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https://www.readbyqxmd.com/read/29656499/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-analysis-of-36-blood-group-alleles-among-396-thai-samples-reveals-region-specific-variants
#1
Philaiphon Jongruamklang, Christoph Gassner, Stefan Meyer, Aksarakorn Kummasook, Marion Darlison, Chayanun Boonlum, Surin Chanta, Beat M Frey, Martin L Olsson, Jill R Storry
BACKGROUND: Blood group phenotype variation has been attributed to potential resistance to pathogen invasion. Variation was mapped in blood donors from Lampang (northern region) and Saraburi (central region), Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized and the data were correlated with phenotypes. The high incidence of the Vel-negative phenotype previously reported in Thais was investigated. STUDY DESIGN AND METHODS: DNA from 396 blood donors was analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry...
April 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29653006/-a-weak-d-type-59-case-identified-in-the-chinese-han-population
#2
Zhaoping Liao, Huiying Xu, Chunhua Liu, Rui Wang, Kaihua Xiang, Jie Feng, Fangjia Le, Ting Wu, Zhihua Tao
OBJECTIVE: To study a case with weak D59 phenotype identified among ethnic Han Chinese population. METHODS: Routine serological tests were used to analyze the reaction patterns, and the RhD epitopes were verified with 12 monoclonal antibodies. Sequence-specific primer PCR was applied for typing the weak RhD and RhD zygosity in the proband and his family members. RESULTS: A c.1148T>C variant was identified in the proband, for which serological test indicated a weak D phenotype...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29642817/rheumatic-heart-disease-in-timor-leste-school-students-an-echocardiography-based-prevalence-study
#3
Kimberly Davis, Bo Remenyi, Anthony Dk Draper, Januario Dos Santos, Noel Bayley, Elizabeth Paratz, Benjamin Reeves, Alan Appelbe, Andrew Cochrane, Timothy D Johnson, Laura M Korte, Ivonia M Do Rosario, Inez T Da Silva Almeida, Kathryn V Roberts, Jonathan R Carapetis, Joshua R Francis
OBJECTIVES: To determine the prevalence of rheumatic heart disease (RHD) in school-aged children and young people in Timor-Leste. DESIGN: Prospective cross-sectional survey. Echocardiography was performed by Australian cardiologists to determine the presence of RHD. Demographic data were also collected. Patients in whom RHD was detected were entered into a register to allow monitoring of adherence to secondary prophylaxis; the first dose of benzathine penicillin G (BPG) was administered on the day of screening...
April 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29621606/rhodamine-binds-to-silk-fibroin-and-inhibits-its-self-aggregation
#4
Laura Ragona, Oktay Gasymov, Aytaj J Guliyeva, Rasim B Aslanov, Serena Zanzoni, Chiara Botta, Henriette Molinari
Amyloid structures are universal structures, widely diffuse in nature. Silk, capable of forming some of the strongest tensile materials on earth represents an important example of formation of functional amyloid fibrils, a process reminiscent of the oligomerization of peptides involved in neurodegenerative diseases. The stability of silk fibroin solutions in different conditions and its transition from α-helix/random coil to β-sheet structures, at the basis of gelation processes and fibril formation, have been here investigated and monitored employing different biophysical approaches...
April 2, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29616835/lessons-learned-from-the-implementation-of-non-invasive-fetal-rhd-screening
#5
Frederik Banch Clausen
Introduction In the fight against hemolytic disease of the fetus and newborn, pregnant RhD negative women are offered antenatal and postnatal anti-D immunoglobulin prophylaxis to prevent the development of antibodies against the fetal D antigen. Antenatal prophylaxis has traditionally been provided to all D negative pregnant women, as the fetal RhD type remains unknown until birth. With noninvasive prenatal testing of cell-free DNA, predicting the fetal RhD type has become highly feasible based on analysis of the fetal RHD gene...
April 4, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29615091/rheumatic-heart-disease-in-the-south-west-region-of-cameroon-a-hospital-based-echocardiographic-study
#6
Clovis Nkoke, Anastase Dzudie, Christelle Makoge, Engelbert Bain Luchuo, Ahmadou Musa Jingi, Samuel Kingue
OBJECTIVE: Rheumatic heart disease (RHD) prevails as a major public health problem in sub-Saharan Africa. In Cameroon, reports on RHD have been so far limited to a few cities. We sought to describe the demographic, clinical and echocardiographic features of rheumatic heart disease in the Buea Regional Hospital, South West region of Cameroon. Echocardiography reports between June 2016 and June 2017 were reviewed. The diagnosis of RHD was based on the World Heart Federation Criteria for the diagnosis of RHD...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29608495/medical-management-of-rheumatic-heart-disease-a-systematic-review-of-the-evidence
#7
E Anne Russell, Warren F Walsh, Ben Costello, Alex Ja McLellan, Alex Brown, Christopher M Reid, Lavinia Tran, Graeme P Maguire
Rheumatic heart disease (RHD) is an important cause of heart disease globally. Its management can encompass medical and procedural (catheter and surgical) interventions. Literature pertaining to the medical management of RHD from PubMed 1990-2016 and via selected article reference lists was reviewed. Areas included symptom management, left ventricular (LV) dysfunction, rate control in mitral stenosis (MS), atrial fibrillation (AF), anticoagulation, infective endocarditis prophylaxis and management in pregnancy...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29607511/identification-of-a-novel-missense-mutation-p-ser230asn-in-rhd-allele-in-a-chinese-individual-with-partial-d-phenotype
#8
Jingwei Zhang, Ming Guo, Li Tian
No abstract text is available yet for this article.
April 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29605140/auns-ag-core-shell-nanocubes-grafted-with-rhodamine-for-concurrent-metal-enhanced-fluorescence-and-surfaced-enhanced-raman-determination-of-mercury-ions
#9
Huanhuan Li, Quansheng Chen, Md Mehedi Hassan, Qin Ouyang, Tianhui Jiao, Yi Xu, Min Chen
Mercury ion (Hg2+ ) is a highly hazardous and widespread pollutant with bio-accumulative properties. Although the existing Hg2+ detection methods have high sensitivity and reliability, whereas there have few reports concerning bimodal detection for Hg2+ with one sensor. Toward this goal, a novel sensor based on rhodamine derivatives (RhD) grafted AuNS@Ag core-shell nanocubes (CSN) has been synthesized and shown the bimodal detection capabilities with metal enhanced fluorescence (MEF) and surface enhanced Raman scattering (SERS) for Hg2+ ...
August 14, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29595460/-distribution-of-rh-blood-group-in-51-283-cases-of-inpatients-and-voluntary-blood-donors
#10
Ting Ma, Jiangcun Yang, Yaojun Song, Wenhua Wang, Xinxin Xie, Ping Chen, Yingqun Yang, Jingyan Chang, Miaoni Wang
Objective To investigate the distribution characteristics of Rh blood group in 51 283 cases of inpatients and voluntary blood donors. Methods Micro-column gel test was used to detect RhD, RhE, Rhe, RhC, Rhc antigen in 31 818 cases of hospitalized patients and 19 465 cases of voluntary blood donors. Results There were significant differences in Rh blood type distribution between inpatients and voluntary blood donors. The mainly phenotype of Rh blood group in the inpatients were DCCee (41.64%) and DCcEe (36.58%), and Rh blood type in voluntary blood donors were DCCee (41...
January 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29590159/motivations-of-women-in-uganda-living-with-rheumatic-heart-disease-a-mixed-methods-study-of-experiences-in-stigma-childbearing-anticoagulation-and-contraception
#11
Andrew Y Chang, Juliet Nabbaale, Haddy Nalubwama, Emmy Okello, Isaac Ssinabulya, Christopher T Longenecker, Allison R Webel
BACKGROUND: Rheumatic heart disease (RHD) is a leading cause of premature mortality in low- and middle-income countries (LMICs). Women of reproductive age are a unique and vulnerable group of RHD patients, due to increased risk of cardiovascular complications and death during pregnancy. Yet, less than 5% of women of childbearing age with RHD in LMICs use contraceptives, and one in five pregnant women with RHD take warfarin despite known teratogenicity. It is unclear whether this suboptimal contraception and anticoagulant use during pregnancy is due to lack of health system resources, limited health literacy, or social pressure to bear children...
2018: PloS One
https://www.readbyqxmd.com/read/29580376/high-throughput-non-invasive-prenatal-testing-for-fetal-rhesus-d-status-in-rhd-negative-women-not-known-to-be-sensitised-to-the-rhd-antigen-a-systematic-review-and-economic-evaluation
#12
Pedro Saramago, Huiqin Yang, Alexis Llewellyn, Ruth Walker, Melissa Harden, Stephen Palmer, Susan Griffin, Mark Simmonds
BACKGROUND: High-throughput non-invasive prenatal testing (NIPT) for fetal rhesus (D antigen) (RhD) status could avoid unnecessary treatment with routine anti-D immunoglobulin for RhD-negative women carrying a RhD-negative fetus, although this may lead to an increased risk of RhD sensitisations. OBJECTIVES: To systematically review the evidence on the diagnostic accuracy, clinical effectiveness and implementation of high-throughput NIPT and to develop a cost-effectiveness model...
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29572293/prominent-inter-scallop-separations-of-the-posterior-leaflet-of-the-mitral-valve-an-important-cause-of-pathological-mitral-regurgitation
#13
L D Hunter, M Monaghan, G Lloyd, A J K Pecoraro, A F Doubell, P G Herbst
The 2012 World Heart Federation (WHF) criteria for echocardiographic diagnosis of rheumatic heart disease (RHD) identify that the finding of 'pathological' mitral regurgitation (MR) in a screened individual increases the likelihood of detecting underlying RHD. Cases of isolated "pathological MR are thus identified as 'borderline RHD'. A large-scale echocardiographic screening program (Echo in Africa) in South Africa has identified that inter-scallop separations of the posterior mitral valve leaflet (PMVL) can give rise to 'pathological' MR...
March 23, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29572239/identification-of-novel-mecom-gene-fusion-and-personalized-therapeutic-targets-through-integrative-clinical-sequencing-in-secondary-acute-myeloid-leukemia-in-a-patient-with-severe-congenital-neutropenia-a-case-report-and-literature-review
#14
James A Connelly, Rajen J Mody, Yi-Mi Wu, Dan R Robinson, Robert J Lonigro, Pankaj Vats, Erica Rabban, Bailey Anderson, Kelly Walkovich
Severe congenital neutropenia (SCN) is a rare hematologic disorder characterized by defective myelopoiesis and a high incidence of malignant transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). SCN patients who develop MDS/AML have excessive toxicities to traditional chemotherapy and safer therapies are needed to improve overall survival in this population. In this report, we outline the use of a prospective integrative clinical sequencing trial (PEDS-MIONCOSEQ) in a patient with SCN and AML to help identify oncogenic targets for less toxic agents...
March 23, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29570206/participation-in-research-improves-overall-patient-management-insights-from-the-global-rheumatic-heart-disease-registry-remedy
#15
E A Prendergast, S Perkins, M E Engel, B Cupido, V Francis, A Joachim, M Al Kebsi, F Bode-Thomas, A Damasceno, A Abul Fadl, A El Sayed, B Gitura, N Kennedy, A Ibrahim, J Mucumbitsi, A M Adeoye, J Musuku, E Okello, T Olunuga, S Sheta, B M Mayosi, L J Zühlke
BACKGROUND: Rheumatic heart disease (RHD) is a major public health problem in low- and middle-income countries (LIMCs), with a paucity of high-quality trial data to improve patient outcomes. Investigators felt that involvement in a recent large, observational RHD study impacted positively on their practice, but this was poorly defined. AIM: The purpose of this study was to document the experience of investigators and research team members from LMICs who participated in a prospective, multi-centre study, the global Rheumatic Heart Disease Registry (REMEDY), conducted in 25 centres in 14 countries from 2010 to 2012...
March 19, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29554040/pre-hospital-low-titer-cold-stored-whole-blood-philosophy-for-ubiquitous-utilization-of-o-positive-product-for-emergency-use-in-hemorrhage-due-to-injury
#16
Ashley C McGinity, Caroline S Zhu, Leslie Greebon, Elly Xenakis, Elizabeth Waltman, Eric Epley, Danielle Cobb, Rachelle Jonas, Susannah E Nicholson, Brian J Eastridge, Ronald M Stewart, Donald H Jenkins
The mortality from hemorrhage in trauma patients remains high. Early balanced resuscitation improves survival. These truths, balanced with the availability of local resources and our goals for positive regional impact, were the foundation for the development of our pre-hospital whole blood initiative-using low titer cold stored O RhD positive whole blood (LTOWB). The main concern with use of RhD positive blood is the potential development of isoimmunization in RhD negative patients. We used our retrospective massive transfusion protocol (MTP) data to analyze the anticipated risk of this change in practice...
March 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29546503/correction-to-lessons-learned-in-the-development-of-sustained-release-penicillin-drug-delivery-systems-for-the-prophylactic-treatment-of-rheumatic-heart-disease-rhd
#17
Oliver D Montagnat, Graham R Webster, Jürgen B Bulitta, Cornelia Landersdorfer, Rosemary Wyber, Meru Sheel, Jonathan R Carapetis, Ben J Boyd
Jürgen B. Bulitta's name was misspelled in the original version of the article. It is correct as reflected here. The original article has been revised.
March 15, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29539628/prenatal-abo-rhd-genotyping-a-new-paradigm-to-allow-for-fresh-whole-blood-for-cardiopulmonary-bypass-in-the-immediate-newborn-period
#18
Juliet Chhay Bishop, Karin Blakemore, Luca Vricella, Priya Sekar, Katelynn Sagaser, Jude Crino, Paul Ness, Benjamin K Kogutt, Joan Boyd, Susan Aucott, Angie C Jelin, Joanne Chiu, Eric Gehrie, Kristen Nelson McMillan
Compared to standard component therapy, fresh whole blood (FWB) offers potential benefits to neonates undergoing cardiopulmonary bypass (CPB) in the context of open cardiac surgery: decreased blood loss and subsequent risk of volume overload, improved coagulation status, higher platelet counts during and following CPB, circumvention of limited vascular access, and significantly reduced donor exposures. Obtaining FWB, however, entails 2-5 days of preparation, which often precludes its availability for neonates requiring CPB in the immediate newborn period...
March 14, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29532485/facilitators-and-barriers-for-rhd-immunized-women-to-become-and-remain-anti-d-donors
#19
Yolentha Maria Slootweg, Johanna Maria Koelewijn, Wim L de Kort, Masja de Haas, Eva-Maria Merz
BACKGROUND: The successful introduction of prophylaxis with anti-RhD immunoglobulin has resulted in a significant decline of pregnancy-related RhD immunizations but also has decreased the availability of naturally immunized women as (new) anti-D donors. An influx of new donors is necessary to maintain a sufficient pool of anti-D donors. We investigated motivators, barriers, and predictors for anti-D donorship in RhD-immunized women. STUDY DESIGN AND METHODS: A mixed-methods design was applied, including focus group discussions and questionnaires...
March 12, 2018: Transfusion
https://www.readbyqxmd.com/read/29519368/transfusion-management-for-patients-taking-an-anti-cd38-monoclonal-antibody
#20
Carolina Bonet Bub, Isabel Nagle Dos Reis, Maria Giselda Aravechia, Leandro Dinalli Santos, Eduardo Peres Bastos, José Mauro Kutner, Lilian Castilho
INTRODUCTION: Pre-transfusion tests, essential for the release of blood components, may be affected by drugs. Monoclonal antibodies represent a class of medications increasingly used in the clinical practice, with anti-CD38 monoclonal antibodies (daratumumab) being a promising resource in the treatment of refractory myeloma. This monoclonal antibody recognizes CD38 in myeloma cells and interferes with pre-transfusion tests by causing panreactivity in indirect antiglobulin tests thereby clinically masking alloantibodies...
January 2018: Revista Brasileira de Hematologia e Hemoterapia
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