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Christopher fletcher

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https://www.readbyqxmd.com/read/28196207/correlation-of-long-term-results-of-imatinib-in-advanced-gastrointestinal-stromal-tumors-with-next-generation-sequencing-results-analysis-of-phase-3-swog-intergroup-trial-s0033
#1
Michael Heinrich, Cathryn Rankin, Charles D Blanke, George D Demetri, Ernest C Borden, Christopher W Ryan, Margaret von Mehren, Martin E Blackstein, Dennis A Priebat, William D Tap, Robert G Maki, Christopher L Corless, Jonathan A Fletcher, Kouros Owzar, John J Crowley, Robert S Benjamin, Laurence H Baker
Importance: After identification of activating mutations of the KIT gene in gastrointestinal stromal tumor (GIST)-the most common sarcomaof the gastrointestinal tract-a phase 2 study demonstrated efficacy of imatinib mesylate in patients with metastatic GIST harboring a KIT exon 11 mutation. Initial results of long-term follow-up have found a survival benefit in this subgroup of patients. Obective: To assess the long-term survival of patients with GIST who were treated in SWOG study S0033 and to present new molecular data regarding treatment outcomes...
February 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28152822/the-value-of-secondary-pathology-review
#2
Tinisha L Mayo, Tracy E Spinks, Richard Cheney, Peiguo Chu, Harry S Cooper, Suzanne Dintzis, Hormoz Ehya, Christopher D Fletcher, Amy Gerwirtz, Anthony Martin Magliocco, Sue Ellen Martin, Andrew E Rosenberg, Andy Sherrod, Lee K Tan, Brent L Wood, Ronald Stewart Walters
: 6 Background: Improving the value of cancer care is a major focus for the Alliance of Dedicated Cancer Centers (ADCC). Looking to align with the Institute of Medicine's (IOM) initiative to "Develop and deploy approaches to identify, learn from, and reduce diagnostic errors and near misses in clinical practice," the ADCC implemented a study to examine the clinical impact of expert secondary pathology review. The goal of this project was to: 1) demonstrate the value of secondary review of outside pathological specimens by ADCC subspecialty pathologists in identifying significant errors that can potentially impact treatment; and 2) create an opportunity to improve patient cancer care...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28138155/corrigendum-mutations-in-snord118-cause-the-cerebral-microangiopathy-leukoencephalopathy-with-calcifications-and-cysts
#3
Emma M Jenkinson, Mathieu P Rodero, Paul R Kasher, Carolina Uggenti, Anthony Oojageer, Laurence C Goosey, Yoann Rose, Christopher J Kershaw, Jill E Urquhart, Simon G Williams, Sanjeev S Bhaskar, James O'Sullivan, Gabriela M Baerlocher, Monika Haubitz, Geraldine Aubert, Kristin W Barañano, Angela J Barnicoat, Roberta Battini, Andrea Berger, Edward M Blair, Janice E Brunstrom-Hernandez, Johannes A Buckard, David M Cassiman, Rosaline Caumes, Duccio M Cordelli, Liesbeth M De Waele, Alexander J Fay, Patrick Ferreira, Nicholas A Fletcher, Alan E Fryer, Himanshu Goel, Cheryl A Hemingway, Marco Henneke, Imelda Hughes, Rosalind J Jefferson, Ram Kumar, Lieven Lagae, Pierre G Landrieu, Charles M Lourenço, Timothy J Malpas, Sarju G Mehta, Imke Metz, Sakkubai Naidu, Katrin Õunap, Axel Panzer, Prab Prabhakar, Gerardine Quaghebeur, Raphael Schiffmann, Elliott H Sherr, Kanaga R Sinnathuray, Calvin Soh, Helen S Stewart, John Stone, Hilde Van Esch, Christine E G Van Mol, Adeline Vanderver, Emma L Wakeling, Andrea Whitney, Graham D Pavitt, Sam Griffiths-Jones, Gillian I Rice, Patrick Revy, Marjo S van der Knaap, John H Livingston, Raymond T O'Keefe, Yanick J Crow
No abstract text is available yet for this article.
January 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28092203/machine-learning-of-three-dimensional-right-ventricular-motion-enables-outcome-prediction-in-pulmonary-hypertension-a-cardiac-mr-imaging-study
#4
Timothy J W Dawes, Antonio de Marvao, Wenzhe Shi, Tristan Fletcher, Geoffrey M J Watson, John Wharton, Christopher J Rhodes, Luke S G E Howard, J Simon R Gibbs, Daniel Rueckert, Stuart A Cook, Martin R Wilkins, Declan P O'Regan
Purpose To determine if patient survival and mechanisms of right ventricular failure in pulmonary hypertension could be predicted by using supervised machine learning of three-dimensional patterns of systolic cardiac motion. Materials and Methods The study was approved by a research ethics committee, and participants gave written informed consent. Two hundred fifty-six patients (143 women; mean age ± standard deviation, 63 years ± 17) with newly diagnosed pulmonary hypertension underwent cardiac magnetic resonance (MR) imaging, right-sided heart catheterization, and 6-minute walk testing with a median follow-up of 4...
January 16, 2017: Radiology
https://www.readbyqxmd.com/read/28032662/5-hydroxymethylcytosine-is-a-nuclear-biomarker-to-assess-biological-potential-in-histologically-ambiguous-heavily-pigmented-melanocytic-neoplasms
#5
Jonathan J Lee, Ricardo E Vilain, Scott R Granter, Nina R Hu, Scott C Bresler, Shuyun Xu, Alexander H Frank, Martin C Mihm, Robyn P M Saw, Christopher D Fletcher, Richard A Scolyer, George F Murphy, Christine G Lian
BACKGROUND: 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was to explore its diagnostic utility in a subset of histologically challenging, heavily pigmented cutaneous melanocytic neoplasms. METHODS: 5-hmC IHC was performed on 54 heavily pigmented melanocytic tumors. Semi-quantitative analysis of immunoreactivity was correlated with clinical, pathologic and follow-up data...
December 29, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28009608/fosb-is-a-useful-diagnostic-marker-for-pseudomyogenic-hemangioendothelioma
#6
Yin P Hung, Christopher D M Fletcher, Jason L Hornick
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for young adults and frequent multifocal presentation. Pseudomyogenic hemangioendothelioma is characterized by loose fascicles of plump spindled and epithelioid cells with abundant eosinophilic cytoplasm and coexpression of keratins and endothelial markers. Recently, a SERPINE1-FOSB fusion has been identified as a consistent genetic alteration in pseudomyogenic hemangioendothelioma...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27998625/a-consensus-driven-agenda-for-emergency-medicine-firearm-injury-prevention-research
#7
Megan L Ranney, Jonathan Fletcher, Harrison Alter, Christopher Barsotti, Vikhyat S Bebarta, Marian E Betz, Patrick M Carter, Magdalena Cerdá, Rebecca M Cunningham, Peter Crane, Jahan Fahimi, Matthew J Miller, Ali Rowhani-Rahbar, Jody A Vogel, Garen J Wintemute, Muhammad Waseem, Manish N Shah
STUDY OBJECTIVE: To identify critical emergency medicine-focused firearm injury research questions and develop an evidence-based research agenda. METHODS: National content experts were recruited to a technical advisory group for the American College of Emergency Physicians Research Committee. Nominal group technique was used to identify research questions by consensus. The technical advisory group decided to focus on 5 widely accepted categorizations of firearm injury...
February 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27927700/cardiac-%C3%AE-v%C3%AE-3-integrin-expression-following-acute-myocardial-infarction-in-humans
#8
William S A Jenkins, Alex T Vesey, Colin Stirrat, Martin Connell, Christophe Lucatelli, Anoushka Neale, Catriona Moles, Anna Vickers, Alison Fletcher, Tania Pawade, Ian Wilson, James H F Rudd, Edwin J R van Beek, Saeed Mirsadraee, Marc R Dweck, David E Newby
OBJECTIVE: Maladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The αvβ3 integrin receptor is a key mediator and determinant of cardiac repair. We aimed to establish whether αvβ3 integrin expression determines myocardial recovery following MI. METHODS: (18)F-Fluciclatide (a novel αvβ3-selective radiotracer) positron emission tomography (PET) and CT imaging and gadolinium-enhanced MRI (CMR) were performed in 21 patients 2 weeks after ST-segment elevation MI (anterior, n=16; lateral, n=4; inferior, n=1)...
December 7, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27918775/association-between-myopia-ultraviolet-b-radiation-exposure-serum-vitamin-d-concentrations-and-genetic-polymorphisms-in-vitamin-d-metabolic-pathways-in-a-multicountry-european-study
#9
Katie M Williams, Graham C G Bentham, Ian S Young, Ann McGinty, Gareth J McKay, Ruth Hogg, Christopher J Hammond, Usha Chakravarthy, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Astrid E Fletcher
Importance: Myopia is becoming increasingly common globally and is associated with potentially sight-threatening complications. Spending time outdoors is protective, but the mechanism underlying this association is poorly understood. Objective: To examine the association of myopia with ultraviolet B radiation (UVB; directly associated with time outdoors and sunlight exposure), serum vitamin D concentrations, and vitamin D pathway genetic variants, adjusting for years in education...
January 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27879515/atypical-spindle-cell-lipomatous-tumor-clinicopathologic-characterization-of-232-cases-demonstrating-a-morphologic-spectrum
#10
Adrian Mariño-Enriquez, Alessandra F Nascimento, Azra H Ligon, Cherwei Liang, Christopher D M Fletcher
The classification of atypical adipocytic neoplasms with spindle cell features remains challenging. To better define this category of low-grade lipomatous neoplasms, we present herein the clinical, histologic, and immunohistochemical characteristics of a large series of 232 atypical spindle cell lipomatous tumors. The lesions affected 140 males and 92 females, at an average age of 54 years (range, 6 to 87 y), clinically presenting as a persistent or enlarging mass with a median size of 5 cm. The anatomic distribution of the tumors was wide, predominating in the limbs and limb girdles (147 cases, 63%), mainly in the hands and feet (17% and 11%, respectively), with equal distribution between subcutaneous and deeper locations...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27803999/use-of-an-extended-inr-follow-up-interval-for-veteran-patients-in-an-anticoagulation-clinic
#11
Andrea L Porter, Amanda R Margolis, Rebecca R Schoen, Carla E Staresinic, Cheryl A Ray, Christopher D Fletcher
A prospective, single-arm study of 50 participants evaluated an extended INR follow-up interval to determine the implementation feasibility and safety of an extended interval in Veterans on a stable dose of warfarin. A protocol was designed to allow for a rigorous, yet pragmatic evaluation of a 12-week INR follow-up interval. Feasibility was determined by study enrollment, retention, and participant achievement rates for the extended INR interval. Safety was determined by bleeding and thromboembolism rates...
November 1, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27800551/open-source-drug-discovery-highly-potent-antimalarial-compounds-derived-from-the-tres-cantos-arylpyrroles
#12
Alice E Williamson, Paul M Ylioja, Murray N Robertson, Yevgeniya Antonova-Koch, Vicky Avery, Jonathan B Baell, Harikrishna Batchu, Sanjay Batra, Jeremy N Burrows, Soumya Bhattacharyya, Felix Calderon, Susan A Charman, Julie Clark, Benigno Crespo, Matin Dean, Stefan L Debbert, Michael Delves, Adelaide S M Dennis, Frederik Deroose, Sandra Duffy, Sabine Fletcher, Guri Giaever, Irene Hallyburton, Francisco-Javier Gamo, Marinella Gebbia, R Kiplin Guy, Zoe Hungerford, Kiaran Kirk, Maria J Lafuente-Monasterio, Anna Lee, Stephan Meister, Corey Nislow, John P Overington, George Papadatos, Luc Patiny, James Pham, Stuart A Ralph, Andrea Ruecker, Eileen Ryan, Christopher Southan, Kumkum Srivastava, Chris Swain, Matthew J Tarnowski, Patrick Thomson, Peter Turner, Iain M Wallace, Timothy N C Wells, Karen White, Laura White, Paul Willis, Elizabeth A Winzeler, Sergio Wittlin, Matthew H Todd
The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to participate, and patents were not sought. One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change...
October 26, 2016: ACS Central Science
https://www.readbyqxmd.com/read/27755742/counteracting-effects-of-a-non-native-prey-on-the-demography-of-a-native-predator-culminate-in-positive-population-growth
#13
Christopher E Cattau, Robert J Fletcher, Brian E Reichert, Wiley M Kitchens
Identifying impacts of non-native species on native populations is central to conservation and ecology. While effects of non-native predators on native prey populations have recently received much attention, impacts of introduced prey on native predator populations are less understood. Non-native prey can influence predator behavior and demography through direct and indirect pathways, yet quantitative assessments of the relative impacts of multiple, potentially counteracting, effects on native predator population growth remain scarce...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27733431/optimization-and-reproducibility-of-aortic-valve-18f-fluoride-positron-emission-tomography-in-patients-with-aortic-stenosis
#14
Tania A Pawade, Timothy R G Cartlidge, William S A Jenkins, Philip D Adamson, Phillip Robson, Christophe Lucatelli, Edwin J R Van Beek, Bernard Prendergast, Alan R Denison, Laura Forsyth, James H F Rudd, Zahi A Fayad, Alison Fletcher, Sharon Tuck, David E Newby, Marc R Dweck
BACKGROUND: 18F-Fluoride positron emission tomography (PET) and computed tomography (CT) can measure disease activity and progression in aortic stenosis. Our objectives were to optimize the methodology, analysis, and scan-rescan reproducibility of aortic valve 18F-fluoride PET-CT imaging. METHODS AND RESULTS: Fifteen patients with aortic stenosis underwent repeated 18F-fluoride PET-CT. We compared nongated PET and noncontrast CT, with a modified approach that incorporated contrast CT and ECG-gated PET...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27733426/effectiveness-of-screening-colonoscopy-in-reducing-the-risk-of-death-from-right-and-left-colon-cancer-a-large-community-based-study
#15
Chyke A Doubeni, Douglas A Corley, Virginia P Quinn, Christopher D Jensen, Ann G Zauber, Michael Goodman, Jill R Johnson, Shivan J Mehta, Tracy A Becerra, Wei K Zhao, Joanne Schottinger, V Paul Doria-Rose, Theodore R Levin, Noel S Weiss, Robert H Fletcher
OBJECTIVE: Screening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and left-colon/rectal cancers. DESIGN: We conducted a nested case-control study with incidence-density matching in screening-eligible Kaiser Permanente members...
October 12, 2016: Gut
https://www.readbyqxmd.com/read/27686458/esicm-lives-2016-part-one-milan-italy-1-5-october-2016
#16
L Bos, L Schouten, L van Vught, M Wiewel, D Ong, O Cremer, A Artigas, I Martin-Loeches, A Hoogendijk, T van der Poll, J Horn, N Juffermans, M Schultz, N de Prost, T Pham, G Carteaux, A Mekontso Dessap, C Brun-Buisson, E Fan, G Bellani, J Laffey, A Mercat, L Brochard, B Maitre, P A Howells, D R Thickett, C Knox, D P Park, F Gao, O Tucker, T Whitehouse, D F McAuley, G D Perkins, T Pham, J Laffey, G Bellani, E Fan, L Pisani, J P Roozeman, F D Simonis, A Giangregorio, L R Schouten, S M Van der Hoeven, J Horn, A Serpa Neto, E Festic, A M Dondorp, S Grasso, L D Bos, M J Schultz, M Koster-Brouwer, D Verboom, B Scicluna, K van de Groep, J Frencken, M Schultz, T van der Poll, M Bonten, O Cremer, J I Ko, K S Kim, G J Suh, W Y Kwon, K Kim, J H Shin, O T Ranzani, E Prina, R Menendez, A Ceccato, R Mendez, C Cilloniz, A Gabarrus, M Ferrer, A Torres, A Urbano, L A Zhang, D Swigon, F Pike, R S Parker, G Clermont, C Scheer, S O Kuhn, A Modler, M Vollmer, C Fuchs, K Hahnenkamp, S Rehberg, M Gründling, A Taggu, N Darang, N Öveges, I László, K Tánczos, M Németh, G Lebák, B Tudor, D Érces, J Kaszaki, W Huber, D Trásy, Z Molnár, G Ferrara, V S Kanoore Edul, H S Canales, E Martins, C Canullán, G Murias, M O Pozo, J F Caminos Eguillor, M G Buscetti, C Ince, A Dubin, H D Aya, A Rhodes, N Fletcher, R M Grounds, M Cecconi, M Jacquet-Lagrèze, M Riche, R Schweizer, P Portran, W Fornier, M Lilot, J Neidecker, J L Fellahi, A Escoresca-Ortega, A Gutiérrez-Pizarraya, L Charris-Castro, Y Corcia-Palomo, E Fernandez-Delgado, J Garnacho-Montero, C Roger, L Muller, L Elotmani, J Lipman, J Y Lefrant, J A Roberts, R Muñoz-Bermúdez, M Samper, C Climent, F Vasco, V Sara, S Luque, N Campillo, S Grau Cerrato, J R Masclans, F Alvarez-Lerma, S Carvalho Brugger, G Jimenez Jimenez, M Miralbés Torner, J Trujillano Cabello, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, M Vallverdú Vidal, M Palomar Martínez, V Gusarov, D Shilkin, M Dementienko, E Nesterova, N Lashenkova, A Kuzovlev, M Zamyatin, A Demoule, S Carreira, S Lavault, O Palancca, E Morawiec, J Mayaux, I Arnulf, T Similowski, B S Rasmussen, R G Maltesen, M Hanifa, S Pedersen, S R Kristensen, R Wimmer, M Panigada, G Li Bassi, O T Ranzani, T Kolobow, A Zanella, M Cressoni, L Berra, V Parrini, H Kandil, G Salati, S Livigni, A Amatu, A Andreotti, F Tagliaferri, G Moise, G Mercurio, A Costa, A Vezzani, S Lindau, J Babel, M Cavana, D Consonni, A Pesenti, L Gattinoni, A Torres, P Mansouri, F Zand, L Zahed, F Dehghanrad, M Bahrani, M Ghorbani, B Cambiaghi, O Moerer, T Mauri, N Kunze-Szikszay, C Ritter, A Pesenti, M Quintel, L M Vilander, M A Kaunisto, S T Vaara, V Pettilä, J L G Haitsma Mulier, S Rozemeijer, A M E Spoelstra-de Man, P E Elbers, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, I H J Koh, M Galindo Martínez, R Jiménez Sánchez, L Martínez Gascón, M D Rodríguez Mulero, A Ortín Freire, A Ojados Muñoz, S Rebollo Acebes, Á Fernández Martínez, S Moreno Aliaga, L Herrera Para, J Murcia Payá, F Rodríguez Mulero, P Guerci, Y Ince, P Heeman, B Ergin, C Ince, Z Uz, M Massey, Y Ince, R Papatella, E Bulent, P Guerci, F Toraman, C Ince, E R Longbottom, H D Torrance, H C Owen, C J Hinds, R M Pearse, M J O'Dywer, Z Trogrlic, M van der Jagt, H Lingsma, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, T van Achterberg, J Bakker, D A M P J Gommers, E Ista, A Krajčová, P Waldauf, F Duška, A Shah, N Roy, S McKechnie, C Doree, S Fisher, S J Stanworth, J F Jensen, D Overgaard, M H Bestle, D F Christensen, I Egerod, A Pivkina, V Gusarov, I Zhivotneva, N Pasko, M Zamyatin, J F Jensen, I Egerod, M H Bestle, D F Christensen, A Alklit, R L Hansen, H Knudsen, L B Grode, D Overgaard, M Hravnak, L Chen, A Dubrawski, G Clermont, M R Pinsky, S M Parry, L D Knight, B C Connolly, C E Baldwin, Z A Puthucheary, L Denehy, N Hart, P E Morris, J Mortimore, C L Granger, H I Jensen, R Piers, B Van den Bulcke, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, B Van den Bulcke, R Piers, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, C Ryan, D Dawson, J Ball, K Noone, B Aisling, S Prudden, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, J Aron, G Lumley, D Milliken, K Dhadwal, B A McGrath, S J Lynch, B Bovento, G Sharpe, E Grainger, S Pieri-Davies, S Wallace, B McGrath, S J Lynch, B Bovento, E Grainger, S Pieri-Davies, G Sharpe, S Wallace, M Jung, J Cho, H Park, G Suh, O Kousha, J Paddle, L Gamrin Gripenberg, M Sundström Rehal, J Wernerman, O Rooyackers, H J de Grooth, W P Choo, A M Spoelstra-de Man, E L Swart, H M Oudemans-van Straaten, L Talan, G Güven, N D Altıntas, M Padar, G Uusvel, L Starkopf, J Starkopf, A Reintam Blaser, M S Kalaiselvan, A S Arunkumar, M K Renuka, R L Shivkumar, M Volbeda, D Ten Kate, M Hoekstra, J M van der Maaten, M W Nijsten, A Komaromi, O Rooyackers, J Wernerman, Å Norberg, M Smedberg, M Mori, L Pettersson, Å Norberg, O Rooyackers, J Wernerman, M Theodorakopoulou, T Christodoulopoulou, A Diamantakis, F Frantzeskaki, M Kontogiorgi, E Chrysanthopoulou, M Lygnos, C Diakaki, A Armaganidis, K Gundogan, E Dogan, R Coskun, S Muhtaroglu, M Sungur, T Ziegler, M Guven, A Kleyman, W Khaliq, D Andreas, M Singer, R Meierhans, R Schuepbach, I De Brito-Ashurst, F Zand, G Sabetian, R Nikandish, F Hagar, M Masjedi, B Maghsudi, A Vazin, M Ghorbani, E Asadpour, K C Kao, L C Chiu, C Y Hung, C H Chang, S H Li, H C Hu, S El Maraghi, M Ali, D Rageb, M Helmy, J Marin-Corral, C Vilà, J R Masclans, A Vàzquez, I Martín-Loeches, E Díaz, J C Yébenes, A Rodriguez, F Álvarez-Lerma, N Varga, A Cortina-Gutiérrez, L Dono, M Martínez-Martínez, C Maldonado, E Papiol, M Pérez-Carrasco, R Ferrer, K Nweze, B Morton, I Welters, M Houard, B Voisin, G Ledoux, S Six, E Jaillette, S Nseir, S Romdhani, R Bouneb, D Loghmari, N Ben Aicha, J Ayachi, K Meddeb, I Chouchène, A Khedher, M Boussarsar, K S Chan, W L Yu, J Marin-Corral, C Vilà, J R Masclans, J Nolla, L Vidaur, J Bonastre, B Suberbiola, J E Guerrero, A Rodriguez, N Ramon Coll, G Jiménez Jiménez, S Carvalho Brugger, J Codina Calero, B Balsera Garrido, M García, M Palomar Martínez, M Vallverdú Vidal, M C de la Torre, E Vendrell, E Palomera, E Güell, J C Yébenes, M Serra-Prat, J F Bermejo-Martín, J Almirall, E Tomas, A Escoval, F Froe, M H Vitoria Pereira, N Velez, E Viegas, E Filipe, C Groves, M Reay, L C Chiu, H C Hu, C Y Hung, C H Chang, S H Li, K C Kao, A Ballin, F Facchin, G Sartori, F Zarantonello, E Campello, C M Radu, S Rossi, C Ori, P Simioni, N Umei, I Shingo, A C Santos, C Candeias, I Moniz, R Marçal, Z Costa E Silva, J M Ribeiro, J F Georger, J P Ponthus, M Tchir, V Amilien, M Ayoub, E Barsam, G Martucci, G Panarello, F Tuzzolino, G Capitanio, V Ferrazza, T Carollo, L Giovanni, A Arcadipane, M López Sánchez, M A González-Gay, F J Llorca Díaz, M I Rubio López, E Zogheib, L Villeret, J Nader, M Bernasinski, P Besserve, T Caus, H Dupont, P Morimont, S Habran, R Hubert, T Desaive, F Blaffart, N Janssen, J Guiot, A Pironet, P Dauby, B Lambermont, F Zarantonello, A Ballin, F Facchin, G Sartori, E Campello, T Pettenuzzo, G Citton, S Rossi, P Simioni, C Ori, C Kirakli, O Ediboglu, S Ataman, M Yarici, F Tuksavul, S Keating, A Gibson, M Gilles, M Dunn, G Price, N Young, P Remeta, P Bishop, M D Fernández Zamora, J Muñoz-Bono, E Curiel-Balsera, E Aguilar-Alonso, R Hinojosa, A Gordillo-Brenes, J A Arboleda-Sánchez, I Skorniakov, D Vikulova, C Whiteley, O Shaikh, A Jones, M Ostermann, L Forni, M Scott, J Sahatjian, W Linde-Zwirble, D Hansell, P Laoveeravat, N Srisawat, M Kongwibulwut, S Peerapornrattana, N Suwachittanont, T O Wirotwan, P Chatkaew, P Saeyub, K Latthaprecha, K Tiranathanagul, S Eiam-Ong, J A Kellum, R E Berthelsen, A Perner, A E K Jensen, J U Jensen, M H Bestle, D J Gebhard, J Price, C E Kennedy, A Akcan-Arikan, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, K Hamed, M M Khaled, R Aly Soliman, M Sherif Mokhtar, G Seller-Pérez, D Arias-Verdú, E Llopar-Valdor, I De-Diós-Chacón, G Quesada-García, M E Herrera-Gutierrez, R Hafes, G Carroll, P Doherty, C Wright, I G Guerra Vera, M Ralston, M L Gemmell, A MacKay, E Black, C Wright, R I Docking, R Appleton, M R Ralston, L Gemmell, R Appleton, C Wright, R I Docking, E Black, A Mackay, S Rozemeijer, J L G Haitsma Mulier, J G Röttgering, P W G Elbers, A M E Spoelstra-de Man, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, N Mejeni, J Nsiala, A Kilembe, P Akilimali, G Thomas, I Egerod, A E Andersson, A M Fagerdahl, V Knudsen, K Meddeb, A Ben Cheikh, Y Hamdaoui, J Ayachi, A Guiga, N Fraj, S Romdhani, N Sma, R Bouneb, I Chouchene, A Khedher, N Bouafia, M Boussarsar, A Amirian, 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T Öhman, E Redondo, M Hallbäck, M Wallin, F Suarez Sipman, A Oldner, C Hällsjö Sander, H Björne, L Colinas, G Hernandez, R Vicho, M Serna, R Cuena, A Canabal, A Chaari, K Abdel Hakim, M Etman, M El Bahr, A El Sakka, K Bousselmi, A Arali, V Kauts, W F Casey, O Bond, P De Santis, E Iesu, F Franchi, J L Vincent, J Creteur, S Scolletta, F S Taccone, Z Marutyan, L Hamidova, A Shakotko, V Movsisyan, I Uysupova, A Evdokimov, S Petrikov, C Gonen, E Haftacı, C Balci, F J Redondo Calvo, N Bejarano, V Baladron, R Villazala, J Redondo, D Padilla, P Villarejo, A Akcan-Arikan, C E Kennedy, M F Aguilar Arzapalo, C Gomez-Gonzalez, S Mas-Font, A Puppo-Moreno, M Herrera-Gutierrez, M Garcia-Garcia, S Aldunate-Calvo, E P Plata-Menchaca, X L Pérez-Fernández, M Estruch, A Betbese-Roig, P Cárdenas Campos, M Rojas Lora, N D Toapanta Gaibor, R S Contreras Medina, V D Gumucio Sanguino, E J Casanova, J Sabater Riera, K Kritmetapak, S Peerapornratana, P Kittiskulnam, T Dissayabutra, K Tiranathanagul, P Susantithapong, K Praditpornsilpa, K Tungsanga, S Eiam-Ong, N Srisawat, T Winkelmann, T Busch, J Meixensberger, S Bercker, E M Flores Cabeza, M Sánchez Sánchez, N Cáceres Giménez, C Gutierrez Melón, E Herrero de Lucas, P Millán Estañ, M Hernández Bernal, A Garcia de Lorenzo Y Mateos, B Ergin, P Guerci, P A C Specht, Y Ince, C Ince, M Balik, M Zakharchenko, F Los, H Brodska, C de Tymowski, P Augustin, M Desmard, P Montravers, S N Stapel, R de Boer, H M Oudemans, A Hollinger, T Schweingruber, F Jockers, M Dickenmann, M Siegemund, N Runciman, M Ralston, R Appleton, T Mauri, L Alban, C Turrini, T Sasso, T Langer, M Panigada, P Taccone, E Carlesso, C Marenghi, G Grasselli, A Pesenti, P Wibart, T Reginault, M Garcia, B Barbrel, A Benard, C Bader, F Vargas, H N Bui, G Hilbert, J M Serrano Simón, P Carmona Sánchez, F Ruiz Ferrón, M García de Acilu, J Marin, V Antonia, L Ruano, M Monica, R Ferrer, J R Masclans, O Roca, G Hong, D H Kim, Y S Kim, J S Park, Y K Jee, Z Yu Xiang, W Jia-Xing, W Xiao Dan, N Wen Long, W Yu, Z Yan, X Cheng, T Kobayashi, Y Onodera, R Akimoto, A Sugiura, H Suzuki, M Iwabuchi, M Nakane, K Kawamae, P Carmona Sanchez, M D Bautista Rodriguez, M Rodriguez Delgado, V Martínez de Pinillos Sánchez, A Mula Gómez, J M Serrano Simón, P Beuret, C Fortes, M Lauer, M Reboul, J C Chakarian, X Fabre, B Philippon-Jouve, S Devillez, M Clerc, N Rittayamai, M Sklar, M Dres, M Rauseo, C Campbell, B West, D E Tullis, L Brochard, Y Onodera, R Akimoto, H Suzuki, M Okada, M Nakane, K Kawamae, N Ahmad, M Wood, A Glossop, J Higuera Lucas, A Blandino Ortiz, D Cabestrero Alonso, R De Pablo Sánchez, L Rey González, R Costa, G Spinazzola, A Pizza, G Ferrone, M Rossi, M Antonelli, G Conti, H Ribeiro, J Alves, M Sousa, P Reis, C S Socolovsky, R P Cauley, J E Frankel, A L Beam, K O Olaniran, F K Gibbons, K B Christopher, J Pennington, P Zolfaghari, H S King, H H Y Kong, H P Shum, W W Yan, C Kaymak, N Okumus, A Sari, B Erdogdu, S Aksun, H Basar, A Ozcan, N Ozcan, D Oztuna, J A Malmgren, S Lundin, K Torén, M Eckerström, A Wallin, A C Waldenström, F C Riccio, D Pogson, A C P Antonio, A F Leivas, F Kenji, E James, P Morgan, G Carroll, L Gemmell, A MacKay, C Wright, J Ballantyne, S Jonnada, C S Gerrard, N Jones, J D Salciccioli, D C Marshall, M Komorowski, A Hartley, M C Sykes, R Goodson, J Shalhoub, J R Fernández Villanueva, R Fernández Garda, A M López Lago, E Rodríguez Ruiz, R Hernández Vaquero, C Galbán Rodríguez, E Varo Pérez, C Hilasque, I Oliva, G Sirgo, M C Martin, M Olona, M C Gilavert, M Bodí, C Ebm, G Aggarwal, S Huddart, N Quiney, M Cecconi, S M Fernandes, J Santos Silva, J Gouveia, D Silva, R Marques, H Bento, A Alvarez, Z Costa Silva, D Díaz Diaz, M Villanova Martínez, E Palencia Herrejon, A Martinez de la Gandara, G Gonzalo, M A Lopez, P Ruíz de Gopegui Miguelena, C I Bernal Matilla, P Sánchez Chueca, M D C Rodríguez Longares, R Ramos Abril, A L Ruíz Aguilar, R Garrido López de Murillas, R Fernández Fernández, P Morales Laborías, M A Díaz Castellanos, M E Morales Laborías, J Cho, J Kim, J Park, S Woo, T West, E Powell, A Rimmer, C Orford, N Jones, J Williams, C I Bernal Matilla, P Ruiz de Gopegui Miguelena, P Sánchez Chueca, R Ramos Abril, M D C Rodríguez Longares, A L Ruíz Aguilar, R Garrido López de Murillas, R S Bourne, R Shulman, M Tomlin, G H Mills, M Borthwick, W Berry, D García Huertas, F Manzano, F Villagrán-Ramírez, A Ruiz-Perea, C Rodríguez-Mejías, F Santiago-Ruiz, M Colmenero-Ruiz, C König, B Matt, A Kortgen, C S Hartog, A Wong, C Balan, G Barker, N Srisawat, S Peerapornratana, P Laoveeravat, S Tachaboon, S Eiam-Ong, J Paratz, G Kayambu, R Boots, M F Aguilar Arzapalo, R Vlasenko, E Gromova, S Loginov, M Kiselevskiy, Y Dolgikova, K B Tang, C M Chau, K N Lam, E Gil, G Y Suh, C M Park, J Park, C R Chung, C T Lee, A Chao, P Y Shih, Y F Chang, C H Lai, Y C Hsu, Y C Yeh, Y J Cheng, V Colella, N Zarrillo, M D'Amico, F Forfori, B Pezza, T Laddomada, V Beltramelli, M L Pizzaballa, A Doronzio, B Balicco, D Kiers, W van der Heijden, J Gerretsen, Q de Mast, S El Messaoudi, G Rongen, M Gomes, M Kox, P Pickkers, N P Riksen, Y Kashiwagi, M Okada, K Hayashi, Y Inagaki, S Fujita, M N Nakamae, Y R Kang, R B Souza, A M A Liberatore, I H J Koh, A Blet, M Sadoune, J Lemarié, N Bihry, R Bern, E Polidano, R Merval, J M Launay, B Lévy, J L Samuel, A Mebazaa, J Hartmann, S Harm, V Weber
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27640304/evidence-that-the-5p12-variant-rs10941679-confers-susceptibility-to-estrogen-receptor-positive-breast-cancer-through-fgf10-and-mrps30-regulation
#17
Maya Ghoussaini, Juliet D French, Kyriaki Michailidou, Silje Nord, Jonathan Beesley, Sander Canisus, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Mahdi Moradi Marjaneh, Jason S Lee, Joe Dennis, Manjeet K Bolla, Qin Wang, Ed Dicks, Roger L Milne, John L Hopper, Melissa C Southey, Marjanka K Schmidt, Annegien Broeks, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, Olivia Fletcher, Nichola Johnson, Elinor J Sawyer, Ian Tomlinson, Barbara Burwinkel, Frederik Marme, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Javier Benitez, Anna González-Neira, M Rosario Alonso, Guillermo Pita, Susan L Neuhausen, Hoda Anton-Culver, Hermann Brenner, Volker Arndt, Alfons Meindl, Rita K Schmutzler, Hiltrud Brauch, Ute Hamann, Daniel C Tessier, Daniel Vincent, Heli Nevanlinna, Sofia Khan, Keitaro Matsuo, Hidemi Ito, Thilo Dörk, Natalia V Bogdanova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli-Matti Kosma, Anna H Wu, David Van Den Berg, Diether Lambrechts, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Paolo Radice, Monica Barile, Fergus J Couch, Emily Hallberg, Graham G Giles, Christopher A Haiman, Loic Le Marchand, Mark S Goldberg, Soo H Teo, Cheng Har Yip, Anne-Lise Borresen-Dale, Wei Zheng, Qiuyin Cai, Robert Winqvist, Katri Pylkäs, Irene L Andrulis, Peter Devilee, Rob A E M Tollenaar, Montserrat García-Closas, Jonine Figueroa, Per Hall, Kamila Czene, Judith S Brand, Hatef Darabi, Mikael Eriksson, Maartje J Hooning, Linetta B Koppert, Jingmei Li, Xiao-Ou Shu, Ying Zheng, Angela Cox, Simon S Cross, Mitul Shah, Valerie Rhenius, Ji-Yeob Choi, Daehee Kang, Mikael Hartman, Kee Seng Chia, Maria Kabisch, Diana Torres, Craig Luccarini, Don M Conroy, Anna Jakubowska, Jan Lubinski, Suleeporn Sangrajrang, Paul Brennan, Curtis Olswold, Susan Slager, Chen-Yang Shen, Ming-Feng Hou, Anthony Swerdlow, Minouk J Schoemaker, Jacques Simard, Paul D P Pharoah, Vessela Kristensen, Georgia Chenevix-Trench, Douglas F Easton, Alison M Dunning, Stacey L Edwards
Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495-45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen-receptor-positive (ER(+)) breast cancer (per-g allele OR ER(+) = 1...
October 6, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27635945/myolipoma-of-soft-tissue-clinicopathologic-analysis-of-34-cases
#18
Mana Fukushima, Inga-Marie Schaefer, Christopher D M Fletcher
Myolipoma of soft tissue, which was first described by Meis and Enzinger (1991), is a rare benign neoplasm characterized by the admixture of mature adipocytes and well-differentiated smooth muscle cells. Recently, cytogenetic alteration of the HMGA2 gene has been reported in 2 myolipomas. We present the clinicopathologic features of 34 cases of myolipoma of soft tissue, study immunoreactivity for HMGA2, and review the previous literature. In our series, there were 32 women and 2 men, with age at presentation ranging from 35 to 94 years (median, 55 y)...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27603901/pro-invasive-effect-of-proto-oncogene-pbf-is-modulated-by-an-interaction-with-cortactin
#19
Rachel J Watkins, Waraporn Imruetaicharoenchoke, Martin L Read, Neil Sharma, Vikki L Poole, Erica Gentilin, Sukhchain Bansal, Emy Bosseboeuf, Rachel Fletcher, Hannah R Nieto, Ujjal Mallick, Allan Hackshaw, Hisham Mehanna, Kristien Boelaert, Vicki E Smith, Christopher J McCabe
CONTEXT: Metastatic disease is responsible for the majority of endocrine cancer deaths. New therapeutic targets are urgently needed to improve patient survival rates. OBJECTIVE: The proto-oncogene PTTG1-binding factor (PBF/PTTG1IP) is overexpressed in multiple endocrine cancers and circumstantially associated with tumor aggressiveness. This study aimed to understand the role of PBF in tumor cell invasion and identify possible routes to inhibit its action. Design, Setting, Patients, and Interventions: Thyroid, breast, and colorectal cells were transfected with PBF and cultured for in vitro analysis...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27601076/functional-mechanisms-underlying-pleiotropic-risk-alleles-at-the-19p13-1-breast-ovarian-cancer-susceptibility-locus
#20
Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Matthias W Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalia Bogdanova, Anders Bojesen, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fiona Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Saundra S Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Canniotto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B M Claes, Linda S Cook, Angela Cox, Daniel W Cramer, Simon S Cross, Cezary Cybulski, Kamila Czene, Mary B Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diez, Jennifer A Doherty, Susan M Domchek, Cecilia M Dorfling, Thilo Dörk, Martine Dumont, Hans Ehrencrona, Bent Ejlertsen, Steve Ellis, Christoph Engel, Eunjung Lee, D Gareth Evans, Peter A Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lenka Foretova, Florentia Fostira, William D Foulkes, Brooke L Fridley, Eitan Friedman, Debra Frost, Gaetana Gambino, Patricia A Ganz, Judy Garber, Montserrat García-Closas, Aleksandra Gentry-Maharaj, Maya Ghoussaini, Graham G Giles, Rosalind Glasspool, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Ellen L Goode, Marc T Goodman, Mark H Greene, Jacek Gronwald, Pascal Guénel, Christopher A Haiman, Per Hall, Emily Hallberg, Ute Hamann, Thomas V O Hansen, Patricia A Harrington, Mikael Hartman, Norhashimah Hassan, Sue Healey, Florian Heitz, Josef Herzog, Estrid Høgdall, Claus K Høgdall, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Peter J Hulick, Tomasz Huzarski, Evgeny N Imyanitov, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Allan Jensen, Esther M John, Nichola Johnson, Maria Kabisch, Daehee Kang, Miroslav Kapuscinski, Beth Y Karlan, Sofia Khan, Lambertus A Kiemeney, Susanne Kruger Kjaer, Julia A Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Jolanta Kupryjanczyk, Ava Kwong, Miguel de la Hoya, Yael Laitman, Diether Lambrechts, Nhu Le, Kim De Leeneer, Jenny Lester, Douglas A Levine, Jingmei Li, Annika Lindblom, Jirong Long, Artitaya Lophatananon, Jennifer T Loud, Karen Lu, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Loic Le Marchand, Sara Margolin, Frederik Marme, Leon F A G Massuger, Keitaro Matsuo, Sylvie Mazoyer, Lesley McGuffog, Catriona McLean, Iain McNeish, Alfons Meindl, Usha Menon, Arjen R Mensenkamp, Roger L Milne, Marco Montagna, Kirsten B Moysich, Kenneth Muir, Anna Marie Mulligan, Katherine L Nathanson, Roberta B Ness, Susan L Neuhausen, Heli Nevanlinna, Silje Nord, Robert L Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Janet E Olson, Curtis Olswold, David O'Malley, Irene Orlow, Nick Orr, Ana Osorio, Sue Kyung Park, Celeste L Pearce, Tanja Pejovic, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Elizabeth M Poole, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Valerie Rhenius, Kerstin Rhiem, Harvey A Risch, Gus Rodriguez, Mary Anne Rossing, Anja Rudolph, Helga B Salvesen, Suleeporn Sangrajrang, Elinor J Sawyer, Joellen M Schildkraut, Marjanka K Schmidt, Rita K Schmutzler, Thomas A Sellers, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Weiva Sieh, Christian F Singer, Olga M Sinilnikova, Susan Slager, Honglin Song, Penny Soucy, Melissa C Southey, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony Swerdlow, Sandrine Tchatchou, Manuel R Teixeira, Soo H Teo, Kathryn L Terry, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Amanda Ewart Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Nadine Tung, Shelley S Tworoger, Celine Vachon, Ans M W van den Ouweland, Helena C van Doorn, Elizabeth J van Rensburg, Laura J Van't Veer, Adriaan Vanderstichele, Ignace Vergote, Joseph Vijai, Qin Wang, Shan Wang-Gohrke, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Hans Wildiers, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Sook-Yee Yoon, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Kum Kum Khanna, Jacques Simard, Alvaro N Monteiro, Juliet D French, Fergus J Couch, Matthew L Freedman, Douglas F Easton, Alison M Dunning, Paul D Pharoah, Stacey L Edwards, Georgia Chenevix-Trench, Antonis C Antoniou, Simon A Gayther
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P<2 × 10(-3))...
September 7, 2016: Nature Communications
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