keyword
MENU ▼
Read by QxMD icon Read
search

Rhd

keyword
https://www.readbyqxmd.com/read/29044588/a-uniform-method-for-the-simultaneous-blood-group-phenotyping-of-fy-a-fy-b-jk-a-jk-b-s-s%C3%AC-p1-k-applying-lateral-flow-technique
#1
A Caesar, S Meyer, N Trost, K Neuenschwander, C Geisen, B M Frey, C Gassner, P Schwind
BACKGROUND AND OBJECTIVES: A lateral flow assay for simultaneous blood group typing of ABO, RhD, C, E, c, e, Cw and K with stable end-point and without centrifugation is in routine use since several years (MDmulticard(®) ). The typing of extended phenotype parameters belonging to the Duffy, Kidd, MNSs blood group systems and others, however, has not yet been demonstrated for this technique. Reliable detection of Fy(x) , a weak Fy(b) phenotype with a pronounced quantitative reduction of the number of Fy(b) antigens on the erythrocyte surface, remains a weakness of current serological blood grouping techniques...
October 16, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29044191/lrrc25-functions-as-an-inhibitor-of-nf-%C3%AE%C2%BAb-signaling-pathway-by-promoting-p65-rela-for-autophagic-degradation
#2
Yanchun Feng, Tianhao Duan, Yang Du, Shouheng Jin, Mingjun Wang, Jun Cui, Rong-Fu Wang
Nuclear factor κB (NF-κB) is a family of critical transcription factors that play a critical role in innate immune responses and inflammation, yet the molecular mechanisms responsible for its tight regulation is not fully understood. In this study, we identified LRRC25, a member of leucine-rich repeat (LRR)-containing protein family, as a negative regulator in the NF-κB signaling pathway. Ectopic expression of LRRC25 impaired NF-κB activation, whereas knockout of LRRC25 potentiated NF-κB activation and enhanced the production of inflammatory cytokines...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043831/del-phenotype
#3
Dong H Kwon, S G Sandler, Willy A Flegel
DEL red blood cells (RBCs) type as D- by routine serologic methods and are transfused routinely, without being identified as expressing a very weak D antigen, to D- recipients. DEL RBCs are detected only by adsorption and elution of anti-D or by molecular methods. Most DEL phenotypes have been reported in population studies conducted in East Asia, although DEL phenotypes have been detected also among Caucasian individuals. Approximately 98 percent of DEL phenotypes in East Asians are associated with the RHD*DEL1 or RHD*01EL...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29042984/bmi1-and-brg1-drive-myocardial-repair-by-regulating-cardiac-stem-cell-function-in-acute-rheumatic-heart-disease
#4
Pingxi Xiao, Kai Zhang, Zhiwen Tao, Niannian Liu, Bangshun Ge, Min Xu, Xinzheng Lu
Rheumatic heart disease (RHD) occurs due to the accumulation of complications associated with rheumatic fever, and it results in high morbidity and mortality. The majority of cases of RHD are diagnosed in the chronic stages, when treatment options are limited. A small reservoir of cardiac stem cells is responsible for maintaining cardiac homeostasis and repairing tissue damage. Understanding the role of cardiac stem cells and the various proteins responsible for their functions in different pathological stages of RHD is an important area of investigation...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29031044/the-archaic-roles-of-the-lamprey-nf-%C3%AE%C2%BAb-lj-nf-%C3%AE%C2%BAb-in-innate-immune-responses
#5
Peng Su, Xin Liu, Yue Pang, Chang Liu, Ranran Li, Qiong Zhang, Hongfang Liang, Hao Wang, Qingwei Li
The nuclear factor-kappa B (NF-κB) is a pleiotropic transcription factor regulating the expression of genes involved in various biological processes including the immune response and inflammation. Lamprey is regarded as a key species to provide meaningful clues for understanding the evolution of immune system; nevertheless, no information about lamprey NF-κB is reported. Thus, we have characterized a NF-κB homolog in lamprey (lj-NF-κB) for the deeper understanding of the role it played in lamprey immune system...
October 11, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29029143/genome-wide-analysis-of-genetic-risk-factors-for-rheumatic-heart-disease-in-aboriginal-australians-provides-support-for-pathogenic-molecular-mimicry
#6
Lesley-Ann Gray, Heather A D'Antoine, Steven Y C Tong, Melita McKinnon, Dawn Bessarab, Ngaire Brown, Bo Reményi, Andrew Steer, Genevieve Syn, Jenefer M Blackwell, Michael Inouye, Jonathan R Carapetis
Background: Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells. Methods: Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls). Single nucleotide polymorphisms (SNPs) were genotyped using Illumina HumanCoreExome BeadChips. Direct typing and imputation was used to fine-map the human leukocyte antigen (HLA) region...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28993013/right-cerebral-hemisphere-specialization-for-quiet-and-perturbed-body-balance-control-evidence-from-unilateral-stroke
#7
Corina Aparecida Fernandes, Daniel Boari Coelho, Alessandra Rezende Martinelli, Luis Augusto Teixeira
Our aim in this investigation was to assess the relative importance of each cerebral hemisphere in quiet and perturbed balance, based on uni-hemispheric lesions by stroke. We tested the hypothesis of right cerebral hemisphere specialization for balance control. Groups of damage either to the right (RHD, n=9) or the left (LHD, n=7) cerebral hemisphere were compared across tasks requiring quiet balance or body balance recovery following a mechanical perturbation, comparing them to age-matched nondisabled individuals (controls, n=24)...
October 7, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28991259/impaired-p65-degradation-by-decreased-chaperone-mediated-autophagy-activity-facilitates-epithelial-to-mesenchymal-transition
#8
J Tang, M-N Zhan, Q-Q Yin, C-X Zhou, C-L Wang, L-L Wo, M He, G-Q Chen, Q Zhao
Aberrant activation of nuclear factor-κB (NF-κB) has been observed in a wide range of human cancers and is thought to promote tumorigenesis and metastasis. As a central component of NF-κB pathway, p65 protein level is tightly regulated and could be subjected to proteasome degradation. Here we demonstrated that p65 can bind to HSC70 with four consensus recognition motif in its RHD domain and be constitutively transported to the lysosome membrane to bind with lysosome-associated membrane protein type 2A and degraded within the lysosome in two epithelial cell lines, proposing that p65 can be degraded by chaperone-mediated autophagy (CMA)...
October 9, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28979173/prevalence-of-rhd-variants-among-blood-donors-at-gulu-regional-blood-bank-gulu-northern-uganda
#9
Polycarp Ojok, Caesar Oyet, Fred Webbo, Bashir Mwambi, Ivan M Taremwa
AIM/OBJECTIVE: The aim of this study was to determine the prevalence of RhD variant phenotypes among voluntary non-remunerated blood donors (VNRBDs) at Gulu Regional Blood Bank (GRBB), Northern Uganda. MATERIALS AND METHODS: We conducted a cross-sectional study, in which the first 4.0 mL of ethylenediaminetetraacetic acid (EDTA) blood samples were collected from VNRBDs and typed for their ABO and RhD blood group status using IgM and IgG monoclonal typing antisera, respectively...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/28974446/assessment-of-cpa-scl1-and-scl2-in-clinical-group-a-streptococcus-isolates-and-patients-from-north-india-an-evaluation-of-the-host-pathogen-interaction
#10
Priyanka Chaudhary, Rajesh Kumar, Vivek Sagar, Subendu Sarkar, Rupneet Singh, Sujata Ghosh, Surjit Singh, Anuradha Chakraborti
Group A streptococcus (GAS) infection remains a major concern due to multiple diseases including pharyngitis, impetigo, acute rheumatic fever (ARF) and rheumatic heart disease (RHD). It uses different adhesins and virulence factors like Cpa (collagen binding protein) and Scl (collagen-like protein) in its pathogenicity. Scl having similarities with human collagen may contribute to inducing autoimmunity in the host. Here we assessed gene expression, antibody titer of Cpa, Scl1 and Scl2 in both clinical GAS isolates (n=45) and blood (n=45) obtained from pharyngisis, ARF (acute rheumatic fever) and RHD respectively...
September 30, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28972003/latent-rheumatic-heart-disease-identifying-the-children-at-highest-risk-of-unfavorable-outcome
#11
Andrea Beaton, Twalib Aliku, Alyssa Dewyer, Marni Jacobs, Jiji Jiang, Chris T Longenecker, Sulaiman Lubega, Robert McCarter, Mariana Mirabel, Grace Mirembe, Judith Namuyonga, Emmy Okello, Amy Scheel, Emmanuel Tenywa, Craig Sable, Peter Lwabi
Background -Screening echocardiography (echo) has emerged as a potentially powerful tool for early diagnosis of rheumatic heart disease (RHD). The utility of screening echo hinges on the rate of RHD progression and the ability of penicillin prophylaxis to improve outcome. We report the longitudinal outcomes of a cohort of children with latent RHD and identify risk factors for unfavorable outcomes. Methods -This was a prospective natural history study conducted under the Ugandan RHD registry. Children with latent RHD and ≥1 year of follow-up were included...
September 27, 2017: Circulation
https://www.readbyqxmd.com/read/28971103/towards-developing-a-vaccine-for-rheumatic-heart-disease
#12
REVIEW
Geethanjali Devadoss Gandhi, Navaneethakrishnan Krishnamoorthy, Ussama M Abdel Motal, Magdi Yacoub
Rheumatic heart disease (RHD) is the most serious manifestations of rheumatic fever, which is caused by group A Streptococcus (GAS or Streptococcus pyogenes) infection. RHD is an auto immune sequelae of GAS pharyngitis, rather than the direct bacterial infection of the heart, which leads to chronic heart valve damage. Although antibiotics like penicillin are effective against GAS infection, improper medical care such as poor patient compliance, overcrowding, poverty, and repeated exposure to GAS, leads to acute rheumatic fever and RHD...
March 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28970678/inra-a-new-high-frequency-antigen-in-the-indian-in023-blood-group-system
#13
Sanmukh R Joshi, Ankita Sheladiya, Kinjal V Mendapara-Dobariya
BACKGROUND: The INDIAN blood group system comprises 4 antigens sensitive to enzymes and 2-aminoethyl isothiouronium bromide (AET). AIM: The patient's antibody was investigated for its specificity to the high-frequency antigens (HFA) of this system. MATERIAL AND METHODS: Low ionic strength solution (LISS)-tube/LISS-indirect antiglobulin test (IAT) methods were used. The patient's red blood cells (RBCs) were tested with antisera to HFA. Her antibody was tested with RBCs lacking the HFA...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28970580/salt-adaptation-and-evolutionary-implication-of-a-nah-related-pahs-dioxygenase-cloned-from-a-halophilic-phenanthrene-degrading-consortium
#14
Chongyang Wang, Guang Guo, Yong Huang, Han Hao, Hui Wang
Polycyclic aromatic hydrocarbons (PAHs) pollutions often occur in marine and other saline environment, largely due to anthropogenic activities. However, study of the PAHs-degradation genotypes in halophiles is limited, compared with the mesophilic terrestrial PAHs degraders. In this study, a bacterial consortium (CY-1) was enriched from saline soil contaminated with crude oil using phenanthrene as the sole carbon source at 10% salinity. CY-1 was dominated by the moderate halophilic Marinobacter species, and its dominant PAHs ring-hydroxylating dioxygenase (RHD) genotypes shared high identity to the classic nah-related RHDs found in the mesophilic species...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28966041/echocardiographic-prevalence-of-rheumatic-heart-disease-in-indian-school-children-using-world-heart-federation-criteria-a-multi-site-extension-of-rheumatic-study-the-e-rheumatic-study
#15
Anita Saxena, Ankush Desai, Kedareshwar Narvencar, Sivasubramanian Ramakrishnan, Rajendra Singh Thangjam, Snehal Kulkarni, Ana Karina Jacques' E Costa, Kalaivani Mani, Amit Dias, Ritesh Sukharamwala
OBJECTIVES: Rheumatic heart disease (RHD) continues to be major public health burden in developing world. Echocardiographic screening in school children has shown that subclinical RHD cases are several times more than clinical cases. Recent reports have used World Heart Federation (WHF) criteria. Objective of present study was to determine RHD prevalence using WHF criteria in Indian children. METHODS: Children (5-15years) from randomly selected schools across four sites were included...
September 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28960314/novel-intronic-rhd-variants-identified-in-serologically-d-negative-blood-donors
#16
M El Wafi, H El Housse, N Zaid, S Zouine, N Nourichafi, K Bouisk, M Benajiba, N Habti
BACKGROUND: Blood group genotyping is used to predict RhD phenotype in transfusion and obstetric medicine. Prediction of antigen D is based on molecular techniques which targets most common RHD-specific polymorphism. However, inactive RHD variants can suggest false-positive RhD phenotype. Their types and frequencies vary among ethnicities. Our study aimed to identify RHD variants among Moroccan blood donors who are serologically D negative. STUDY DESIGN AND METHODS: DNA from 53 blood donors who are serologically D negative RhC and/or RhE positive were screened for RHD exon 10 by PCR-SSP...
September 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28956196/novel-bacteria-capable-of-degrading-phenanthrene-in-activated-sludge-revealed-by-stable-isotope-probing-coupled-with-high-throughput-sequencing
#17
Jibing Li, Dayi Zhang, Mengke Song, Longfei Jiang, Yujie Wang, Chunling Luo, Gan Zhang
The indigenous microorganisms responsible for degrading phenanthrene (PHE) in activated biosludge were identified using DNA-based stable isotope probing. Besides the well-known PHE degraders Burkholderia, Ralstonia, Sinobacteraceae and Arthrobacter, we for the first time linked the taxa Paraburkholderia and Kaistobacter with in situ PHE biodegradation. Analysis of PAH-RHDα gene detected in the heavy DNA fraction of (13)C-PHE treatment suggested the mechanisms of horizontal gene transfer or inter-species hybridisation in PAH-RHD gene spread within the microbial community...
September 27, 2017: Biodegradation
https://www.readbyqxmd.com/read/28937404/genotyping-to-prevent-rh-disease-has-the-time-come
#18
C Ellen van der Schoot, Masja de Haas, Frederik Banch Clausen
PURPOSE OF REVIEW: In this review, we analyzed the current literature on noninvasive fetal RHD typing to answer the question whether the administration of RhIg to prevent D-alloimmunization during pregnancy can be safely guided by fetal RHD typing. RECENT FINDINGS: Recently the first centers that implemented large-scale nationwide fetal RHD typing in the second trimester for targeted RhIg administration have published their studies evaluating the diagnostic accuracy of their screening programs...
September 20, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28932963/echocardiographic-screening-of-rheumatic-heart-disease-in-american-samoa
#19
Jennifer H Huang, Michael Favazza, Arthur Legg, Kathryn W Holmes, Laurie Armsby, Ipuniuesea Eliapo-Unutoa, Thomas Pilgrim, Erin J Madriago
While rheumatic heart disease (RHD) is a treatable disease nearly eradicated in the United States, it remains the most common form of acquired heart disease in the developing world. This study used echocardiographic screening to determine the prevalence of RHD in children in American Samoa. Screening took place at a subset of local schools. Private schools were recruited and public schools underwent cluster randomization based on population density. We collected survey information and performed a limited physical examination and echocardiogram using the World Heart Federation protocol for consented school children aged 5-18 years old...
September 20, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28926139/the-synonymous-nucleotide-substitution-rhd-1056c-g-alters-mrna-splicing-associated-with-serologically-weak-d-phenotype
#20
Sejong Chun, Jae Won Yun, Geon Park, Duck Cho
BACKGROUND: D antigen is one of the most clinically significant blood group antigens. Variation of the RHD gene can cause weak D or partial D phenotypes. While most variations are missense substitutions with amino acid changes, those without are called "silent" or "synonymous" substitutions. Synonymous substitutions often have little effect on the protein, not altering the phenotype. However, effect on splicing can affect end-product protein. We report a new synonymous variation, RHD 1056C>G, that resulted in weak D phenotype, and predicted its effect with various in silico methods...
September 19, 2017: Journal of Clinical Laboratory Analysis
keyword
keyword
82641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"