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https://www.readbyqxmd.com/read/29743025/risk-of-incident-atrial-fibrillation-in-patients-presenting-with-retinal-artery-or-vein-occlusion-a-nationwide-cohort-study
#1
Christine Benn Christiansen, Christian Torp-Pedersen, Jonas Bjerring Olesen, Gunnar Gislason, Morten Lamberts, Nicholas Carlson, Mathias Buron, Nikolai Juul, Gregory Y H Lip
BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. METHODS: Patients with retinal occlusions from 1997 to 2011 were identified through Danish nationwide registries and matched 1:5 according to sex and age...
May 10, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29708803/a-5-year-follow-up-study-of-the-treatment-of-macular-edema-due-to-retinal-vein-occlusion-using-dexamethasone-intravitreal-implants
#2
Gonzaga Garay-Aramburu, Ángela Gómez-Moreno
PURPOSE: To evaluate the long-term effects of intravitreal dexamethasone implants (IDIs) in eyes with macular edema (ME) due to retinal vein occlusion (RVO). METHODS: We reviewed the records of 10 patients followed for 5 years after they received their first IDI. The main outcome measures included changes in best corrected visual acuity (BCVA), central macular thickness (CMT), and central macular volume (CMV), and the incidence of side effects. RESULTS: Ten patients were included in the study with a mean follow-up of 65...
April 30, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29705175/ischemic-retinal-vein-occlusion-characterizing-the-more-severe-spectrum-of-retinal-vein-occlusion
#3
REVIEW
Meiaad Khayat, Michael Williams, Noemi Lois
Retinal vein occlusion (RVO), including central (CRVO), branch (BRVO) and hemicentral and hemispheric RVO, is the second most common vascular cause of visual loss, surpassed only by diabetic retinopathy. The presence and extent of retinal ischemia in RVO is associated with a worse prognosis. On this basis, most previously conducted studies considered iRVO and non-iRVO as separate entities based on set thresholds of existing retinal ischemia, as determined by fundus fluorescein angiography (FFA). Other diagnostic technologies have been used specifically in the differentiation of iCRVO and non-iCRVO...
April 26, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29699979/changes-in-retinal-ischaemic-index-correlate-with-recalcitrant-macular-oedema-in-retinal-vein-occlusion-wave-study
#4
Soonil Kwon, Charles Clifton Wykoff, David M Brown, Jano van Hemert, Wenying Fan, SriniVas R Sadda
AIM: To evaluate changes in the ischaemic index (ISI) after targeted retinal photocoagulation (TRP) and to investigate the correlation between these changes and macular oedema (ME). METHOD: Twenty-four eyes of 24 patients with retinal vein occlusion (RVO) with recurrent ME were included. Ultra-widefield fluorescein angiography (UWFFA; Optos 200Tx) was obtained at baseline and every 4 months. The regions of retinal non-perfusion and the total gradable retina were manually segmented on UWFFA images for calculating the global ISI...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664983/longitudinal-quantification-of-retinal-nonperfusion-in-the-macula-of-eyes-with-retinal-vein-occlusion-receiving-anti-vegf-therapy-secondary-analysis-of-the-wave-randomized-trial
#5
William C Ou, Shaun I R Lampen, Charles C Wykoff
BACKGROUND AND OBJECTIVE: Longitudinal quantification of retinal nonperfusion (RNP) in eyes with retinal vein occlusion (RVO) undergoing anti-vascular endothelial growth factor therapy. PATIENTS AND METHODS: Thirty eyes with ischemic RVO were randomized to ranibizumab (Lucentis; Genentech, South San Francisco, CA) (monotherapy) or ranibizumab plus peripheral laser (combination therapy) in a 12-month, prospective trial. RNP on fluorescein angiography was quantified within the macula through 12 months of follow-up...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29662298/anti-vegf-treatment-of-macular-edema-associated-with-retinal-vein-occlusion-patterns-of-use-and-effectiveness-in-clinical-practice-echo-study-report-2
#6
J Michael Jumper, Pravin U Dugel, Sanford Chen, Kevin J Blinder, John G Walt
Purpose: To evaluate the efficacy, safety, and injection frequency of vascular endothelial growth factor (VEGF) antagonists in the treatment of macular edema secondary to retinal vein occlusion (RVO) in clinical practice. Patients and methods: A multicenter retrospective study of the medical records of 165 patients (95 branch RVO, 70 central RVO) treated with at least three anti-VEGF injections in the study eye was conducted. Available data collected for at least 6 months after the first injection included Snellen best-corrected visual acuity (BCVA), central retinal thickness (CRT) by time-domain optical coherence tomography (TD-OCT) or spectral-domain optical coherence tomography (SD-OCT), anti-VEGF injections, other treatments/procedures for RVO, and adverse events...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29600177/intravitreal-anti-vegf-agents-oral-glucocorticoids-and-laser-photocoagulation-combination-therapy-for-macular-edema-secondary-to-retinal-vein-occlusion-preliminary-report
#7
Xiao-Xiao Feng, Cheng Li, Wan-Wen Shao, Yong-Guang Yuan, Xiao-Bing Qian, Qi-Shan Zheng, Yu-Jie Li, Qian-Ying Gao
AIM: To evaluate the efficacy and safety of combined anti-vascular endothelial growth factor (VEGF) agents, oral glucocorticoid, and laser photocoagulation therapy for macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: This study included 16 eyes of 16 patients with RVO-associated ME. Patients were initially treated with oral prednisone and an intravitreal anti-VEGF agent. Two weeks later, patients underwent standard laser photocoagulation. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and retinal vessel oxygenation were examined over 12mo...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29595656/the-association-between-myocardial-infarction-and-intravitreal-bevacizumab-injection
#8
Jin-Woo Kwon, Donghyun Jee, Tae Yoon La
To evaluate the risk of myocardial infarction (MI) after receiving intravitreal bevacizumab (IVB) injection. We retrospectively reviewed the charts of patients who had received IVB injection in 2016, and grouped them according to whether they received the injection for age-related macular degeneration (AMD), diabetes-related complications, or retinal vein occlusion (RVO). We then investigated the prevalence of MI within 2 months after IVB injection and analyzed the possible association of IVB with MI. During 2016, 724 patients were enrolled and received a total of 1870 IVB injections...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594610/extended-field-imaging-using-swept-source-optical-coherence-tomography-angiography-in-retinal-vein-occlusion
#9
Shinji Kakihara, Takao Hirano, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Toshinori Murata
PURPOSE: To evaluate the degree of ischemia in eyes with retinal vein occlusion (RVO) using swept-source optical coherence tomography angiography (SS-OCTA) with the extended field imaging (EFI) technique, which extends the area encompassed by SS-OCTA by scanning through trial frames fitted with a +20-diopter lens. STUDY DESIGN: Retrospective observational study. METHODS: Twenty-three consecutive eyes of 22 patients with RVO underwent 12 × 12 mm SS-OCTA imaging both with and without EFI for determination of extension rate...
March 28, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29589187/erythrocyte-compression-index-is-impaired-in-patients-with-residual-vein-obstruction
#10
Michal Zabczyk, Joanna Natorska, Anetta Undas
Defective clot contraction has been postulated to contribute to thrombosis. We aimed to evaluate the association of residual vein obstruction (RVO) with erythrocyte compression within the whole-blood clot. We studied 32 patients with venous thromboembolism (VTE) taking vitamin K antagonists (VKAs) for at least 3 months (median time in therapeutic range 60%), including 12 (37.5%) with RVO, and 32 age- and sex-matched controls. In all study participants we evaluated whole blood clot retraction, expressed as the erythrocyte compression index (ECI), defined as a ratio of mean polyhedrocyte area to mean native erythrocyte area, along with clot area covered by polyhedrocytes, plasma clot permeability (Ks), clot lysis time (CLT), and thrombin generation...
March 27, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29572577/mechanisms-of-vision-loss-in-eyes-with-macular-edema-associated-with-retinal-vein-occlusion
#11
REVIEW
Hiroyuki Iijima
Anti-vascular endothelial growth factor agents reduce macular edema and improve vision in eyes with macular edema associated with retinal vein occlusion (RVO), including branch RVO (BRVO) and central RVO. However, not all eyes with resolved macular edema show satisfactory best corrected visual acuity. Photoreceptor impairment can mostly explain the vision loss in these cases. Photoreceptor damage can be caused by subretinal hemorrhage in the central fovea and hard exudates or their precursor derived from concentrated lipoproteins originating from leaky retinal vessel extravasation...
March 23, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29558315/altered-cardiovascular-function-is-related-to-reduced-bdnf-in-parkinson-s-disease
#12
Mahmoud A Alomari, Hanan Khalil, Omar F Khabour, Karem H Alzoubi, Esraa H Dersieh
Brain-derived neurotrophic factor (BDNF) has been linked to cardiovascular health and function, however, the exact role is yet to be understood. The current study examined the relationship of circulatory BDNF with vascular function in Parkinson's disease (PD). ELISA was used to determine plasma BDNF in PD patients and healthy control (CT). Additionally, forearm resting blood flow (RBf), vascular resistance (RVr), venous capacitance (RVc), and venous outflow (RVo) as well as post occlusion blood flow (OcBf), vascular resistance (OcVr), venous capacitance (OcVc), and venous outflow (OcVo) were obtained using strain-gauge plethysmography...
March 20, 2018: Experimental Aging Research
https://www.readbyqxmd.com/read/29529099/gene-expression-profiling-in-a-mouse-model-of-retinal-vein-occlusion-induced-by-laser-treatment-reveals-a-predominant-inflammatory-and-tissue-damage-response
#13
Gottfried Martin, David Conrad, Bertan Cakir, Günther Schlunck, Hansjürgen T Agostini
PURPOSE: Retinal vein occlusion (RVO) has been investigated in several laser-induced animal models using pigs, rabbits and rats. However, laser-induced RVO has been rarely reported in mice, despite the impressive number of available mutants, ease of handling and cost effectiveness. The aim of this study was to further assess the feasibility of a RVO mouse model for gene expression analysis and its possible use to investigate effects of hypoxia. METHODS: C57Bl/6J mice were injected with eosin Y for photo-sensitization...
2018: PloS One
https://www.readbyqxmd.com/read/29511062/neuroretinal-atrophy-following-resolution-of-macular-oedema-in-retinal-vein-occlusion
#14
Dominika Podkowinski, Ana-Maria Philip, Wolf-Dieter Vogl, Jutta Gamper, Hrvoje Bogunovic, Bianca S Gerendas, Bilal Haj Najeeb, Sebastian M Waldstein, Ursula Schmidt-Erfurth
BACKGROUND/AIMS: To characterise neuroretinal atrophy in retinal vein occlusion (RVO). METHODS: We included patients with central/branch RVO (CRVO=196, BRVO=107) who received ranibizumab according to a standardised protocol for 6 months. Retinal atrophy was defined as the presence of an area of retinal thickness (RT) <260 µm outside the foveal centre. Moreover, the thickness of three distinct retinal layer compartments was computed as follows: (1) retinal nerve fibre layer to ganglion cell layer, (2) inner plexiform layer (IPL) to outer nuclear layer (ONL) and (3) inner segment/outer segment junction to retinal pigment epithelium...
March 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29493707/projection-of-eye-disease-burden-in-singapore
#15
John P Ansah, Victoria Koh, Dirk F de Korne, Steffen Bayer, Chong Pan, Jayabaskar Thiyagarajan, David B Matchar, Ecosse Lamoureux, Desmond Quek
INTRODUCTION: Singapore's ageing population is likely to see an increase in chronic eye conditions in the future. This study aimed to estimate the burden of eye diseases among resident Singaporeans stratified for age and ethnicity by 2040. MATERIALS AND METHODS: Prevalence data on myopia, epiretinal membrane (ERM), retinal vein occlusion (RVO), age macular degeneration (AMD), diabetic retinopathy (DR), cataract, glaucoma and refractive error (RE) by age cohorts and educational attainment from the Singapore Epidemiology of Eye Diseases (SEED) study were applied to population estimates from the Singapore population model...
January 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29485235/extension-of-peripheral-nonperfusion-in-eyes-with-retinal-vein-occlusion-during-intravitreal-dexamethasone-treatment
#16
Sandra Rezar-Dreindl, Katharina Eibenberger, Wolf Buehl, Günther Weigert, Michael Georgopoulos, Ursula Schmidt-Erfurth, Stefan Sacu
BACKGROUND: To evaluate the change in peripheral perfusion status in patients with retinal vein occlusion (RVO) during dexamethasone treatment. METHODS: Thirty-five eyes of patients with macular oedema due to either branch or central retinal vein occlusion were included. At baseline, patients were treated with an intravitreal dexamethasone implant (Ozurdex® ) and followed until month 6. Wide-field angiographies were classified as ischaemic and nonischaemic. Peripheral nonperfusion (PNP) was determined manually by calculating the percentage of nonperfusion area in relation to the total visible retina (ischaemic index)...
February 27, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29399095/predicting-the-visual-acuity-for-retinal-vein-occlusion-after-ranibizumab-therapy-with-an-original-ranking-for-macular-microstructure
#17
Haiyang Liu, Suyan Li, Zhengpei Zhang, Jie Shen
The study investigated predictive factors for best-corrected visual acuity (BCVA) after ranibizumab treatment in patients with macular edema (ME) associated with retinal vein occlusion (RVO) with an original ranking for the impairment of macular microstructure. In this retrospective study, 31 eyes of 31 patients with RVO received 3 monthly consecutive ranibizumab injections and another 3 months of follow-up. An original method was applied to rank the impairment of the external limiting membrane (ELM) and the ellipsoid zone (previously called the photoreceptor inner and outer segment junction, IS/OS) integrity on the baseline optical coherence tomography (OCT) images...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29374830/correlations-between-near-infrared-spectroscopy-perfusion-index-and-cardiac-outputs-in-extremely-preterm-infants-in-the-first-72-h-of-life
#18
Marie Janaillac, Thierry P Beausoleil, Keith J Barrington, Marie-Josée Raboisson, Oliver Karam, Mathieu Dehaes, Anie Lapointe
Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2 ), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty newborns born at < 28 weeks of gestation were continuously monitored with CrSO2 and preductal PI. Cardiac output was measured at H6, H24, H48, and H72. The median gestational age and birth weight were 25...
April 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29366614/correlation-between-ischemic-index-of-retinal-vein-occlusion-and-oxygen-saturation-in-retinal-vessels
#19
Irena Šínová, Jiří Řehák, Jana Nekolová, Nad'a Jirásková, Petra Haluzová, Tereza Řeháková, Barbora Bábková, Libor Hejsek, Martin Šín
PURPOSE: To evaluate the relationship between the ischemic index and the oxygen saturation in retinal vessels in patients with retinal vein occlusion. DESIGN: Prospective, cross-sectional study. METHODS: We performed a prospective study. The cohort consisted of 43 eyes of 43 patients with retinal vein occlusions (RVO), 23 of whom had central retinal vein occlusions (CRVO) and 20 who had branch retinal vein occlusions (BRVO). We evaluated the retinal vessel saturation using an automatic retinal oximetry device...
April 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29360215/incidence-of-retinal-vein-occlusion-in-open-angle-glaucoma-a-nationwide-population-based-study-using-the-korean-health-insurance-review-and-assessment-database
#20
Kyeong Ik Na, Jin Wook Jeoung, Young Kook Kim, Won June Lee, Ki Ho Park
IMPORTANCE: We determined the association between retinal vein occlusion (RVO) and open-angle glaucoma (OAG) in a Korean population by reviewing a dataset obtained from the Korean Health Insurance Review and Assessment (HIRA). BACKGROUND: To compare the RVO incidence for OAG patients with that for the general population in order to determine the association between RVO and OAG. DESIGN: Nationwide population-based retrospective study. PARTICIPANTS: HIRA data for 2011 through 2015...
January 23, 2018: Clinical & Experimental Ophthalmology
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