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Manar Adam, Gihan O M Elhassan, Sakina Yagi, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdel Azim Ahmed, Thomas Efferth
We investigated the antioxidant potential and cytotoxicity towards human CCRF-CEM leukemia cells of 57 extracts obtained from 18 plants collected in the Erkowit region, eastern Sudan. The antioxidant activity was determined by measuring the radical scavenging effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N-dimethyl-p-phenylendiamine (DMPD), metal-chelation capacity, ferric-reducing (FRAP) and phosphomolibdenum-reducing antioxidant power (PRAP) methods using ELISA microtiter assays. Total phenol and flavonoid amounts of the extracts were determined spectrophotometrically...
February 16, 2018: Natural Products and Bioprospecting
Hua Zhao, Aihua Liu, Longqiang Shen, Cuiping Xu, Ziwei Zhu, Jiaru Yang, Xinling Han, Fukai Bao, Weimin Yang
The plant Coleus forskohlii is distributed primarily in India, Thailand, China, Egypt and Brazil and has a history of use in the treatment of multiple diseases. Isoforskolin (ISOF) is the principle active component of C. forskohlii native to China and has previously been studied for its biological effects. The aim of the present study was to evaluate the effect of ISOF on the proinflammatory responses induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In in vitro experiments, the proinflammatory effects of rBmpA and the anti-inflammatory function of ISOF were evaluated in murine macrophages, human macrophages and dendritic cells by detecting the transcription and expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6...
December 2017: Experimental and Therapeutic Medicine
Rui Pan, Le Xu, Qiao Wei, Chu Wu, Wenlin Tang, Ralf Oelmüller, Wenying Zhang
Flowering in plants is synchronized by both environmental cues and internal regulatory factors. Previous studies have shown that the endophytic fungus Piriformospora indica promotes the growth and early flowering in Coleus forskohlii (a medicinal plant) and Arabidopsis. To further dissect the impact of P. indica on pathways responsible for flowering time in Arabidopsis, we co-cultivated Arabidopsis with P. indica and used RT-qPCR to analyze the main gene regulation networks involved in flowering. Our results revealed that the symbiotic interaction of Arabidopsis with P...
2017: PloS One
Tahir Mehmood Khan, David Bin-Chia Wu, Anton V Dolzhenko
A systematic review and network-meta analysis (NMA) were performed to test significance of the galactagogue effect of fenugreek administrated to lactating women versus other comparators (i.e., placebo/control/other galactagogues). A pairwise comparison for the treatment effect was carried out to generate the forest plot for the NMA. League tables were generated using treatment effect, weighted mean difference (WMD; 95% confidence interval, CI) for all pairwise comparisons, where WMD > 0 favors the column-defining treatment...
November 30, 2017: Phytotherapy Research: PTR
Swabha Takshak, Shashi Bhushan Agrawal
Ultraviolet (UV)-B radiation and the growth hormone indole-3-acetic acid (IAA) have been known to cause various changes in plants at morphological and physiological levels as individual entities, but their interactive effects on the overall plant performance remain practically unknown. The present study was conducted under near-natural field conditions to evaluate the effects of supplemental (s)-UV-B (ambient+3.6kJm(-2)day(-1)) treatment alone, and in combination with two doses of IAA (200ppm and 400ppm) exogenously applied as foliar spray on various growth-, morphological-, physiological-, and biochemical parameters of an indigenous medicinal plant, Coleus forskohlii...
January 2018: Ecotoxicology and Environmental Safety
Dongjin Kim, Mohamad E Abdelaziz, Valentine Otang Ntui, Xiujie Guo, Salim Al-Babili
Piriformospora indica is an endophytic fungus colonizing roots of a wide variety of plants. Previous studies showed that P. indica promotes early flowering and plant growth in the medicinal plant Coleus forskohlii. To determine the impact of P. indica on flowering time in Arabidopsis, we co-cultivated the plants with P. indica under long day condition. P. indica inoculated Arabidopsis plants displayed significant early flowering phenotype. qRT-PCR analysis of colonized plants revealed an up-regulation of flowering regulatory (FLOWERING LOCUS T, LEAFY, and APETALA1) and gibberellin biosynthetic (Gibberellin 20-Oxidase2, Gibberellin 3-Oxidase1 and Gibberellin requiring1) genes, while the flowering-repressing gene FLOWERING LOCUS C was down regulated...
September 2, 2017: Biochemical and Biophysical Research Communications
Qinlong Zhu, Suize Yu, Dongchang Zeng, Hongmei Liu, Huicong Wang, Zhongfang Yang, Xianrong Xie, Rongxin Shen, Jiantao Tan, Heying Li, Xiucai Zhao, Qunyu Zhang, Yuanling Chen, Jingxing Guo, Letian Chen, Yao-Guang Liu
Anthocyanins have high antioxidant activities, and engineering of anthocyanin biosynthesis in staple crops, such as rice (Oryza sativa L.), could provide health-promoting foods for improving human health. However, engineering metabolic pathways for biofortification remains difficult, and previous attempts to engineer anthocyanin production in rice endosperm failed because of the sophisticated genetic regulatory network of its biosynthetic pathway. In this study, we developed a high-efficiency vector system for transgene stacking and used it to engineer anthocyanin biosynthesis in rice endosperm...
July 5, 2017: Molecular Plant
Yigal Cohen, Yariv Ben-Naim, Lidan Falach, Evgenia Rubin
Basil downy mildew (BDM) caused by the oomycete Peronospora belbahrii is a destructive disease of sweet basil (Ocimum basilicum) worldwide. It has originated in Uganda in the 1930's and recently spread to Europe, Middle East, Americas and the Far East. Seed transmission may be responsible to its quick global spread. The pathogen attacks leaf blades, producing chlorotic lesions with ample dark asexual spores on the lower leaf surface. Oospores may occur in the mesophyll of infected leaves. The asexual spores germinate on a wet leaf surface within 2h and penetrate into the epidermis within 4h...
April 24, 2017: Phytopathology
Irini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen, Sileshi Gizachew Wubshet, Allison Maree Heskes, Victor Forman, Björn Hallström, Britta Hamberger, Mohammed Saddik Motawia, Carl Erik Olsen, Dan Staerk, Jørgen Hansen, Birger Lindberg Møller, Björn Hamberger
Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant Coleus forskohlii, in which forskolin accumulates in the root cork. Here, we report the discovery of five cytochrome P450s and two acetyltransferases which catalyze a cascade of reactions converting the forskolin precursor 13R-manoyl oxide into forskolin and a diverse array of additional labdane-type diterpenoids...
March 14, 2017: ELife
Narangerel Altangerel, Gombojav O Ariunbold, Connor Gorman, Masfer H Alkahtani, Eli J Borrego, Dwight Bohlmeyer, Philip Hemmer, Michael V Kolomiets, Joshua S Yuan, Marlan O Scully
Development of a phenotyping platform capable of noninvasive biochemical sensing could offer researchers, breeders, and producers a tool for precise response detection. In particular, the ability to measure plant stress in vivo responses is becoming increasingly important. In this work, a Raman spectroscopic technique is developed for high-throughput stress phenotyping of plants. We show the early (within 48 h) in vivo detection of plant stress responses. Coleus ( Plectranthus scutellarioides ) plants were subjected to four common abiotic stress conditions individually: high soil salinity, drought, chilling exposure, and light saturation...
March 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
Dadasaheb D Wadikar, Prakash E Patki
The herb Coleus aromaticus belonging to Lamiaceae family and Coleus genus is known by numerous names in different parts of the world and several language specific vernacular names. The herb has been extensively studied as well as reported in several fields of science. The multiple potential of the herb includes allelopathic potential, antibacterial property, antimicrobial activity, insecticidal property; free radical scavenging and radio-protective components from herb extracts and most recently the appetizing potential of the herb have been reported...
July 2016: Journal of Food Science and Technology
Luigi Sapio, Monica Gallo, Michela Illiano, Emilio Chiosi, Daniele Naviglio, Annamaria Spina, Silvio Naviglio
Cancer is a major public health problem and the second leading cause of mortality around the world. Although continuous advances in the science of oncology and cancer research are now leading to improved outcomes for many cancer patients, novel cancer treatment options are strongly demanded. Naturally occurring compounds from a variety of vegetables, fruits, and medicinal plants have been shown to exhibit various anticancer properties in a number of in vitro and in vivo studies and represent an attractive research area for the development of new therapeutic strategies to fight cancer...
May 2017: Journal of Cellular Physiology
Praveen Awasthi, Vidushi Mahajan, Vijay Lakshmi Jamwal, Nitika Kapoor, Shafaq Rasool, Yashbir S Bedi, Sumit G Gandhi
Flavonoids are an important class of secondary metabolites that play various roles in plants such as mediating defense, floral pigmentation and plant-microbe interaction. Flavonoids are also known to possess antioxidant and antimicrobial activities. Coleus forskohlii (Willd.) Briq. (Lamiaceae) is an important medicinal herb with a diverse metabolic profile, including production of a flavonoid, genkwanin. However, components of the flavonoid pathway have not yet been studied in this plant. Chalcone synthase (CHS) catalyses the first committed step of flavonoid biosynthetic pathway...
September 2016: Journal of Genetics
Praveen Awasthi, Ajai Prakash Gupta, Yashbir S Bedi, Ram A Vishwakarma, Sumit G Gandhi
Cytochrome P450 monooxygenases (CYP450s) are known to play important roles in biosynthesis of all secondary metabolites, including flavonoids. Despite this, few CYP450s have been functionally characterized in model plants and roles of fewer CYP450s are known in non-model, medicinal, and aromatic plants. Our study in Coleus forskohlii indicates that flavone synthase (CYP93B) and flavonoid 3' monooxygenase (CYP706C) are key enzymes positioned at a metabolic junction, to execute the biosynthesis of different sub-classes of flavonoids (flavones, flavonol, anthocynanin, isoflavones etc...
2016: Frontiers in Plant Science
Saraschandra Naraginti, P Lakshmi Kumari, Raunak Kumar Das, A Sivakumar, Sagar Hindurao Patil, Vaibhav Vilas Andhalkar
Wound healing, a complex biological process, has attained a lot of attention as dermatologists are primarily interested in stimulated wound closure without formation of scar or a faint scar. The recent upsurgence of nanotechnology has provided novel therapeutic materials in the form of silver and gold nanoparticles which accelerate the wound healing process. The effect of formulated nanoparticles using Coleus forskohlii root extract (green synthesized) has been tried out for ameliorating full thickness excision wounds in albino Wistar male rats...
May 2016: Materials Science & Engineering. C, Materials for Biological Applications
Shivaprasad Hebbani Nagarajappa, Subrata Pandit, Manohar Divanji, Bhanumathy Mariyanna, Pavan Kumar, Ashok Godavarthi
Coleus forskohlii Briq. has been used traditionally for the treatment of several ailments since antiquity in Ayurveda. In the present study, an approach has been made to evaluate the effect of C. forskohlii and its major constituents on cytochrome P450 (CYP3A, CYP2B, and CYP2C) mRNA expression in rat hepatocytes. To gain better understanding of the herb-drug interaction potential of the chemical constituents present in C. forskohlii, the extract was subjected to column chromatography followed by standardization with respect to forskolin, 1-deoxyforskolin, and 1,9-dideoxyforskolin using reversed-phase high-performance liquid chromatography (RP-HPLC)...
January 2016: Journal of Traditional and Complementary Medicine
Sidney J Stohs, Vladimir Badmaev
Obesity and overweight are major health issues. Exercise and calorie intake control are recognized as the primary mechanisms for addressing excess body weight. Naturally occurring thermogenic plant constituents offer adjunct means for assisting in weight management. The controlling mechanisms for thermogenesis offer many intervention points. Thermogenic agents can act through stimulation of the central nervous system with associated adverse cardiovascular effects and through metabolic mechanisms that are non-stimulatory or a combination thereof...
May 2016: Phytotherapy Research: PTR
Vidya Vilas, Daizy Philip, Joseph Mathew
Our quest for a green, non-toxic and environmentally benign synthetic design for the fabrication of metal nanoparticles has led to the use of essential oil present in plant parts as the bioreductant. In this report, silver particles at nanoscale have been synthesized using essential oil present in the leaves of Coleus aromaticus at physiological pH and at 373 K. UV-vis spectra of the colloid display strong plasmon bands centred around 396-411 nm, characteristic of silver nanoparticles. Comparative studies of the FTIR spectra of essential oil and silver nanoparticles reveal the involvement of terpenes and their phenolic derivatives in reduction and subsequent stabilization...
April 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Nitin Chopra, Lon Hays
There have been very limited reports of the euphoria experienced under the influence of Coleus blumei--part of a large genus with similarities to various mints and herbs, naturally found in abundance and popular in home gardens. There have been reports of similar properties to Salvia divinorum, which contains the psychoactive neocleordane diterpene salvinorin-A. We present a case of a man in his twenties, with no significant known personal or family psychiatric history, presenting to an emergency room with a psychotic episode after the ingestion of C...
January 2016: Journal of Addiction Medicine
Ennus Tajuddin Tamboli, Karishma Chester, Sayeed Ahmad
OBJECTIVE: Current trend of commercialization of herbal medicines draw a huge need of maintaining their quality. The declaration of quality, safety and efficacy of medicinal plants as well as poly-herbal formulations has become an important issue. Hence, qualitative and quantitative analysis of herbal drugs and formulations viz., fingerprint profiles and quantification of the various markers become key factors of quality control. MATERIALS AND METHODS: Present investigation is a detailed report for quality control of well-known herb Coleus forskohlii Briq, which includes physicochemical parameter determination, safety evaluation, microscropical evaluation, and chromatographic fingerprinting as well...
October 2015: Journal of Pharmacy & Bioallied Sciences
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