qxmd.com/read/38491225/pictorial-review-challenges-in-distinguishing-bilateral-metaphyseal-marrow-abnormalities-on-magnetic-resonance-imaging
#21
JOURNAL ARTICLE
Sean M Booth, Tejas H Kapadia, Vivian Tang, Amit F Maniyar
The paediatric metaphysis is afflicted by a wide range of pathological processes as it is the most metabolically active and well-vascularised part of the developing skeleton. This review focuses on metaphyseal marrow signal change detected with magnetic resonance imaging, which is most often occult on radiographs. When bilateral, these imaging appearances frequently present a diagnostic quandary. This review assists the radiologist to confidently dismiss physiological signal change and confidently work through the differential diagnosis...
March 16, 2024: Pediatric Radiology
https://read.qxmd.com/read/38491129/synthetic-mri-and-amide-proton-transfer-weighted-mri-for-differentiating-between-benign-and-malignant-sinonasal-lesions
#22
JOURNAL ARTICLE
Ying Xiang, Qiujuan Zhang, Xin Chen, Honghong Sun, Xiaohui Li, Xiaocheng Wei, Jinman Zhong, Bo Gao, Wei Huang, Wenbin Liang, Haiqiao Sun, Quanxin Yang, Xiaoyong Ren
OBJECTIVES: To explore the value of the synthetic MRI (SyMRI), combined with amide proton transfer-weighted (APTw) MRI for quantitative and morphologic assessment of sinonasal lesions, which could provide relative scale for the quantitative assessment of tissue properties. METHODS: A total of 80 patients (31 malignant and 49 benign) with sinonasal lesions, who underwent the SyMRI and APTw examination, were retrospectively analyzed. Quantitative parameters (T1, T2, proton density (PD)) and APT % were obtained through outlining the region of interest (ROI) and comparing the two groups utilizing independent Student t test or a Wilcoxon test...
March 16, 2024: European Radiology
https://read.qxmd.com/read/38490982/parainfectious-brown-sequard-syndrome-associated-with-mycoplasma-pneumoniae-in-an-adult-patient-a-case-report
#23
JOURNAL ARTICLE
Michail Papantoniou, Konstantinos -Vasileios Tsatinas, Maria Gryllia
INTRODUCTION: Acute transverse myelitis (ATM) refers to a rare severe acquired spinal cord inflammation, with a challenging diagnostic work-up and treatment. CASE PRESENTATION: We report the case of a 42-year-old patient who presented with loss of temperature and pain sensation beneath the C5 dermatome in her left side and reported a history of a possible respiratory tract illness 10 days ago. Within 2 days, clinical worsening was noted, compatible with Brown-Sequard syndrome...
March 15, 2024: Spinal Cord Series and Cases
https://read.qxmd.com/read/38490702/sensory-neuropathy-as-a-manifestation-of-multiple-acyl-coenzyme-a-dehydrogenase-deficiency
#24
JOURNAL ARTICLE
Jessica N Harding, Nika Mohannak, Zoya Georgieva, Nicholas G Cunniffe
Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is a rare metabolic disorder which typically manifests with muscle weakness. However, despite late-onset MADD being treatable, it is often misdiagnosed, due in part to the heterogeneity of presentations. We report a case of late-onset MADD manifesting first as a sensory neuropathy before progressing to myopathic symptoms and acute metabolic decompensation. Early diagnostic workup with acylcarnitine profiling and organic acid analysis was critical in patient outcome; metabolic decompensation and myopathic symptoms were completely reversed with riboflavin supplementation and dietary modification, although sensory neuropathy persisted...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38490700/interesting-case-of-regional-left-ventricular-hypertrophy
#25
JOURNAL ARTICLE
Ahmad Elsaid, Robin Egdell, Vikram Singh, Stuart Russell
This is an account of an interesting case with an unusual cardiac presentation. He is a man in his 60s who presented with chest tightness to the accident and emergency unit. The initial thoughts were of acute coronary syndrome or acute aortic syndrome. The initial set of investigations was non-conclusive. His echocardiogram which was done during hospital admission showed asymmetric hypertrophy of the heart muscle. It was prudent to assess that new finding with an MRI scan. The patient presented to the hospital twice during the investigation and was treated for a lower respiratory tract infection...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38490340/epigenetics-of-diabetes-a-bioinformatic-approach
#26
REVIEW
Sulistyo Emantoko Dwi Putra, Farizky Martriano Humardani, Yulanda Antonius, Jonathan Jonathan, Lisa Thalia Mulyanata
The adaptability of epigenetics offers a compelling research avenue, notably in the context of Type 2 Diabetes Mellitus (T2DM) biomarkers and provides a nuanced approach to managing biological systems for diagnosis. However, challenges such as DNA degradation during methylation studies are prominent, especially with cell-free DNA (cfDNA) which is present in small quantities in plasma, calling for innovative solutions. To tackle these challenges, four methodological approaches have been identified: firstly, selecting an appropriate DNA extraction method and enhancing DNA yield through amplification; secondly, adapting bisulfite modification techniques to minimize DNA degradation; thirdly, utilizing tools capable of working with minimal DNA quantities; and lastly, employing bisulfite-free methylation techniques...
March 13, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38490316/risk-of-cancer-in-patients-with-diverticular-disease-a-population-based-cohort-study
#27
JOURNAL ARTICLE
Frederikke S Troelsen, Dóra K Farkas, Rune Erichsen, Lisa L Strate, John A Baron, Henrik T Sørensen
BACKGROUND AND AIMS: Several studies have investigated the association between diverticular disease (DD) and colorectal cancer. However, whether there is an association between DD and malignancies other than those in the colorectum remains uncertain. METHODS: For the 1978-2019 period, we conducted a nationwide, population-based cohort study using national Danish healthcare data. We followed DD patients for up to 20 years, beginning one year after the date of DD diagnosis until the first occurrence of incident cancer, emigration, death, 20 years of follow-up, or December 31st , 2019...
March 13, 2024: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/38490136/the-impact-of-raising-a-child-with-a-developmental-or-physical-health-condition-in-ethiopia
#28
JOURNAL ARTICLE
Anne de Leeuw, Wietske A Ester, Mersha Kinfe, Fikirte Girma, Rehana Abdurahman, Tigist Zerihun, Atsede Teklehaimanot, Charlotte Hanlon, Hans W Hoek, Rosa A Hoekstra
OBJECTIVE: Raising a child with a developmental disability or physical health condition can have a major impact on the lives of their families, especially in low-income countries. We explored the impact on such families in Ethiopia. STUDY DESIGN: A total of 241 child-caregiver dyads were recruited from two public hospitals in Addis Ababa, Ethiopia. Of these, 139 children were diagnosed with a developmental disability (e.g. autism, intellectual disability) and 102 children with a physical health condition (e...
March 14, 2024: Research in Developmental Disabilities
https://read.qxmd.com/read/38490098/uncommon-diagnosis-of-multinodular-goiter-isolated-extrapulmonary-manifestation-of-sarcoidosis-in-thyroid-gland-scientific-case-reports
#29
Marcel Neumann, Frank Meyer, Tatiana Oksentyuk Polyakova, Udo Barth, Dörthe Jechorek, Roland S Croner, Manuela Petersen
AIM: By means of the scientific description of two uncommon cases who underwent. surgical resection of multinodous goiter and following histopathological investigation revealing isolated extrapulmonary manifestation of sarcoidosis, this uncommon diagnosis including symptomatology, clinical findings, diagnostic and therapeutic management is to be illustrated. CASE DESCRIPTIONS: Diagnostics: Scintigraphy of the thyroid gland with a left-thyroid cold node; ultrasound-guided puncture (cytological investigation, non-suspicious)...
March 8, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38490025/advancing-amyotrophic-lateral-sclerosis-disease-diagnosis-a-lab-on-chip-electrochemical-immunosensor-for-ultra-sensitive-tdp-43-protein-detection-and-monitoring-in-serum-patients
#30
JOURNAL ARTICLE
Antonio Turco, Elisabetta Primiceri, Maria Serena Chiriacò, Velia La Pesa, Francesco Ferrara, Nilo Riva, Angelo Quattrini, Alessandro Romano, Giuseppe Maruccio
The global increase in population aging has led to a rise in neurodegenerative diseases (NDs), posing significant challenges to public health. Developing selective and specific biomarkers for early diagnosis and drug development is crucial addressing the growing burden of NDs. In this context, the RNA-binding protein TDP-43 has emerged as a promising biomarker for amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and TDP-43-associated proteinopathies. However, existing detection methods suffer from limitations such as cost, complexity, and operator dependence...
March 6, 2024: Talanta
https://read.qxmd.com/read/38490013/parapharyngeal-and-retropharyngeal-infections-in-children-kawasaki-disease-needs-vigilance
#31
JOURNAL ARTICLE
Jia Liu, Shui-Hong Zhou
OBJECTIVE: Kawasaki Disease (KD) may mimic Parapharyngeal (PPI) and Retropharyngeal Infections (RPI), leading to misdiagnosis as Deep Neck Infections (DNIs). The treatment plans for the two diseases are different, and delayed treatment can lead to serious complications. Therefore, prompt diagnosis and management are necessary. This study was performed to evaluate the clinical features of KD mimicking DNIs and explore the treatment options. METHODS: Children with cellulitis or abscess in parapharyngeal or retropharyngeal space in neck CT were included in this study...
February 22, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38489935/reliable-prediction-of-difficult-airway-for-tracheal-intubation-from-patient-preoperative-photographs-by-machine-learning-methods
#32
JOURNAL ARTICLE
Fernando García-García, Dae-Jin Lee, Francisco J Mendoza-Garcés, Susana García-Gutiérrez
BACKGROUND: Estimating the risk of a difficult tracheal intubation should help clinicians in better anaesthesia planning, to maximize patient safety. Routine bedside screenings suffer from low sensitivity. OBJECTIVE: To develop and evaluate machine learning (ML) and deep learning (DL) algorithms for the reliable prediction of intubation risk, using information about airway morphology. METHODS: Observational, prospective cohort study enrolling n=623 patients who underwent tracheal intubation: 53/623 difficult cases (prevalence 8...
March 12, 2024: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38489725/development-of-an-immune-related-diagnostic-predictive-model-for-oral-lichen-planus
#33
JOURNAL ARTICLE
Jiamin Bian, Jiayu Yan, Chu Chen, Li Yin, Panpan Liu, Qi Zhou, Jianfeng Yu, Qin Liang, Qingmei He
Oral lichen planus (OLP) was a chronic inflammatory disease of unknown etiology with a 1.4% chance of progressing to malignancy. However, it has been suggested in several studies that immune system disorders played a dominant role in the onset and progression of OLP. Therefore, this experiment aimed to develop a diagnostic prediction model for OLP based on immunopathogenesis to achieve early diagnosis and treatment and prevent cancer. In this study, 2 publicly available OLP datasets from the gene expression omnibus database were filtered...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489594/distinguish-response-of-low-dose-radiation-with-different-dose-rate-on-gene-expression-of-human-coronary-artery-endothelial-cells-a-bioinformatic-study-based-on-transcriptomic-sequencing
#34
JOURNAL ARTICLE
Soo-Ho Lee, Yeonghoon Son, Kyu Jin Choi, Chang Geun Lee, Hae-June Lee
PURPOSE: People are exposed to low-dose radiation in medical diagnosis, occupational, or life circumstances, but the effect of low-dose radiation on human health is still controversial. The biological effects of radiation below 100 mGy are still unproven. In this study, we observed the effects of low-dose radiation (100 mGy) on gene expression in human coronary artery endothelial cells (HCAECs) and its effect on molecular signaling. MATERIALS AND METHODS: HCAECs were exposed to 100 mGy ionizing radiation at 6 mGy/h (low-dose-rate) or 288 mGy/h (high-dose-rate)...
March 15, 2024: International Journal of Radiation Biology
https://read.qxmd.com/read/38489087/ethnic-group-differences-in-the-timing-of-autism-diagnosis-intellectual-disability-and-educational-placement-of-autistic-children-in-singapore
#35
JOURNAL ARTICLE
Taralyn Teo, Hwan Cui Koh, Nurhafizah Mohd Zambri, Michele L Zaccario, K Mark Sossin, Chui Mae Wong
AIM: Given Singapore's distinct multicultural identity, this study examined the hypotheses that there may be ethnic group differences in diagnosis and outcomes in autistic children in Singapore. METHODS: Retrospective data were obtained from medical records of all children born between 2008 and 2011 who were diagnosed with clinical or confirmed autism. One-way ANOVAs and regression analyses were used to analyze data. RESULTS: Data from 2577 medical records were extracted...
March 15, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38488990/cerebrospinal-fluid-liquid-biopsies-in-the-evaluation-of-adult-gliomas
#36
REVIEW
Allison R Valerius, Mason J Webb, Nouran Hammad, Ugur Sener, Rachna Malani
PURPOSE OF REVIEW: This review aims to discuss recent research regarding the biomolecules explored in liquid biopsies and their potential clinical uses for adult-type diffuse gliomas. RECENT FINDINGS: Evaluation of tumor biomolecules via cerebrospinal fluid (CSF) is an emerging technology in neuro-oncology. Studies to date have already identified various circulating tumor DNA, extracellular vesicle, micro-messenger RNA and protein biomarkers of interest. These biomarkers show potential to assist in multiple avenues of central nervous system (CNS) tumor evaluation, including tumor differentiation and diagnosis, treatment selection, response assessment, detection of tumor progression, and prognosis...
March 15, 2024: Current Oncology Reports
https://read.qxmd.com/read/38488965/hypertrophic-cardiomyopathy
#37
REVIEW
Jason N Dungu, Amy Hardy-Wallace, Anthony D Dimarco, Henry O Savage
PURPOSE OF REVIEW: Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition with potential for severe complications including sudden cardiac death. Early diagnosis allows appropriate risk stratification and prompt intervention to minimise the potential for adverse outcomes. The implications of poorly coordinated screening are significant, either missing relatives at high-risk or burdening low-risk individuals with a diagnosis associated with reduced life expectancy. We aim to guide clinicians through the diagnostic pathway through to novel treatment options...
March 15, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38488663/error-detection-using-a-multi-channel-hybrid-network-with-a-low-resolution-detector-in-patient-specific-quality-assurance
#38
JOURNAL ARTICLE
Bing Yan, Jun Shi, Xudong Xue, Hu Peng, Aidong Wu, Xiao Wang, Chi Ma
PURPOSE: This study aimed to develop a hybrid multi-channel network to detect multileaf collimator (MLC) positional errors using dose difference (DD) maps and gamma maps generated from low-resolution detectors in patient-specific quality assurance (QA) for Intensity Modulated Radiation Therapy (IMRT). METHODS: A total of 68 plans with 358 beams of IMRT were included in this study. The MLC leaf positions of all control points in the original IMRT plans were modified to simulate four types of errors: shift error, opening error, closing error, and random error...
March 15, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38488417/association-between-cbs-gene-t833c-g919a-and-844ins68-polymorphisms-in-the-8th-exon-region-and-coronary-artery-disease-a-meta-analysis
#39
REVIEW
Zijiang Zhu, Yuhan Geng, Long Ma, Keying Yao, Ruitong Chang, Yongming Ma, Jialong Li
BACKGROUND: Several studies indicate that the cystathionine β-synthase (CBS) gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region may be correlated with coronary artery disease (CAD) susceptibility, but the results have been inconsistent and inconclusive. Thus, a meta-analysis was conducted to provide a comprehensive estimate of these associations. METHODS: On the basis of searches in the PubMed, EMBASE, Cochrane Library, Wanfang, VIP, and CNKI databases, we selected 14 case - control studies including 2123 cases and 2368 controls for this meta-analysis...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38488410/low-and-very-low-birthweight-disadvantage-in-compulsory-education-achievement-and-the-transition-to-upper-secondary-education-in-the-finnish-birth-cohorts-of-1987-to-1997
#40
JOURNAL ARTICLE
Matti Lindberg
BACKGROUND: We compared the educational achievements of very low-birthweight (VLBW) and low-birthweight (LBW) adolescents (ages 16 to 19) to those of their normal-birthweight (NBW) peers in the complete Finnish birth cohorts of 1987 to 1997. We focused on three key phases of the education process: the end of compulsory education (9th-grade completion), and the transition to and the completion of upper secondary-level education. METHODS: We used register data on grades, educational transitions and completed education...
March 2024: Child: Care, Health and Development
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