Mara Aparecida Maricato Poma, Howard Lopes Ribeiro Junior, Eugênio Araújo Costa, Carlos Roberto Koscky Paier, Laís Lacerda Brasil, Luína Benevides Lima, Livia Maria Soares Nobre, Tayales Tavares Leite, Roberto César Pereira Lima-Júnior, Ana Rosa Pinto Quidute, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes Filho
BACKGROUND: The aim of this study was to investigate the effect of CYB2B6 (c.516G>T, rs3745274), CYP2C9 (c.1075A>C, rs1057910) and UGT1A9 (c.98T>C, rs72551330) polymorphisms on the pharmacokinetics of single-drug propofol in adult patients undergoing intravenous sedation. METHODS: In this prospective clinical study, a total of 124 patients undergoing anaesthesia with propofol, as a single drug, were evaluated when undergoing colonoscopy procedure. Clinical variables were obtained from the patient's anamnesis prior to performing the anaesthetic procedure, in the moment of the patient's loss of consciousness, during the colonoscopy exam (recorded every 5 min) and in the awakening time...
May 22, 2023: Postgraduate Medical Journal