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José R Valverde, Sonia Gullón, Rafael Pérez Mellado
INTRODUCTION: Biological communities present in soil are essential to sustainable and productive agricultural practices; however, an accurate determination of the ecological status of agricultural soils remains to date an elusive task. An ideal indicator should be pervasive, play a relevant role in the ecosystem, show a rapid and proportional answer to external perturbations and be easily and economically measurable. Rhizobacteria play a major role in determining soil properties, becoming an attractive candidate for the detection of ecological indicators...
2016: PloS One
Xinying Shi, Simpson Joseph
Release factors 1 and 2 (RF1 and RF2) bind to ribosomes that have a stop codon in the A site and catalyze the release of the newly synthesized protein. Following peptide release, the dissociation of RF1 and RF2 from the ribosome is accelerated by release factor 3 (RF3). The mechanism for RF3-promoted dissociation of RF1/RF2 is unclear. It was previously proposed that RF3 hydrolyzes GTP and dissociates from the ribosome after RF1 dissociation. Here we monitored directly the dissociation kinetics of RF1 and RF3 using Förster resonance energy transfer (FRET) based assays...
October 25, 2016: Biochemistry
Biswaranjan Mohanty, Martin L Williams, Bradley C Doak, Mansha Vazirani, Olga Ilyichova, Geqing Wang, Wolfgang Bermel, Jamie S Simpson, David K Chalmers, Glenn F King, Mehdi Mobli, Martin J Scanlon
We describe a general approach to determine the binding pose of small molecules in weakly bound protein-ligand complexes by deriving distance constraints between the ligand and methyl groups from all methyl-containing residues of the protein. We demonstrate that using a single sample, which can be prepared without the use of expensive precursors, it is possible to generate high-resolution data rapidly and obtain the resonance assignments of Ile, Leu, Val, Ala and Thr methyl groups using triple resonance scalar correlation data...
October 24, 2016: Journal of Biomolecular NMR
Shilpa Nagaraju, Naomi Kathleen Davies, David Jeffrey Fraser Walker, Michael Köpke, Séan Dennis Simpson
BACKGROUND: Impactful greenhouse gas emissions abatement can now be achieved through gas fermentation using acetogenic microbes for the production of low-carbon fuels and chemicals. However, compared to traditional hosts like Escherichia coli or yeast, only basic genetic tools exist for gas-fermenting acetogens. To advance the process, a robust genetic engineering platform for acetogens is essential. RESULTS: In this study, we report scarless genome editing of an industrially used model acetogen, Clostridium autoethanogenum, using the CRISPR/Cas9 system...
2016: Biotechnology for Biofuels
Yongmin Kim, Sheng-Min Wang, Kyung-Phil Kwak, Ho-Kyoung Yoon, Chi-Un Pae, Jung-Jin Kim, Won-Myong Bahk
Objective: Despite numerous atypical antipsychotics (AAP) available, many patients with schizophrenia still experience lack of efficacy and persistent side-effects. Switching from one AAP to another with a different side-effect profile has become a common clinical strategy. We aimed to investigate effect of switching to amisulpride in patients who showed suboptimal effect and /or tolerability to current antipsychotics treatment. Methods: This was a 6-week, prospective, multicenter, open-label, flexible-dose study in patients with schizophrenia...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Stefano R Del Giacco, Arzu Bakirtas, Elizabeth Bel, Adnan Custovic, Zuzana Diamant, Eckard Hamelmann, Enrico Heffler, Ömer Kalayci, Sejal Saglani, Svetlana Sergejeva, Sven Seys, Angela Simpson, Leif Bjermer
It is well recognized that atopic sensitisation is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term "Severe Asthma" encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming "uncontrolled", or whose disease remains "uncontrolled" despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations...
October 24, 2016: Allergy
Robert Mark Simpson
Murrow and Murrow offer a novel account of dehumanization, by synthesizing data which suggest that where subject S has a dehumanized view of group G, S's neural mechanisms of empathy show a dampened response to the suffering of members of G, and S's judgments about the humanity of members of G are largely non-conscious. Here I examine Murrow and Murrow's suggestions about how identity-based hate speech bears responsibility for dehumanization in the first place. I identify a distinction between (i) accounts of the nature of the harm effected by identity prejudice, and (ii) accounts of how hate speech contributes to the harms of identity prejudice...
April 2016: Journal of Law and the Biosciences
Ludi Simpson, Stephen Jivraj, James Warren
The instability of ethnicity measured in the national census is found to have doubled from the period 1991-2001 to the period 2001-2011, using the Longitudinal Study that links a sample of individuals' census records across time. From internal evidence and comparison with results from the Census Quality Survey and the Labour Force Survey, estimates are made of instability due to changing question wording, imputation of missing answers, proxy reporting, recording errors and changes in the allocation of write-in answers...
October 2016: Journal of the Royal Statistical Society. Series A, (Statistics in Society)
Gopalan Nair Rajesh, Pradeep Sreekumar, Vellani Haridasan, C G Sajeev, Cicy Bastian, D Vinayakumar, P Kadermuneer, Dolly Mathew, Biju George, M N Krishnan
AIM: Mitral stenosis (MS) is found to produce left ventricular (LV) dysfunction in some studies. We sought to study the left ventricular function in patients with rheumatic MS undergoing balloon mitral valvotomy (BMV). Ours is the first study to analyze effect of BMV on mitral annular plane systolic excursion (MAPSE), and to quantify prevalence of longitudinal left ventricular dysfunction in rheumatic MS. METHODS: In this prospective cohort study, we included 43 patients with severe rheumatic mitral stenosis undergoing BMV...
September 2016: Indian Heart Journal
M M Salib, A J Simpson, P E Hickman, S Apostoloska, C Yu, J M Potter
No abstract text is available yet for this article.
February 2016: Pathology
Sean Ricciardo, Ian Simpson
No abstract text is available yet for this article.
February 2016: Pathology
Stephen J Simpson
No abstract text is available yet for this article.
February 2016: Pathology
Amanda V Jenson, Robert Scranton, Danielle D Antosh, Richard K Simpson
[This corrects the article DOI: 10.7759/cureus.671.].
October 12, 2016: Curēus
Jalie A Tucker, Cathy A Simpson, Susan D Chandler, Casey A Borch, Susan L Davies, Shatomi J Kerbawy, Terri H Lewis, M Scott Crawford, JeeWon Cheong, Max Michael
Emerging adulthood often entails heightened risk-taking with potential life-long consequences, and research on risk behaviors is needed to guide prevention programming, particularly in under-served and difficult to reach populations. This study evaluated the utility of Respondent Driven Sampling (RDS), a peer-driven methodology that corrects limitations of snowball sampling, to reach at-risk African American emerging adults from disadvantaged urban communities. Initial "seed" participants from the target group recruited peers, who then recruited their peers in an iterative process (110 males, 234 females; M age = 18...
2016: Journal of Health Care for the Poor and Underserved
Earnestine Willis, Svapna Sabnis, Chelsea Hamilton, Fue Xiong, Keli Coleman, Matt Dellinger, Michelle Watts, Richard Cox, Janice Harrell, Dorothy Smith, Melodee Nugent, Pippa Simpson
No abstract text is available yet for this article.
2016: Progress in Community Health Partnerships: Research, Education, and Action
Dominic Simpson
As a third-year nursing student my final placement was with an anaesthetic team. Two months into the placement, the emergency telephone rang at 4am, with the message 'obstetric airway emergency' - a call that no nurse or midwife wants to receive.
October 12, 2016: Nursing Standard
Zephon Lister, Colwick Wilson, Curtis Fox, R Patricia Herring, Cheryl Simpson, Lucretia Smith, Lincoln Edwards
Introduction: Expressed emotion has been consistently shown to be a significant predictor of relapse and poor disease management across numerous physical and mental health conditions, however very little research has been conducted on its relationship to the management practices of individuals living with Type 2 diabetes. This study examines the relationship between expressed emotion (EE) and diabetes management among couples where 1 spouse has Type 2 diabetes. Methods: The authors surveyed 106 couples where 1 partner was diagnosed with Type 2 diabetes...
October 20, 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
Thomas McCaffrey, Michela Guglieri, Alexander P Murphy, Katherine Md Bushby, Anna Johnson, John P Bourke
Introduction The significance of abnormal cardiac measures in asymptomatic females who harbor dystrophin gene mutations is controversial. Methods Echo-measures of ventricular function were compared with published norms in a cross-sectional study of 130 (age 39 ± 15.7 years) 'carriers' of Duchenne or Becker muscular dystrophy (DBMD). Correlations between cardiomyopathy (CM) and mutation, CK levels, age, and muscle symptoms were investigated. Results Depending on definition, CM prevalence was 3-33%. Ejection fraction (Simpson) was < 55% in 9 (13%) and < 40% in 2 (2...
October 19, 2016: Muscle & Nerve
T A Cranga, M A Simpson, P Featherstone
Acute generalised exanthematous pustulosis is a rare drug-induced dermatosis with an incidence of 1-5 cases per million cases per year, characterised by the appearance of hundreds of sterile pustules over erythematous and oedematous skin. Fever and neutrophilia are usually present. It has a rapid course and usually resolves following discontinuation of the precipitating drug or as a result of topical corticosteroid treatment. A patient with AGEP, who presented with generalized pustulosis lesions after the use of Flucloxacillin for cellulitis is described, along with the management and differential diagnosis of this condition...
2016: Acute Medicine
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