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https://www.readbyqxmd.com/read/28323847/role-of-the-mapks-tgf-%C3%AE-1-traf6-signaling-pathway-in-postoperative-atrial-fibrillation
#1
Daoliang Zhang, Xiaoqing Chen, Qian Wang, Shaohui Wu, Yue Zheng, Xu Liu
OBJECTIVES: To explore the relationship between the MAPKs/TGF-β1/TRAF6 signaling pathway and atrial fibrosis in patients with rheumatic heart disease (RHD) and its role in atrial fibrillation (AF) after cardiac surgery on the basis of our previous animal study of the MAPKs/TGF-β1/TRAF6 signaling pathway in atrial fibrosis. METHODS: A total of 57 patients with RHD without a history of AF consented to left atrial biopsy. Histopathology quantified the percentage of fibrosis, and real-time PCR and western blot assessed the mRNA and protein expression of TGF-β1, TRAF6, and connective tissue growth factor (CTGF), respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28302546/rheumatic-heart-disease-epidemiology-and-health-systems-barriers-and-facilitators-a-systematic-review-of-studies-from-uganda-and-tanzania
#2
Annesinah H Moloi, Sumaya Mall, Mark E Engel, Renae Stafford, Zhang Wan Zhu, Liesl J Zuhlke, David A Watkins
BACKGROUND: Rheumatic heart disease (RHD) is an important and preventable cause of cardiovascular disease. OBJECTIVES: As part of a recent RHD initiative in Uganda and Tanzania, we systematically reviewed group A streptococcal disease (GAS), acute rheumatic fever (ARF), and RHD in these countries. METHODS: Using a systematic review and meta-analysis/meta-synthesis, we searched PubMed, Embase, and grey literature for quantitative and qualitative studies conducted in Uganda and Tanzania that included individuals affected by GAS, ARF, and RHD...
March 14, 2017: Global Heart
https://www.readbyqxmd.com/read/28294063/cerebral-microbleeds-do-not-predict-hemorrhagic-transformation-in-acute-ischemic-stroke-patients-with-atrial-fibrillation-and-or-rheumatic-heart-disease
#3
Junfeng Liu, Deren Wang, Jie Li, Jing Lin, Yao Xiong, Bian Liu, Chenchen Wei, Bo Wu, Zhenxing Ma, Shihong Zhang, Ming Liu
Background and Purpose Cerebral microbleeds (CMBs) are known to be potential risk factors for intracerebral hemorrhage (ICH), but there is controversy on the relationship between CMBs and hemorrhagic transformation (HT) after ischemic stroke. Besides, the question regarding whether the relationship between CMBs and HT can be affected by antithrombotic drugs in acute stage of ischemic stroke has not yet reached a consensus. Methods 174 acute ischemic stroke patients with atrial fibrillation (AF) and/or rheumatic heart disease (RHD) were prospectively and consecutively enrolled in the study, of which 160 patients (mean 68...
March 13, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28290168/early-results-of-rheumatic-mitral-valve-repair
#4
Giuseppe Petrone, Panagiotis Theodoropoulos, Prakash P Punjabi
BACKGROUND: Mitral valve repair (MVr) in rheumatic heart disease (RHD) remains challenging. The present authors' surgical experience of MVr in 56 patients with RHD operated in between January 2011 and September 2014 is reported. METHODS: Among the patients (mean age 32 ± 11 years), 11 were in NYHA functional class II, 32 in class III, and seven in class IV. An adequate or oversized autologous pericardial patch was sutured to extend the coaptating edge of both the anterior leaflet (in 18 patients) and the posterior leaflet (in 30 patients)...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28287381/a-preliminary-evaluation-of-next-generation-sequencing-as-a-screening-tool-for-targeted-genotyping-of-erythrocyte-and-platelet-antigens-in-blood-donors
#5
Agnieszka Orzińska, Katarzyna Guz, Michał Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Monika Pelc-Kłopotowska, Jerzy Ostrowski, Ewa Brojer
BACKGROUND: Matching the compatibility of donor blood with the recipient's antigens prevents alloimmunisation. Next-generation sequencing (NGS) technology is a promising method for extensive blood group and platelet antigen genotyping of blood donors. It circumvents the limitations of detecting known alleles based on predefined polymorphisms and enables targeted sequencing on a massive scale. The aim of this study was to evaluate the NGS AmpliSeq application on the Ion Torrent platform as a screening tool for genotyping blood donors' erythrocyte/platelet antigens...
March 10, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28285457/group-a-streptococcus-acute-rheumatic-fever-and-rheumatic-heart-disease-epidemiology-and-clinical-considerations
#6
REVIEW
Liesl J Zühlke, Andrea Beaton, Mark E Engel, Christopher T Hugo-Hamman, Ganesan Karthikeyan, Judith M Katzenellenbogen, Ntobeko Ntusi, Anna P Ralph, Anita Saxena, Pierre R Smeesters, David Watkins, Peter Zilla, Jonathan Carapetis
Early recognition of group A streptococcal pharyngitis and appropriate management with benzathine penicillin using local clinical prediction rules together with validated rapi-strep testing when available should be incorporated in primary health care. A directed approach to the differential diagnosis of acute rheumatic fever now includes the concept of low-risk versus medium-to-high risk populations. Initiation of secondary prophylaxis and the establishment of early medium to long-term care plans is a key aspect of the management of ARF...
February 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28283470/rheumatic-fever-with-severe-carditis-still-prevalent-in-the-south-west-pacific
#7
Taran Kaur Nandra, Nigel J Wilson, John Artrip, Bruno Pagis
Rheumatic heart disease (RHD) has a worldwide prevalence of 33 million cases and 270 000 deaths annually, making it the most common acquired heart disease in the world. There is a disparate global burden in developing countries. This case report aims to address the minimal RHD coverage by the international medical community. A Tahitian boy aged 10 years was diagnosed with advanced heart failure secondary to RHD at a local clinic. Previous, subtle symptoms of changes in handwriting and months of fever had gone unrecognised...
March 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28272901/attentional-impairments-following-right-hemisphere-damage-with-and-without-hemispatial-neglect-a-comparative-study
#8
Cristina Elizabeth Izábal Wong, Laura Damiani Branco, Charles Cotrena, Yves Joanette, Rochele Paz Fonseca
This study aimed to evaluate the performance of patients with right hemisphere damage (RHD) with or without hemispatial neglect (HN) on a cancellation task. The study involved 31 control participants and 31 patients with RHD, matched by age, education, and frequency of reading and writing habits. The numbers of omission and random errors as well as the mean time to task completion were compared between adults with and without RHD, as well as between patients with and without HN. The latter made more left-sided omission errors, and more overall omission errors, than patients with RHD and no HN...
March 8, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28256442/a-comprehensive-needs-assessment-tool-for-planning-rheumatic-heart-disease-control-programs-in-limited-resource-settings
#9
Liesl J Zühlke, David A Watkins, Susan Perkins, Rosemary Wyber, Jeremiah Mwangi, Joanna Markbreiter, Hlengiwe S Moloi, Mark E Engel, Thembikile Shato, Tayla Hermanus, Jantina DeVries, Clancy Read
Rheumatic heart disease (RHD) is an important cause of disability and death in low- and middle-income countries. However, evidence-based interventions have not been implemented systematically in many countries. We present a RHD Needs Assessment Tool (NAT) that can be used at country or regional levels to systematically develop and plan comprehensive RHD control programs and to provide baseline data for program monitoring and evaluation. The RHD NAT follows a mixed-methods approach using quantitative and qualitative data collection instruments...
February 27, 2017: Global Heart
https://www.readbyqxmd.com/read/28255077/echocardiographic-screening-for-rheumatic-heart-disease-in-indigenous-australian-children-a-cost-utility-analysis
#10
Kathryn Roberts, Jeffrey Cannon, David Atkinson, Alex Brown, Graeme Maguire, Bo Remenyi, Gavin Wheaton, Elizabeth Geelhoed, Jonathan R Carapetis
BACKGROUND: Rheumatic heart disease (RHD) remains a leading cause of cardiovascular morbidity and mortality in children and young adults in disadvantaged populations. The emergence of echocardiographic screening provides the opportunity for early disease detection and intervention. Using our own multistate model of RHD progression derived from Australian RHD register data, we performed a cost-utility analysis of echocardiographic screening in indigenous Australian children, with the dual aims of informing policy decisions in Australia and providing a model that could be adapted in other countries...
March 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28255075/rheumatic-heart-disease-severity-progression-and-outcomes-a-multi-state-model
#11
Jeffrey Cannon, Kathryn Roberts, Catherine Milne, Jonathan R Carapetis
BACKGROUND: Rheumatic heart disease (RHD) remains a disease of international importance, yet little has been published about disease progression in a contemporary patient cohort. Multi-state models provide a well-established method of estimating rates of transition between disease states, and can be used to evaluate the cost-effectiveness of potential interventions. We aimed to create a multi-state model for RHD progression using serial clinical data from a cohort of Australian patients...
March 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28252675/prevalence-of-rheumatic-valvular-heart-disease-in-rwandan-school-children-echocardiographic-evaluation-using-the-world-heart-federation-criteria
#12
J Mucumbitsi, B Bulwer, L Mutesa, V Ndahindwa, M Semakula, E Rusingiza, P Arya, S Breakey, C Patton-Bolman, E L Kaplan
BACKGROUND: Rheumatic fever (RF) and rheumatic valvular heart disease (RHD) remain important medical, surgical and public health concerns in many parts of the world, especially in sub-Saharan Africa. However, there are no published data from Rwanda. We performed a RHD prevalence study in a randomly selected sample of Rwandan school children using the 2012 World Heart Federation (WHF) criteria. METHODS: Echocardiographic assessment of 2 501 Rwandan school children from 10 schools in the Gasabo district near Kigali was carried out...
March 1, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28250675/determination-of-the-frequency-of-the-most-immunogenic-rhesus-antigens-among-saudi-donors-in-king-abdulaziz-medical-city-riyadh
#13
Mohieldin Elsayid, Faris Saeed Al Qahtani, Abdulaziz Mohammed Al Qarni, Faisal Almajed, Faisal Al Saqri, Shoeb Qureshi
BACKGROUND: The Rhesus (Rh) blood group system is one of the most polymorphic and immunogenic systems known in humans, because of its immunogenicity along with ABO grouping, RhD antigen testing was made mandatory before issuing a compatible blood. At present, there are five major antigens, i.e., D, C, E, c, and e in Rh blood group system. AIMS: The aim of this study is to provide essential data about the distribution of the major Rh antigens and the most common phenotype among the Saudi population...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28238245/rheumatic-fever-and-rheumatic-heart-disease-collaboration-patterns-and-research-core-topics
#14
Alejandro Salinas, Gregorio González, Jose Manuel Ramos
BACKGROUND: Rheumatic fever and rheumatic heart disease (RHD) are important health problems in developing countries. The study aim was to provide a review and content analysis of the scientific literature on rheumatic fever and RHD over a 70-year period. METHODS: Medline was employed via the online PubMed service of the US National Library of Medicine, to search for all documents containing the MeSH terms 'rheumatic fever' or 'rheumatic heart disease' between January 1945 and December 2013...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28228305/clinical-presentation-management-and-outcomes-in-the-indian-heart-rhythm-society-atrial-fibrillation-ihrs-af-registry
#15
A Vora, A Kapoor, M Nair, Y Lokhandwala, C Narsimhan, A G Ravikishore, S K Dwivedi, N Namboodiri, R Hygriv, A Saxena, A Nabar, S Garg, N Bardoloi, R Yadav, A Nambiar, U Pandurangi, D Jhala, A Naik, Nagmallesh, S Rajagopal, R Selvaraj, V Arora, A Thachil, J Thomas, G Panicker
AIM: A national atrial fibrillation (AF) registry was conducted under the aegis of the Indian Heart Rhythm Society (IHRS), to capture epidemiological data-type of AF, clinical presentation and comorbidities, current treatment practices, and 1-year follow-up outcomes. METHODS: A total of 1537 patients were enrolled from 24 sites in India in the IHRS-AF registry from July 2011 to August 2012. Their baseline characteristics and follow-up data were recorded in case report forms and subsequently analyzed...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28220510/diverse-and-novel-rhd-variants-in-australian-blood-donors-with-a-weak-d-phenotype-implication-for-transfusion-management
#16
E C McGowan, G H Lopez, C M Knauth, Y-W Liew, J A Condon, L Ramadi, K Parsons, E M Turner, R L Flower, C A Hyland
BACKGROUND AND OBJECTIVES: Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype against D-epitope profile. MATERIALS AND METHODS: Following automated and manual serology, blood samples from donors reported as 'weak D' (n = 100) were RHD genotyped by a commercial SNP-typing platform and Sanger sequencing...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28196473/2-7-million-samples-genotyped-for-hla-by-next-generation-sequencing-lessons-learned
#17
Gerhard Schöfl, Kathrin Lang, Philipp Quenzel, Irina Böhme, Jürgen Sauter, Jan A Hofmann, Julia Pingel, Alexander H Schmidt, Vinzenz Lange
BACKGROUND: At the DKMS Life Science Lab, Next Generation Sequencing (NGS) has been used for ultra-high-volume high-resolution genotyping of HLA loci for the last three and a half years. Here, we report on our experiences in genotyping the HLA, CCR5, ABO, RHD and KIR genes using a direct amplicon sequencing approach on Illumina MiSeq and HiSeq 2500 instruments. RESULTS: Between January 2013 and June 2016, 2,714,110 samples largely from German, Polish and UK-based potential stem cell donors have been processed...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28191636/cancer-type-predicts-alloimmunization-following-rhd-incompatible-rbc-transfusions
#18
Komal Arora, James Kelley, Dawen Sui, Jing Ning, Fernando Martinez, Benjamin Lichtiger, Ashok Tholpady
BACKGROUND: Immunosuppressed, RhD-negative oncology patients tend to have lower rates of sensitization to the D antigen when they receive transfusion with RhD-positive blood components. Clinical factors associated with alloimmunization to the D antigen in RhD-negative oncology patients when they receive transfusion with RhD-positive red blood cells (RBCs) have not been well defined. STUDY DESIGN AND METHODS: This was a 4-year, retrospective analysis identifying RhD-negative oncology patients who received RhD-positive RBCs and were not previously alloimmunized to the D antigen...
February 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28181806/biodegradation-of-phenanthrene-in-polycyclic-aromatic-hydrocarbon-contaminated-wastewater-revealed-by-coupling-cultivation-dependent-and-independent-approaches
#19
Jibing Li, Chunling Luo, Mengke Song, Qing Dai, Longfei Jiang, Dayi Zhang, Gan Zhang
The indigenous microorganisms responsible for degrading phenanthrene (PHE) in polycyclic aromatic hydrocarbons (PAHs)-contaminated wastewater were identified by DNA-based stable isotope probing (DNA-SIP). In addition to the well-known PHE degraders Acinetobacter and Sphingobium, Kouleothrix and Sandaracinobacter were found, for the first time, to be directly responsible for indigenous PHE biodegradation. Additionally, a novel PHE degrader, Acinetobacter tandoii sp. LJ-5, was identified by DNA-SIP and direct cultivation...
February 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28168674/clinical-implications-of-biliary-confluence-pattern-for-bismuth-corlette-type-iv-hilar-cholangiocarcinoma-applied-to-hemihepatectomy
#20
Gu-Wei Ji, Fei-Peng Zhu, Ke Wang, Chen-Yu Jiao, Zi-Cheng Shao, Xiang-Cheng Li
BACKGROUND: Since biliary variations are commonly seen, our aims are to clarify these insidious variations and discuss their surgicopathologic implications for Bismuth-Corlette (BC) type IV hilar cholangiocarcinoma (HC) applied to hemihepatectomy. METHODS: Three-dimensional images of patients with distal bile duct obstruction (n = 97) and advanced HC (n = 79) were reconstructed and analyzed retrospectively. Normal biliary confluence pattern was defined as the peripheral segment IV duct (B4) joining the common trunk of segment II (B2) and segment III (B3) ducts to form the left hepatic duct (LHD) that then joined the right hepatic duct (RHD)...
April 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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