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https://www.readbyqxmd.com/read/28636950/structural-evidence-of-quercetin-multi-target-bioactivity-a-reverse-virtual-screening-strategy
#1
Diego Carvalho, Margot Paulino, Fabio Polticelli, Florencia Arredondo, Robert J Williams, Juan A Abin-Carriquiry
The ubiquitous flavonoid quercetin is broadly recognized for showing diverse biological and health-promoting effects, such as anti-cancer, anti-inflammatory and cytoprotective activities. The therapeutic potential of quercetin and similar compounds for preventing such diverse oxidative stress-related pathologies has been generally attributed to their direct antioxidant properties. Nevertheless, accumulated evidence indicates that quercetin is also able to interact with multiple cellular targets influencing the activity of diverse signaling pathways...
June 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28634160/high-throughput-characterization-of-cascade-type-i-e-crispr-guide-efficacy-reveals-unexpected-pam-diversity-and-target-sequence-preferences
#2
Becky Xu Hua Fu, Michael Wainberg, Anshul Kundaje, Andrew Z Fire
Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are transcribed and processed to produce small CRISPR RNAs (crRNAs), with degradation of invading genetic material directed by a combination of complementarity between RNA and DNA and in some cases recognition of adjacent motifs called PAMs (Protospacer Adjacent Motifs)...
June 20, 2017: Genetics
https://www.readbyqxmd.com/read/28632104/bimanual-lifting-do-fingertip-forces-work-independently-or-interactively
#3
Pan Dimitriou, Gavin Buckingham
Bimanual coordination is a commonplace activity, but the consequences of using both hands simultaneously are not well understood. The authors examined fingertip forces across 4 experiments in which participants undertook a range of bimanual tasks. They first measured fingertip forces during simultaneous lifts of 2 identical objects, noting that individuals held the objects with more force bimanually than unimanually. They then varied the mass of the objects held by each hand, noting that when both hands lifted together performance was equivalent to unimanual lifts...
March 2, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28631981/patient-centered-radiology-where-are-we-where-do-we-want-to-be-and-how-do-we-get-there
#4
Jennifer L Kemp, Mary C Mahoney, Vincent P Mathews, Max Wintermark, Judy Yee, Stephen D Brown
Purpose The objectives of the Radiological Society of North America (RSNA) Patient-Centered Radiology Steering Committee survey were to (a) assess RSNA members' general attitudes and experiences concerning patient-centered radiology, with specific attention paid to radiologist-to-patient communication; (b) examine the members' barriers to communicating more directly with patients; and (c) explore their perceptions of how such barriers can be overcome. Materials and Methods A total of 5999 radiologists were invited by e-mail to complete an anonymous electronic survey developed by the Steering Committee and the RSNA Department of Research...
June 20, 2017: Radiology
https://www.readbyqxmd.com/read/28631291/folate-deficiency-disturbs-hsa-let-7-g-level-through-methylation-regulation-in-neural-tube-defects
#5
Li Wang, Shaofang Shangguan, Yu Xin, Shaoyan Chang, Zhen Wang, Xiaolin Lu, Lihua Wu, Bo Niu, Ting Zhang
Folic acid deficiency during pregnancy is believed to be a high-risk factor for neural tube defects (NTDs). Disturbed epigenetic modifications, including miRNA regulation, have been linked to the pathogenesis of NTDs in those with folate deficiency. However, the mechanism by which folic acid-regulated miRNA influences this pathogenesis remains unclear. It is believed that DNA methylation is associated with dysregulated miRNA expression. To clarify this issue, here we measured the methylation changes of 22 miRNAs in 57 human NTD cases to explore whether such changes are involved in miRNA regulation in NTD cases through folate metabolism...
June 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28630456/rare-disruptive-variants-in-the-disc1-interactome-and-regulome-association-with-cognitive-ability-and-schizophrenia
#6
S Teng, P A Thomson, S McCarthy, M Kramer, S Muller, J Lihm, S Morris, D C Soares, W Hennah, S Harris, L M Camargo, V Malkov, A M McIntosh, J K Millar, D H Blackwood, K L Evans, I J Deary, D J Porteous, W R McCombie
Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that are involved in brain development and signaling. Modulation of DISC1 expression alters the expression of a circumscribed set of genes (DISC1 Regulome) that are also implicated in brain biology and disorder...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28628994/tio2-surfaces-support-neuron-growth-during-electric-field-stimulation
#7
M Canillas, B Moreno, E Chinarro, A M Rajnicek
TiO2 is proposed here for the first time as a substrate for neural prostheses that involve electrical stimulation. Several characteristics make TiO2 an attractive material: Its electrochemical behaviour as an insulator prevents surface changes during stimulation. Hydration creates -OH groups at the surface, which aid cell adhesion by interaction with inorganic ions and macromolecules in cell membranes. Its ability to neutralize reactive oxygen and nitrogen species that trigger inflammatory processes confers biocompatibility properties in dark conditions...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627722/pterostilbene-inhibits-lipogenic-activity-similar-to-resveratrol-or-caffeine-but-differently-modulates-lipolysis-in-adipocytes
#8
Saioa Gomez-Zorita, Chloé Belles, Anaïs Briot, Alfredo Fernández-Quintela, Maria P Portillo, Christian Carpéné
The anti-obesity effects of resveratrol shown in rodents are not transposed into an efficient therapy of human obesity. Consequently, the search for molecules mimicking or surpassing resveratrol actions is ongoing. The natural phenolic compound pterostilbene exhibits beneficial health effects and has the capacity to limit fat mass in animal models. In this study, we tested whether pterostilbene modulates triacylglycerol accumulation/breakdown. Prolonged exposure to pterostilbene or resveratrol inhibited adipocyte differentiation in 3T3-F442A preadipocytes...
June 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28627424/channeling-in-native-microbial-pathways-implications-and-challenges-for-metabolic-engineering
#9
REVIEW
Mary H Abernathy, Lian He, Yinjie J Tang
Intracellular enzymes can be organized into a variety of assemblies, shuttling intermediates from one active site to the next. Eukaryotic compartmentalization within mitochondrion and peroxisomes and substrate tunneling within multi-enzyme complexes have been well recognized. Intriguingly, the central pathways in prokaryotes may also form extensive channels, including the heavily branched glycolysis pathway. In vivo channeling through cascade enzymes is difficult to directly measure, but can be inferred from in vitro tests, reaction thermodynamics, transport/reaction modeling, analysis of molecular diffusion and protein interactions, or steady state/dynamic isotopic labeling...
June 13, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28626934/thermal-phsyiology-a-new-dimension-of-the-pace-of-life-syndrome
#10
C T Goulet, M B Thompson, M Michelangeli, B B M Wong, D G Chapple
1.Current syndrome research focuses primarily on behavior with few incorporating components of physiology. One such syndrome is the Pace-of-Life Syndrome (POLS) which describes covariation between behaviour, metabolism immunity, hormonal response, and life history traits. Despite the strong effect temperature has on behavior, thermal physiology has yet to be considered within this syndrome framework. 2.We proposed the POLS to be extended to include a new dimension, the cold-hot axis. Under this premise, it is predicted that thermal physiology and behavior would covary whereby individual positioning along the thermal continuum would coincide with that of the behavioral continuum...
June 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28626786/interaction-between-estradiol-and-5-ht1a-receptors-in-the-median-raphe-nucleus-on-acquisition-of-aversive-information-and-association-to-the-context-in-ovariectomized-rats
#11
Telma Gonçalves Carneiro Spera de Andrade, João Victor Dos Santos Silva, Matheus Fitipaldi Batistela, Fernando Frei, Ana Beatriz Sant'Ana
The median raphe nucleus (MRN) is related to stress resistance and defensive responses, a crucial source of serotonergic neurons that project to prosencephalic structures related to stress and anxiety. Estrogen receptors were identified in this mesencephalic structure. It is possible that the estrogen action is related to serotonin effect on somatodendritic 5-HT1A receptors, inhibiting the function of serotonergic neurons and thus preventing of the stress effect and inducing anxiolysis. So, in order to evaluate these aspects, female Wistar rats were ovariectomized and 21 days later were given a direct microinjection of estradiol benzoate (EB) (1200 ng) into the MRN, preceded by microinjections of saline or WAY100...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28623762/cortisol-stress-response-in-post-traumatic-stress-disorder-panic-disorder-and-major-depressive-disorder-patients
#12
Susann Wichmann, Clemens Kirschbaum, Carsten Böhme, Katja Petrowski
BACKGROUND: Previous research has focussed extensively on the distinction of HPA-axis functioning between patient groups and healthy volunteers, with relatively little emphasis on a direct comparison of patient groups. The current study's aim was to analyse differences in the cortisol stress response as a function of primary diagnosis of panic disorder (PD), post-traumatic stress disorder (PTSD), and major depressive disorder (MDD). METHODS: A total of n=30 PD (mean age±SD: 36...
June 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28623390/disturbed-cervical-proprioception-affects-perception-of-spatial-orientation-while-in-motion
#13
Eva-Maj Malmström, Per-Anders Fransson, Terese Jaxmar Bruinen, Semir Facic, Fredrik Tjernström
The proprioceptive, visual and vestibular sensory systems interact to maintain dynamic stability during movement. The relative importance and interplay between these sensory systems is still not fully understood. Increased knowledge about spatial perception and postural orientation would provide better understanding of balance disorders, and their rehabilitation. Displacement of the body in space was recorded in 16 healthy subjects performing a sequence of stepping-in-place tests without any visual or auditory cues...
June 17, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28623006/a-longevity-study-with-enhancer-substances-selegiline-bpap-detected-an-unknown-tumor-manifestation-suppressing-regulation-in-rat-brain
#14
J Knoll, K Baghy, S Eckhardt, P Ferdinandy, M Garami, L G Harsing, P Hauser, Z Mervai, T Pocza, Z Schaff, D Schuler, I Miklya
AIMS: First proof to show that (-)-deprenyl/selegiline (DEP), the first selective inhibitor of MAO-B, later identified as the first β-phenylethylamine (PEA)-derived synthetic catecholaminergic activity enhancer (CAE) substance and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP), the tryptamine-derived presently known most potent, selective, synthetic enhancer substance, are specific markers of unknown enhancer-sensitive brain regulations. MAIN METHODS: Longevity study disclosing the operation of tumor-manifestation-suppressing (TMS) regulation in rat brain...
June 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28620979/an-application-of-cifap-for-predicting-the-binding-affinity-of-chk1-inhibitors-derived-from-2-aminothiazole-4-carboxamide
#15
Dilan Konyar, Ozlem Erdas, Ferda Nur Alpaslan, Erdem Buyukbingol
Investigation of protein-ligand interactions obtained from experiments has a crucial part in the design of newly discovered and effective drugs. Analyzing the data extracted from known interactions could help scientists to predict the binding affinities of promising ligands before conducting experiments. The objective of this study is to advance the CIFAP (compressed images for affinity prediction) method, which is relevant to a protein-ligand model, identifying 2D electrostatic potential images by separating the binding site of protein-ligand complexes and using the images for predicting the computational affinity information represented by pIC50 values...
June 16, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28619943/increase-in-predator-prey-size-ratios-throughout-the-phanerozoic-history-of-marine-ecosystems
#16
Adiël A Klompmaker, Michał Kowalewski, John Warren Huntley, Seth Finnegan
The escalation hypothesis posits that predation by increasingly powerful and metabolically active carnivores has been a major driver of metazoan evolution. We test a key tenet of this hypothesis by analyzing predatory drill holes in fossil marine shells, which provide a ~500-million-year record of individual predator-prey interactions. We show that drill-hole size is a robust predictor of body size among modern drilling predators and that drill-hole size (and thus inferred predator size and power) rose substantially from the Ordovician to the Quaternary period, whereas the size of drilled prey remained stable...
June 16, 2017: Science
https://www.readbyqxmd.com/read/28619159/original-mycobacterial-sin-a-consequence-of-highly-homologous-antigens
#17
REVIEW
A O Jenkins, A Michel, V Rutten
The role of antigens shared between Mycobacteria in in-vivo cross-reactive immune responses in host animals, have been reported to be responsible for reduced BCG vaccination efficacy as well reduced specificity of routine immunological diagnostic tests. This presents with significant disease control challenges in humans and animals. The present review highlights the results of previous studies on the effect of pre-sensitization to environmental mycobacteria on either pathogenic mycobacteria and/or M. bovis BCG, in experimental animals...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28617825/concurrent-development-of-facial-identity-and-expression-discrimination
#18
Kirsten A Dalrymple, Matteo Visconti di Oleggio Castello, Jed T Elison, M Ida Gobbini
Facial identity and facial expression processing both appear to follow a protracted developmental trajectory, yet these trajectories have been studied independently and have not been directly compared. Here we investigated whether these processes develop at the same or different rates using matched identity and expression discrimination tasks. The Identity task begins with a target face that is a morph between two identities (Identity A/Identity B). After a brief delay, the target face is replaced by two choice faces: 100% Identity A and 100% Identity B...
2017: PloS One
https://www.readbyqxmd.com/read/28617527/impact-of-motility-and-chemotaxis-features-of-the-rhizobacterium-pseudomonas-chlororaphis-pcl1606-on-its-biocontrol-of-avocado-white-root-rot
#19
Álvaro Polonio, Carmen Vida, Antonio de Vicente, Francisco M Cazorla
The biocontrol rhizobacterium Pseudomonas chlororaphis PCL1606 has the ability to protect avocado plants against white root rot produced by the phytopathogenic fungus Rosellinia necatrix. Moreover, PCL1606 displayed direct interactions with avocado roots and the pathogenic fungus. Thus, nonmotile (flgK mutant) and non-chemotactic (cheA mutant) derivatives of PCL1606 were constructed to emphasize the importance of motility and chemotaxis in the biological behaviour of PCL1606 during the biocontrol interaction...
June 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28617226/contextualization-of-drug-mediator-relations-using-evidence-networks
#20
Hai Joey Tran, Gil Speyer, Jeff Kiefer, Seungchan Kim
BACKGROUND: Genomic analysis of drug response can provide unique insights into therapies that can be used to match the "right drug to the right patient." However, the process of discovering such therapeutic insights using genomic data is not straightforward and represents an area of active investigation. EDDY (Evaluation of Differential DependencY), a statistical test to detect differential statistical dependencies, is one method that leverages genomic data to identify differential genetic dependencies...
May 31, 2017: BMC Bioinformatics
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