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https://www.readbyqxmd.com/read/29053004/effect-of-inositol-and-its-derivatives-on-diabetes-a-systematic-review
#1
Ayçıl Özturan, Sabriye Arslan, Betül Kocaadam, Emine Elibol, İdil İmamoğlu, Makbule Gezmen Karadağ
A growing body of research has investigated the association between inositol and diabetes. The purpose of this review is to report through a systematic way the current scientific evidence relating potential benefits of inositol isomers on diabetes/gestational diabetes. The screening of the studies published last decade was performed in 4 databases (Pubmed-Web of Science-The Cochrane Library-Lilacs). Among the 1640 studies identified in the search, only 26 studies had sufficient data to be included in the systematic review...
October 20, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29052558/cesarean-section-rate-in-singleton-primiparae-and-related-factors-in-beijing-china
#2
Geng Song, Yu-Mei Wei, Wei-Wei Zhu, Hui-Xia Yang
BACKGROUND: The cesarean section rate (CSR) has been a main concern worldwide. The present study aimed to investigate the CSR in Beijing, China, and to analyze the related factors of CS delivery. METHODS: An observational study was conducted in 15 medical centers in Beijing using a systemic cluster sampling method. In total, 15,194 pregnancies were enrolled in the study between June 20, 2013 and November 30, 2013. Independent t-tests and Pearson's Chi-square test were used to examine differences between two groups, and related factors of the CSR were examined by multivariable logistic regression...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29051780/sensitivity-of-postnatal-fasting-plasma-glucose-in-identifying-impaired-glucose-tolerance-in-women-with-gestational-diabetes-25-years-data
#3
Habiba Kapaya, Lucy May, Richard Jacques, Priya Madhuvrata
OBJECTIVE: To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance. METHODS: Retrospective study of 1961 women diagnosed with gestational diabetes mellitus. All women were offered oral glucose tolerance test six weeks post-delivery. RESULTS: Of 1961 women, 1090 (56%) returned for postpartum oral glucose tolerance test. A fasting plasma glucose of ≥6...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29051779/childhood-maltreatment-and-inflammation-among-pregnant-women-with-gestational-diabetes-mellitus-a-pilot-study
#4
Margaret Bublitz, Suzanne De La Monte, Susan Martin, Lucia Larson, Ghada Bourjeily
BACKGROUND: Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes. METHODS: This pilot study was a secondary data analysis of 24 women with gestational diabetes mellitus; 17% of the sample also reported a maltreatment history. Women provided a blood sample to measure inflammatory cytokines and insulin resistance, and saliva samples to measure diurnal cortisol...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29051520/longitudinal-assessment-of-hla-and-mic-a-antibodies-in-uneventful-pregnancies-and-pregnancies-complicated-by-preeclampsia-or-gestational-diabetes
#5
Lorenz Küssel, Harald Herkner, Markus Wahrmann, Farsad Eskandary, Konstantin Doberer, Julia Binder, Petra Pateisky, Harald Zeisler, Georg A Böhmig, Gregor Bond
The significance of antibodies directed against paternal epitopes in the context of obstetric disorders is discussed controversially. In this study anti-HLA and anti-MIC-A antibodies were analysed in sera of women with uneventful pregnancy (n = 101), preeclampsia (PE, n = 55) and gestational diabetes (GDM, n = 36) using antigen specific microbeads. While two thirds of the women with uneventful pregnancy or GDM were HLA and MIC-A antibody positive in gestational week 11 to 13 with a modest increase towards the end of pregnancy, women with PE showed an inverse kinetic: 90% were HLA antibody positive in gestational week 11 to 13 and only 10% showed HLA reactivities at the end of the pregnancy...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051041/retinal-vasculature-and-5-year-metabolic-syndrome-among-women-with-gestational-diabetes-mellitus
#6
Ling-Jun Li, Kok Hian Tan, Izzuddin M Aris, Ryan Eyn Kidd Man, Alfred Tau Liang Gan, Yap Seng Chong, Seang Mei Saw, Peter Gluckman, Tien Yin Wong, Ecosse Lamoureux
BACKGROUND: Women with gestational diabetes mellitus (GDM) are at greater risk of metabolic syndrome (MetS). We studied the association between second-trimester retinal microvasculature and 5-year MetS incidence in women with GDM. METHODS: A total of 142 mothers with GDM were recruited and followed up 5 years after delivery. Retinal photography was performed at 26-28 weeks gestation and metabolic outcomes were assessed at the 5-year postpartum follow-up visit. GDM and MetS were defined based on World Health Organization (WHO) guidelines and Adults Treatment Panel (ATP) III guidelines, respectively...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29050787/transplantation-routes-affect-the-efficacy-of-human-umbilical-cord-mesenchymal-stem-cells-in-a-rat-gdm-model
#7
Dan Wu, Shan Zou, Haibin Chen, Xiaoyan Li, Yetao Xu, Qing Zuo, Yi Pan, Shi-Wen Jiang, Huan Huang, Lizhou Sun
Gestational diabetes mellitus (GDM) is harmful to both the mother and fetus. Although transplantation of human umbilical cord mesenchymal stem cells (HUMSCs) could be a useful therapy for GDM, the influences of different transplantation routes on the therapeutic effects remain unclear. In this study, we isolated and cultured the HUMSCs for transplantation, and the biological activity of HUMSCs was verified by flow cytometric analysis (the positive markers, CD44, CD73, CD105 and CD90, the negative markers, CD45, CD34, CD19, HLA-DR, and CD11b) and potency of osteogenic, adipogenic and chondrogenic differentiation...
October 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29050747/soluble-pro-renin-receptor-in-preeclampsia-and-diabetic-pregnancies
#8
Meryam Sugulle, Harald Heidecke, Ulrike Maschke, Florian Herse, A H Jan Danser, Dominik N Mueller, Anne Cathrine Staff, Ralf Dechend
Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro)renin receptor has enzymatic activity. We hypothesized that soluble (pro)renin receptor levels are elevated in high-risk pregnancies. Third trimester maternal blood samples from complicated pregnancies (n = 165), (preeclampsia [n = 76], diabetes mellitus [type I diabetes, n = 35; type II diabetes, n = 11; gestational diabetes mellitus, n = 43]), and healthy pregnancies (n = 49) were analyzed for prorenin, renin, and soluble (pro)renin receptor...
October 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29049820/association-of-history-of-gestational-diabetes-with-long-term-cardiovascular-disease-risk-in-a-large-prospective-cohort-of-us-women
#9
Deirdre K Tobias, Jennifer J Stuart, Shanshan Li, Jorge Chavarro, Eric B Rimm, Janet Rich-Edwards, Frank B Hu, JoAnn E Manson, Cuilin Zhang
Importance: Previous studies identify gestational diabetes (GD) as a risk factor for intermediate markers of cardiovascular disease (CVD) risk; however, few are prospective, evaluate hard CVD end points, or account for shared risk factors including body weight and lifestyle. Objective: To prospectively evaluate history of GD in relation to incident CVD risk. Design, Setting, and Participants: The Nurses' Health Study II (NHS II) is an observational cohort study of US female nurses established in 1989, with ongoing follow-up...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049303/a-mediterranean-diet-with-additional-extra-virgin-olive-oil-and-pistachios-reduces-the-incidence-of-gestational-diabetes-mellitus-gdm-a-randomized-controlled-trial-the-st-carlos-gdm-prevention-study
#10
Carla Assaf-Balut, Nuria García de la Torre, Alejandra Durán, Manuel Fuentes, Elena Bordiú, Laura Del Valle, Cristina Familiar, Ana Ortolá, Inés Jiménez, Miguel A Herraiz, Nuria Izquierdo, Noelia Perez, María J Torrejon, María I Ortega, Francisco J Illana, Isabelle Runkle, Maria P de Miguel, Carmen Montañez, Ana Barabash, Martín Cuesta, Miguel A Rubio, Alfonso L Calle-Pascual
BACKGROUND: Gestational diabetes mellitus (GDM) prevalence is increasing and becoming a major public health concern. Whether a Mediterranean diet can help prevent GDM in unselected pregnant women has yet to be studied. METHODS: We conducted a prospective, randomized controlled trial to evaluate the incidence of GDM with two different dietary models. All consecutive normoglycemic (<92 mg/dL) pregnant women at 8-12 gestational weeks (GW) were assigned to Intervention Group (IG, n = 500): MedDiet supplemented with extra virgin olive oil (EVOO) and pistachios; or Control Group (CG, n = 500): standard diet with limited fat intake...
2017: PloS One
https://www.readbyqxmd.com/read/29048747/association-between-gestational-diabetes-mellitus-exposure-and-childhood-adiposity-is-not-substantially-explained-by-offspring-genetic-risk-of-obesity
#11
S Raghavan, W Zhang, I V Yang, L A Lange, E M Lange, T E Fingerlin, D Dabelea
AIM: To examine the extent to which offspring obesity-associated genetic risk explains the association between gestational diabetes mellitus and childhood adiposity. METHODS: We studied 282 children aged 7-12 years who were enrolled in the Exploring Perinatal Outcomes in Children Study. A genetic risk score for BMI was calculated as the count of 91 established BMI-raising risk alleles. Multivariable linear and logistic regression models were used to estimate associations between the offspring genetic risk score and exposure to gestational diabetes and childhood adiposity (BMI and waist circumference), adjusting for clinical and demographic covariates...
October 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29048742/permanent-neonatal-diabetes-caused-by-abnormalities%C3%A2-in%C3%A2-chromosome%C3%A2-6q24
#12
B Y Cao, C X Gong, D Wu, X Q Li
BACKGROUND: Methylation defects at chromosome 6q24 usually induce transient neonatal diabetes mellitus. There are few reports of permanent neonatal diabetes mellitus caused by abnormalities of 6q24. We report the first case of permanent neonatal diabetes mellitus to be associated with confirmed methylation defects at chromosome 6q24. CASE REPORT: A baby girl, small for her gestational age, was found to have high blood glucose 1 day after birth, with no systematic congenital anomalies...
October 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29048411/early-versus-6-12-week-postpartum-glucose-tolerance-testing-for-women-with-gestational-diabetes
#13
E B Carter, S Martin, L A Temming, G A Colditz, G A Macones, M G Tuuli
OBJECTIVE: The objective of this study is to estimate the accuracy of early oral glucose tolerance testing (GTT), to predict impaired glucose tolerance. STUDY DESIGN: This was a prospective cohort study. Women received an early 75 g 2 h GTT between postpartum days 2-4 and again 6-12 weeks postpartum. The ability of the early GTT to accurately detect impaired glucose tolerance and diabetes was assessed by calculating sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPVs)...
October 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29047402/associations-of-physical-activity-and-sedentary-behavior-during-pregnancy-with-gestational-diabetes-mellitus-among-asian-women-in-singapore
#14
Natarajan Padmapriya, Jonathan Y Bernard, Shen Liang, See Ling Loy, Shirong Cai, Iris Shen Zhe, Kenneth Kwek, Keith M Godfrey, Peter D Gluckman, Seang Mei Saw, Yap-Seng Chong, Jerry Kok Yen Chan, Falk Müller-Riemenschneider
BACKGROUND: Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. METHODS: As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26-28 weeks' gestation we measured FG, 2hPG levels and GDM (FG ≥ 7...
October 18, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29046229/fetal-overnutrition-and-adolescent-hepatic-fat-fraction-the-exploring-perinatal-outcomes-in-children-study
#15
Anna Bellatorre, Ann Scherzinger, Elizabeth Stamm, Mercedes Martinez, Brandy Ringham, Dana Dabelea
OBJECTIVE: To determine if fetal overnutrition resulting from maternal obesity or gestational diabetes mellitus (GDM) is associated with increased liver fat during adolescence, adjusting for past and current metabolic risk factors. STUDY DESIGN: Data come from a historical prospective cohort study (Exploring Perinatal Outcomes in Children) of 254 mother-child pairs in Colorado who participated in 2 research visits at T1 (mean age 10.4, SD = 1.5 years) and at T2 (mean age 16...
October 15, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29045765/oral-anti-diabetic-agents-for-women-with-established-diabetes-impaired-glucose-tolerance-or-previous-gestational-diabetes-planning-pregnancy-or-pregnant-women-with-pre-existing-diabetes
#16
REVIEW
Joanna Tieu, Suzette Coat, William Hague, Philippa Middleton, Emily Shepherd
BACKGROUND: While most guidance recommends the use of insulin in women whose pregnancies are affected by pre-existing diabetes, oral anti-diabetic agents may be more acceptable to women. The effects of these oral anti-diabetic agents on maternal and infant health outcomes need to be established in pregnant women with pre-existing diabetes or impaired glucose tolerance, as well as in women with previous gestational diabetes mellitus preconceptionally or during a subsequent pregnancy. OBJECTIVES: To investigate the effects of oral anti-diabetic agents in women with established diabetes, impaired glucose tolerance or previous gestational diabetes who are planning a pregnancy, or pregnant women with pre-existing diabetes, on maternal and infant health...
October 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29044502/factors-associated-with-patients-with-gestational-diabetes-in-japan-being-at-increased-risk-of-requiring-intensive-care
#17
Hiroshi Yamashita, Ichiro Yasuhi, Yukari Kugishima, So Sugimi, Yasushi Umezaki, Sachie Suga, Masashi Fukuda, Nobuko Kusuda
OBJECTIVE: To investigate factors associated with high-risk gestational diabetes (GDM) among patients with GDM. METHODS: The present retrospective study included women with singleton pregnancies diagnosed with GDM using International Association of Diabetes and Pregnancy Study Group criteria at a single tertiary perinatal care center in Japan between July 1, 2010, and October 31, 2014. High-risk GDM was defined as patients who required at least 20 units of insulin therapy a day, delivering a large-for-gestational age neonate regardless of insulin therapy, or both...
October 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29038315/adiposity-dysmetabolic-traits-and-earlier-onset-of-female-puberty-in-adolescent-offspring-of-women-with-gestational-diabetes-mellitus-a-clinical-study-within-the-danish-national-birth-cohort
#18
Louise G Grunnet, Susanne Hansen, Line Hjort, Camilla M Madsen, Freja B Kampmann, Anne Cathrine B Thuesen, Charlotta Granstrømi, Marin Strøm, Ekaterina Maslova, Ruth Frikke-Schmidt, Peter Damm, Jorge E Chavarro, Frank B Hu, Sjurdur F Olsen, Allan Vaag
OBJECTIVE: Offspring of pregnancies affected by gestational diabetes mellitus (GDM) are at increased risk of the development of type 2 diabetes. However, the extent to which these dysmetabolic traits may be due to offspring and/or maternal adiposity is unknown. We examined body composition and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. RESEARCH DESIGN AND METHODS: We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipids levels; and conducted a DEXA scan in a subset of the cohort...
October 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29037224/maternal-and-fetal-blood-lipid-concentrations-during-pregnancy-differ-by-maternal-body-mass-index-findings-from-the-rolo-study
#19
Aisling A Geraghty, Goiuri Alberdi, Elizabeth J O'Sullivan, Eileen C O'Brien, Brenda Crosbie, Patrick J Twomey, Fionnuala M McAuliffe
BACKGROUND: Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations have been associated with adverse pregnancy outcomes such as gestational diabetes, pregnancy-induced hypertension and high birth weight. As blood lipids are not routinely measured during pregnancy, there is limited information on what is considered normal during pregnancy and in fetal blood...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29036213/the-value-of-real-time-continuous-glucose-monitoring-in-premature-infants-of-diabetic-mothers
#20
Hean-Pat Saw, Nai-Wei Yao, Cheng-Di Chiu, Jia-Yuh Chen
To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk of blood sugar abnormalities. Thirty preterm babies (M = 15 and F = 15; ≤ 36 week gestation age) were studied from within 72 hours of delivery. These babies were admitted to the newborn intensive care and were further categorized into groups based on whether their mothers with or without diabetic mellitus. Blood sugar levels were monitored by both RTGMS and the traditional intermittent arterial line (A-Line) glucose method...
2017: PloS One
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