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https://www.readbyqxmd.com/read/28634000/dose-dependent-effects-of-abobotulinumtoxina-dysport%C3%A2-on-spasticity-and-active-movements-in-adults-with-upper-limb-spasticity-secondary-analysis-of-a-phase-3-study
#1
Michael W O'Dell, Allison Brashear, Robert Jech, Thierry Lejeune, Philippe Marque, Djamel Bensmail, Ziyad Ayyoub, David M Simpson, Magali Volteau, Claire Vilain, Philippe Picaut, Jean Michel Gracies
BACKGROUND: AbobotulinumtoxinA has beneficial effects on spasticity and active movements in hemiparetic adults with upper limb spasticity (ULS). However, evidence-based information on optimal dosing for clinical use is limited. OBJECTIVE: To describe joint-specific dose effects of abobotulinumtoxinA in adults with ULS. DESIGN: Secondary analysis of a phase 3 study (NCT01313299). SETTING: Multi-center, international, double-blind, placebo-controlled clinical trial...
June 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28633672/influence-of-the-number-and-timing-of-malaria-episodes-during-pregnancy-on-prematurity-and-small-for-gestational-age-in-an-area-of-low-transmission
#2
Kerryn A Moore, Julie A Simpson, Jacher Wiladphaingern, Aung Myat Min, Mupawjay Pimanpanarak, Moo Kho Paw, Jathee Raksuansak, Sasithon Pukrittayakamee, Freya J I Fowkes, Nicholas J White, François Nosten, Rose McGready
BACKGROUND: Most evidence on the association between malaria in pregnancy and adverse pregnancy outcomes focuses on falciparum malaria detected at birth. We assessed the association between the number and timing of falciparum and vivax malaria episodes during pregnancy on small-for-gestational-age (SGA) and preterm birth. METHODS: We analysed observational data collected from antenatal clinics on the Thailand-Myanmar border (1986-2015). We assessed the effects of the total number of malaria episodes in pregnancy on SGA and the effects of malaria in pregnancy on SGA, very preterm birth, and late preterm birth, by the gestational age at malaria detection and treatment using logistic regression models with time-dependent malaria variables (monthly intervals)...
June 21, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28632180/preview-prevention-of-diabetes-through-lifestyle-intervention-and-population-studies-in-europe-and-around-the-world-design-methods-and-baseline-participant-description-of-an-adult-cohort-enrolled-into-a-three-year-randomised-clinical-trial
#3
Mikael Fogelholm, Thomas Meinert Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J Alfredo Martinez, Nadka Boyadjieva, Sally Poppitt, Wolfgang Schlicht, Gareth Stratton, Jouko Sundvall, Tony Lam, Elli Jalo, Pia Christensen, Mathijs Drummen, Elizabeth Simpson, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Roslyn Muirhead, Marta P Silvestre, Daniela Kahlert, Laura Pastor-Sanz, Jennie Brand-Miller, Anne Raben
Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28632120/basolateral-amygdala-ventromedial-prefrontal-cortex-connectivity-predicts-cognitive-behavioural-therapy-outcome-in-adults-with-obsessive-compulsive-disorder
#4
Miquel A Fullana, Xi Zhu, Pino Alonso, Narcís Cardoner, Eva Real, Clara López-Solà, Cinto Segalàs, Marta Subirà, Hanga Galfalvy, José M Menchón, H Blair Simpson, Rachel Marsh, Carles Soriano-Mas
BACKGROUND: Cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD. METHODS: We investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts CBT outcome in patients with OCD...
June 20, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28631889/microrna-containing-extracellular-vesicles-released-from-endothelial-colony-forming-cells-modulate-angiogenesis-during-ischaemic-retinopathy
#5
Margaret Dellett, Eoin D Brown, Jasenka Guduric-Fuchs, Anna O'Connor, Alan W Stitt, Reinhold J Medina, David A Simpson
Endothelial colony-forming cells (ECFCs) are a defined subtype of endothelial progenitors that modulate vascular repair and promote perfusion in ischaemic tissues. Their paracrine activity on resident vasculature is ill-defined, but mediated, at least in part, by the transfer of extracellular vesicles (EVs). To evaluate the potential of isolated EVs to provide an alternative to cell-based therapies, we first performed a physical and molecular characterization of those released by ECFCs. Their effects upon endothelial cells in vitro and angiogenesis in vivo in a model of proliferative retinopathy were assessed...
June 20, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28631208/pulmonary-vein-doppler-patterns-in-infants-with-single-right-ventricle-anomalies-after-initial-staged-palliations
#6
Edward C Kirkpatrick, Jessica Steltzer, Pippa Simpson, Amy Pan, Andrea Dragulescu, Christine B Falkensammer, Sarah Gelehrter, Wyman W Lai, Jami Levine, Stephen Miller, Thomas A Miller, Jay Pruetz, Ritu Sachdeva, Deepika Thacker, Peter Frommelt
The aim of this study was to describe serial changes in echocardiographic Doppler pulmonary vein flow (PVF) patterns in infants with single right ventricle (RV) anomalies enrolled in the Single Ventricle Reconstruction trial. Measurement of PVF peak systolic (S) and diastolic (D) velocities, velocity time integrals (VTI), S/D peak velocity and VTI ratios, and frequency of atrial reversal (Ar) waves were made at three postoperative time points in 261 infants: early post-Norwood, pre-stage II surgery, and 14 months...
June 19, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28631029/syngas-biorefinery-and-syngas-utilization
#7
Sashini De Tissera, Michael Köpke, Sean D Simpson, Christopher Humphreys, Nigel P Minton, Peter Dürre
Autotrophic acetogenic bacteria are able to capture carbon (CO or CO2) through gas fermentation, allowing them to grow on a spectrum of waste gases from industry (e.g., steel manufacture and oil refining, coal, and natural gas) and to produce ethanol. They can also consume syn(thesis) gas (CO and H2) made from the gasification of renewable/sustainable resources, such as biomass and domestic/agricultural waste. Acetogenic gas fermentation can, therefore, produce ethanol in any geographic region without competing for food or land...
June 20, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28630066/porphyromonas-gulae-activates-unprimed-and-ifn%C3%AE-primed-macrophages-via-the-pattern-recognition-receptors-tlr-2-tlr-4-and-nod2
#8
James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca K H Orth, Ashley Mansell, Eric C Reynolds
Porphyromonas gulae is an anaerobic, Gram-negative coccobacillus that has been associated with periodontal disease in companion animals. The aims of this study were to analyse the ligation of pattern recognition receptors by P. gulae and the subsequent activation of macrophages. Exposure of HEK cells transfected with Toll-like receptors or NOD-like receptors to P. gulae resulted in the ligation of TLR2, TLR4 and NOD2. The effect of this engagement of receptors was investigated by measuring the synthesis of nitric oxide, CD86 expression and inflammatory cytokine production using wild type, TLR2-/- and TLR4-/- macrophages...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28629902/relationship-between-vessel-diameter-and-depth-measurements-within-the-limbus-using-ultra-high-resolution-optical-coherence-tomography
#9
Emmanuel Alabi, Natalie Hutchings, Kostadinka Bizheva, Trefford Simpson
PURPOSE: To establish a relationship between the diameter and depth position of vessels in the superior and inferior corneo-scleral limbus using ultra-high resolution optical coherence tomography (UHR-OCT). METHODS: Volumetric OCT images of the superior and inferior limbus were acquired from 14 healthy subjects with a research-grade UHR-OCT system. Differences in vessel diameter and depth between superior and inferior limbus were analyzed using repeated measured ANOVA in SPSS and R...
June 16, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28629747/mitochondrial-dna-depletion-induces-innate-immune-dysfunction-rescued-by-interferon-%C3%AE
#10
John D Widdrington, Aurora Gomez-Duran, Jannetta S Steyn, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V Baudouin, Anthony J Rostron, John Simpson, Patrick F Chinnery FMedSci
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by interferon-γ treatment.
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28629423/understanding-consumer-and-clinician-preferences-and-decision-making-for-rehabilitation-following-arthroplasty-in-the-private-sector
#11
Mark A Buhagiar, Justine M Naylor, Grahame Simpson, Ian A Harris, Friedbert Kohler
BACKGROUND: To understand private consumer and clinician preferences towards different rehabilitation modes following knee or hip arthroplasty, and identify factors which influence the chosen rehabilitation pathway. METHODS: Mixed methods cross-sectional study involving 95 semi-structured interviews of consumers (patients and carers) and clinicians (arthroplasty surgeons, physiotherapists and rehabilitation physicians) in Sydney, Australia, during 2014-2015. Participants were asked about the acceptability of different modes of rehabilitation provision, and factors influencing their chosen rehabilitation pathway...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28628513/indicators-to-measure-pre-hospital-care-quality-a-scoping-review-protocol
#12
Robin Pap, Craig Lockwood, Matthew Stephenson, Paul Simpson
The current scoping review seeks to locate, examine and describe international literature on indicators used to measure pre-hospital care quality. Specifically, the review will.
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28628106/variants-in-the-fetal-genome-near-flt1-are-associated-with-risk-of-preeclampsia
#13
Ralph McGinnis, Valgerdur Steinthorsdottir, Nicholas O Williams, Gudmar Thorleifsson, Scott Shooter, Sigrun Hjartardottir, Suzannah Bumpstead, Lilja Stefansdottir, Lucy Hildyard, Jon K Sigurdsson, John P Kemp, Gabriela B Silva, Liv Cecilie V Thomsen, Tiina Jääskeläinen, Eero Kajantie, Sally Chappell, Noor Kalsheker, Ashley Moffett, Susan Hiby, Wai Kwong Lee, Sandosh Padmanabhan, Nigel A B Simpson, Vivien A Dolby, Eleonora Staines-Urias, Stephanie M Engel, Anita Haugan, Lill Trogstad, Gulnara Svyatova, Nodira Zakhidova, Dilbar Najmutdinova, Anna F Dominiczak, Håkon K Gjessing, Juan P Casas, Frank Dudbridge, James J Walker, Fiona Broughton Pipkin, Unnur Thorsteinsdottir, Reynir T Geirsson, Debbie A Lawlor, Ann-Charlotte Iversen, Per Magnus, Hannele Laivuori, Kari Stefansson, Linda Morgan
Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5...
June 19, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28625575/overexpression-of-stmn1-is-associated-with-the-prognosis-of-meningioma-patients
#14
Haifeng Wang, Wenchen Li, Guangming Wang, Shuyan Zhang, Li Bie
There is a small part of the pathological type of the meningioma has a malignant tendency and patients have the poor prognosis. Looking for effective biomarkers to predict the degree of malignancy of the tumors, will help us to better manage the patient and guide the treatment. The present study aims at investigating the prognostic value of the expression of Stathmin in a series of meningiomas of different grade. We integrated eight published microarray datasets of meningiomas to screen grade biomarkers in meningiomas patients using the WebArrayDB platform...
June 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28621544/interrogating-charge-storage-on-redox-active-colloids-via-combined-raman-spectroscopy-and-scanning-electrochemical-microscopy
#15
Zachary T Gossage, Noah Benjamin Schorr, Kenneth Hernandez-Burgos, Jingshu Hui, Burton H Simpson, Elena C Montoto, Joaquin Rodriguez-Lopez
Redox active colloids (RACs) are dispersible, cross-linked polymeric materials that incorporate a high concentration of redox-active motifs, making them attractive for next-generation size-exclusion redox flow batteries. In order to tap into their full potential for energy storage, it is essential to understand their internal charge mobility, capacity, and cyclability. Here we focus on using a combined suite of Raman spectroscopy and scanning electrochemical microscopy (SECM) tools for evaluating three important parameters that govern charge storage in viologen-RACs: their intra-particle redox active concentration, their reduction/oxidation mechanism, and their charge transfer rate...
June 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28621012/supporting-people-with-aphasia-to-settle-into-a-new-way-to-be-speech-and-language-therapists-views-on-providing-psychosocial-support
#16
Sarah Northcott, Alan Simpson, Becky Moss, Nafiso Ahmed, Katerina Hilari
BACKGROUND: People with aphasia are at risk of becoming depressed and isolated. Online surveys have found that the majority of speech and language therapists (SLTs) lack confidence in addressing the psychological needs of people with aphasia. AIMS: To explore how SLTs conceptualize the scope of their role; barriers and facilitators to SLTs addressing psychosocial needs; and SLTs' experiences of specialist training and support, and working with mental health professionals (MHPs)...
June 16, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28620815/radiation-related-toxicities-and-outcomes-in-endometrial-cancer-are-obese-women-at-a-disadvantage
#17
A Smits, J McGrane, A Lopes, E Kent, R Bekkers, L Massuger, N Simpson, K Galaal
OBJECTIVE: To assess the impact of body mass index (BMI) on radiotherapy toxicities in endometrial cancer patients. METHODS: This was a retrospective cohort study of women diagnosed with endometrial cancer between January 2006 and December 2014 at the Royal Cornwall Hospital Trust. Women who received radiotherapy as part of their treatment, including external beam radiotherapy (EBRT) and/or vaginal brachytherapy were included. Radiation-related toxicities were graded according to the Radiation Therapy Oncology Group (RTOG) guidelines...
June 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28619804/permanent-draft-genome-sequence-for-frankia-sp-strain-cc1-17-a-nitrogen-fixing-actinobacterium-isolated-from-root-nodules-of-colletia-cruciata
#18
Erik Swanson, Rediet Oshone, Imen Nouioui, Feseha Abebe-Akele, Stephen Simpson, Krystalynne Morris, W Kelley Thomas, Arnab Sen, Faten Ghodhbane-Gtari, Maher Gtari, Louis S Tisa
Frankia sp. strain Cc1.17 is a member of the Frankia lineage 3, the organisms of which are able to reinfect plants of the Eleagnaceae, Rhamnaceae, and Myricaceae families and the genera Gynmnostoma and Alnus Here, we report the 8.4-Mbp draft genome sequence, with a G+C content of 72.14% and 6,721 candidate protein-coding genes.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28619013/mlst-genotypes-of-campylobacter-jejuni-isolated-from-broiler-products-dairy-cattle-and-human-campylobacteriosis-cases-in-lithuania
#19
Sigita Ramonaite, Egle Tamuleviciene, Thomas Alter, Neringa Kasnauskyte, Mindaugas Malakauskas
BACKGROUND: Campylobacter (C.) jejuni is the leading cause of human campylobacteriosis worldwide. We performed a molecular epidemiological study to investigate the genetic relationship among C. jejuni strains isolated from human diarrhoeal patients, broiler products and dairy cattle in Lithuania. METHODS: The C. jejuni isolates from human clinical cases, dairy cattle and broiler products were genotyped using multilocus sequence typing (MLST). Allele numbers for each housekeeping gene, sequence type (ST), and clonal complex (CC) were assigned by submitting the DNA sequences to the C...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28618164/is-liver-transplant-education-patient-centered
#20
Yanik J Bababekov, Zhi Ven Fong, David C Chang, Mary Ann Simpson, Heidi Yeh, James J Pomposelli
No abstract text is available yet for this article.
June 15, 2017: Liver Transplantation
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