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https://www.readbyqxmd.com/read/29334538/sickle-cell-trait-testing-should-not-be-a-player-in-ncaa-athletics-examining-the-media-s-role-in-disseminating-awareness-and-information
#1
Anil P George, Antonio Logan, Mindy Simpson, Paul M Kent
No abstract text is available yet for this article.
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29334235/impact-of-an-assertive-community-treatment-model-of-care-on-the-treatment-of-prisoners-with-a-serious-mental-illness
#2
Brian McKenna, Jeremy Skipworth, Rees Tapsell, Krishna Pillai, Dominic Madell, Alexander Simpson, James Cavney, Paul Rouse
OBJECTIVES: This study aims to describe the impact of a mental health assertive community treatment prison model of care (PMOC) on improving the ability to identify prisoner needs, provide interventions and monitor their efficacy. METHODS: We carried out a file review across five prisons of referrals in the year before the implementation of the PMOC in 2010 ( n = 423) compared with referrals in the year after ( n = 477). RESULTS: Some improvements in the identification of needs and providing interventions were detected...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29331783/comparative-study-of-novel-in-situ-decorated-porous-chitosan-selenium-scaffolds-and-porous-chitosan-silver-scaffolds-towards-antimicrobial-wound-dressing-application
#3
Dhee P Biswas, Neil M O'Brien-Simpson, Eric C Reynolds, Andrea J O'Connor, Phong A Tran
Dermal defects caused by trauma or disease are challenging to treat due to difficult-to-treat infections that impair wound healing. Due to the widespread emergence of drug-resistant bacteria and dwindling discoveries of new antibiotics, there is currently an urgent need to introduce novel antimicrobials effective against antibiotic-resistant bacteria without causing damage to host tissues. As selenium (Se) and silver (Ag) are known for their antimicrobial properties, we investigated the separate loading of these materials into porous chitosan/PVA (CS) scaffolds through a simple in situ deposition method to create two distinct wound dressing materials (CS-Se and CS-Ag)...
January 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331161/hormone-therapy-gender-affirmation-surgery-and-their-association-with-recent-suicidal-ideation-and-depression-symptoms-in-transgender-veterans
#4
Raymond P Tucker, Rylan J Testa, Tracy L Simpson, Jillian C Shipherd, John R Blosnich, Keren Lehavot
BACKGROUND: Access to transition-related medical interventions (TRMIs) for transgender veterans has been the subject of substantial public interest and debate. To better inform these important conversations, the current study investigated whether undergoing hormone or surgical transition intervention(s) relates to the frequency of recent suicidal ideation (SI) and symptoms of depression in transgender veterans. METHODS: This study included a cross-sectional, national sample of 206 self-identified transgender veterans...
January 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29330667/diversity-and-phenology-of-wild-bees-in-a-highly-disturbed-tropical-dry-forest-desierto-de-la-tatacoa-huila-colombia
#5
C A Poveda-Coronel, D Riaño-Jiménez, J R Cure
Colombian tropical dry forest is considered the most endangered tropical biome due to anthropic activities. Desierto de la Tatacoa (DsT) is an example of high disturbed tropical dry forest which still maintains a high biodiversity. The objective of the study was to record the diversity and phenology of wild bees in this place by monthly sampling between December 2014 and December 2016 in a 9-km2 area. During the study, there was a prolonged El Niño-Southern Oscillation period. Bees were collected by entomological nets, malaise traps, eugenol scent trapping, and nest traps...
January 12, 2018: Neotropical Entomology
https://www.readbyqxmd.com/read/29330346/underestimation-of-staphylococcus-aureus-mrsa-and-mssa-carriage-associated-with-standard-culturing-techniques-one-third-of-carriers-missed
#6
S T J Tsang, M P McHugh, D Guerendiain, P J Gwynne, J Boyd, A H R W Simpson, T S Walsh, I F Laurenson, K E Templeton
OBJECTIVES: Nasal carriers of Staphylococcus (S.) aureus (MRSA and MSSA) have an increased risk for healthcare-associated infections. There are currently limited national screening policies for the detection of S. aureus despite the World Health Organization's recommendations. This study aimed to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening, determine the cause of any discrepancy between the diagnostic techniques, and model the potential effect of different diagnostic techniques on S...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29330168/mrb7260-is-essential-for-productive-protein-rna-interactions-within-the-rna-editing-substrate-binding-complex-during-trypanosome-rna-editing
#7
Natalie M McAdams, Rachel M Simpson, Runpu Chen, Yijun Sun, Laurie Read
The trypanosome RNA Editing Substrate Binding Complex (RESC) acts as the platform for mitochondrial uridine insertion/deletion RNA editing and facilitates the protein-protein and protein-RNA interactions required for the editing process. RESC is broadly comprised of two subcomplexes: GRBC (Guide RNA Binding Complex) and REMC (RNA Editing Mediator Complex). Here, we characterize the function and position in RESC organization of a previously unstudied RESC protein, MRB7260. We show that MRB7260 forms numerous RESC-related complexes, including a novel, small complex with the guide RNA binding protein, GAP1, which is a canonical GRBC component, and REMC components MRB8170 and TbRGG2...
January 12, 2018: RNA
https://www.readbyqxmd.com/read/29328791/how-noisy-are-total-knee-and-hip-replacements
#8
Jonathan P Simpson, Andrew J Hamer
Orthopaedic theatre can be noisy. Fifty percent of orthopaedic theatre staff have features of noise-induced hearing loss (NIHL). In this study, decibel (dB) levels were recorded in 17 total knee replacements (TKRs) and 11 total hip replacements (THRs). Noise levels reached 105.6dB(A) using a hammer and 97.9dB(A) with an oscillating saw. Exposure to levels above 90dB (which occurred in every case) even for short time periods is proven to cause irreversible loss of hearing. Tools used in orthopaedic theatre produce impulse noises that can cause NIHL...
December 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29327446/current-and-military-specific-gender-minority-stress-factors-and-their-relationship-with-suicide-ideation-in-transgender-veterans
#9
Raymond P Tucker, Rylan J Testa, Mark A Reger, Tracy L Simpson, Jillian C Shipherd, Keren Lehavot
Research suggests the prevalence of suicide ideation and suicide attempts in the transgender veteran community may be upwards of 20 times higher than nontransgender veterans, who are known to be at increased risk than the general US population. This study aimed to understand the potential influence of external and internal minority stress experienced during and after military service on past-year and recent suicide ideation in a sample of 201 transgender veterans. Nonparametric bootstrapping analyses indicated past-year transgender-specific discrimination and rejection (external minority stress) indirectly predicted frequency of both past-year and past 2-week suicide ideation through past-year shame related to gender identity (internal minority stress)...
January 12, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29327188/temporal-variation-in-bacterial-and-methanogenic-communities-of-three-full-scale-anaerobic-digesters-treating-swine-wastewater
#10
Gyuseong Han, Seung Gu Shin, Kyungjin Cho, Joonyeob Lee, Woong Kim, Seokhwan Hwang
To investigate the effects of temporal variations of process parameters on microbial community structures in the two types of full-scale anaerobic digester treating swine wastewater, three full-scale anaerobic digesters were monitored. An anaerobic filter (AF)-type digester located in Gong-Ju (GJ) showed the highest COD removal among three digesters and maintained stable efficiency. A digester in Hong-Seong (HS) was of the same type as it GJ and showed improved efficiency over the sampling period. A continuously stirred tank reactor (CSTR)-type digester in Soon-Cheon (SC) showed decreasing efficiency due to a high residual concentration of VFAs and NH4+...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29325959/agreement-between-extent-of-meningioma-resection-based-on-the-surgical-simpson-grade-and-based-on-postoperative-mri-findings
#11
K Mariam Slot, Dagmar Verbaan, Lisette Bosscher, Esther Sanchez, W Peter Vandertop, Saskia M Peerdeman
BACKGROUND: and Purpose: The surgical Simpson Grade, introduced in 1957 is the standard measure for meningioma resection and prediction of recurrences. We used an MR-based grading system for the radiological extent of resection, and assessed agreement of the extent of resection between the surgical Simpson Grade and the MR-based scale. MATERIALS AND METHODS: Patients were prospectively included during a two-year period. Immediately after surgery the surgeon determined the Simpson Grade...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325940/clinical-features-treatment-and-prognostic-factors-of-56-intracranial-and-intraspinal-clear-cell-meningiomas
#12
Xiaogang Tao, Jinqian Dong, Zonggang Hou, Shuyu Hao, Junting Zhang, Zhen Wu, Baiyun Liu
OBJECTIVE: Intracranial and intraspinal clear cell meningiomas (CCMs) are rarely reported because of their extremely low incidence, and the current understanding of CCM is poor. The purpose of this study was to analyze the incidence and the clinical, radiological, pathological, and prognostic features of intracranial and intraspinal CCMs. METHODS: Among 14310 cases of intracranial and intraspinal meningiomas that were surgically treated between 2006 and 2016 at Beijing Tian Tan Hospital, 56 were chosen for analysis and retrospectively reviewed...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29324602/antecedents-of-abnormally-invasive-placenta-in-primiparous-women-risk-associated-with-gynecologic-procedures
#13
Heather J Baldwin, Jillian A Patterson, Tanya A Nippita, Siranda Torvaldsen, Ibinabo Ibiebele, Judy M Simpson, Jane B Ford
OBJECTIVE: To evaluate the association between prior invasive gynecologic procedures and the risk of subsequent abnormally invasive placenta (ie, placenta accreta, increta, and percreta). METHODS: We conducted a population-based data linkage study including all primiparous women who delivered in New South Wales, Australia, between 2003 and 2012. Data were obtained from linked birth and hospital admissions with a minimum lookback period of 2 years. Prior procedures invasive of the uterus were considered including gynecologic laparoscopy with instrumentation of the uterus; hysteroscopy, including operative hysteroscopy; curettage, including suction curettage and surgical termination; and endometrial ablation...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29322978/chromosomal-aberrations-in-chordoid-meningioma-an-analysis
#14
Harsha Sugur, Arun H Shastry, Nishant Sadashiva, Dwarakanath Srinivas, Vani Santosh, Sampath Somanna
INTRODUCTION: Chordoid meningiomas (CMs) are a rare subgroup of tumors, accounting for approximately 0.5% of all meningiomas. These tumors correspond to World Health Organization (WHO) Grade II lesions and behave aggressively, with an increased likelihood of recurrence. There are only two studies that have described the genetic alterations in CMs. While a majority of meningiomas are known to have deletion at many chromosomal loci such as 22q, 18p, 14q, and 1p, which are found to be associated with initiation, progression, and malignancy of these tumors, these have not yet been studied in CMs...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322420/a-comprehensive-protocol-resource-for-performing-pooled-shrna-and-crispr-screens
#15
Leonie A Cluse, Iva Nikolic, Deborah Knight, Piyush B Madhamshettiwar, Jennii Luu, Karla J Cowley, Timothy Semple, Gisela Mir Arnau, Jake Shortt, Ricky W Johnstone, Kaylene J Simpson
This chapter details a compendium of protocols that collectively enable the reader to perform a pooled shRNA and/or CRISPR screen-with methods to identify and validate positive controls and subsequent hits; establish a viral titer in the cell line of choice; create and screen libraries, sequence strategies, and bioinformatics resources to analyze outcomes. Collectively, this provides an overarching resource from the start to finish of a screening project, making this technology possible in all laboratories.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29322248/a-reversible-liquid-drop-aggregation-controls-glucose-response-in-yeast
#16
REVIEW
Kobi Simpson-Lavy, Martin Kupiec
Glucose is the preferred carbon of the yeast Saccharomyces cerevisiae. Depletion of glucose activates SNF1 (yeast AMP-activated protein kinase-AMPK), allowing cells to switch from fermentation to respiration. We have recently characterized the mechanism by which SNF1 activity is regulated by the Std1 protein, and its regulator Sip5. The hitherto uncharacterized protein kinase Vhs1 phosphorylates Sip5 in response to glucose availability, disengaging it from Std1 and promoting the sequestering of the SNF1 activator out of the nucleus into cytoplasmic puncta...
January 10, 2018: Current Genetics
https://www.readbyqxmd.com/read/29321237/differences-in-risk-factors-for-3-types-of-stroke-uk-prospective-study-and-meta-analyses
#17
Alison J Price, F Lucy Wright, Jane Green, Angela Balkwill, Sau Wan Kan, TienYu Owen Yang, Sarah Floud, Mary E Kroll, Rachel Simpson, Cathie L M Sudlow, Valerie Beral, Gillian K Reeves
OBJECTIVE: To compare associations of behavioral and related factors for incident subarachnoid hemorrhage and intracerebral hemorrhage and ischemic stroke. METHODS: A total of 712,433 Million Women Study participants without prior stroke, heart disease, or cancer reported behavioral and related factors at baseline (1999-2007) and were followed up by record linkage to national hospital admission and death databases. Cox regression yielded adjusted relative risks (RRs) by type of stroke...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29320892/the-effect-of-the-global-financial-crisis-on-preventable-hospitalizations-among-the-homeless-in-new-york-state
#18
Brandi White, Charles Ellis, Walter Jones, William Moran, Kit Simpson
Objective Periods of economic instability may increase preventable hospitalizations because of increased barriers to accessing primary care. For underserved populations such as the homeless, these barriers may be more pronounced due to limited resources in the health care safety net. This study examined the impact of the global financial crisis of 2007-2008 on access to care for the homeless in New York State. Methods Hospitalizations for ambulatory care sensitive conditions (ACSCs) were used as a proxy measure for primary care access...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29320750/the-many-faces-of-intestinal-tract-gastric-heterotopia-a-series-of-four-cases-highlighting-clinical-and-pathological-heterogeneity
#19
Aqsa Nasir, Stuart K Amateau, Sabina Khan, Ross W Simpson, Dale C Snover, Khalid Amin
Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 year, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual clinical presentation was iron deficiency anemia, seen in three cases, while one patient presented with abdominal pain. Endoscopically two cases were visualized as pedunculated polyps and two as sessile/plaques like lesions...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29319189/epidemiology-of-atopic-dermatitis-in-adults-results-from-an-international-survey
#20
S Barbarot, S Auziere, A Gadkari, G Girolomoni, L Puig, E L Simpson, D J Margolis, M de Bruin-Weller, L Eckert
BACKGROUND: There are gaps in our knowledge of the prevalence of adult atopic dermatitis (AD). OBJECTIVE: To estimate prevalence of AD in adults and by disease severity. METHODS: This international, cross-sectional, web-based survey was performed in the United States, Canada, France, Germany, Italy, Spain, United Kingdom, and Japan. Adult members of online respondent panels were sent a questionnaire for AD identification and severity assessment; demographic quotas ensured population representativeness for each country...
January 10, 2018: Allergy
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