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https://www.readbyqxmd.com/read/28817824/parametric-linkage-analysis-identifies-five-novel-genome-wide-significant-loci-for-familial-lung-cancer
#1
Anthony M Musolf, Claire L Simpson, Mariza de Andrade, Diptasri Mandal, Colette Gaba, Ping Yang, Yafang Li, Ming You, Elena Y Kupert, Marshall W Anderson, Ann G Schwartz, Susan M Pinney, Christopher I Amos, Joan E Bailey-Wilson
OBJECTIVE: One of four American cancer patients dies of lung cancer. Environmental factors such as tobacco smoking are known to affect lung cancer risk. However, there is a genetic factor to lung cancer risk as well. Here, we perform parametric linkage analysis on family-based genotype data in an effort to find genetic loci linked to the disease. METHODS: 197 individuals from families with a high-risk history of lung cancer were recruited and genotyped using an Illumina array...
August 18, 2017: Human Heredity
https://www.readbyqxmd.com/read/28817371/phase-i-ii-trial-of-labetuzumab-govitecan-anti-ceacam5-sn-38-antibody-drug-conjugate-in-patients-with-refractory-or-relapsing-metastatic-colorectal-cancer
#2
Efrat Dotan, Steven J Cohen, Alexander N Starodub, Christopher H Lieu, Wells A Messersmith, Pamela S Simpson, Michael J Guarino, John L Marshall, Richard M Goldberg, J Randolph Hecht, William A Wegener, Robert M Sharkey, Serengulam V Govindan, David M Goldenberg, Jordan D Berlin
Purpose The objectives were to evaluate dosing schedules of labetuzumab govitecan, an antibody-drug conjugate targeting carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) for tumor delivery of 7-ethyl-10-hydroxycamptothecin (SN-38), in an expanded phase II trial of patients with relapsed or refractory metastatic colorectal cancer. Patients and Methods Eligible patients with at least one prior irinotecan-containing therapy received labetuzumab govitecan once weekly at 8 and 10 mg/kg, or two times per week at 4 and 6 mg/km on weeks 1 and 2 of 3-week repeated cycles...
August 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28816930/associations-among-circulating-csf-1-estrogen-and-bone-mineral-density-in-postmenopausal-women-results-from-a-randomized-placebo-controlled-trial
#3
Andrea V Haas, Elaine Cong, Christine A Simpson, Nitin Sukumar, Yanhong Deng, Karl L Insogna
OBJECTIVE: This study addresses the relationship between circulating levels of colony-stimulating factor 1 (CSF-1) and rates of postmenopausal bone loss. The purpose was to test the hypothesis that CSF-1 levels would correlate with the rate of bone loss in estrogen-deficient woman. We further hypothesized that estrogen replacement would eliminate this association. METHODS: This was an ancillary study to the parent Kronos Early Estrogen Prevention Study (KEEPS)-a 4-year randomized placebo-controlled study that evaluated the effects of estrogen therapy on cardiovascular endpoints...
August 14, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28816857/the-authors-reply
#4
Bristol B Whiles, Amanda S Deis, Steven Q Simpson
No abstract text is available yet for this article.
September 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28816814/safe-nurse-staffing-is-more-than-numbers-and-ratios
#5
Kathleen Rice Simpson
No abstract text is available yet for this article.
September 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28815634/effect-of-trapping-methods-on-the-estimation-of-alpha-diversity-of-a-phlebotomine-sandfly-assemblage-in-southern-mexico
#6
J J Rodríguez-Rojas, E A Rebollar-Téllez
The aims of the study were to (a) investigate the effect of trapping methods on alpha diversity; and (b) enhance the knowledge of the sandfly assemblage in the state of Quintana Roo. Field work was undertaken in a tropical forest of southern Mexico from August 2013 to July 2014. Sampling was conducted monthly during three consecutive nights. For each trapping night, 12 different types of trap were operated from 18.00 to 24.00 hours in four transects. Measures of alpha community diversity were based on the quantification of the number of species (Chao 2, Jackknife 2, Clench's equation, Margalef's index) and the community structure, as well as the dominance (Simpson and Berger-Parker indexes) and evenness (Shannon's entropy index, true diversity of the Jost and Pielou index)...
August 17, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28815427/learning-about-love-a-meta-analytic-study-of-individually-oriented-relationship-education-programs-for-adolescents-and-emerging-adults
#7
David M Simpson, Nathan D Leonhardt, Alan J Hawkins
Despite recent policy initiatives and substantial federal funding of individually oriented relationship education programs for youth, there have been no meta-analytic reviews of this growing field. This meta-analytic study draws on 17 control-group studies and 13 one-group/pre-post studies to evaluate the effectiveness of relationship education programs on adolescents' and emerging adults' relationship knowledge, attitudes, and skills. Overall, control-group studies produced a medium effect (d = .36); one-group/pre-post studies also produced a medium effect (d = ...
August 16, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28815409/insulin-like-growth-factor-igf-pathway-targeting-in-cancer-role-of-the-igf-axis-and-opportunities-for-future-combination-studies
#8
Aaron Simpson, Wilfride Petnga, Valentine M Macaulay, Ulrike Weyer-Czernilofsky, Thomas Bogenrieder
Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been largely disappointing, and any potential success has been limited by the lack of validated predictive biomarkers for patient enrichment. A large body of preclinical evidence suggests that the key role of the IGF axis in cancer is in driving treatment resistance, via general proliferative/survival mechanisms, interactions with other mitogenic signaling networks, and class-specific mechanisms such as DNA damage repair...
August 16, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28814432/minimal-to-no-transfer-of-certolizumab-pegol-into-breast-milk-results-from-cradle-a-prospective-postmarketing-multicentre-pharmacokinetic-study
#9
Megan Eb Clowse, Frauke Förger, Caroline Hwang, John Thorp, Radboud Jem Dolhain, Astrid van Tubergen, Laura Shaughnessy, Jeff Simpson, Marie Teil, Nathalie Toublanc, Maggie Wang, Thomas W Hale
BACKGROUND: Women with chronic inflammatory diseases face uncertainty regarding the safety of biologics during breast feeding. CRADLE was the first industry-sponsored study to evaluate certolizumab pegol (CZP) concentrations in human breast milk and estimate average daily infant dose (ADID) of maternal CZP. METHODS: CRADLE (NCT02154425) was a pharmacokinetic study of lactating mothers receiving CZP. After ≥3 CZP doses, breast milk samples were collected across one dosing period (14 days for 200 mg every 2 weeks [Q2W]; 28 days for 400 mg every 4 weeks [Q4W])...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28813789/simulating-the-impact-of-sensorimotor-deficits-on-reaching-performance
#10
Sean M Sketch, Cole S Simpson, Frederic Crevecoeur, Allison M Okamura
The healthy human nervous system accurately and robustly controls movements despite nonlinear dynamics, noise, and delays. After a stroke, motor ability frequently becomes impaired. To provide insight into the relative impact of specific sensorimotor deficits on motor performance, we modeled neural control of reaching with the human upper limb as a near-optimally feedback-controlled two-degree-of-freedom system with biologically based parameters. We added three sensorimotor impairments commonly associated with post-stroke hemiparesis - abnormal joint coupling, increased noise on internally modeled dynamics, and muscular weakness - and examined the impact on reaching performance...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813304/editorial-overview-contemporary-insights-into-the-relationships-and-stress-nexus-contexts-processes-and-outcomes
#11
EDITORIAL
Gery C Karantzas, Jeffry A Simpson, Marita P McCabe
No abstract text is available yet for this article.
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813293/effects-of-relationship-functioning-on-the-biological-experience-of-stress-and-physical-health
#12
REVIEW
Allison K Farrell, Jeffry A Simpson
In this paper, we outline how relationship functioning affects the biological experience of stress and its consequences for physical health. Negative relationship perceptions and processes, such as attachment insecurity, hostility, and frequent conflict, tend to heighten stress responses and generate worse health over time, whereas positive relationship perceptions and processes, such as responsiveness, support, and intimacy, are generally associated with reduced or buffered stress responses and improved health (with some caveats)...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813288/adult-attachment-stress-and-romantic-relationships
#13
REVIEW
Jeffry A Simpson, W Steven Rholes
In this article, we discuss theory and research on how individuals who have insecure adult romantic attachment orientations typically think, feel, and behave when they or their romantic partners encounter certain types of chronic or acute stress. We first review basic principles of attachment theory and then discuss how two forms of attachment insecurity-anxiety and avoidance-are associated with unique patterns of emotion regulation in response to certain types of threatening/distressing situations. We then discuss a Diathesis-Stress Process Model that has guided our research, highlighting studies that provide support for certain pathways of the model...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28810425/psychological-and-behavioral-effects-of-obesity-prevention-campaigns
#14
Courtney C Simpson, Brandon J Griffin, Suzanne E Mazzeo
Public health campaigns are often used to prevent or reduce obesity. However, social psychological theory suggests these efforts might not be universally helpful and could potentially have detrimental consequences. This investigation explored the effects of obesity prevention campaigns. Participants were randomized to view either weight-focused or weight-neutral campaigns. Assessments at three time points (pre, post, and follow-up) examined the differences between groups in reactions to campaigns and changes in health behaviors and psychological outcomes...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28809902/tunable-low-phase-noise-microwave-signals-from-an-optically-injected-semiconductor-laser-with-opto-electronic-feedback
#15
Joseph S Suelzer, Thomas B Simpson, Preetpaul Devgan, Nicholas G Usechak
We experimentally demonstrate the generation of microwave signals with linewidths below 3 Hz and a tuning range over 35 GHz from a semiconductor laser subject to optical injection and opto-electronic feedback. The feedback loop uses neither a microwave spectral filter nor an amplifier to achieve a reduction in the microwave linewidth of six orders of magnitude. Two microwave frequencies, 25.4 and 45.9 GHz, are chosen to highlight single-sideband phase measurements of -105 and -95  dBc/Hz at a 10-kHz offset, respectively...
August 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28808932/visual-attention-and-action-how-cueing-direct-mapping-and-social-interactions-drive-orienting
#16
REVIEW
Mark A Atkinson, Andrew A Simpson, Geoff G Cole
Despite considerable interest in both action perception and social attention over the last 2 decades, there has been surprisingly little investigation concerning how the manual actions of other humans orient visual attention. The present review draws together studies that have measured the orienting of attention, following observation of another's goal-directed action. Our review proposes that, in line with the literature on eye gaze, action is a particularly strong orienting cue for the visual system. However, we additionally suggest that action may orient visual attention using mechanisms, which gaze direction does not (i...
August 14, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28806371/transgender-veterans-satisfaction-with-care-and-unmet-health-needs
#17
Keren Lehavot, Jodie G Katon, Tracy L Simpson, Jillian C Shipherd
BACKGROUND: Transgender individuals are overrepresented among Veterans. However, little is known regarding their satisfaction with Veterans Administration (VA) care and unmet health needs. OBJECTIVES: This study examined transgender Veterans' satisfaction with VA medical and mental health care, prevalence of delaying care, and correlates of these outcomes. RESEARCH DESIGN: We used data from transgender Veterans collected in 2014 through an online, national survey...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28805942/maternal-and-neonatal-outcomes-following-abnormally-invasive-placenta-a-population-based-record-linkage-study
#18
Heather J Baldwin, Jillian A Patterson, Tanya A Nippita, Siranda Torvaldsen, Ibinabo Ibiebele, Judy M Simpson, Jane B Ford
INTRODUCTION: Abnormally invasive placenta (AIP) involves abnormal adherence of the placenta to the myometrium, and is associated with severe pregnancy complications such as blood transfusion and hysterectomy. Knowledge of outcomes has been limited by small sample sizes and a focus on maternal rather than neonatal outcomes. This study uses population-level data collected over ten years to investigate maternal and neonatal outcomes and trends in incidence of AIP (also known as placenta accreta, increta and percreta)...
August 14, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28803668/when-does-atopic-dermatitis-warrant-systemic-therapy-recommendations-from-an-expert-panel-of-the-international-eczema-council
#19
Eric L Simpson, Marjolein Bruin-Weller, Carsten Flohr, Michael R Ardern-Jones, Sebastien Barbarot, Mette Deleuran, Thomas Bieber, Christian Vestergaard, Sara J Brown, Michael J Cork, Aaron M Drucker, Lawrence F Eichenfield, Regina Foelster-Holst, Emma Guttman-Yassky, Audrey Nosbaum, Nick J Reynolds, Jonathan I Silverberg, Jochen Schmitt, Marieke M B Seyger, Phyllis I Spuls, Jean-Francois Stalder, John C Su, Roberto Takaoka, Claudia Traidl-Hoffmann, Jacob P Thyssen, Jorien van der Schaft, Andreas Wollenberg, Alan D Irvine, Amy S Paller
BACKGROUND: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. OBJECTIVE: To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy...
August 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28800122/increased-expression-of-plasma-induced-abcc1-mrna-in-cystic-fibrosis
#20
Justin E Ideozu, Xi Zhang, Amy Pan, Zainub Ashrafi, Katherine J Woods, Martin J Hessner, Pippa Simpson, Hara Levy
The ABCC1 gene is structurally and functionally related to the cystic fibrosis transmembrane conductance regulator gene (CFTR). Upregulation of ABCC1 is thought to improve lung function in patients with cystic fibrosis (CF); the mechanism underlying this effect is unknown. We analyzed the ABCC1 promoter single nucleotide polymorphism (SNP rs504348), plasma-induced ABCC1 mRNA expression levels, and ABCC1 methylation status and their correlation with clinical variables among CF subjects with differing CFTR mutations...
August 11, 2017: International Journal of Molecular Sciences
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