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Habib Bouguenina, Danièle Salaun, Aurélie Mangon, Leslie Muller, Emilie Baudelet, Luc Camoin, Taro Tachibana, Sarah Cianférani, Stéphane Audebert, Pascal Verdier-Pinard, Ali Badache
Control of microtubule dynamics underlies several fundamental processes such as cell polarity, cell division, and cell motility. To gain insights into the mechanisms that control microtubule dynamics during cell motility, we investigated the interactome of the microtubule plus-end-binding protein end-binding 1 (EB1). Via molecular mapping and cross-linking mass spectrometry we identified and characterized a large complex associating a specific isoform of myomegalin termed "SMYLE" (for short myomegalin-like EB1 binding protein), the PKA scaffolding protein AKAP9, and the pericentrosomal protein CDK5RAP2...
December 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
P Luna-Massey, L Smyle
The purpose of this study was to identify attitudes of California physical therapy consumers toward the professional image of physical therapists. Attitudes toward the professional image of physicians were elicited for comparative purposes. Independent variables were selected to determine their influence on the perceived professional images. The results indicated that consumers viewed physical therapists as possessing four of the five criteria of professionalism; the exception was autonomy of judgment. No significant difference existed between the consumer views of the professional image of physical therapists and the professional image of physicians...
March 1982: Physical Therapy
E Ashayeri, J Smyles, T Calhoun, E T Carreno, N Hagler
Preoperative radiation therapy is one of the major indications for the use of ionizing radiation in the treatment of malignant disease. The preoperative application of radiation treatment is given with the intention of reducing the size of bulky cancers, thus converting unresectable tumors into resectable ones. Other benefits are reduction in the risk of locoregional recurrence and in the risk of blood-borne dissemination of malignant cells promoted during surgical resection.This paper presents and discusses three cases of unresectable intrapelvic tumors initially treated by radiation therapy with the primary goal of palliation...
August 1988: Journal of the National Medical Association
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