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https://www.readbyqxmd.com/read/28732368/meta-analysis-of-micrornas-expression-in-head-and-neck-cancer-uncovering-association-with-outcome-and-mechanisms
#1
Joshua Lubov, Mariana Maschietto, Iman Ibrahim, Alex Mlynarek, Michael Hier, Luiz Paulo Kowalski, Moulay A Alaoui-Jamali, Sabrina Daniela da Silva
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at advanced stages, incurring significant high mortality and morbidity. This review explored the risk stratification of miRNAs, and investigated the impact of miRNA networking in HNSCC prognostication. We performed a meta-analysis and a systematic literature search on online databases for papers published prior to December 1, 2016. The list of miRNAs was uploaded to MetacoreTM to construct a protein-protein interaction network, which was used to identify targets of the miRNAs and potential drugs...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28730540/gigaspora-margarita-with-and-without-its-endobacterium-shows-adaptive-responses-to-oxidative-stress
#2
Francesco Venice, Maria Concetta de Pinto, Mara Novero, Stefano Ghignone, Alessandra Salvioli, Paola Bonfante
Arbuscular mycorrhizal (AM) fungi experience oxidative stress during the plant-fungal interaction, due to endogenous reactive oxygen species (ROS) produced by fungal metabolism and exogenous ROS produced by plant cells. Here, we examine the responses to H2O2 in Gigaspora margarita, an AM fungus containing the endobacterial symbiont Candidatus Glomeribacter gigasporarum (CaGg). Previous studies revealed that G. margarita with its endobacterium produces more ATP and has higher respiratory activity than a cured line that lacks the endobacterium...
July 20, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28729689/metal-nanoclusters-with-synergistically-engineered-optical-and-buffering-activity-of-intracellular-reactive-oxygen-species-by-compositional-and-supramolecular-design
#3
B Santiago-Gonzalez, A Monguzzi, M Caputo, C Villa, M Prato, C Santambrogio, Y Torrente, F Meinardi, S Brovelli
Metal nanoclusters featuring tunable luminescence and high biocompatibility are receiving attention as fluorescent markers for cellular imaging. The recently discovered ability of gold clusters to scavenge cytotoxic reactive oxygen species (ROS) from the intracellular environment extends their applicability to biomedical theranostics and provides a novel platform for realizing multifunctional luminescent probes with engineered anti-cytotoxic activity for applications in bio-diagnostics and conceivably cellular therapy...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729417/mathematical-modeling-of-tumor-tumor-distant-interactions%C3%A2-supports-a-systemic-control-of-tumor-growth
#4
Sebastien Benzekry, Clare Lamont, Dominique Barbolosi, Lynn Hlatky, Philip Hahnfeldt
Interactions between different tumors within the same organism have major clinical implications, especially in the context of surgery and metastatic disease. Three main explanatory theories (competition, angiogenesis inhibition and proliferation inhibition) have been proposed but precise determinants of the phenomenon remain poorly understood. Here we formalized these theories into mathematical models and performed biological experiments to test them with empirical data. In syngeneic mice bearing two simultaneously implanted tumors, growth of only one of the tumors was significantly suppressed (61% size reduction at day 15, p<0...
July 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28729221/sensitivity-to-cocaine-in-adult-mice-is-due-to-interplay-between-genetic-makeup-early-environment-and-later-experience
#5
Matteo Di Segni, Diego Andolina, Alessandra Coassin, Alessandra Accoto, Alessandra Luchetti, Tiziana Pascucci, Carla Luzi, Anna Rita Lizzi, Francesca R D'Amato, Rossella Ventura
Although early aversive postnatal events are known to increase the risk to develop psychiatric disorders later in life, rarely they determine alone the nature and outcome of the psychopathology, indicating that interaction with genetic factors is crucial for expression of psychopathologies in adulthood. Moreover, it has been suggested that early life experiences could have negative consequences or confer adaptive value in different individuals. Here we suggest that resilience or vulnerability to adult cocaine sensitivity depends on a "triple interaction" between genetic makeup x early environment x later experience...
July 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28725190/reliability-of-eeg-interactions-differs-between-measures-and-is-specific-for-neurological-diseases
#6
Yvonne Höller, Kevin Butz, Aljoscha Thomschewski, Elisabeth Schmid, Andreas Uhl, Arne C Bathke, Georg Zimmermann, Santino O Tomasi, Raffaele Nardone, Wolfgang Staffen, Peter Höller, Markus Leitinger, Julia Höfler, Gudrun Kalss, Alexandra C Taylor, Giorgi Kuchukhidze, Eugen Trinka
Alterations of interaction (connectivity) of the EEG reflect pathological processes in patients with neurologic disorders. Nevertheless, it is questionable whether these patterns are reliable over time in different measures of interaction and whether this reliability of the measures is the same across different patient populations. In order to address this topic we examined 22 patients with mild cognitive impairment, five patients with subjective cognitive complaints, six patients with right-lateralized temporal lobe epilepsy, seven patients with left lateralized temporal lobe epilepsy, and 20 healthy controls...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28724444/adaptation-effects-in-static-postural-control-by-providing-simultaneous-visual-feedback-of-center-of-pressure-and-center-of-gravity
#7
Kenta Takeda, Hiroki Mani, Naoya Hasegawa, Yuki Sato, Shintaro Tanaka, Hiroshi Maejima, Tadayoshi Asaka
BACKGROUND: The benefit of visual feedback of the center of pressure (COP) on quiet standing is still debatable. This study aimed to investigate the adaptation effects of visual feedback training using both the COP and center of gravity (COG) during quiet standing. METHODS: Thirty-four healthy young adults were divided into three groups randomly (COP + COG, COP, and control groups). A force plate was used to calculate the coordinates of the COP in the anteroposterior (COPAP) and mediolateral (COPML) directions...
July 19, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28724430/egfr-modulates-monounsaturated-fatty-acid-synthesis-through-phosphorylation-of-scd1-in-lung-cancer
#8
Jiqin Zhang, Fei Song, Xiaojing Zhao, Hua Jiang, Xiuqi Wu, Biao Wang, Min Zhou, Mi Tian, Bizhi Shi, Huamao Wang, Yuanhui Jia, Hai Wang, Xiaorong Pan, Zonghai Li
BACKGROUND: Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monounsaturated fatty acids (MUFA) is recognized as a hallmark of cancer. However, how EGFR regulates MUFA synthesis in cancer remains elusive. This is the focus of our study. METHODS: The interaction between EGFR and stearoyl-CoA desaturase-1 (SCD1) was detected byco-immunoprecipitation...
July 19, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28724394/development-of-newborn-screening-connect-nbs-connect-a-self-reported-patient-registry-and-its-role-in-improvement-of-care-for-patients-with-inherited-metabolic-disorders
#9
Yetsa Osara, Kathryn Coakley, Aishwarya Devarajan, Rani H Singh
BACKGROUND: Newborn Screening Connect (NBS Connect) is a web-based self-reported patient registry and resource for individuals and families affected by disorders included in the newborn screening panel. NBS Connect was launched in 2012 by Emory University after years of planning and grassroots work by professionals, consumers, and industry. Individuals with phenylketonuria (PKU), maple syrup urine disease (MSUD) or tyrosinemia (TYR) have been recruited through distribution of outreach materials, presentations at parent organization meetings and direct recruitment at clinic appointments...
July 19, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28723760/bioinformatics-analysis-to-identify-the-critical-genes-micrornas-and-long-noncoding-rnas-in-melanoma
#10
Qian Zhang, Yang Wang, Jiulong Liang, Yaguang Tian, Yu Zhang, Kai Tao
Melanoma, which is usually induced by ultraviolet light exposure and the following DNA damage, is the most dangerous skin cancer. The purpose of the present study was to screen key molecules involved in melanoma.Microarray data of E-MTAB-1862 were downloaded from the ArrayExpress database, which included 21 primary melanoma samples and 11 benign nevus samples. In addition, the RNASeq version 2 and microRNA (miRNA) sequencing data of cutaneous melanoma were downloaded from The Cancer Genome Atlas database. After identifying the differentially expressed genes (DEGs) using Limma package, enrichment analysis and protein-protein interaction (PPI) network analysis were performed separately for them using DAVID software and Cytoscape software...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722534/valence-evaluation-with-approaching-or-withdrawing-cues-directly-testing-valence-arousal-conflict-theory
#11
Yan Mei Wang, Ting Li, Lin Li
The valence-arousal conflict theory assumes that both valence and arousal will trigger approaching or withdrawing tendencies. It also predicts that the speed of processing emotional stimuli will depend on whether valence and arousal trigger conflicting or congruent motivational tendencies. However, most previous studies have provided evidence of the interaction between valence and arousal only, and have not provided direct proof of the interactive links between valence, arousal and motivational tendencies. The present study provides direct evidence for the relationship between approach-withdrawal tendencies and the valence-arousal conflict...
July 19, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28722272/development-of-a-thiol-ene-based-screening-platform-for-enzyme-immobilization-demonstrated-using-horseradish-peroxidase
#12
Christian Hoffmann, Manuel Pinelo, John M Woodley, Anders E Daugaard
Efficient immobilization of enzymes on support surfaces requires an exact match between the surface chemistry and the specific enzyme. A successful match would normally be identified through time consuming screening of conventional resins in multiple experiments testing individual immobilization strategies. In this study we present a versatile strategy that largely expands the number of possible surface functionalities for enzyme immobilization in a single, generic platform. The combination of many individual surface chemistries and thus immobilization methods in one modular system permits faster and more efficient screening, which we believe will result in a higher chance of discovery of optimal surface/enzyme interactions...
July 19, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28721495/diversity-and-survival-of-artificial-lifeforms-under-sedimentation-and-random-motion
#13
Nicolas Glade, Olivier Bastien, Pascal Ballet
Cellular automata are often used to explore the numerous possible scenarios of what could have occurred at the origins of life and before, during the prebiotic ages, when very simple molecules started to assemble and organise into larger catalytic or informative structures, or to simulate ecosystems. Artificial self-maintained spatial structures emerge in cellular automata and are often used to represent molecules or living organisms. They converge generally towards homogeneous stationary soups of still-life creatures...
July 18, 2017: Theory in Biosciences, Theorie in Den Biowissenschaften
https://www.readbyqxmd.com/read/28720903/pharmacological-modulation-of-5-ht2c-receptor-activity-produces-bidirectional-changes-in-locomotor-activity-responding-for-a-conditioned-reinforcer-and-mesolimbic-da-release-in-c57bl-6-mice
#14
Caleb J Browne, Xiaodong Ji, Guy A Higgins, Paul J Fletcher, Colin Harvey-Lewis
Converging lines of behavioral, electrophysiological, and biochemical evidence suggest that 5-HT2C receptor signaling may bidirectionally influence reward-related behavior through an interaction with the mesolimbic dopamine (DA) system. Here we directly test this hypothesis by examining how modulating 5-HT2C receptor activity affects DA-dependent behaviors and relate these effects to changes in nucleus accumbens (NAc) DA release. In C57BL/6 mice, locomotor activity and responding for a conditioned reinforcer (CRf), a measure of incentive motivation, were examined following treatment with three 5-HT2C receptor ligands: the agonist CP809101 (0...
June 13, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28720707/intrinsically-disordered-chromatin-protein-nupr1-binds-to-the-c-terminal-region-of-polycomb-ring1b
#15
Patricia Santofimia-Castaño, Bruno Rizzuti, Ángel L Pey, Philippe Soubeyran, Miguel Vidal, Raúl Urrutia, Juan L Iovanna, José L Neira
Intrinsically disordered proteins (IDPs) are ubiquitous in eukaryotes, and they are often associated with diseases in humans. The protein NUPR1 is a multifunctional IDP involved in chromatin remodeling and in the development and progression of pancreatic cancer; however, the details of such functions are unknown. Polycomb proteins are involved in specific transcriptional cascades and gene silencing. One of the proteins of the Polycomb complex is the Ring finger protein 1 (RING1). RING1 is related to aggressive tumor features in multiple cancer types...
July 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28718283/disordered-linker-in-p53-participates-in-non-specific-binding-to-and-1d-sliding-along-dna-revealed-by-single-molecule-fluorescence-measurements
#16
Dwiky Rendra Graha Subekti, Agato Murata, Yuji Itoh, Satoshi Fukuchi, Hiroto Takahashi, Saori Kanbayashi, Satoshi Takahashi, Kiyoto Kamagata
The tumor suppressor p53 is a multidomain transcription factor that can quickly bind to its target DNA by sliding along the DNA strand. We hypothesized that the intrinsically disordered and positively charged linker of p53 regulates its search dynamics first by directly interacting with DNA and second by modulating hopping of the core domain. To test the two hypotheses, we prepared five variants of p53 in which the length and charge of the linker were modulated. Affinity to and sliding along non-specific DNA of p53 were altered by the charge of the linker, but not by the linker length...
July 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28717405/my-command-my-act-observation-inflation-in-face-to-face-interactions
#17
Roland Pfister, Katharina A Schwarz, Robert Wirth, Isabel Lindner
When observing another agent performing simple actions, these actions are systematically remembered as one's own after a brief period of time. Such observation inflation has been documented as a robust phenomenon in studies in which participants passively observed videotaped actions. Whether observation inflation also holds for direct, face-to-face interactions is an open question that we addressed in two experiments. In Experiment 1, participants commanded the experimenter to carry out certain actions, and they indeed reported false memories of self-performance in a later memory test...
2017: Advances in Cognitive Psychology
https://www.readbyqxmd.com/read/28717221/individual-recognition-of-opposite-sex-vocalizations-in-the-zebra-finch
#18
Pietro B D'Amelio, Milena Klumb, Mauricio N Adreani, Manfred L Gahr, Andries Ter Maat
Individual vocal recognition plays an important role in the social lives of many vocally active species. In group-living songbirds the most common vocalizations during communal interactions are low-intensity, soft, unlearned calls. Being able to tell individuals apart solely from a short call would allow a sender to choose a specific group member to address, resulting in the possibility to form complex communication networks. However, little research has yet been carried out to discover whether soft calls contain individual identity...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716966/hierarchically-organized-medial-frontal-cortex-basal-ganglia-loops-selectively-control-task-and-response-selection
#19
Franziska M Korb, Jiefeng Jiang, Joseph A King, Tobias Egner
Adaptive behavior requires context-sensitive configuration of task-sets that specify time-varying stimulus-response mappings. Intriguingly, response time costs associated with changing task-sets and motor responses are known to be strongly interactive: switch costs at the task-level are small in the presence of a response-switch but large when accompanied by a response-repetition, and vice versa for response-switch costs. The reasons behind this well-known inter-dependence between task- and response-level control processes are currently not well understood...
July 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28716545/effect-of-ageing-on-neurocognitive-function-by-stage-of-hiv-infection-evidence-from-the-multicenter-aids-cohort-study
#20
Karl Goodkin, Eric N Miller, Christopher Cox, Sandra Reynolds, James T Becker, Eileen Martin, Ola A Selnes, David G Ostrow, Ned C Sacktor
BACKGROUND: The demographics of the HIV epidemic in the USA have shifted towards older age. We aimed to establish the relationship between the processes of ageing and HIV infection in neurocognitive impairment. METHODS: With longitudinal data from the Multicenter AIDS Cohort Study, a long-term prospective cohort study of the natural and treated history of HIV infection among men who have sex with men in the USA, we examined the effect of ageing, HIV infection (by disease stage), and their interaction on five neurocognitive domains: information processing speed, executive function, episodic memory, working memory, and motor function...
July 14, 2017: Lancet HIV
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