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https://www.readbyqxmd.com/read/28806729/erk2-and-jnk1-contribute-to-tnf-%C3%AE-induced-il-8-expression-in-synovial-fibroblasts
#1
Shinichi Namba, Rei Nakano, Taku Kitanaka, Nanako Kitanaka, Tomohiro Nakayama, Hiroshi Sugiya
Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8), which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the onset of RA, we used synovial fibroblasts without autoimmune inflammatory diseases and investigated MAPK signaling pathways in TNF-α-induced IL-8 expression. Synovial fibroblasts isolated from healthy dogs were characterized by flow cytometry, which were positive for the fibroblast markers CD29, CD44, and CD90 but negative for the hematopoietic cell markers CD14, CD34, CD45, and HLA-DR...
2017: PloS One
https://www.readbyqxmd.com/read/28806406/terminal-differentiation-of-t-cells-is-strongly-associated-with-cmv-infection-and-increased-in-hiv-positive-individuals-on-art-and-lifestyle-matched-controls
#2
Thijs Booiman, Ferdinand W Wit, Arginell F Girigorie, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Claudio Franceschi, Steven G Deeks, Alan Winston, Peter Reiss, Neeltje A Kootstra
HIV-1-positive individuals on successful antiretroviral therapy (ART) are reported to have higher rates of age-associated non-communicable comorbidities (AANCCs). HIV-associated immune dysfunction has been suggested to contribute to increased AANCC risk. Here we performed a cross-sectional immune phenotype analysis of T cells in ART-treated HIV-1-positive individuals with undetectable vireamia (HIV-positives) and HIV-1-negative individuals (HIV-negatives) over 45 years of age. In addition, two control groups were studied: HIV negative adults selected based on lifestyle and demographic factors (Co-morBidity in Relation to AIDS, or COBRA) and unselected age-matched donors from a blood bank...
2017: PloS One
https://www.readbyqxmd.com/read/28806205/response-to-dr-o-reilly-shah-et-al
#3
Brian S Rothman, Rajnish K Gupta, Matthew D McEvoy
No abstract text is available yet for this article.
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28805524/response-to-the-editorial-by-dr-geraghty
#4
Peter D White, Trudie Chalder, Michael Sharpe, Brian J Angus, Hannah L Baber, Jessica Bavinton, Mary Burgess, Lucy V Clark, Diane L Cox, Julia C DeCesare, Kimberley A Goldsmith, Anthony L Johnson, Paul McCrone, Gabrielle Murphy, Maurice Murphy, Hazel O'Dowd, Laura Potts, Rebacca Walwyn, David Wilks
This article is written in response to the linked editorial by Dr Geraghty about the adaptive Pacing, graded Activity and Cognitive behaviour therapy; a randomised Evaluation (PACE) trial, which we led, implemented and published. The PACE trial compared four treatments for people diagnosed with chronic fatigue syndrome. All participants in the trial received specialist medical care. The trial found that adding cognitive behaviour therapy or graded exercise therapy to specialist medical care was as safe as, and more effective than, adding adaptive pacing therapy or specialist medical care alone...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28802832/retroviral-gene-transfer-into-primary-human-nk-cells-activated-by-il-2-and-k562-feeder-cells-expressing-membrane-bound-il-21
#5
Maria A Streltsova, Eugene Barsov, Sofia A Erokhina, Elena I Kovalenko
Natural killer (NK) cells are capable of rapidly recognizing and efficiently killing tumor cells. This makes them a potentially promising agent for cancer immunotherapy. Additional genetic modifications of NK cells may further improve their anti-tumor efficacy. Numerous technical challenges associated with gene delivery into NK cells have significantly tempered this approach. We achieved efficient retroviral vector transduction of primary human NK cells that were stimulated by a combination of IL-2 and engineered K562 cells expressing membrane-bound IL-21...
August 9, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28802400/mycobacterium-tuberculosis-myma-is-a-tlr2-agonist-that-activate-macrophages-and-a-th1-response
#6
Iti Saraav, Swati Singh, Kirti Pandey, Monika Sharma, Sadhna Sharma
Cell wall of Mycobacterium tuberculosis (M.tb) is a major source of immunogenic proteins that can be tested as vaccine candidates. MymA (Rv3083), a 55 kDa M.tb flavin containing monooxygenase, is involved in modification of mycolic acids during acidic shock following M.tb internalization in macrophage. In this study, we have investigated the role of this cell wall associated protein in activation of macrophages by toll like receptor (TLRs) engagement and subsequent signaling. Our results showed that MymA stimulation of THP1 cells and human monocyte derived macrophages (MDM) lead to upregulation of TLR2 and co-stimulatory molecules CD40, CD80, CD86 and HLA-DR...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28801852/phase-1-study-of-darolutamide-odm-201-a-new-generation-androgen-receptor-antagonist-in-japanese-patients-with-metastatic-castration-resistant-prostate-cancer
#7
Nobuaki Matsubara, Hirofumi Mukai, Ako Hosono, Mai Onomura, Masaoki Sasaki, Yoko Yajima, Kensei Hashizume, Masanobu Yasuda, Miho Uemura, Christian Zurth
PURPOSE: This trial assessed the safety, pharmacokinetics, and efficacy of darolutamide (ODM-201), a new-generation nonsteroidal androgen receptor antagonist, in Japanese patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: In this open-label, nonrandomized, two-cohort, dose-escalating phase 1 study, Japanese patients with mCRPC were enrolled after a screening period. In the single-dose period (≈1 week), darolutamide was administered at 300 mg (Cohort 1) or 600 mg (Cohort 2) on day-5 (fasting state) and day-2 (fed condition)...
August 11, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28801812/a%C3%A2-synopsis-of-the-history-of-hansen-s-disease
#8
Raissa Gonçalves Couto Dal Secco, Katlein França, David Castillo, Mana AlHarbi, Torello Lotti, Massimo Fioranelli, Maria Grazia Roccia
Leprosy is a contagious infectious disease caused by the bacillus Mycobacterium leprae. This microorganism was discovered by Dr. Gerhard Hansen, and the illness was then baptized as Hansen's disease. For a long time, Hansen's disease was thought to be hereditary-a curse or a punishment from God. The disease affects skin and nerves and can cause severe damage. Due to its destructive effects, leprosy has caused fear, segregation, and prejudice in all societies since Biblical times. Patients with Hansen's disease have not been treated humanely around the world throughout the ages...
August 11, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28801733/-obituary-for-prof-dr-med-helmuth-deicher
#9
EDITORIAL
H-H Peter, J R Kalden, W J Pichler, R E Schmidt
No abstract text is available yet for this article.
August 11, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28801669/balance-between-estrogens-and-proinflammatory-cytokines-regulates-chemokine-production-involved-in-thymic-germinal-center-formation
#10
Nadine Dragin, Patrice Nancy, José Villegas, Régine Roussin, Rozen Le Panse, Sonia Berrih-Aknin
The early-onset form of Myasthenia Gravis (MG) is prevalent in women and associates with ectopic germinal centers (GCs) development and inflammation in the thymus. we aimed to investigate the contribution of estrogens in the molecular processes involved in thymic GCs formation. We examined expression of genes involved in anti-acetylcholine receptor (AChR) response in MG, MHC class II and α-AChR subunit as well as chemokines involved in GC development (CXCL13, CCL21and CXCL12). In resting conditions, estrogens have strong regulatory effects on thymic epithelial cells (TECs), inducing a decreased protein expression of the above molecules...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800603/genetic-variants-specific-to-aging-related-verbal-memory-insights-from-gwass-in-a-population-based-cohort
#11
Thalida E Arpawong, Neil Pendleton, Krisztina Mekli, John J McArdle, Margaret Gatz, Chris Armoskus, James A Knowles, Carol A Prescott
Verbal memory is typically studied using immediate recall (IR) and delayed recall (DR) scores, although DR is dependent on IR capability. Separating these components may be useful for deciphering the genetic variation in age-related memory abilities. This study was conducted to (a) construct individual trajectories in IR and independent aspects of delayed recall, or residualized-DR (rDR), across older adulthood; and (b) identify genetic markers that contribute to four estimated phenotypes: IR and rDR levels and changes after age 60...
2017: PloS One
https://www.readbyqxmd.com/read/28798741/deinococcus-radiodurans-toxin-antitoxin-mazef-dr-mediates-cell-death-in-response-to-dna-damage-stress
#12
Tao Li, Yulan Weng, Xiaoqiong Ma, Bing Tian, Shang Dai, Ye Jin, Mengjia Liu, Jiulong Li, Jiangliu Yu, Yuejin Hua
Here we identified a functional MazEF-dr system in the exceptionally stress-resistant bacterium D. radiodurans. We showed that overexpression of the toxin MazF-dr inhibited the growth of Escherichia coli. The toxic effect of MazF-dr was due to its sequence-specific endoribonuclease activity on RNAs containing a consensus 5'ACA3', and it could be neutralized by MazE-dr. The MazF-dr showed a special cleavage preference for the nucleotide present before the ACA sequence with the order by U>A>G>C. MazEF-dr mediated the death of D...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28796671/what-is-new-in-evaluation-of-asymptomatic-microscopic-hematuria-in-women-best-articles-from-the-past-year
#13
Kimberly Kenton
This month we focus on current research in asymptomatic microscopic hematuria. Dr. Kenton discusses four recent publications, which are concluded with a "bottom line" that is a take-home message. A complete reference for each can be found on Box 1 on this page along with direct links to abstracts.
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28796623/dimensionality-reduction-using-similarity-induced-embeddings
#14
Nikolaos Passalis, Anastasios Tefas
The vast majority of dimensionality reduction (DR) techniques rely on the second-order statistics to define their optimization objective. Even though this provides adequate results in most cases, it comes with several shortcomings. The methods require carefully designed regularizers and they are usually prone to outliers. In this paper, a new DR framework that can directly model the target distribution using the notion of similarity instead of distance is introduced. The proposed framework, called similarity embedding framework (SEF), can overcome the aforementioned limitations and provides a conceptually simpler way to express optimization targets similar to existing DR techniques...
August 8, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28796168/reply-comment-on-chocolate-consumption-and-risk-of-coronary-heart-disease-stroke-and-diabetes-a-meta-analysis-of-prospective-studies-nutrients-2017-9-688
#15
Sheng Yuan, Jinping Lu
To the editor, We would like to thank Dr. Hurtado-Torres for his valuable comments on our article entitled "Chocolate Consumption and Risk of Coronary Heart Disease, Stroke, and Diabetes: A Meta-Analysis of Prospective Studies", which was published in Nutrients in July 2017 [1]. [...].
August 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28795493/-molecularly-imprinted-chromatography-fails-to-distinguish-homeopatic-remedy-from-placebo
#16
Roman Kaliszan, Małgorzata Waszczuk-Jankowska, Danuta Siluk, Bartosz Wielgomas
It was sensation when Dr. J. Beneviste reported alleged experimental biological evidence of the water memory effect (E. Dayenas et al. Nature 333, 816-818, 1988; https://doi.org/10.1038/333816a0). These experiments have never been reproduced in controlled conditions, however. Instead, the hypothesis that water can be imprinted with the memory of past solutes was ruled out (J. Maddox et al. Nature 334, 287-290, 1988; https://doi.org/10.1038/334287a0). At present, so-called "molecular imprinting" is a technology of preparing polymer matrices as affinity-based analyte separation media (J...
August 10, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28795147/impact-of-the-trough-level-of-calcineurin-inhibitor-on-the-prevalence-of-donor-specific-human-leukocyte-antigen-antibodies-during-long-term-follow-up-after-pediatric-liver-transplantation-antibody-strength-and-complement-binding-ability
#17
Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Masafumi Goto, Michiaki Unno, Takashi Kamei
BACKGROUND: In pediatric patients, long-term immunosuppression after liver transplantation (LT) is typically minimal. However, posttransplant donor-specific HLA antibodies (DSAs) may be prevalent under these conditions. Here, we evaluated the effects of minimized calcineurin inhibitor (CNI) on DSA development to assess the validity of minimized/withdrawn immunosuppression. METHODS: We retrospectively examined 66 patients who underwent pediatric LT at our institution between July 1991 and October 2013...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28794935/label-free-direct-electrical-detection-of-a-histidine-rich-protein-with-sub-femtomolar-sensitivity-using-an-organic-field-effect-transistor
#18
Tsukuru Minamiki, Yui Sasaki, Shizuo Tokito, Tsuyoshi Minami
The front cover artwork is provided by the group of Dr. Tsuyoshi Minami at the Institute of Industrial Science, the University of Tokyo (Japan). Easy-to-use sensing systems for on-site biomarker testing have been researched numerously, because conventional approaches for biomarker detection (e.g. enzyme linked-immunosorbent assays, etc.) are too complicated. In that regard, organic filed-effect transistors (OFETs) are some of the most promising platforms for construction of on-site testing systems. As OFETs can be easily fabricated on flexible substrates using wet processes, these are not only valuable transducers for chemo-/biosensors, but also the prospective device for rollable displays and low-cost radio frequency identification tags...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28794886/evaluation-of-genexpert-mtb-rif-for-determination-of-rifampicin-resistance-among-new-tuberculosis-cases-in-west-and-northwest-iran
#19
S Atashi, B Izadi, S Jalilian, S H Madani, A Farahani, P Mohajeri
Despite a Mycobacterium tuberculosis control programme and anti-tuberculosis drugs, drug-resistant tuberculosis (DR-TB) is one of the most serious public health issues worldwide. Rapid laboratory diagnosis of M. tuberculosis is needed for the diagnosis of multidrug-resistant (MDR) TB and to find the optimal treatment protocol. The purpose of this study was to detect resistance to rifampicin in new cases of TB using the GeneXpert MTB/RIF (M. tuberculosis/rifampicin) assay and the standard proportional method in west and northwest Iran...
September 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28793881/patients-preferences-for-involvement-in-the-decision-making-process-for-treating-diabetic-retinopathy
#20
Lydia Marahrens, Raimar Kern, Tjalf Ziemssen, Andreas Fritsche, Peter Martus, Focke Ziemssen, Daniel Roeck
BACKGROUND: To assess factors associated with the preferred role of the attending ophthalmologist in the decision-making processes before treating diabetic retinopathy (DR). METHODS: Cross-sectional study of 810 adults attending secondary diabetes care centers (NCT02311504). Diabetes patients were classified using a validated questionnaire in an ophthalmologist-dominant decision-making (ODM), shared decision-making (SDM) and patient-dominant decision-making (PDM) style...
August 9, 2017: BMC Ophthalmology
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