keyword
MENU ▼
Read by QxMD icon Read
search

Rhd

keyword
https://www.readbyqxmd.com/read/28617789/adequate-adherence-to-benzathine-penicillin-secondary-prophylaxis-following-the-diagnosis-of-rheumatic-heart-disease-by-echocardiographic-screening
#1
Nicola Culliford-Semmens, Elizabeth Tilton, Rachel Webb, Diana Lennon, Belinda Paku, John Malcolm, Sandi French, Nikki Blair, Nigel Wilson
AIMS: The primary aim of this study was to determine adherence to benzathine penicillin (BPG) for individuals diagnosed with rheumatic heart disease (RHD) by echocardiographic screening between 2007-2012. METHODS: BPG records were obtained for 57 patients, median age 12 at time of diagnosis. A 'days at risk' analysis was undertaken. Annual adherence was calculated for each individual. A comparison with the Wellington region's Rheumatic Fever 2013 adherence data was undertaken...
June 16, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28616570/a-study-of-spectrum-of-rheumatic-heart-disease-in-a-tertiary-care-hospital-in-central-nepal
#2
S Laudari, G Subramanyam
BACKGROUND AND AIMS: Rheumatic heart disease is one of the most common cause for heart failure and associated mortalities/morbidities in the young population in developing countries like Nepal imparting huge familial, social and manpower burden. MATERIALS AND METHODS: This is a hospital based descriptive cross-sectional study during June 2014 to April 2016 over a period of 22 months at College of Medical Sciences-Bharatpur including 235 patients with clinical and/or echocardiographic evidence of definite rheumatic heart disease...
June 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28615230/rapid-rhd-zygosity-determination-using-digital-pcr
#3
Kelly A Sillence, Amr J Halawani, Wajnat A Tounsi, Kirsty A Clarke, Michele Kiernan, Tracey E Madgett, Neil D Avent
BACKGROUND: Paternal zygosity testing is used for determining homo- or hemizygosity of RHD in pregnancies that are at a risk of hemolytic disease of the fetus and newborn. At present, this is achieved by using real-time PCR or the Rhesus box PCR, which can be difficult to interpret and unreliable, particularly for black African populations. METHODS: DNA samples extracted from 58 blood donors were analyzed using 2 multiplex reactions for RHD-specific targets against a reference (AGO1)(2) to determine gene dosage by digital PCR...
June 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28612558/-significance-and-expressions-of-mmp-1-timp-1-and-tgf-%C3%AE-1-in-valve-tissue-of-rheumatic-heart-disease
#4
Yi Yu, Zeng-Qi Li, Kun Chen, Ping Zhan, Jian Liao, Qin-Yun Ruan
OBJECTIVES: To explore expressions of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and transforming growth factor-β1 (TGF-β1) in valve tissue of rheumatic heart disease (RHD), and to analyzed their roles in RHD. METHODS: The expressions of MMP-1, TIMP-1 and TGF-β1 proteins and mRNAs were tested by Western blot and RT-PCR methods in valve tissues in participants with (experimental group, n=30) and without RHD (control group, n=15)...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28594430/substrate-characteristics-and-ablation-outcome-of-left-atrial-tachycardia-in-rheumatic-mitral-valve-disease
#5
Hongwu Chen, Bing Yang, Weizhu Ju, Fengxiang Zhang, Gang Yang, Kai Gu, Mingfang Li, Hailei Liu, Zidun Wang, Kejiang Cao, Minglong Chen
BACKGROUND: Right atrial tachycardia (AT) is common arrhythmia post-surgical valve replacement in patients with rheumatic heart disease (RHD). However, the substrate and the mechanism of left AT in such patients and the ablation efficacy is less known. METHODS AND RESULTS: Twenty-seven RHD patients with AT were enrolled in this study, nine of them (33%) had Left AT. Five and four patients had left AT during the first and second procedure, respectively. A spontaneous scar in the left posterior wall was identified in all patients, and obvious anterior scar in three patients...
June 8, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28579111/clinical-features-and-prognosis-of-infective-endocarditis-in-children-insights-from-a-tunisian-multicentre-registry
#6
Walid Jomaa, Imen Ben Ali, Dorra Abid, Samia Hajri Ernez, Leila Abid, Faten Triki, Samir Kammoun, Anissa Gharbi, Oussama Ben Rejeb, Abdallah Mahdhaoui, Gouider Jeridi, Mohamed A Azaiez, Aymen El Hraiech, Khaldoun Ben Hamda, Faouzi Maatouk
BACKGROUND: Infective endocarditis (IE) is a rare condition in the paediatric setting. No data on the epidemiology and prognosis of IE in children are available from North African countries. AIM: To investigate the epidemiological profile and prognosis of IE in children in Tunisia. METHODS: All patients aged≤18 years presenting with IE in three Tunisian tertiary care centres between January 1997 and September 2013 were included. Clinical features and 30-day and 6-month mortality rates were studied...
May 31, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28578399/transcription-factor-forkhead-regulates-expression-of-antimicrobial-peptides-in-the-tobacco-hornworm-manduca-sexta
#7
Xue Zhong, Munmun Chowdhury, Chun-Feng Li, Xiao-Qiang Yu
Antimicrobial peptides (AMPs) play an important role in defense against microbial infections in insects. Expression of AMPs is regulated mainly by NF-κB factors Dorsal, Dif and Relish. Our previous study showed that both NF-κB and GATA-1 factors are required for activation of moricin promoter in the tobacco hornworm, Manduca sexta, and a 140-bp region in the moricin promoter contains binding sites for additional transcription factors. In this study, we identified three forkhead (Fkh)-binding sites in the 140-bp region of the moricin promoter and several Fkh-binding sites in the lysozyme promoter, and demonstrated that Fkh-binding sites are required for activation of both moricin and lysozyme promoters by Fkh factors...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28566370/enhanced-effector-functions-due-to-antibody-defucosylation-depend-on-the-effector-cell-fc%C3%AE-receptor-profile
#8
Christine W Bruggeman, Gillian Dekkers, Arthur E H Bentlage, Louise W Treffers, Sietse Q Nagelkerke, Suzanne Lissenberg-Thunnissen, Carolien A M Koeleman, Manfred Wuhrer, Timo K van den Berg, Theo Rispens, Gestur Vidarsson, Taco W Kuijpers
Abs of the IgG isotype are glycosylated in their Fc domain at a conserved asparagine at position 297. Removal of the core fucose of this glycan greatly increases the affinity for FcγRIII, resulting in enhanced FcγRIII-mediated effector functions. Normal plasma IgG contains ∼94% fucosylated Abs, but alloantibodies against, for example, Rhesus D (RhD) and platelet Ags frequently have reduced fucosylation that enhances their pathogenicity. The increased FcγRIII-mediated effector functions have been put to use in various afucosylated therapeutic Abs in anticancer treatment...
May 31, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28566189/association-between-leukoaraiosis-and-hemorrhagic-transformation-after-cardioembolic-stroke-due-to-atrial-fibrillation-and-or-rheumatic-heart-disease
#9
Chen-Chen Wei, Shu-Ting Zhang, Yun-Han Wang, Jun-Feng Liu, Jie Li, Ruo-Zhen Yuan, Ge Tan, Shi-Hong Zhang, Ming Liu
Cardioembolic stroke due to atrial fibrillation (AF) and/or rheumatic heart disease (RHD) often involves hemorrhagic transformation (HT), and we examined whether leukoaraiosis (LA) was associated with HT in these cases. We prospectively enrolled 251 patients who were admitted to two hospitals within one month of experiencing cardioembolic stroke due to AF/RHD. LA severity was assessed using three visual rating scales. HT was identified in 99 patients (39.4%) based on baseline computed tomography (CT) and post-admission magnetic resonance imaging or second CT...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28559267/a-penicillin-dried-blood-spot-assay-for-use-in-patients-receiving-intramuscular-benzathine-penicillin-g-and-other-penicillin-preparations-to-prevent-rheumatic-fever
#10
Madhu Page-Sharp, Jonathan Coward, Brioni R Moore, Sam Salman, Lewis Marshall, Timothy M E Davis, Kevin T Batty, Laurens Manning
Background: Rheumatic heart disease (RHD) remains an important global health challenge. Benzathine penicillin (BPG) is recommended every 3-4 weeks as secondary prophylaxis to prevent recurrent episodes of acute rheumatic fever and subsequent RHD. Following intramuscular injection, BPG is hydrolysed to penicillin G (benzylpenicillin). However, little is known of the pharmacokinetics (PK) of BPG in paediatric populations at high risk of RHD or the pharmacokinetic-pharmacodynamic relationship between penicillin exposure and clinically relevant outcomes...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28552221/rf-and-rhd-research
#11
George A Mensah, Michael M Engelgau
No abstract text is available yet for this article.
March 2017: Global Heart
https://www.readbyqxmd.com/read/28552220/can-we-eliminate-rheumatic-fever-and-premature-deaths-from-rhd
#12
EDITORIAL
Salim Yusuf, Jagat Narula, Habib Gamra
No abstract text is available yet for this article.
March 2017: Global Heart
https://www.readbyqxmd.com/read/28552219/moving-forward-the-rhd-agenda-at-global-and-national-levels
#13
EDITORIAL
David A Watkins, Liesel J Zühlke, Jagat Narula
No abstract text is available yet for this article.
March 2017: Global Heart
https://www.readbyqxmd.com/read/28541297/risk-factors-susceptibility-allele-identified-in-rhd
#14
Dario Ummarino
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28538419/magnetic-resonance-imaging-evaluation-of-the-labrum-to-predict-acetabular-development-in-developmental-dysplasia-of-the-hip-a-strobe-compliant-study
#15
Yasuhiro Shirai, Kenjiro Wakabayashi, Ikuo Wada, Yoshiaki Tsuboi, Myongsu Ha, Takanobu Otsuka
Recently, more attention has been paid to the role of the acetabular labrum. Therefore, we designed a retrospective cohort study of patients with residual hip dysplasia (RHD) who underwent magnetic resonance imaging (MRI). The objective of this study was to investigate an association between the MRI appearance of the labrum before school age and the natural history of RHD.We retrospectively investigated 45 hips of 40 patients who underwent MRI at about 3 and 4 years of age for RHD and were conservatively followed up with until 6 years of age or older...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535394/red-blood-cell-alloimmunization-in-184-patients-with-myeloid-neoplasms-treated-with-azacitidine-a-retrospective-single-center-experience
#16
M Leisch, L Weiss, N Lindlbauer, C Jungbauer, A Egle, E Rohde, R Greil, C Grabmer, L Pleyer
Alloimmunization to Red Blood Cell (RBC) antigens frequently occurs in patients with myeloid neoplasms (AML, MDS and CMML) and potentially poses the patient at risk for delayed hemolytic transfusion reactions and limited supply of compatible RBC-units. However, there is comparatively little data on transfusion associated characteristics in this patient cohort. We therefore retrospectively analyzed transfusion requirements and clinical outcomes of 184 patients with myloid neoplasms treated with azacitidine at the Paracelsus Medical University Salzburg, which were included in the Austrian Registry of Hypomethylating Agents...
May 9, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28512327/prognostic-value-of-hypoalbuminemia-for-adverse-outcomes-in-patients-with-rheumatic-heart-disease-undergoing-valve-replacement-surgery
#17
Xue-Biao Wei, Lei Jiang, Yuan-Hui Liu, Du Feng, Peng-Cheng He, Ji-Yan Chen, Dan-Qing Yu, Ning Tan
High-risk patients with rheumatic heart disease (RHD) who were undergoing valve replacement surgery (VRS) were not identified entirely. This study included 1782 consecutive patients with RHD who were undergoing VRS to explore the relationship between hypoalbuminemia and adverse outcomes and to confirm whether hypoalbuminemia plays a role in risk evaluation. A total of 27.3% of the RHD patients had hypoalbuminemia. In-hospital deaths were significantly higher in the hypoalbuminemic group than in the non-hypoalbuminemic group (6...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511387/erythrocyte-alloimmunization-and-autoimmunization-among-blood-donors-and-recipients-visiting-a-tertiary-care-hospital
#18
Daljit Kaur, Lovenish Bains, Manoj Kandwal, Indu Parmar
INTRODUCTION: The ultimate aim of pretransfusion testing is the acceptable survival of donor red cells in recipient's body and antibody detection plays a critical role in achieving the same. The cornerstone of antibody detection method is detecting an unexpected antibody as against the expected antibodies of ABO blood group system. Autoantibodies can also interfere with the detection of clinically significant alloantibodies. AIM: To study the frequency of alloantibodies and autoantibodies in the healthy blood donors and patient population visiting our hospital...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508562/can-serological-methods-help-distinguish-between-prophylactic-and-alloimmune-anti-d
#19
C Irving, M Crennan, T Vanniasinkam
OBJECTIVES: Enzyme indirect antiglobulin test (EIAT) and polyethylene glycol IAT (PIAT) were evaluated for their potential use as tests to distinguish between prophylactic and alloimmune anti-D in plasma by comparing with a tube variation of the standard low ionic strength solution-IAT (LISS-IAT). BACKGROUND: Laboratories performing the screening of RhD-negative pregnant women are required to provide clinicians with guidance as to the source of detected RhD antibodies...
May 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28508413/serological-weak-d-phenotypes-a-review-and-guidance-for-interpreting-the-rhd-blood-type-using-the-rhd-genotype
#20
REVIEW
S Gerald Sandler, Leonard N Chen, Willy A Flegel
Approximately 0·2-1% of routine RhD blood typings result in a "serological weak D phenotype." For more than 50 years, serological weak D phenotypes have been managed by policies to protect RhD-negative women of child-bearing potential from exposure to weak D antigens. Typically, blood donors with a serological weak D phenotype have been managed as RhD-positive, in contrast to transfusion recipients and pregnant women, who have been managed as RhD-negative. Most serological weak D phenotypes in Caucasians express molecularly defined weak D types 1, 2 or 3 and can be managed safely as RhD-positive, eliminating unnecessary injections of Rh immune globulin and conserving limited supplies of RhD-negative RBCs...
May 16, 2017: British Journal of Haematology
keyword
keyword
82641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"