keyword
https://read.qxmd.com/read/38493433/the-impact-of-pulmonary-hydatid-cyst-rupture-on-covid-19-symptom-severity
#1
JOURNAL ARTICLE
Abdol Sattar Pagheh, Hossein Pazoki, Ghodsiyeh Azarkar, Effat Alemzadeh, Jafar Hajavi, Masood Ziaee
BACKGROUND: Co-infection with other microorganisms such as parasites in patients with COVID-19 can affect the clinical outcome and require prompt diagnosis and appropriate therapy. CASE PRESENTATION: We present a case of an adult male with chest pain, dyspnea, cough, diplopia, and anorexia who was confirmed to have acute COVID-19 pneumonia. 2 weeks prior to admission, a hydatid lung cyst was identified on examination, but the patient refused surgery. Thoracoabdominal computed tomography (CT) revealed a rupture of the lung hydatid cyst and co-infection with COVID-19...
March 17, 2024: Acta Parasitologica
https://read.qxmd.com/read/38493325/amyloid-typing-in-cardiac-amyloidosis-using-western-blotting
#2
JOURNAL ARTICLE
Batia Kaplan, Rivka Goldis, Tamar Ziv, Amir Dori, Hila Magen, Amos J Simon, Alexander Volkov, Elad Maor, Michael Arad
BACKGROUND: Cardiac amyloidosis (CA) is characterized by the extracellular deposition of misfolded protein in the heart. Precise identification of the amyloid type is often challenging, but critical, since the treatment and prognosis depend on the disease form and the type of deposited amyloid. Coexistence of clinical conditions such as old age, monoclonal gammopathy, chronic inflammation, or peripheral neuropathy in a patient with cardiomyopathy creates a differential diagnosis between the major types of CA: amyloidosis light chains (AL), amyloidosis transthyretin (ATTR) and amyloidosis A (AA)...
March 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38493183/redox-proteomics-of-panc-1-cells-reveals-the-significance-of-hif-1-signaling-protein-oxidation-in-pancreatic-ductal-adenocarcinoma-pathogenesis
#3
JOURNAL ARTICLE
Chaochao Tan, Lichun Chen, Xiaoyu Guan, Wenyi Huang, Yinhong Feng, Ziyi Li, Ling Wu, Xiangping Huang, Qianhui Ouyang, Sixiang Liu, Ying Huang, Jiliang Hu
BACKGROUND: Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic cancer development remains poorly understood. METHODS AND RESULTS: In this study, we performed a global characterization of protein oxidation targets in PDAC cells through iodoTMT-based quantitative proteomics, which identified over 4300 oxidized cysteine sites in more than 2100 proteins in HPDE6c7 and PANC-1 cells. Among them, 1715 cysteine residues were shown to be differentially oxidized between HPDE6c7 and PANC-1 cells...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38493181/corneal-confocal-microscopy-may-help-to-distinguish-multiple-system-atrophy-from-parkinson-s-disease
#4
JOURNAL ARTICLE
Xuebin Niu, Peixiao Yin, Chenyang Guan, Qiuyue Shao, Guiyun Cui, Kun Zan, Chuanying Xu
Multiple system atrophy (MSA) and Parkinson's disease (PD) have clinical overlapping symptoms, which makes differential diagnosis difficult. Our research aimed to distinguish MSA from PD using corneal confocal microscopy (CCM), a noninvasive and objective test. The study included 63 PD patients, 30 MSA patients, and 31 healthy controls (HC). When recruiting PD and MSA, questionnaires were conducted on motor and non-motor functions, such as autonomic and cognitive functions. Participants underwent CCM to quantify the corneal nerve fibers...
March 16, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38493179/identification-and-validation-of-irf6-related-to-ovarian-cancer-and-biological-function-and-prognostic-value
#5
JOURNAL ARTICLE
Shihao Hong, Ni Fu, Shanliang Sang, Xudong Ma, Fangying Sun, Xiao Zhang
BACKGROUND: Ovarian cancer (OC) is a severe gynecological malignancy with significant diagnostic and therapeutic challenges. The discovery of reliable cancer biomarkers can be used to adjust diagnosis and improve patient care. However, serous OC lacks effective biomarkers. We aimed to identify novel biomarkers for OC and their pathogenic causes. METHODS: The present study used the differentially expressed genes (DEGs) obtained from the "Limma" package and WGCNA modules for intersection analysis to obtain DEGs in OC...
March 16, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38493114/high-throughput-sequencing-reveals-differences-in-microbial-community-structure-and-diversity-in-the-conjunctival-tissue-of-healthy-and-type-2-diabetic-mice
#6
JOURNAL ARTICLE
Fengjiao Li, Shuo Yang, Ji Ma, Xiaowen Zhao, Meng Chen, Ye Wang
BACKGROUND: To investigate the differences in bacterial and fungal community structure and diversity in conjunctival tissue of healthy and diabetic mice. METHODS: RNA-seq assays and high-throughput sequencing of bacterial 16 S rDNA and fungal internal transcribed spacer (ITS) gene sequences were used to identify differentially expressed host genes and fungal composition profiles in conjunctival tissues of diabetic BKS-db/db mice and BKS (control) mice. Functional enrichment analysis of differentially expressed genes and the correlation between the relative abundance of bacterial and fungal taxa in the intestinal mucosa were also performed...
March 16, 2024: BMC Microbiology
https://read.qxmd.com/read/38492810/understanding-the-intricacies-of-cellular-senescence-in-atherosclerosis-mechanisms-and-therapeutic-implications
#7
REVIEW
Ilyas Ali, Hongliang Zhang, Syed Aqib Ali Zaidi, Guangqian Zhou
Cardiovascular disease is currently the largest cause of mortality and disability globally, surpassing communicable diseases, and atherosclerosis is the main contributor to this epidemic. Aging is intimately linked to atherosclerosis development and progression, however, the mechanism of aging in atherosclerosis is not well known. To emphasize the significant research on the involvement of senescent cells in atherosclerosis, we begin by outlining compelling evidence that indicates various types of senescent cells and SASP factors linked to atherosclerotic phenotypes...
March 14, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38492463/characterization-and-classification-of-oleogels-and-edible-oil-using-vibrational-spectroscopy-in-tandem-with-one-class-and-multiclass-chemometric-methods
#8
JOURNAL ARTICLE
Ingrid A Moraes, Marina G Neves, Heinz W Siesler, Javier E L Villa, Rosiane L Cunha, Douglas F Barbin
Oleogel represents a promising healthier alternative to act as a substitute for conventional fat in various food products. Oil selection is a crucial factor in determining the technological properties and applications of oleogels due to their distinct fatty acid composition, molecular weight, and thermal properties, as well as the presence of antioxidants and oxidative stability. Hence, the relevance of monitoring oleogel properties by non-destructive, eco-friendly, portable, fast, and effective techniques is a relevant task and constitutes an advance in the evaluation of oleogels quality...
March 11, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38492357/endobronchial-solitary-fibrous-tumors-an-enigma-for-diagnosis
#9
Fátima Ramalhosa, Federica Pezzuto, Francesco Fortarezza, Gianluca Canu, Davide Biondini, Eleonora Faccioli, Roberta Polverosi, Chiara Giraudo, Fiorella Calabrese
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms constituting less than 2% of all soft tissue tumors. They typically originate in the thoracic cavity, mainly in the pleura, but can also occur in other various sites such as lung parenchyma, pericardium, and bronchus. In this study, a 49-year-old non-smoking female with a history of allergies presented to our pulmonary clinic with a chronic cough. An explorative bronchoscopy revealed an intrabronchial mass in the left superior bronchi, and a 68 Ga-DOTATOC positron emission computed tomography suggested a carcinoid tumor...
March 4, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38492284/geographical-discrimination-of-paw-san-rice-cultivated-in-different-regions-of-myanmar-using-near-infrared-spectroscopy-headspace-gas-chromatography-ion-mobility-spectrometry-and-chemometrics
#10
JOURNAL ARTICLE
Saw Thantar, Alina Mihailova, Marivil D Islam, Florence Maxwell, Islam Hamed, Christina Vlachou, Simon D Kelly
Paw San rice, also known as "Myanmar pearl rice", is considered the highest quality rice in Myanmar. There are considerable differences in terms of the premium commercial value of Paw San rice, which is an incentive for fraud, e.g. adulteration with cheaper rice varieties or mislabelling its geographical origin. Shwe Bo District is one of the most popular rice growing areas in the Sagaing region of Myanmar which produces the most valued and highly priced Paw San rice (Shwe Bo Paw San). The verification of the geographical origin of Paw San rice is not readily undertaken in the rice supply chain because the existing analytical approaches are time-consuming and expensive...
March 12, 2024: Talanta
https://read.qxmd.com/read/38492258/sarcomatoid-renal-pelvis-carcinoma-experience-of-treatment-at-a-single-institution
#11
JOURNAL ARTICLE
Tian Liu, Yu Yao, Chaoqun Geng, Fengju Guan, Guiming Zhang
OBJECTIVES: Sarcomatoid renal pelvis carcinoma (SRPC) is a rare variant of RPC. We aimed to summarize the clinicopathological features and prognostic factors of SRPC. METHODS: In this retrospective study, we collected data from 24 patients with SRPC who were treated at the Department of Urology, Affiliated Hospital of Qingdao University between 2008 and 2021. The clinicopathological features of the patients were obtained from their medical records to evaluate the diagnosis, prognostic factors, and response to systemic therapy...
March 5, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38492061/the-potential-of-posterior-cruciate-ligament-buckling-phenomenon-as-a-sign-for-partial-anterior-cruciate-ligament-tears
#12
JOURNAL ARTICLE
Mehmet Ali Tokgoz, Ethem Burak Oklaz, Oguzhan Ak, Elif Banu Guler Oklaz, Muhammet Baybars Ataoglu, Ulunay Kanatli
INTRODUCTION: Diagnosis of a partial tear of the anterior cruciate ligament (ACL) can be challenging with physical examination and imaging techniques. Although magnetic resonance imaging (MRI) has high sensitivity and specificity for diagnosing complete ACL tears, its effectiveness may be limited when it is used to diagnose for partial tears. The hypothesis of the present study is that the posterior cruciate ligament (PCL) buckling phenomenon, which is a secondary sign of complete ACL tears on MRI, may be a useful method for diagnosing partial ACL tears...
March 16, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38491959/clinical-and-molecular-characterization-of-patients-with-ywhag-related-epilepsy
#13
JOURNAL ARTICLE
Valentina Cetica, Tiziana Pisano, Gaetan Lesca, Dana Marafi, Laura Licchetta, Florence Riccardi, Davide Mei, Hon-Yin B Chung, Allan Bayat, Meena Balasubramanian, Daniel H Lowenstein, Milda Endzinienė, Maha Alotaibi, Nathalie Villeneuve, Julia Jacobs, Bertrand Isidor, Roberta Solazzi, Nicolette S den Hollander, Dragan Marjanovic, Christelle Rougeot-Jung, Julien Jung, Marion Lesieur-Sebellin, Andrea Accogli, Vincenzo Salpietro, Nebal W Saadi, Eleni Panagiotakaki, Thomas Foiadelli, Sylvia Redon, Meng-Han Tsai, Francesca Bisulli, Trine B Hammer, James R Lupski, Elena Parrini, Renzo Guerrini
OBJECTIVE: YWHAG variant alleles have been associated with a rare disease trait whose clinical synopsis includes an early onset epileptic encephalopathy with predominantly myoclonic seizures, developmental delay/intellectual disability, and facial dysmorphisms. Through description of a large cohort, which doubles the number of reported patients, we further delineate the spectrum of YWHAG-related epilepsy. METHODS: We included in this study 24 patients, 21 new and three previously described, with pathogenic/likely pathogenic variants in YWHAG...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38491808/novel-metabolic-biomarker-for-early-detection-and-diagnosis-to-the-patients-with-gastric-cardia-adenocarcinoma
#14
JOURNAL ARTICLE
Meng Xia Wei, Zheng Yang, Pan Pan Wang, Xue Ke Zhao, Xin Song, Rui Hua Xu, Jing Feng Hu, Kan Zhong, Ling Ling Lei, Wen Li Han, Miao Miao Yang, Fu You Zhou, Xue Na Han, Zong Min Fan, Jia Li, Ran Wang, Bei Li, Li Dong Wang
BACKGROUND: Gastric cardia adenocarcinoma (GCA) is classified as Siewert type II adenocarcinoma at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% of diagnoses at an advanced stage, resulting in a grim prognosis, with less than a 20% 5-year survival rate. METHOD: Metabolic features of 276 GCA and 588 healthy controls were characterized through a widely-targeted metabolomics by UPLC-MS/MS analysis...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491779/the-great-imitator-a-case-of-lyme-carditis-mimicking-st-elevation-myocardial-infarction
#15
JOURNAL ARTICLE
Sacide S Ozgur, Muhammad Adil Afzal, Dhruv Patel, Nida Ansari, Arielle Aiken, Yezin Shamoon, Rachel Abboud, Fayez Shamoon
Lyme disease, caused by Borrelia burgdorferi and transmitted via Ixodes ticks, is a common vector-borne illness in the United States, with an estimated 476,000 annual cases. While primarily known for its neurological and rheumatological manifestations, Lyme disease can also involve the cardiac system, known as Lyme carditis, which occurs in about 4% to 10% of cases. This case report details a rare instance of Lyme carditis presenting as ST-segment elevation myocardial infarction (STEMI) in a 31-year-old female with no significant medical history...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38491749/adherence-to-adhesive-patch-electrocardiographic-monitoring-among-adults-with-disabilities
#16
JOURNAL ARTICLE
Patricia A Patrick, Andrew J Flatley, Izel Steinmann Obermeyer, Ian A Lentnek
BACKGROUND: Individuals with developmental and/or intellectual disabilities (I/DD) are at a greater risk for atrial fibrillation (AF), the most common type of cardiac arrhythmia. AF is associated with heart failure, stroke, poor mental health, and reduced quality of life. Management and treatment decisions are based on the ability to detect AF; however, noninvasive, remote cardiac monitoring may not be tolerated by individuals with I/DD. OBJECTIVE: To examine adherence to the placement of an ambulatory cardiac rhythm monitoring patch device by adult patients with I/DD...
March 15, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38491719/discrimination-between-ventricular-tachycardia-and-wide-qrs-preexcited-tachycardia
#17
JOURNAL ARTICLE
Jae Hoon Lee
BACKGROUND: To develop a new algorithm to differentiate ventricular tachycardia (VT) from preexcited tachycardia (pre-ET) according to left bundle branch block (LBBB) and right bundle branch block (RBBB) patterns. METHODS: This study included 67 electrocardiograms (ECGs) with VT and 63 ECGs with pre-ET, collected from our hospital and through PubMed. Of those, 64 were allocated to the derivation cohort and the rest to the validation cohort. The diagnoses of the ECGs were confirmed using an electrophysiological study...
March 2024: Annals of Noninvasive Electrocardiology
https://read.qxmd.com/read/38491513/identification-of-mir-20b-5p-as-an-inhibitory-regulator-in-cardiac-differentiation-via-tet2-and-dna-hydroxymethylation
#18
JOURNAL ARTICLE
Ke-Xin Li, Jia-Ru Li, Sheng-Jia Zuo, Xudong Li, Xian-Tong Chen, Pei-Yi Xiao, Hui-Tao Li, Ling Sun, Tao Qian, Hao-Min Zhang, Dongxing Zhu, Xi-Yong Yu, Guojun Chen, Xue-Yan Jiang
BACKGROUND: Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, provide potential biomarkers for the diagnosis and treatment of CHD. However, the mechanisms underlying miRNAs-mediated regulation of cardiac development and CHD malformation remain to be further elucidated. This study aimed to explore the function of microRNA-20b-5p (miR-20b-5p) in cardiac development and CHD pathogenesis...
March 15, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38491427/using-team-based-precision-medicine-to-advance-understanding-of-rare-genetic-brain-disorders
#19
REVIEW
Steven U Walkley, Sophie Molholm, Bryen Jordan, Robert W Marion, Melissa Wasserstein
We describe a multidisciplinary teamwork approach known as "Operation IDD Gene Team" developed by the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC) at the Albert Einstein College of Medicine. This initiative brings families affected by rare genetic diseases that cause intellectual and developmental disability together with physicians, basic scientists, and their trainees. At team meetings, family members share their child's medical and personal history, physicians describe the broader clinical consequences of the condition, and scientists provide accessible tutorials focused on the fundamental biology of relevant genes...
March 15, 2024: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/38491234/differential-diagnosis-of-diabetic-foot-osteomyelitis-and-charcot-neuropathic-osteoarthropathy-with-deep-learning-methods
#20
JOURNAL ARTICLE
Maide Cakir, Gökalp Tulum, Ferhat Cuce, Kerim Bora Yilmaz, Ayse Aralasmak, Muhammet İkbal Isik, Hüseyin Canbolat
Our study aims to evaluate the potential of a deep learning (DL) algorithm for differentiating the signal intensity of bone marrow between osteomyelitis (OM), Charcot neuropathic osteoarthropathy (CNO), and trauma (TR). The local ethics committee approved this retrospective study. From 148 patients, segmentation resulted in 679 labeled regions for T1-weighted images (comprising 151 CNO, 257 OM, and 271 TR) and 714 labeled regions for T2-weighted images (consisting of 160 CNO, 272 OM, and 282 TR). We employed both multi-class classification (MCC) and binary-class classification (BCC) approaches to compare the classification outcomes of CNO, TR, and OM...
March 15, 2024: J Imaging Inform Med
keyword
keyword
82679
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.