keyword
https://read.qxmd.com/read/38538223/tanshinone-iia-regulates-synaptic-plasticity-in-mg-2-free-induced-epileptic-hippocampal-neurons-via-the-pi3k-akt-signaling-pathway
#21
JOURNAL ARTICLE
Meile Ma, Xi Hua, Chen Jia, Nan Xiao, Li Zhang, Liming Wei, Haisheng Jiao
BACKGROUND: Tanshinone IIA (TSIIA) is an element of the effective ingredients of Salvia miltiorrhiza Bunge (Labiatae), exhibits a significant therapeutic effect in brain neuroprotection. The focus of this study was the examination of synaptic plasticity of in Mg2+-free-induced epileptic hippocampus neurons and how TSIIA protects against it. METHODS: The purity of the primary hippocampal neurons extracted from Sprague Dawley rats was assessed within 24 hours by microtubule-associated protein (MAP2) immunofluorescence staining...
March 19, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38537259/towards-the-establishment-of-national-diagnostic-reference-levels-for-abdomen-kub-and-lumbar-spine-x-ray-examinations-in-sri-lanka-a-multi-centric-study
#22
JOURNAL ARTICLE
Sachith Welarathna, Sivakumar Velautham, Sivananthan Sarasanandarajah
Diagnostic reference levels (DRLs) and achievable doses (ADs) provide guidance to optimise radiation doses for patients undergoing medical imaging procedures. This multi-centre study aimed to compare institutional DRLs (IDRLs) across hospitals, propose ADs and multi-centric DRLs (MCDRLs) for four common x-ray examinations in Sri Lanka, and assess the potential for dose reduction. A prospective cross-sectional study of 894 adult patients referred for abdomen anteroposterior (AP), kidney-ureter-bladder (KUB) AP, lumbar spine AP, and lumbar spine lateral (LAT) x-ray examinations was conducted...
March 27, 2024: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/38536722/accuracy-and-risk-factors-of-magerl-screw-placement-in-robot-assisted-atlantoaxial-surgery-a-case-series-study
#23
JOURNAL ARTICLE
Wu Jiayuan, Wei Yi, Duan Fangfang, He Da, Jiang Xieyuan, Tian Wei
BACKGROUND: To assess the accuracy of robot-assisted Magerl screw placement and explore the factors affecting the accuracy. METHODS: A retrospective analysis of patients who underwent robot-assisted Magerl screw placement was performed. The accuracy of Magerl screw placement was evaluated according to the Gertzbein and Robbins scale. RESULTS: 47 Magerl screws were placed in 24 consecutive patients. 32 Magerl screws were narrower than the C2 isthmus height and 26 of them were grade A...
February 2024: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://read.qxmd.com/read/38536497/large-symptomatic-sacral-tarlov-cyst-in-a-paediatric-patient-case-report-and-technical-note-on-a-new-variation-of-surgical-technique-to-overcome-one-way-check-valve-mechanism
#24
JOURNAL ARTICLE
Sebastian Siller, Jonathan P Funnell, Tim Bishop, Darren Lui, Jason Bernard
PURPOSE: Symptomatic Tarlov cysts in children with a possible underlying one-way check-valve mechanism are very rare. We aim to introduce a new variation of the surgical technique to overcome a check-valve mechanism. METHODS: A 15-years-old girl presented with double incontinence and anogenital numbness due to a large sacral Tarlov-cyst with possibly underlying one-way check valve mechanisms as suggested by preoperative computed tomography myelography. Intraoperatively, one-way check-valve was confirmed and could be eliminated by creating an artificial inner ostium between the Tarlov cyst and thecal sac with blunt perforation...
March 27, 2024: European Spine Journal
https://read.qxmd.com/read/38536450/surgical-management-of-chiari-ii-malformation-a-systematic-review-of-literature
#25
REVIEW
Rafael C C Vencio, Adriano M Lino-Filho, Renata C F Bonfim, Nayara M Pereira, Cilmária L Franco, Paulo Ronaldo J Ribeiro, Bárbara A Morais
PURPOSE: Chiari II malformation (CM-II) is a congenital malformation of the posterior fossa associated with myelomeningocele. Of the symptomatic patients, 10-33% require surgical treatment. To this date, there is not a consensus about the best surgical technique, and whether to do duroplasty. METHODS: A literature search of the PubMed database and crossed references was performed, per PRISMA guidelines. Data regarding demographic features, extent of cervicomedullary deformity, clinical presentation, surgical techniques, and clinical outcomes were extracted...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38535435/disc-degeneration-and-cervical-spine-intervertebral-motion-a-cross-sectional-study-in-patients-with-neck-pain-and-matched-healthy-controls
#26
JOURNAL ARTICLE
Jonathan Branney, Alexander Breen, Alister du Rose, Philip Mowlem, Alan Breen
While neck pain can be defined in clinical terms, in most cases the underlying pathophysiology is largely unknown. Regional cervical spine range of motion is often found to be reduced in patients with neck pain compared to persons without pain although it is not clear if the decreased range is cause or effect. Less is known about the role of intervertebral kinematics and how that might be related to the presence of disc degeneration. In this study, the prevalence of intervertebral disc degeneration and continuous cervical intervertebral motion were both measured utilizing quantitative fluoroscopy (QF) in patients with subacute or chronic neck pain ( n = 29) and gender-matched healthy controls ( n = 30)...
March 19, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38533920/when-will-peer-review-become-a-i-review
#27
EDITORIAL
Karsten Wiechert, Jeffrey C Wang, Jens R Chapman
No abstract text is available yet for this article.
March 27, 2024: Global Spine Journal
https://read.qxmd.com/read/38532704/causes-of-intraoperative-neuromonitoring-events-in-adult-spine-deformity-surgery-a-systematic-review
#28
REVIEW
Chloe Cottone, David Kim, Christopher Lucasti, Maxwell M Scott, Benjamin C Graham, Nell Aronoff, Bilal Hasanspahic, David Kowalski, Justin Bird, Dil Patel
STUDY DESIGN: Systematic review. OBJECTIVES: Intraoperative neuromonitoring (IOMN) has become a standard practice in the detection and prevention of nerve damage and postoperative deficit. While multicenter studies have addressed this inquiry, there have been no systematic reviews to date. This systematic review identifies the leading causes of IONM alerts during adult spinal deformity (ASD) surgeries. METHODS: Following PRISMA guidelines, a literature search was performed in PubMed and Embase...
March 27, 2024: Global Spine Journal
https://read.qxmd.com/read/38532182/a-pig-model-of-symptomatic-spinal-epidural-hematoma
#29
JOURNAL ARTICLE
Jiasheng Chen, Haozheng Li, Shengxin Zeng, Hua Zhou, Xiao Liu, Panpan Hu, Xiaoguang Liu, Zhongjun Liu, Feng Wei, Zihe Li
PURPOSE: The purpose of this study was to establish an animal model capable of simulating the development and decompression process of symptomatic spinal epidural hematoma (SSEH). METHODS: A total of 16 male Bama miniature pigs were included in this study and randomly allocated into four groups: Group A (4 h 20 mmHg hematoma compression), Group B (4 h 24 mmHg hematoma compression), Group C (4 h 28 mmHg hematoma compression), and Group Sham (control)...
March 27, 2024: European Spine Journal
https://read.qxmd.com/read/38531193/association-between-phase-angle-and-clinical-outcomes-in-patients-with-lumbar-spinal-stenosis-from-the-preoperative-to-12-month-postoperative-period-a-prospective-observational-study
#30
JOURNAL ARTICLE
Takashi Wada, Shinji Tanishima, Yuki Kitsuda, Mari Osaki, Chikako Takeda, Hisashi Noma, Hideki Nagashima, Hiroshi Hagino
No reports of longitudinal studies on phase angle (PhA) in lumbar spinal stenosis (LSS) exist, and its association with postoperative clinical outcomes is unclear. We longitudinally investigated PhA in patients with LSS preoperatively to 12 months postoperatively and determined the association between PhA and the Japanese Orthopedic Association (JOA) score. This prospective observational study included patients who underwent consecutive surgical treatments for clinically and radiologically defined LSS...
March 25, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38531148/a-new-centrohelid-heliozoan-pterocystis-polycristalepis-sp-nov-and-taxonomic-and-phylogenetic-concerns-within-pterista-haptista-centroplasthelida
#31
JOURNAL ARTICLE
Dmitry G Zagumyonnyi, Denis V Tikhonenkov
A new species of centrohelid heliozoans, Pterocystis polycristalepis sp. nov. (Pterocystidae), was examined using light and electron microscopy. The novel centrohelid is characterized by the presence of leaf-like spine-scales with a broad pedicel-like structure on the proximal part and many subparallel ribs on the lateral wing surface. The plate-scales are ovoid with medial tubular thickening and many subparallel ribs on the very extensive marginal rim. The closely related species Pterocystis striata has also been studied in detail using light and electron microscopy...
February 20, 2024: European Journal of Protistology
https://read.qxmd.com/read/38530478/tip-of-the-iceberg-unveiling-the-impact-on-back-disorders-from-cumulative-physical-job-exposure-and-evaluating-bias-from-the-healthy-worker-effect-using-a-nationwide-longitudinal-cohort-study
#32
JOURNAL ARTICLE
Amalie Wiben, Christian Skovsgaard, Karen Søgaard, Berit Schiøttz-Christensen, Kim Rose Olsen
PURPOSE: Longitudinal studies across various sectors with physically demanding jobs are notably absent in back disorder risk research. This study aimed to investigate the relationship between cumulative physical job exposure (PJE) and hospital-diagnosed back disorders among individuals in Denmark. To assess the healthy worker effect, we compared the cumulative risk estimate with results from a naive cross-sectional model ignoring PJE history. METHODS: A nationwide longitudinal cohort study was conducted using Danish registers, encompassing individuals born between 1975 and 1978 and working in 1996...
March 26, 2024: European Spine Journal
https://read.qxmd.com/read/38529258/knowledge-and-awareness-of-osteoporosis-a-survey-of-physical-therapy-providers-in-saudi-arabia
#33
JOURNAL ARTICLE
Muataz Almaddah, Fahad Alzahrani, RiziqAllah Gaowgzeh, Abdullah Alqarni, Rani Othman, Afnan Gmmash
BACKGROUND: Osteoporosis "OP" is classified as one of the most serious health conditions worldwide. OP increases the skeletal fracture risk by 35%, particularly at hip, spine, and wrist joints. Healthcare professionals should be aware of OP clinical signs and have good knowledge while managing all patients. OBJECTIVES: This study aims to investigate the current level of osteoporosis knowledge and awareness among physical therapy providers in Saudi Arabia. METHODS: One hundred and sixty-eight physical therapy providers participated in this cross-sectional electronic survey from February to July of 2021...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38528694/automated-detection-and-segmentation-of-bone-metastases-on-spine-mri-using-u-net-a-multicenter-study
#34
MULTICENTER STUDY
Dong Hyun Kim, Jiwoon Seo, Ji Hyun Lee, Eun-Tae Jeon, DongYoung Jeong, Hee Dong Chae, Eugene Lee, Ji Hee Kang, Yoon-Hee Choi, Hyo Jin Kim, Jee Won Chai
OBJECTIVE: To develop and evaluate a deep learning model for automated segmentation and detection of bone metastasis on spinal MRI. MATERIALS AND METHODS: We included whole spine MRI scans of adult patients with bone metastasis: 662 MRI series from 302 patients (63.5 ± 11.5 years; male:female, 151:151) from three study centers obtained between January 2015 and August 2021 for training and internal testing (random split into 536 and 126 series, respectively) and 49 MRI series from 20 patients (65...
April 2024: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://read.qxmd.com/read/38528514/landet-an-efficient-physics-informed-deep-learning-approach-for-automatic-detection-of-anatomical-landmarks-and-measurement-of-spinopelvic-alignment
#35
JOURNAL ARTICLE
AliAsghar MohammadiNasrabadi, Gemah Moammer, Ahmed Quateen, Kunal Bhanot, John McPhee
PURPOSE: An efficient physics-informed deep learning approach for extracting spinopelvic measures from X-ray images is introduced and its performance is evaluated against manual annotations. METHODS: Two datasets, comprising a total of 1470 images, were collected to evaluate the model's performance. We propose a novel method of detecting landmarks as objects, incorporating their relationships as constraints (LanDet). Using this approach, we trained our deep learning model to extract five spine and pelvis measures: Sacrum Slope (SS), Pelvic Tilt (PT), Pelvic Incidence (PI), Lumbar Lordosis (LL), and Sagittal Vertical Axis (SVA)...
March 25, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38528161/preoperative-fatty-infiltration-of-paraspinal-muscles-assessed-by-mri-is-associated-with-less-improvement-of-leg-pain-2%C3%A2-years-after-surgery-for-lumbar-spinal-stenosis
#36
JOURNAL ARTICLE
Hasan Banitalebi, Erland Hermansen, Christian Hellum, Ansgar Espeland, Kjersti Storheim, Tor Åge Myklebust, Kari Indrekvam, Helena Brisby, Clemens Weber, Masoud Anvar, Jørn Aaen, Anne Negård
PURPOSE: Fatty infiltration (FI) of the paraspinal muscles may associate with pain and surgical complications in patients with lumbar spinal stenosis (LSS). We evaluated the prognostic influence of MRI-assessed paraspinal muscles' FI on pain or disability 2 years after surgery for LSS. METHODS: A muscle fat index (MFI) was calculated (by dividing signal intensity of psoas to multifidus and erector spinae) on preoperative axial T2-weighted MRI of patients with LSS...
March 25, 2024: European Spine Journal
https://read.qxmd.com/read/38528160/diagnostic-and-prognostic-significance-of-mir-486-5p-in-patients-who-underwent-minimally-invasive-surgery-for-lumbar-spinal-stenosis
#37
JOURNAL ARTICLE
Heqing Zhang, Dong Liu, Xiaoguang Fan
BACKGROUND: This study aimed to investigate the expression and clinical value of microRNA miR-486-5p in diagnosing lumbar spinal stenosis (LSS) patients and predicting the clinical outcomes after minimally invasive spinal surgery (MISS) in LSS patients, and the correlation of miR-486-5p with inflammatory responses in LSS patients. METHODS: This study included 52 LSS patients, 46 patients with lumbar intervertebral disk herniation (LDH) and 42 healthy controls. Reverse transcription quantitative PCR was used to detect miR-486-5p expression...
March 25, 2024: European Spine Journal
https://read.qxmd.com/read/38527456/daily-pain-severity-but-not-vertebral-fractures-is-associated-with-lower-physical-activity-in-postmenopausal-women-with-back-pain
#38
JOURNAL ARTICLE
Gallin Montgomery, Jon H Tobias, Zoe Paskins, Tarnjit K Khera, Cameron J Huggins, Sarah J Allison, Daniel Abasolo, Emma M Clark, Alex Ireland
Back pain lifetime incidence is 60%-70%, while 12%-20% of older women have vertebral fractures (VFs), often with back pain. We aimed to provide objective evidence, currently lacking, regarding whether back pain and VFs affect physical activity (PA). We recruited 69 women with recent back pain (age 74.5 ± 5.4 years). Low- (0.5 < g < 1.0), medium- (1.0 ≤ g < 1.5), and high-impact (g ≥ 1.5) PA and walking time were measured (100 Hz for 7 days, hip-worn accelerometer)...
March 23, 2024: Journal of Aging and Physical Activity
https://read.qxmd.com/read/38526931/interventions-to-optimize-spinal-cord-perfusion-in-patients-with-acute-traumatic-spinal-cord-injury-an-updated-systematic-review
#39
JOURNAL ARTICLE
Nathan Evaniew, Benjamin Davies, Farzin Farahbakhsh, Michael G Fehlings, Mario Ganau, Daniel Graves, James D Guest, Radha Korupolu, Allan R Martin, Stephen L McKenna, Lindsay A Tetreault, Aditya Vedantam, Erika D Brodt, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Systematic review update. OBJECTIVES: Interventions that aim to optimize spinal cord perfusion are thought to play an important role in minimizing secondary ischemic damage and improving outcomes in patients with acute traumatic spinal cord injuries (SCIs). However, exactly how to optimize spinal cord perfusion and enhance neurologic recovery remains controversial. We performed an update of a recent systematic review (Evaniew et al, J. Neurotrauma 2020) to evaluate the effects of Mean Arterial Pressure (MAP) support or Spinal Cord Perfusion Pressure (SCPP) support on neurological recovery and rates of adverse events among patients with acute traumatic SCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526930/ao-spine-praxis-clinical-practice-guidelines-for-the-management-of-acute-spinal-cord-injury-an-introduction-to-a-focus-issue
#40
JOURNAL ARTICLE
Brian K Kwon, Lindsay A Tetreault, Nathan Evaniew, Andrea C Skelly, Michael G Fehlings
STUDY DESIGN: Narrative overview and summary. OBJECTIVES: The objective of this introductory manuscript is to provide an overview of the effort that was undertaken to establish clinical practice guidelines for a number of important topics in spinal cord injury (SCI). These topics included: 1. The role and timing of surgical decompression after acute traumatic SCI; 2. The hemodynamic management of acute traumatic SCI; and 3. The definition, diagnosis, and management of intra-operative SCI...
March 2024: Global Spine Journal
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