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https://www.readbyqxmd.com/read/28723611/parent-reported-nutritional-risk-and-laboratory-indices-of-cardiometabolic-risk-and-in-preschool-aged-children
#1
Navindra Persaud, Hedyeh Ziai, Gerald Lebovic, Jonathon L Maguire, Marina Khovratovich, Janis A Randall Simpson, Khosrow Adeli, Jill Hamilton, Brian W McCrindle, Patricia C Parkin, Catherine S Birken
BACKGROUND: Eating habits formed during childhood may contribute to the increasing prevalence of cardiometabolic disorders. Assessing nutritional risk in young children may help to prevent later cardiometabolic disease. The objective of this study was to determine whether parent-reported nutritional risk in preschool-aged children was associated with laboratory indices of cardiometabolic risk, namely leptin and insulin. METHODS: In this cross-sectional study, the relationship between nutritional risk as determined by the parent-completed NutriSTEP® questionnaire was assessed and compared to the serum leptin and insulin concentrations, hormones involved in regulation of food intake and biomarkers of adiposity and cardiometabolic risk...
July 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28723478/low-t-cell-receptor-diversity-high-somatic-mutation-burden-and-high-neoantigen-load-as-predictors-of-clinical-outcome-in-muscle-invasive-bladder-cancer
#2
Noura J Choudhury, Kazuma Kiyotani, Kai Lee Yap, Alexa Campanile, Tatjana Antic, Poh Yin Yew, Gary Steinberg, Jae Hyun Park, Yusuke Nakamura, Peter H O'Donnell
BACKGROUND: The success of cancer immunotherapies has highlighted the potent ability of local adaptive immune responses to eradicate cancer cells by targeting neoantigens generated by somatic alterations. However, how these factors interact to drive the natural history of muscle-invasive bladder cancer (MIBC) is not well understood. OBJECTIVE: To investigate the role of immune regulation in MIBC disease progression, we performed massively parallel T-cell receptor (TCR) sequencing of tumor-infiltrating T cells (TILs), in silico neoantigen prediction from exome sequences, and expression analysis of immune-related genes...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721851/development-and-evaluation-of-a-multiple-locus-variable-number-tandem-repeats-analysis-assay-for-subtyping-salmonella-typhi-strains-from-sub-saharan-africa
#3
Nomsa P Tau, Anthony M Smith, John R Wain, Andrew Tarupiwa, Kalpy J Coulibaly, Karen H Keddy, Germs-Sa
PURPOSE: Molecular epidemiological investigations of the highly clonal Salmonella enterica subspecies enterica serovar Typhi (S. Typhi) are important in outbreak detection and in tracking disease transmission. In this study, we developed and evaluated a multiple-locus variable-number tandem-repeats (VNTR) analysis (MLVA) assay for characterization of S. Typhi isolates from sub-Saharan Africa. METHODOLOGY: Twelve previously reported VNTR loci were evaluated and an MLVA assay consisting of five polymorphic loci was adopted...
July 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28720906/trail-tnf-related-apoptosis-inducing-ligand-induces-an-inflammatory-response-in-human-adipocytes
#4
Verena Zoller, Jan-Bernd Funcke, Julian Roos, Meike Dahlhaus, Muad Abd El Hay, Karlheinz Holzmann, Ralf Marienfeld, Thomas Kietzmann, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky
High serum concentrations of TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor protein family, are found in patients with increased BMI and serum lipid levels. In a model of murine obesity, both the expression of TRAIL and its receptor (TRAIL-R) is elevated in adipose tissue. Accordingly, TRAIL has been proposed as an important mediator of adipose tissue inflammation and obesity-associated diseases. The aim of this study was to investigate if TRAIL regulates inflammatory processes at the level of the adipocyte...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720267/a-systematic-review-of-the-supportive-care-needs-of-people-living-with-and-beyond-cancer-of-the-colon-and-or-rectum
#5
REVIEW
Grigorios Kotronoulas, Constantina Papadopoulou, Kathryn Burns-Cunningham, Mhairi Simpson, Roma Maguire
PURPOSE: Gaining a clear understanding of the health needs and concerns of people with cancer of the colon and/or rectum can help identify ways to offer a comprehensive care package. Our aim was to systematically assess the relevant literature and synthesise current available evidence. METHODS: A systematic review was conducted according to the PRISMA Statement guidelines. Five electronic databases were searched to identify studies employing qualitative and/or quantitative methods...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28720258/feasibility-and-acceptability-of-the-use-of-patient-reported-outcome-measures-proms-in-the-delivery-of-nurse-led-supportive-care-to-people-with-colorectal-cancer
#6
Grigorios Kotronoulas, Constantina Papadopoulou, Lorna MacNicol, Mhairi Simpson, Roma Maguire
PURPOSE: Logistical issues pertinent to the use of patient-reported outcome measures (PROMs) by colorectal cancer nurse specialists (CNS) to identify the needs of people with colorectal cancer (CRC) in acute care remain unknown. We explored the feasibility and acceptability of PROMs-driven, CNS-led consultations to enhance delivery of supportive care to people with CRC completing adjuvant chemotherapy. METHODS: A systematic literature review and focus groups with patients and CNS (Phase 1) were followed by a repeated-measures, exploratory study (Phase 2), whereby pre-consultation PROM data were collected during three consecutive, monthly consultations, and used by the CNS to enable delivery of personalised supportive care...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28720202/a-novel-surgical-approach-to-mechanical-circulatory-support-in-univentricular-infants
#7
Avihu Z Gazit, Orlando Petrucci, Peter Manning, Mark Shepard, Sirine Baltagi, Kathleen Simpson, Chesney Castleberry, Charles Canter, Pirooz Eghtesady
BACKGROUND: Historically, the options for mechanical circulatory support in infants, particularly those with single-ventricle physiology, have been limited and outcomes have generally been poor. We report a new approach implemented for long-term support in a series of such patients. METHODS: This study is a single-center case series of 7 patients with single-ventricle physiology after stage 1 palliation supported with mechanical circulatory support using a novel technique, between May 2014 and September 2015...
July 15, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28715588/caucasian-families-exhibit-significant-linkage-of-myopia-to-chromosome-11p
#8
Anthony M Musolf, Claire L Simpson, Bilal A Moiz, Kyle A Long, Laura Portas, Federico Murgia, Elise B Ciner, Dwight Stambolian, Joan E Bailey-Wilson
Purpose: Myopia is a common visual disorder caused by eye overgrowth, resulting in blurry vision. It affects one in four Americans, and its prevalence is increasing. The genetic mechanisms that underpin myopia are not completely understood. Here, we use genotype data and linkage analyses to identify high-risk genetic loci that are significantly linked to myopia. Methods: Individuals from 56 Caucasian families with a history of myopia were genotyped on an exome-based array, and the single nucleotide polymorphism (SNP) data were merged with microsatellite genotype data...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28714836/the-importance-of-the-evaluation-of-expectations-and-perceptions-to-improve-the-dental-service-quality
#9
Juliana Rocha, Andres Pinto, Marilia Batista, Janice Simpson de Paula, Glaucia Ambrosano
Purpose The purpose of this paper is to evaluate the use of SERVQUAL to assess service quality in Dentistry, by evaluating patients' expectations and perceptions of dental care and their association to patients' sociodemographic data. Design/methodology/approach The sample constituted of 379 subjects in the first assessment and 155 in the second phase. All employees of the companies that were clients of the dental insurance participated, a total of four companies in two states (São Paulo and Minas Gerais) of Brazil...
July 10, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28714774/small-sided-games-in-elite-soccer-does-one-size-fits-all
#10
Mathieu Lacome, Ben M Simpson, Yannick Cholley, Philippe Lambert, Martin Buchheit
PURPOSE: To compare the peak intensity of typical Small Sided Games (SSGs) with those of official matches in terms of running demands and mechanical work over different rolling average durations and playing positions. METHOD: Data were collected in 21 players (25±5 y, 181±7 cm, 77±7 kg) belonging to an elite French football team. SSG data were collected over two seasons during typical training sessions (249 files, 12±4 per player) and official matches (n=12)...
July 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28712704/impact-of-perioperative-voice-therapy-on-outcomes-in-the-surgical-management-of-vocal-fold-cysts
#11
Kathleen M Tibbetts, Laura M Dominguez, C Blake Simpson
INTRODUCTION: Vocal fold cysts are benign mid-membranous lesions of the true vocal fold, classified as mucus retention or epidermal inclusion cysts. Treatment is surgical excision with or without postoperative voice therapy. METHODS: A retrospective review was performed of the demographics, treatment approach, and outcomes of patients treated for vocal fold cysts between 2009 and 2014. Voice Handicap Index (VHI)-10 scores before and after treatment were compared using the Wilcoxon Rank-Sum test and the two-tailed Student's t test...
July 13, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28711848/long-term-litter-manipulation-alters-soil-organic-matter-turnover-in-a-temperate-deciduous-forest
#12
Jun-Jian Wang, Oliva Pisani, Lisa H Lin, Olivia O Y Lun, Richard D Bowden, Kate Lajtha, André J Simpson, Myrna J Simpson
Understanding soil organic matter (OM) biogeochemistry at the molecular-level is essential for assessing potential impacts from management practices and climate change on shifts in soil carbon storage. Biomarker analyses and nuclear magnetic resonance (NMR) spectroscopy were used in an ongoing detrital input and removal treatment experiment in a temperate deciduous forest in Pennsylvania, USA, to examine how above- and below-ground plant inputs control soil OM quantity and quality at the molecular-level. From plant material to surface soils, the free acyclic lipids and cutin, suberin, and lignin biomarkers were preferentially retained over free sugars and free cyclic lipids...
July 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28711780/localised-delivery-of-doxorubicin-to-prostate-cancer-cells-through-a-psma-targeted-hyperbranched-polymer-theranostic
#13
Amanda K Pearce, Joshua D Simpson, Nicholas L Fletcher, Zachary H Houston, Adrian V Fuchs, Pamela J Russell, Andrew K Whittaker, Kristofer J Thurecht
The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were synthesised via RAFT polymerisation to feature glutamate urea targeting ligands for PSMA on the periphery. The chemotherapeutic, doxorubicin, was attached to the hyperbranched polymers through hydrazone formation, which allowed controlled release of the drug from the polymers in vitro endosomal conditions, with 90% release of the drug over 36 h...
July 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28711111/to-do-or-not-to-do-task-control-deficit-in-obsessive-compulsive-disorder
#14
Eyal Kalanthroff, Avishai Henik, Helen Blair Simpson, Doron Todder, Gideon E Anholt
Task control is an executive control mechanism that facilitates goal-directed task selection by suppressing irrelevant automatic "stimulus-driven" behaviors. In the current study, we test the hypothesis that less efficient task control in individuals diagnosed with obsessive-compulsive disorder (OCD) is associated with OCD symptoms, and specifically, with the inability to inhibit unwanted behaviors in OCD. Thirty-five healthy controls, 30 participants with OCD, and 26 participants with generalized anxiety disorder (GAD) completed the object-interference (OI) task to measure task control, the stop-signal task to measure response inhibition, and the arrow-flanker task to evaluate executive abilities not contingent upon task control...
September 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28710305/autism-spectrum-disorder-in-say-barber-biesecker-young-simpson-syndrome
#15
Jessica Merritt, Joseph C Hart, Tracy L LeGrow
Say-Barber-Biesecker-Young-Simpson syndrome (SBBYSS), also known as Ohdo syndrome SBBYS type, is a rare genetic disorder characterised by dysmorphic facial features and severe intellectual disability, as well as cardiac, dental and hearing abnormalities. There has been little psychiatric or psychological description of children with SBBYSS, although previous reports noted repetitive self-injurious behaviours, sensitivity to light and noise and severe deficits in communication. In this report, a 4-year-old male with SBBYSS is described with a focus on psychiatric and psychological assessment, including formal testing for autism spectrum disorder (ASD)...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28709004/mapping-the-neural-substrates-of-behavior
#16
Alice A Robie, Jonathan Hirokawa, Austin W Edwards, Lowell A Umayam, Allen Lee, Mary L Phillips, Gwyneth M Card, Wyatt Korff, Gerald M Rubin, Julie H Simpson, Michael B Reiser, Kristin Branson
Assigning behavioral functions to neural structures has long been a central goal in neuroscience and is a necessary first step toward a circuit-level understanding of how the brain generates behavior. Here, we map the neural substrates of locomotion and social behaviors for Drosophila melanogaster using automated machine-vision and machine-learning techniques. From videos of 400,000 flies, we quantified the behavioral effects of activating 2,204 genetically targeted populations of neurons. We combined a novel quantification of anatomy with our behavioral analysis to create brain-behavior correlation maps, which are shared as browsable web pages and interactive software...
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28708041/microendoscopic-laminotomy-versus-conventional-laminoplasty-for-cervical-spondylotic-myelopathy-5-year-follow-up-study
#17
Akihito Minamide, Munehito Yoshida, Andrew K Simpson, Hiroshi Yamada, Hiroshi Hashizume, Yukihiro Nakagawa, Hiroshi Iwasaki, Shunji Tsutsui, Motohiro Okada, Masanari Takami, Shin-Ichi Nakao
OBJECTIVE The goal of this study was to characterize the long-term clinical and radiological results of articular segmental decompression surgery using endoscopy (cervical microendoscopic laminotomy [CMEL]) for cervical spondylotic myelopathy (CSM) and to compare outcomes to conventional expansive laminoplasty (ELAP). METHODS Consecutive patients with CSM who required surgical treatment were enrolled. All enrolled patients (n = 78) underwent CMEL or ELAP. All patients were followed postoperatively for more than 5 years...
July 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28706767/surgical-excision-of-a-symptomatic-thoracic-nerve-root-perineural-cyst-resulting-in-complete-resolution-of-symptoms-a-case-report
#18
Zaid Aljuboori, Alae Yaseen, Jessica Simpson, Maxwell Boakye
Tarlov (perineural) cysts of the nerve root are common and usually incidental findings during magnetic resonance imaging (MRI) of the lumbosacral spine. There are a few case reports where symptomatic thoracic perineural cysts have been described in the literature. We report a case of a high thoracic nerve root perineural cyst that failed conservative therapy, requiring surgical intervention. Our patient presented with radicular symptoms involving the left hand. Imaging workup revealed a cystic lesion of the left T1 nerve root at the level of the foramen...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28705490/deformation-correction-for-image-guided-liver-surgery-an%C3%A2-intraoperative-assessment-of%C3%A2-fidelity
#19
Logan W Clements, Jarrod A Collins, Jared A Weis, Amber L Simpson, T Peter Kingham, William R Jarnagin, Michael I Miga
BACKGROUND: Although systems of 3-dimensional image-guided surgery are a valuable adjunct across numerous procedures, differences in organ shape between that reflected in the preoperative image data and the intraoperative state can compromise the fidelity of such guidance based on the image. In this work, we assessed in real time a novel, 3-dimensional image-guided operation platform that incorporates soft tissue deformation. METHODS: A series of 125 alignment evaluations were performed across 20 patients...
July 10, 2017: Surgery
https://www.readbyqxmd.com/read/28705349/cumulative-advantage-in-collective-action-groups-how-competition-for-group-members-alters-the-provision-of-public-goods
#20
Brent Simpson, Ozan Aksoy
Research on collective action problems and the provision of public goods has yielded an array of important insights into why people sacrifice for their groups, but ignores the processes that bring people into those groups in the first place. The literature is also silent on the fact that groups providing similar public goods often compete with one another to attract new members. We extend the reach of theories of collective action problems to bring them to bear on these interrelated issues. Results from four experiments support our predictions about when group members compete to attract new adherents by sacrificing more for group goals...
August 2017: Social Science Research
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