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https://www.readbyqxmd.com/read/28904948/recent-progress-in-deciphering-the-etiopathogenesis-of-primary-membranous-nephropathy
#1
REVIEW
Andreas Kronbichler, Jun Oh, Björn Meijers, Gert Mayer, Jae Il Shin
Primary membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. Discovery of several antibodies has contributed to an increased understanding of MN. Antibodies against the M-type phospholipase A2 receptor (PLA2R) are present in 50-100% with primary MN and are associated with a lower frequency of spontaneous remission. High levels are linked with a higher probability of treatment resistance, higher proteinuria, and impaired renal function, as well as a more rapid decline of kidney function during follow-up...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904664/-pregnancy-and-delivery-in-patients-with-a-personal-history-of-cesarean-section-in-dakar-epidemiological-clinical-therapeutic-and-prognostic-aspects
#2
Cyr Espérance Koulimaya-Gombet, Abdoul Aziz Diouf, Moussa Diallo, Anna Dia, Codou Sène, Jean Charles Moreau, Alassane Diouf
The aim of our study was to determine hospitalization rate for vaginal birth after cesarean section in Pikine, to evaluate the quality of the management of pregnant women with previous cesarean section and to determine prognostic factors of the outcome of a trial of scar. We conducted a retrospective study based on medical records and operational protocols of patients who underwent vaginal birth after cesarean section over the period 1 January 2010 - 31 December 2011. We analyzed socio-demographic data, pregnancy follow-up, therapeutic modalities and prognosis...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904112/modeling-the-impact-of-nutrition-interventions-on-birth-outcomes-in-the-lives-saved-tool-list
#3
REVIEW
Rebecca Heidkamp, Adrienne Clermont, Erica Phillips
Background: Negative birth outcomes [small-for-gestational age (SGA) and preterm birth (PTB)] are common in low- and middle-income countries and have important subsequent health and developmental impacts on children. There are numerous nutritional and non-nutritional interventions that can decrease the risk of negative birth outcomes and reduce subsequent risk of mortality and growth faltering.Objective: The objective of this article was to review the current evidence for the impact of nutritional interventions in pregnancy [calcium supplementation, iron and folic acid supplementation, multiple micronutrient (MMN) supplementation, and balanced energy supplementation (BES)] and risk factors (maternal anemia) on birth outcomes, with the specific goal of determining which intervention-outcome linkages should be included in the Lives Saved Tool (LiST) software...
September 13, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28901005/delivery-arrangements-for-health-systems-in-low-income-countries-an-overview-of-systematic-reviews
#4
REVIEW
Agustín Ciapponi, Simon Lewin, Cristian A Herrera, Newton Opiyo, Tomas Pantoja, Elizabeth Paulsen, Gabriel Rada, Charles S Wiysonge, Gabriel Bastías, Lilian Dudley, Signe Flottorp, Marie-Pierre Gagnon, Sebastian Garcia Marti, Claire Glenton, Charles I Okwundu, Blanca Peñaloza, Fatima Suleman, Andrew D Oxman
BACKGROUND: Delivery arrangements include changes in who receives care and when, who provides care, the working conditions of those who provide care, coordination of care amongst different providers, where care is provided, the use of information and communication technology to deliver care, and quality and safety systems. How services are delivered can have impacts on the effectiveness, efficiency and equity of health systems. This broad overview of the findings of systematic reviews can help policymakers and other stakeholders identify strategies for addressing problems and improve the delivery of services...
September 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28899439/psychological-morbidity-and-parenting-stress-in-mothers-of-primary-school-children-by-timing-of-acquisition-of-hiv-infection-a-longitudinal-cohort-study-in-rural-south-africa
#5
T J Rochat, B Houle, A Stein, R M Pearson, M L Newell, R M Bland
Longitudinal maternal mental health data are needed from high HIV prevalence settings. The Siyakhula Cohort (SC) is a population-based cohort of HIV-positive and negative mothers (n=1506) with HIV-negative children (n=1536) from rural South Africa. SC includes 767 HIV-negative mothers; 465 HIV-positive in pregnancy; 272 HIV-positive since pregnancy (n=2 missing HIV status). A subgroup (n=890) participated in a non-randomized breastfeeding intervention [Vertical Transmission Study (VTS)]; the remaining (n=616) were resident in the same area and received antenatal care at the time of the VTS, but were not part of the VTS, instead receiving the standard of care Prevention of Mother-to-Child Transmission (PMTCT) Programme...
September 13, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28870047/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-gitelman-syndrome
#6
(no author information available yet)
Gitelman syndrome (GS) is an autosomal recessive, salt-losing tubulopathy caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is characterized by hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. GS is one of the most common inherited renal tubulopathy with a prevalence estimated at about one to ten per 40 000 people. The prevalence of GS is even higher in Asia than other countries. The majority of GS patients present mild and nonspecific symptoms during adolescence or adulthood...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28868251/maternal-and-fetal-tuberous-sclerosis-do-we-know-enough-as-an-obstetrician
#7
Nalini Sharma, Shriram Sharma, Jion Lalnunnem Thiek, Santa Singh Ahanthem, Arnab Kalita, Donboklang Lynser
BACKGROUND: Tuberous sclerosis, also known as tuberous sclerosis complex (TSC), is a rare genetic condition that mainly causes hamartomas to develop in different parts of the body. TSC, an autosomal dominant trait with variable penetrance, can adversely affect maternal and fetal outcome. CASE PRESENTATION: In this paper, a case of maternal and fetal tuberous sclerosis having fetal cardiac rhabdomyoma detected in utero at 26 weeks was reported who subsequently had fetal demise at 31 weeks...
April 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28867425/the-association-between-substantiated-childhood-maltreatment-asthma-and-lung-function-a-prospective-investigation
#8
Amanuel Alemu Abajobir, Steve Kisely, Gail Williams, Lane Strathearn, Sadasivam Suresh, Jake Moses Najman
BACKGROUND: Asthma reflects multiple and likely complex causal pathways. We investigate the possibility that childhood maltreatment is one such causal pathway. Childhood maltreatment can be interpreted as a form of early life adversity and like other life adversities may predict a range of negative health outcomes, including asthma. METHODS: A total of 3762 young adults (52.63% female) from the Mater Hospital-University of Queensland Study of Pregnancy (MUSP) participated in this study...
August 3, 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28861312/effective-predictors-for-surgical-decision-in-antenatal-hydronephrosis-a-prospective-multiparameter-analysis
#9
İsa Kıllı, Dinçer Avlan, Hakan Taşkınlar, Pınar Pelin Kara, Feramuz Demir Apaydın, Ali Delibaş, Ali Nayci
OBJECTIVE: The majority of antenatal hydronephrosis disappears spontaneously. In our study, we have investigated the effective predictors for surgical decision in antenatal hydronephrosis. MATERIAL AND METHODS: Forty-four patients found to have renal pelvic anteroposterior (AP) diameter more than 10-mm on antenatal ultrasonograpy were followed after birth. The study groups were divided into two groups: follow-up and surgery group. On follow-up, longitudinal diameter of the kidney, parenchymal thickness of the kidney, AP diameter of renal pelvis, AP diameter of middle calyces on ultrasonograpy, and differential renal function, 20th minute clearance, half-life of radionuclide tracer (T1/2), Tmax, Tmax-T1/2, normalised residual activity (NORA) on diuretic renography were evaluated...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28858117/exacerbation-of-primary-intestinal-lymphangiectasia-during-late-pregnancy-and-recovery-after-delivery-a-case-report-and-literature-review
#10
REVIEW
Jianyang Lu, Hongbo Zhai
RATIONALE: Primary intestinal lymphangiectasia (PIL) is a rare disease characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen. Main clinical features include intermittent diarrhea, hypoproteinemia. Scattered case reports suggested that PIL is compatible to pregnancy, but with increased complications. PATIENT CONCERNS: A 34-year-old woman with endoscopically diagnosed PIL presented to antenatal our clinic at 10 weeks into gestation...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28854944/hiv-status-disclosure-and-associated-outcomes-among-pregnant-women-enrolled-in-antiretroviral-therapy-in-uganda-a-mixed-methods-study
#11
Rose Naigino, Fredrick Makumbi, Aggrey Mukose, Esther Buregyeya, Jim Arinaitwe, Joshua Musinguzi, Rhoda K Wanyenze
BACKGROUND: Disclosure of HIV positive status to sexual partners is promoted by HIV prevention programs including those targeting the prevention of mother-to-child transmission. Among other benefits, disclosure may enhance spousal support and reduce stigma, violence and discrimination. HIV status disclosure and associated outcomes were assessed among a cohort of women, newly initiating lifelong antiretroviral therapy in Uganda between October 2013 and May 2014. METHODS: This was a mixed method study, drawing data from a prospective cohort study of 507 HIV positive pregnant women on lifelong antiretroviral therapy, who were followed for four months to determine disclosure and its outcomes...
August 30, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28852281/scorecard-an-innovative-simplified-tool-to-supplement-the-existing-monitoring-mechanism-to-assess-and-improve-performance-of-antiretroviral-treatment-centers
#12
Sudhir Chawla, Bhautik Modi, Bharat Bhusan Rewari, Pramod B Verma, Sonia Chetandas Chhabra
INTRODUCTION: All 26 antiretroviral treatment (ART) centers of Gujarat were monitored by Gujarat State AIDS Control Society under the National AIDS Control Program. A comprehensive tool is needed to identify gap in service delivery and to prioritize monitoring visits. OBJECTIVES: To supplement the existing monitoring system, identify strengths/weakness of ART centers, and give recommendations. METHODOLOGY: Scorecard was developed in spreadsheet format with 17 scoring indicators on monthly base from March 2014 onward...
July 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28842756/the-comorbidity-of-axis-i-disorders-in-depressed-pregnant-women
#13
Lilian Dindo, Alexis Elmore, Michael O'Hara, Scott Stuart
Depression during pregnancy is highly prevalent and is associated with increased risk of a variety of negative psychological and medical outcomes in both mothers and offspring. Antenatal depression often co-occurs with significant anxiety, potentially exacerbating morbidities for women and their children. However, screening during the antenatal period is frequently limited to assessment of depression so that other significant comorbid disorders may be missed. Follow-up assessment by clinicians has similarly focused primarily on detection of depressive symptoms...
August 25, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28839077/alcohol-consumption-in-a-general-antenatal-population-and-child-neurodevelopment-at-2-years
#14
Jane L Halliday, Evelyne Muggli, Sharon Lewis, Elizabeth J Elliott, David J Amor, Colleen O'Leary, Susan Donath, Della Forster, Cate Nagle, Jeffrey M Craig, Peter J Anderson
BACKGROUND: Prenatal alcohol exposure (PAE) is a community health problem with up to 50% of pregnant women drinking alcohol. The relationship between low or sporadic binge PAE and adverse child outcomes is not clear. This study examines the association between PAE in the general antenatal population and child neurodevelopment at 2 years, accounting for relevant contributing factors. METHODS: This prospective population-based cohort recruited 1570 pregnant women, providing sociodemographic, psychological and lifestyle information and alcohol use for five time periods...
August 24, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28834003/breastfeeding-beyond-the-big-smoke-who-provides-support-for-mothers-in-rural-western-australia
#15
Kylee Cox, Roslyn Giglia, Colin W Binns
INTRODUCTION: Despite strong and growing evidence for the benefits of exclusive breastfeeding to 6 months of age, few infants in developed countries reach this milestone. Although breastfeeding practice and its determinants are well described for women in metropolitan areas, there is limited evidence for rural and regional areas of Australia. This paper describes the influence of advice and support on breastfeeding duration for women in rural areas of Western Australia in the first 6 months of their infants' lives...
August 23, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28830395/antenatal-depressive-symptoms-and-perinatal-complications-a-prospective-study-in-rural-ethiopia
#16
Tesera Bitew, Charlotte Hanlon, Eskinder Kebede, Simone Honikman, Abebaw Fekadu
BACKGROUND: Antenatal depressive symptoms affect around 12.3% of women in in low and middle income countries (LMICs) and data are accumulating about associations with adverse outcomes for mother and child. Studies from rural, low-income country community samples are limited. This paper aims to investigate whether antenatal depressive symptoms predict perinatal complications in a rural Ethiopia setting. METHODS: A population-based prospective study was conducted in Sodo district, southern Ethiopia...
August 22, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28826258/fetal-intracranial-hemorrhage-prenatal-diagnosis-and-postnatal-outcomes
#17
Begoña Adiego, Pilar Martínez-Ten, Carmina Bermejo, María Estévez, Manuel Recio Rodriguez, Tamara Illescas
OBJECTIVE: To present our experience with 14 cases of fetal intracranial hemorrhage (ICH). METHODS: Cases of fetal ICH detected in our institution between 2005 and 2016 by ultrasonography. Maternal characteristics, ultrasound and MRI findings, and postnatal outcome were noted. RESULTS: Twelve cases (86.7%) were identified during a third trimester routine scan at a median gestational age of 30.6 weeks. The ICH was classified as Grade 2 in two cases, Grade 3 in three cases and Grade 4 in nine cases...
August 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28811050/vaccine-decision-making-begins-in-pregnancy-correlation-between-vaccine-concerns-intentions-and-maternal-vaccination-with-subsequent-childhood-vaccine-uptake
#18
M H Danchin, J Costa-Pinto, K Atwell, H Willaby, K Wiley, M Hoq, J Leask, K P Perrett, Jacinta O'Keefe, M L Giles, H Marshall
INTRODUCTION: Maternal and childhood vaccine decision-making begins prenatally. Amongst pregnant Australian women we aimed to ascertain vaccine information received, maternal immunisation uptake and attitudes and concerns regarding childhood vaccination. We also aimed to determine any correlation between a) intentions and concerns regarding childhood vaccination, (b) concerns about pregnancy vaccination, (c) socioeconomic status (SES) and (d) uptake of influenza and pertussis vaccines during pregnancy and routine vaccines during childhood...
August 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28805595/prenatal-diagnosis-of-congenital-lobar-fluid-overload
#19
REVIEW
Pei-Shan Tsai, Chih-Ping Chen, Dao Chen Lin, Yu-Peng Liu
Prenatal congenital lobar fluid overload (CLFO), which was first described by Ramsay and Byron, is identical to postnatal congenital lobar overinflation. It is characterized by progressive lobar overexpansion that compresses the other adjacent lung lobes. The underlying cause can be an intrinsic cartilaginous abnormality or an extrinsic airway compression. It may be associated with cardiovascular anomalies in 12%-14% of cases and affects males more frequently than females. Most cases are diagnosed postnatally, but early antenatal diagnosis and sequential follow-up are attempted for early treatment, if clinically indicated...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28798895/prevalence-and-identification-of-serum-markers-associated-with-vertical-transmission-of-hepatitis-b-in-pregnant-women-in-yaounde-cameroon
#20
Lucien Honoré Etame Sone, Roger Ahouga Voufo, Henriette Thérèse Dimodi, Michel Kengne, Cédric Gueguim, Nnanga Ngah, Julius Oben, Judith Laure Ngondi
OBJECTIVE: To determine the prevalence of Hepatitis B Virus (HBV) infection in pregnant women and identify markers associated with vertical transmission of HBV. METHODS: Prospective and cross-sectional study over 10 months on 298 pregnant women attending antenatal clinics in the Cité Verte and Efoulan District hospitals in Cameroon. A dry tube blood collection was performed on all pregnant women and babies born to HBsAg-positive mothers. Serum from the women was used to test for HBsAg through immunochromatography and then confirmed by ELISA...
2017: International Journal of MCH and AIDS
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