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Pasqualina M Coffey, Anna P Ralph, Vicki L Krause
BACKGROUND: Rheumatic heart disease (RHD) poses a major disease burden among disadvantaged populations globally. It results from acute rheumatic fever (ARF), a complication of Group A Streptococcal (GAS) infection. These conditions are acknowledged as diseases of poverty, however the role of specific social and environmental factors in GAS infection and progression to ARF/RHD is not well understood. The aim of this systematic review was to determine the association between social determinants of health and GAS infection, ARF and RHD, and the effect of interventions targeting these...
June 13, 2018: PLoS Neglected Tropical Diseases
Marja Isomursu, Aleksija Neimanis, Veera Karkamo, Minna Nylund, Riikka Holopainen, Tiina Nokireki, Tuija Gadd
Rabbit hemorrhagic disease (RHD) was detected in European rabbits ( Oryctolagus cuniculus) for the first time ever in Finland in 2016. Reports of dead feral rabbits in Helsinki started to accumulate from April 2016. The Finnish Food Safety Authority Evira received the first animals in late April, and the main necropsy finding was severe, acute necrotizing hepatitis. Genetic material from RHD virus (RHDV) was detected in the liver and was further characterized as RHDV2. The Finnish virus did not group with RHDV strains from a concurrent outbreak in neighboring Sweden, suggesting another origin...
June 11, 2018: Journal of Wildlife Diseases
Ebru Dündar Yenilmez, Umut Kökbaş, Kezban Kartlaşmış, Levent Kayrın, Abdullah Tuli
Prenatal detection of the fetal RHD status can be useful in the management of RhD incompatibility to identify fetuses at risk of hemolytic disease. Hemolytic disease causes morbidity and mortality of the fetus in the neonatal period. The routine use of antenatal and postnatal anti-D prophylaxis has reduced the incidence of hemolytic disease of the fetus and newborn. This study describe the detection of fetal RhD antigens in blood of RhD negative pregnant women using a nanopolymer coated electrochemical biosensor for medical diagnosis...
2018: PloS One
Kirsten Sørensen, Jens Kjeldsen-Kragh, Henrik Husby, Çiğdem Akalın Akkök
Alloimmunization against the RhD antigen is the most common cause of hemolytic disease of the fetus and newborn. Antenatal anti-D prophylaxis in addition to postnatal anti-D prophylaxis reduces the number of RhD-immunizations compared to only postnatal administration. Cell-free fetal DNA released from the apoptotic trophoblastic placental cells into the maternal circulation can be used to determine the fetal RHD type in a blood sample from an RhD negative mother. Based on this typing, antenatal anti-D prophylaxis can be recommended only to RhD negative women carrying an RhD positive fetus, since only these women are at risk of developing anti-D...
June 5, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
Daniel Lyon Fink, Yoram Chaiter, Samuel Menahem, Rivka Farkash, Yossy Machluf
Background: Rheumatic heart disease (RHD) among Ethiopian school children was recently found to be 1.4%. Immigration of the Jewish population from the Gondar region to Israel created an opportunity for further enquiry. Methods: A cross-sectional study of the cardiac status of 113,671 adolescent recruits aged 16-19 years from the northern district of Israel who completed the medical profiling process over a 22-year period. Results: 140 recruits had a history of rheumatic fever (0...
2018: Frontiers in Public Health
L Laget, C Izard, E Durieux-Roussel, J Gouvitsos, I Dettori, J Chiaroni, V Ferrera-Tourenc
OBJECTIVES: For pregnant women, the serologic test results of D antigen will determine the frequency of RBC antibody detection as well as the indication for RhIG prophylaxis. RHD genotyping is the only method that may provide clear guidance on prophylaxis for women with a weak D phenotype. This analysis evaluated the economical implications of using RHD genotyping to guide RhIG prophylaxis among pregnant women with a serological weak D phenotype. METHODS: We compared the costs of 2 strategies in a cohort of 273 women with weak D phenotype...
June 1, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Aleksija Neimanis, Ulrika Larsson Pettersson, Nina Huang, Dolores Gavier-Widén, Tanja Strive
Lagovirus europaeus GI.2, also known as RHDV2 or RHDVb, is an emerging virus that causes rabbit haemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus). In contrast to L. europaeus GI.1 (or RHDV/RHDVa) viruses that are only pathogenic for adults, GI.2 causes clinical disease in both adults and kittens. However, detailed descriptions of the pathology of this virus that may provide insight into its pathogenicity and emergence are lacking. Using an Australian GI.2 field strain isolated in 2015, we provide the first detailed description of pathology, viral antigen distribution and tissue load of GI...
June 5, 2018: Veterinary Research
Rongjun Zou, Wanting Shi, Jun Tao, Xifeng Lin, Dingwen Zhang, Songran Yang, Ping Hua
Background: Renal impairment increases the risk of cardiovascular events and perioperative complications in patients with heart valve disease. This study aimed to determine the perioperative benefit of statin treatment related to baseline renal function in patients with rheumatic heart disease (RHD) who had cardiac surgery. Methods and Results: We performed a retrospective study on 136 patients with RHD who underwent valve replacement surgery. The mean age of the patients was 56...
2018: BioMed Research International
Azza M A M Abul-Fadl, Maha M Mourad, Alaa Ghamrawy, Ayah Ebada Sarhan
Rheumatic heart disease (RHD) is a preventable disease that is prevalent in developing regions of the world. Its eradication from most of the developed world indicates that this disease can be controlled and eliminated. Aim: To conduct an in-depth analysis of the trends and challenges of controlling RHD in the Eastern Mediterranean region (EMR). Methodology: Global data from the World Health Organization (WHO) data banks were retrieved for total deaths and age standardized death rate per 100,000 (ASDR) by age group, sex, and year (from 2000 to 2015)...
May 30, 2018: Journal of Cardiovascular Development and Disease
Isabel Tissieres, Sonia Crottaz-Herbette, Stephanie Clarke
BACKGROUND: The key symptoms of auditory neglect include left extinction on tasks of dichotic and/or diotic listening and rightward shift in locating sounds. The anatomical correlates of the latter are relatively well understood, but no systematic studies have examined auditory extinction. Here, we performed a systematic study of anatomo-clinical correlates of extinction by using dichotic and/or diotic listening tasks. METHODS: In total, 20 patients with right hemispheric damage (RHD) and 19 with left hemispheric damage (LHD) performed dichotic and diotic listening tasks...
May 23, 2018: Annals of Physical and Rehabilitation Medicine
Anneke S de Vos, C Ellen van der Schoot, Dimitris Rizopoulos, Mart P Janssen
[This corrects the article DOI: 10.1371/journal.pone.0196382.].
2018: PloS One
Carlos Calvete, Manuel Mendoza, Ana Alcaraz, María P Sarto, María P Jiménez-de-Bagüéss, Antonio J Calvo, Fernando Monroy, Jorge H Calvo
European rabbits (Oryctolagus cuniculus) are severely affected by rabbit haemorrhagic disease (RHD). Caused by a lagovirus, the disease leads to losses in the rabbit industry and has implications for wildlife conservation. Past RHD outbreaks have been caused by GI.1/RHDV genotype viruses. A new virus belonging to the GI.2/RHDV2/b genotype emerged in 2010, quickly spreading and replacing the former in several countries; however, limited data are available on its pathogenicity and epidemiological factors. The present work extends these issues and evaluates cross-protection between both genotypes...
June 2018: Veterinary Microbiology
John G Howe, Gary Stack
BACKGROUND: The intrinsic properties of polypeptide blood group antigens that determine their relative immunogenicities are unknown. Because size, composition, charge, dose, and epitope glycosylation affect the immunogenicity of other polypeptides, we examined whether similar properties were related to the immunogenicity of blood group antigens. STUDY DESIGN AND METHODS: Amino acid (AA) sequences of antithetical blood group antigens were searched for N- and O-glycosylation sites...
May 16, 2018: Transfusion
Silvia Manfroi, Chiara Calisesi, Pietro Fagiani, Annalisa Gabriele, Gianluca Lodi, Simonetta Nucci, Susanna Pelliconi, Laura Righini, Vanda Randi
BACKGROUND: Foetal RHD genotyping can be predicted by real-time polymerase chain reaction (qPCR) using cell-free foetal DNA extracted from maternal plasma. The object of this study was to determine the diagnostic accuracy and feasibility of non-invasive RHD foetal genotyping, using a commercial multiple-exon assay, as a guide to appropriate administration of targeted antenatal immunoprophylaxis. MATERIAL AND METHODS: Cell-free foetal DNA was extracted from plasma of RhD-negative women between 11-30 weeks of pregnancy...
April 9, 2018: Blood Transfusion, Trasfusione del Sangue
Raphaël Leman, Pascaline Gaildrat, Gérald L Gac, Chandran Ka, Yann Fichou, Marie-Pierre Audrezet, Virginie Caux-Moncoutier, Sandrine M Caputo, Nadia Boutry-Kryza, Mélanie Léone, Sylvie Mazoyer, Françoise Bonnet-Dorion, Nicolas Sevenet, Marine Guillaud-Bataille, Etienne Rouleau, Brigitte Bressac-de Paillerets, Barbara Wappenschmidt, Maria Rossing, Danielle Muller, Violaine Bourdon, Françoise Revillon, Michael T Parsons, Antoine Rousselin, Grégoire Davy, Gaia Castelain, Laurent Castéra, Joanna Sokolowska, Florence Coulet, Capucine Delnatte, Claude Férec, Amanda B Spurdle, Alexandra Martins, Sophie Krieger, Claude Houdayer
Variant interpretation is the key issue in molecular diagnosis. Spliceogenic variants exemplify this issue as each nucleotide variant can be deleterious via disruption or creation of splice site consensus sequences. Consequently, reliable in silico prediction of variant spliceogenicity would be a major improvement. Thanks to an international effort, a set of 395 variants studied at the mRNA level and occurring in 5' and 3' consensus regions (defined as the 11 and 14 bases surrounding the exon/intron junction, respectively) was collected for 11 different genes, including BRCA1, BRCA2, CFTR and RHD, and used to train and validate a new prediction protocol named Splicing Prediction in Consensus Elements (SPiCE)...
May 10, 2018: Nucleic Acids Research
Sulafa Ali, Sara Domi, Bahja Abbo, Rabab Abbas, Tajudeen Bushari, Khalid Al Awad, Abdelrahman Elhassan, Manar E Abdel-Rahman
INTRODUCTION: Echocardiographic (echo) screening has unmasked a high prevalence of subclinical rheumatic heart disease (RHD) in many countries, and it can be used as a surveillance tool to control the disease. METHODS: School children of 10 to 15 years of age were selected in two areas of Sudan, Khartoum, the capital, and Niyala in western Sudan. Echo screening using a hand-held echo (HHE) was conducted in Khartoum using a three-view protocol, and in Niyala, a one-view protocol, both modified from the World Heart Federation protocol...
April 16, 2018: Cardiovascular Journal of Africa
Antonella Matteocci, Tommaso Mancuso, Federica Pirelli, Tiruneh Hailemariam, Alessandra Moscetti, Katiuscia Castagna, Angela Collaretti, Letizia Rogai, Guido Nespoli, Paola Grammatico, Luca Pierelli
No abstract text is available yet for this article.
May 6, 2018: Transfusion
Tatiane Aparecida de Paula Vendrame, Flavia Roche Moreira Latini, Rosangela de Medeiros Person, Afonso José Pereira Cortez, Lilian Castilho, Carine Prisco Arnoni
No abstract text is available yet for this article.
May 6, 2018: Transfusion
Corey Lyon, Aimee English
Can cell-free DNA testing reduce unnecessary use of anti-D immunoglobulin in RhD-negative women and still prevent harm to their RhD-positive infants?
May 2018: Journal of Family Practice
Martin Termathe, Sebastian A Leidel
Eukaryotic ubiquitin-like proteins (UBLs) have evolved from prokaryotic sulfur-carrier proteins (SCPs). Ubiquitin related modifier 1 (Urm1) shares biochemical and structural features of UBLs and SCPs and is essential for 2-thiolation of cytoplasmic tRNA. This chemical modification of wobble uridine is highly conserved amongst species and is achieved via Urm1 thiocarboxylation by the non-canonical ubiquitin activating 4 enzyme (Uba4), which contains an E1- and a Rhodanese (RHD) domain. While the RHD catalyzes the last step in Urm1-thiocarboxylate formation, the previous steps in Urm1 activation and the interplay between the two domains have remained elusive...
April 30, 2018: Nucleic Acids Research
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