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https://www.readbyqxmd.com/read/28323870/contribution-of-sortase-srta2-to-lactobacillus-casei-bl23-inhibition-of-staphylococcus-aureus-internalization-into-bovine-mammary-epithelial-cells
#1
Renata F S Souza, Julien Jardin, Chantal Cauty, Lucie Rault, Damien S Bouchard, Luis G Bermúdez-Humarán, Philippe Langella, Vicente Monedero, Núbia Seyffert, Vasco Azevedo, Yves Le Loir, Sergine Even
Probiotics have been considered as a promising strategy to prevent various diseases in both humans and animals. This approach has gained interest in recent years as a potential means to control bovine mastitis. In a previous study, we found that several L. casei strains, including BL23, were able to inhibit the internalization of S. aureus, a major etiologic agent of mastitis, into bovine mammary epithelial cells (bMEC). This antagonism required a direct contact between L. casei and bMEC or S. aureus, suggesting the inhibition relied on interactions between L...
2017: PloS One
https://www.readbyqxmd.com/read/28318992/anonymity-and-electronics-adapting-preparation-for-radiology-resident-examination
#2
Teresa Chapman, Janet R Reid, Erin E O'Conner
RATIONALE AND OBJECTIVES: Diagnostic radiology resident assessment has evolved from a traditional oral examination to computerized testing. Teaching faculty struggle to reconcile the differences between traditional teaching methods and residents' new preferences for computerized testing models generated by new examination styles. We aim to summarize the collective experiences of senior residents at three different teaching hospitals who participated in case review sessions using a computer-based, interactive, anonymous teaching tool, rather than the Socratic method...
March 17, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28317104/contact-and-contagion-bighorn-sheep-demographic-states-vary-in-probability-of-transmission-given-contact
#3
Kezia R Manlove, E Frances Cassirer, Raina K Plowright, Paul C Cross, Peter J Hudson
1.Understanding both contact and probability of transmission given contact are key to managing wildlife disease. However, wildlife disease research tends to focus on contact heterogeneity, in part because probability of transmission given contact is notoriously difficult to measure. Here we present a first step toward empirically investigating probability of transmission given contact in free-ranging wildlife. 2.We used measured contact networks to test whether bighorn sheep demographic states vary systematically in infectiousness or susceptibility to Mycoplasma ovipneumoniae, an agent responsible for bighorn sheep pneumonia...
March 20, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28317091/staphylococcus-aureus-colonization-in-atopic-eczema-and-its-association-with-filaggrin-gene-mutations
#4
M-L Clausen, S M Edslev, P S Andersen, K Clemmensen, K A Krogfelt, T Agner
BACKGROUND: Atopic dermatitis (AD) is a prevalent disease with significant impact on physical health and quality of life. Staphylococcus aureus (S. aureus) has been directly correlated to disease severity, and may also be a contributing causal factor in the pathogenesis of AD. The primary aim of the present study was to assess differences in S. aureus colonization in AD patients with and without filaggrin gene (FLG) mutations. Secondarily, to assess disease severity in relation to S. aureus colonization...
March 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28306638/the-proinflammatory-cytokines-il-1%C3%A3-and-tnf-%C3%AE-influence-human-annulus-cell-signaling-cues-for-neurite-growth-in-vitro-co-culture-studies
#5
Helen E Gruber, Brittany Jones, Emilio Marrero, Edward N Hanley
STUDY DESIGN: IRB-approved research using human annulus cells co-cultured with F11 nerve cells. OBJECTIVE: To perform functional, kinetic assays of neurite dynamics and media neurotrophin measurement to test whether proinflammatory cytokines influence annulus cells' signaling cues for neurite growth/repulsion. SUMMARY OF BACKGROUND DATA: Nerves grow in response to signaling molecules called neurotrophins which disc cells produce (e.g. brain-derived neurotrophic factor (BDNF), glial cell-line derived neurotrophic factor (GDNF) and neurotrophin 3 (NT3)) and which influence neuron survival, differentiation and migration...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28303164/adverse-drug-reactions-triggered-by-the-common-hla-b-57-01-variant-a-molecular-docking-study
#6
George Van Den Driessche, Denis Fourches
BACKGROUND: Human leukocyte antigen (HLA) surface proteins are directly involved in idiosyncratic adverse drug reactions. Herein, we present a structure-based analysis of the common HLA-B*57:01 variant known to be responsible for several HLA-linked adverse effects such as the abacavir hypersensitivity syndrome. METHODS: First, we analyzed three X-ray crystal structures involving the HLA-B*57:01 protein variant, the anti-HIV drug abacavir, and different co-binding peptides present in the antigen-binding cleft...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28302574/the-arginine-vasotocin-and-serotonergic-systems-affect-interspecific-social-behaviour-of-client-fish-in-marine-cleaning-mutualism
#7
Zegni Triki, Redouan Bshary, Alexandra S Grutter, Albert F H Ros
Many species engage in mutualistic relationships with other species. The physiological mechanisms that affect the course of such social interactions are little understood. In the cleaning mutualism, cleaner fish Labroides dimidiatus do not always act cooperatively by eating ectoparasites, but sometimes cheat by taking bites of mucus from so-called "client" reef fish. The physiological mechanisms in these interspecific interactions, however, are little studied. Here, we focussed on three neuromodulator systems known to play important roles in intraspecific social behaviour of vertebrates to examine their role in clients' interspecific behaviour...
March 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28301443/can-neck-strength-be-measured-using-a-single-maximal-contraction-in-a-simulated-contact-position
#8
Danielle M Salmon, Phil Handcock, S John Sullivan, Nancy J Rehrer, Brian Niven
Neck strengthening has been postulated to potentially reduce the incidence/severity of concussions and neck injuries in collision based sports. A quick and reliable method to assess neck strength would permit identification of those at risk and tracking of progress following injury. The purpose of this study was to determine if neck strength could be reliably assessed in a simulated contact posture using a single maximal contraction. During a single session 30 healthy male university students performed 3 maximal voluntary contractions of the neck musculature in each of the following directions: extension (Ext), flexion (Flx), left (LtFlx), and right lateral flexion (RtFlx)...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28300834/heterodimers-of-photoreceptor-specific-nuclear-receptor-pnr-nr2e3-and-peroxisome-proliferator-activated-receptor-%C3%AE-ppar%C3%AE-are-disrupted-by-retinal-disease-associated-mutations
#9
Joel Fulton, Bismoy Mazumder, Jonathan B Whitchurch, Cintia J Monteiro, Hilary M Collins, Chun M Chan, Maria P Clemente, Miguel Hernandez-Quiles, Elizabeth A Stewart, Winfried M Amoaku, Paula M Moran, Nigel P Mongan, Jenny L Persson, Simak Ali, David M Heery
Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the nuclear receptor (NR) superfamily of transcription factors. We assessed the ability of these NRs to form heterodimers with other members of the human NRs representing all major subgroups. The TLX ligand-binding domain (LBD) did not appear to form homodimers or interact directly with any other NR tested. The PNR LBD was able to form homodimers, but also exhibited robust interactions with the LBDs of peroxisome proliferator-activated receptor-γ (PPARγ)/NR1C3 and thyroid hormone receptor b (TRb) TRβ/NR1A2...
March 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28300368/reduction-in-stray-radiation-dose-using-a-body-shielding-device-during-external-radiation-therapy
#10
Shuxu Zhang, Shaohui Jiang, Quanbin Zhang, Shengqu Lin, Ruihao Wang, Xiang Zhou, Guoqian Zhang, Huaiyu Lei, Hui Yu
With the purpose of reducing stray radiation dose (SRD) in out-of-field region (OFR) during radiotherapy with 6 MV intensity-modulated radiation therapy (IMRT), a body-shielding device (BSD) was prepared according to the measurements obtained in experimental testing. In experimental testing, optimal shielding conditions, such as 1 mm lead, 2 mm lead, and 1 mm lead plus 10 mm bolus, were investigated along the medial axis of a phantom using thermoluminescent dosimeters (TLDs). The SRDs at distances from field edge were then measured and analyzed for a clinical IMRT treatment plan for nasopharyngeal carcinoma before and after shielding using the BSD...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28300147/emigration-dynamics-of-cockroaches-under-different-disturbance-regimes-do-not-depend-on-individual-personalities
#11
I Planas-Sitjà, M O Laurent Salazar, G Sempo, J L Deneubourg
Group-level properties, such as collective movements or decisions, can be considered an outcome of the interplay between individual behavior and social interactions. However, the respective influences of individual preferences and social interactions are not evident. In this research, we study the implications of behavioral variability on the migration dynamics of a group of gregarious insects (Periplaneta americana) subjected to two different disturbance regimes (one without disturbances and another one with high frequency of disturbances)...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299793/foxo1-ampk-ulk1-regulates-ethanol-induced-autophagy-in-muscle-by-enhanced-atg14-association-with-the-becn1-pik3c3-complex
#12
Ly Q Hong-Brown, C Randell Brown, Maithili Navaratnarajah, Charles H Lang
BACKGROUND: Excessive alcohol (EtOH) consumption causes imbalances in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a FoxO1-AMPK-TSC2-mTORC1 pathway and also induces degradation. As the underlying regulatory signaling cascades for these processes are currently poorly defined, we tested the hypothesis that alcohol-induced autophagy is mediated via activation of the PIK3C3 complex that is regulated by FoxO1-AMPK. METHODS: C2C12 myoblasts were incubated with EtOH for various periods of time and autophagy pathway-related proteins were assessed by Western blotting and immunoprecipitation...
March 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28299468/gw-sem-a-statistical-package-to-conduct-genome-wide-structural-equation-modeling
#13
Brad Verhulst, Hermine H Maes, Michael C Neale
Improving the accuracy of phenotyping through the use of advanced psychometric tools will increase the power to find significant associations with genetic variants and expand the range of possible hypotheses that can be tested on a genome-wide scale. Multivariate methods, such as structural equation modeling (SEM), are valuable in the phenotypic analysis of psychiatric and substance use phenotypes, but these methods have not been integrated into standard genome-wide association analyses because fitting a SEM at each single nucleotide polymorphism (SNP) along the genome was hitherto considered to be too computationally demanding...
March 15, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28297071/association-between-smoking-at-diagnosis-and-cause-specific-survival-in-patients-with-rectal-cancer-results-from-a-population-based-analysis-of-10-794-cases
#14
Linda Sharp, Joseph McDevitt, Christopher Brown, Anne-Elie Carsin, Harry Comber
BACKGROUND: Currently, the 5-year survival rate for rectal cancer remains at <60%. The identification of potentially modifiable prognostic factors would be of considerable public health importance. A few studies have suggested associations between smoking and survival in rectal cancer; however, the evidence is inconsistent, and most of these studies were relatively small. In a large population-based cohort study, we investigated whether smoking at diagnosis is an independent prognostic factor for cancer-specific survival in rectal cancer and whether the association varies by sex, age, or treatment...
March 15, 2017: Cancer
https://www.readbyqxmd.com/read/28296955/the-gaga-factor-regulatory-network-identification-of-gaga-factor-associated-proteins
#15
Dmitry Lomaev, Anna Mikhailova, Maksim Erokhin, Alexander V Shaposhnikov, James J Moresco, Tatiana Blokhina, Daniel Wolle, Tsutomu Aoki, Vladimir Ryabykh, John R Yates, Yulii V Shidlovskii, Pavel Georgiev, Paul Schedl, Darya Chetverina
The Drosophila GAGA factor (GAF) has an extraordinarily diverse set of functions that include the activation and silencing of gene expression, nucleosome organization and remodeling, higher order chromosome architecture and mitosis. One hypothesis that could account for these diverse activities is that GAF is able to interact with partners that have specific and dedicated functions. To test this possibility we used affinity purification coupled with high throughput mass spectrometry to identify GAF associated partners...
2017: PloS One
https://www.readbyqxmd.com/read/28295810/local-adaptation-along-an-environmental-cline-in-a-species-with-an-inversion-polymorphism
#16
Maren Wellenreuther, Hanna Rosenquist, Peter Jaksons, Keith Larson W
Polymorphic inversions are ubiquitous across the animal kingdom and are frequently associated with clines in inversion frequencies across environmental gradients. Such clines are thought to result from selection favouring local adaptation, however, empirical tests are scarce. The seaweed fly Coelopa frigida has an α/β inversion polymorphism and previous work demonstrated that the α inversion frequency declines from the North Sea to the Baltic Sea, and is correlated with changes in tidal range, salinity, algal composition and wrackbed stability...
March 10, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28294967/single-lipid-molecule-dynamics-on-supported-lipid-bilayers-with-membrane-curvature
#17
Philip P Cheney, Alan W Weisgerber, Alec M Feuerbach, Michelle K Knowles
The plasma membrane is a highly compartmentalized, dynamic material and this organization is essential for a wide variety of cellular processes. Nanoscale domains allow proteins to organize for cell signaling, endo- and exocytosis, and other essential processes. Even in the absence of proteins, lipids have the ability to organize into domains as a result of a variety of chemical and physical interactions. One feature of membranes that affects lipid domain formation is membrane curvature. To directly test the role of curvature in lipid sorting, we measured the accumulation of two similar lipids, 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine (DHPE) and hexadecanoic acid (HDA), using a supported lipid bilayer that was assembled over a nanopatterned surface to obtain regions of membrane curvature...
March 15, 2017: Membranes
https://www.readbyqxmd.com/read/28293204/what-are-the-ingredients-for-an-inequity-paradigm-manipulating-the-experimenter-s-involvement-in-an-inequity-task-with-dogs
#18
Désirée Brucks, Sarah Marshall-Pescini, Jennifer L Essler, Jim McGetrick, Ludwig Huber, Friederike Range
Cooperation is only beneficial if the outcome is equally shared between individuals involved in the cooperative interaction. A mechanism to limit the development of unequal cooperation is inequity aversion, the negative reaction to unequal treatment. While inequity aversion has been studied extensively across many animal species, it remains unclear whether inequity aversion elicited in experimental settings is directed to the cooperative partner animal or rather to the experimenter distributing the rewards unequally...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28293202/automating-individualized-formative-feedback-in-large-classes-based-on-a-directed-concept-graph
#19
Henry E Schaffer, Karen R Young, Emily W Ligon, Diane D Chapman
Student learning outcomes within courses form the basis for course completion and time-to-graduation statistics, which are of great importance in education, particularly higher education. Budget pressures have led to large classes in which student-to-instructor interaction is very limited. Most of the current efforts to improve student progress in large classes, such as "learning analytics," (LA) focus on the aspects of student behavior that are found in the logs of Learning Management Systems (LMS), for example, frequency of signing in, time spent on each page, and grades...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28293190/gaba-selank-and-olanzapine-affect-the-expression-of-genes-involved-in-gabaergic-neurotransmission-in-imr-32-cells
#20
Elena Filatova, Anastasiya Kasian, Timur Kolomin, Ekaterina Rybalkina, Anelya Alieva, Lyudmila Andreeva, Svetlana Limborska, Nikolay Myasoedov, Galina Pavlova, Petr Slominsky, Maria Shadrina
Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability to affect the performance of the GABAergic system. To test this hypothesis, we studied the changes in expression of 84 genes involved in the functioning of the GABAergic system and in the processes of neurotransmission in the culture of neuroblastoma IMR-32 cells using qPCR method...
2017: Frontiers in Pharmacology
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