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Concept mapping

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https://www.readbyqxmd.com/read/29352123/tumor-tissue-detection-using-blood-oxygen-level-dependent-functional-mri-based-on-independent-component-analysis
#1
Huiyuan Huang, Junfeng Lu, Jinsong Wu, Zhongxiang Ding, Shuda Chen, Lisha Duan, Jianling Cui, Fuyong Chen, Dezhi Kang, Le Qi, Wusi Qiu, Seong-Whan Lee, ShiJun Qiu, Dinggang Shen, Yu-Feng Zang, Han Zhang
Accurate delineation of gliomas from the surrounding normal brain areas helps maximize tumor resection and improves outcome. Blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) has been routinely adopted for presurgical mapping of the surrounding functional areas. For completely utilizing such imaging data, here we show the feasibility of using presurgical fMRI for tumor delineation. In particular, we introduce a novel method dedicated to tumor detection based on independent component analysis (ICA) of resting-state fMRI (rs-fMRI) with automatic tumor component identification...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29350223/what-is-career-success-for-academic-hospitalists-a-qualitative-analysis-of-early-career-faculty-perspectives
#2
Ethan Cumbler, Essey Yirdaw, Patrick Kneeland, Read Pierce, Patrick Rendon, Carrie Herzke, Christine D Jones
BACKGROUND: Understanding the concept of career success is critical for hospital medicine groups seeking to create sustainably rewarding faculty positions. Conceptual models of career success describe both extrinsic (compensation and advancement) and intrinsic (career satisfaction and job satisfaction) domains. How hospitalists define career success for themselves is not well understood. In this study, we qualitatively explore perspectives on how early-career clinician-educators define career success...
January 19, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29348569/genomelandscaper-landscape-analysis-of-genome-fingerprints-maps-assessing-chromosome-architecture
#3
Hannan Ai, Yuncan Ai, Fanmei Meng
Assessing correctness of an assembled chromosome architecture is a central challenge. We create a geometric analysis method (called GenomeLandscaper) to conduct landscape analysis of genome-fingerprints maps (GFM), trace large-scale repetitive regions, and assess their impacts on the global architectures of assembled chromosomes. We develop an alignment-free method for phylogenetics analysis. The human Y chromosomes (GRCh.chrY, HuRef.chrY and YH.chrY) are analysed as a proof-of-concept study. We construct a galaxy of genome-fingerprints maps (GGFM) for them, and a landscape compatibility among relatives is observed...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347653/stochastic-thermodynamics-of-quantum-maps-with-and-without-equilibrium
#4
Felipe Barra, Cristóbal Lledó
We study stochastic thermodynamics for a quantum system of interest whose dynamics is described by a completely positive trace-preserving (CPTP) map as a result of its interaction with a thermal bath. We define CPTP maps with equilibrium as CPTP maps with an invariant state such that the entropy production due to the action of the map on the invariant state vanishes. Thermal maps are a subgroup of CPTP maps with equilibrium. In general, for CPTP maps, the thermodynamic quantities, such as the entropy production or work performed on the system, depend on the combined state of the system plus its environment...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346732/microscopic-theory-of-coupled-slow-activated-dynamics-in-glass-forming-binary-mixtures
#5
Rui Zhang, Kenneth S Schweizer
The Elastically Collective Nonlinear Langevin Equation theory for one-component viscous liquids and suspensions is generalized to treat coupled slow activated relaxation and diffusion in glass-forming binary sphere mixtures of any composition, size ratio and inter-particle interactions. A trajectory-level dynamical coupling parameter concept is introduced to construct two coupled dynamic free energy functions for the smaller penetrant and larger matrix particle. A two-step dynamical picture is proposed where the first step process involves matrix-facilitated penetrant hopping quantified in a self-consistent manner based on a temporal coincidence condition...
January 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29342139/structure-and-mutagenesis-reveal-essential-capsid-protein-interactions-for-kshv-replication
#6
Xinghong Dai, Danyang Gong, Hanyoung Lim, Jonathan Jih, Ting-Ting Wu, Ren Sun, Z Hong Zhou
Kaposi's sarcoma-associated herpesvirus (KSHV) causes Kaposi's sarcoma, a cancer that commonly affects patients with AIDS and which is endemic in sub-Saharan Africa. The KSHV capsid is highly pressurized by its double-stranded DNA genome, as are the capsids of the eight other human herpesviruses. Capsid assembly and genome packaging of herpesviruses are prone to interruption and can therefore be targeted for the structure-guided development of antiviral agents. However, herpesvirus capsids-comprising nearly 3,000 proteins and over 1,300 Å in diameter-present a formidable challenge to atomic structure determination and functional mapping of molecular interactions...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29338149/injection-pressure-mapping-of-intraneural-vs-perineural-injections-further-lessons-from-cadaveric-studies
#7
Andrzej Krol, Arber Vala, Leonidas Phylactides, Matthew Szarko, Miguel A Reina, Jose de Andrés
BACKGROUND: The aim of the study was to investigate the difference between intraneural and perineural injection pressures in human cadavers. Targeted nerves included the cervical roots, the supraclavicular and infraclavicular brachial plexus, the sciatic-subgluteal nerve and the common peroneal and tibial nerves. METHODS: Ten readings were obtained for each nerve location. 1mL of 0.9% NaCl was injected over ten seconds - deliberately slower than in clinical practice to eliminate the risk of aberrant readings relating to the speed of injection...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29338060/biofeedback-effect-of-hybrid-assistive-limb-in-stroke-rehabilitation-a-proof-of-concept-study-using-functional-near-infrared-spectroscopy
#8
Kazuya Saita, Takashi Morishita, Hisatomi Arima, Koichi Hyakutake, Toshiyasu Ogata, Kenji Yagi, Etsuji Shiota, Tooru Inoue
INTRODUCTION: Robot-assisted rehabilitation has been increasingly drawing attention in the field of neurorehabilitation. The hybrid assistive limb (HAL) is an exoskeleton robot developed based on the "interactive biofeedback" theory, and several studies have shown its efficacy for patients with stroke. We aimed to investigate the mechanisms of the facilitative effect of neurorehabilitation using a single-joint HAL (HAL-SJ) and functional near-infrared spectroscopy (fNIRS). MATERIALS AND METHODS: Subacute stroke patients admitted to our hospital were assessed in this study for HAL eligibility...
2018: PloS One
https://www.readbyqxmd.com/read/29335563/visualization-and-analysis-of-non-covalent-contacts-using-the-protein-contacts-atlas
#9
Melis Kayikci, A J Venkatakrishnan, James Scott-Brown, Charles N J Ravarani, Tilman Flock, M Madan Babu
Visualizations of biomolecular structures empower us to gain insights into biological functions, generate testable hypotheses, and communicate biological concepts. Typical visualizations (such as ball and stick) primarily depict covalent bonds. In contrast, non-covalent contacts between atoms, which govern normal physiology, pathogenesis, and drug action, are seldom visualized. We present the Protein Contacts Atlas, an interactive resource of non-covalent contacts from over 100,000 PDB crystal structures. We developed multiple representations for visualization and analysis of non-covalent contacts at different scales of organization: atoms, residues, secondary structure, subunits, and entire complexes...
January 15, 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29335223/electron-channeling-orientation-determination-echord-an-original-approach-to-crystalline-orientation-mapping
#10
C Lafond, T Douillard, S Cazottes, P Steyer, C Langlois
We present a proof-of-concept attesting the feasability to obtain orientation maps of polycrystalline materials within a conventional Scanning Electron Microscope (SEM) using a standard goniometer and Back Scattered Electron (BSE) detector. The described method is based on the analysis of the contrast variation of grains due to the channeling of incident electrons on a rotating sample. On each pixel of the map, experimental intensity profiles as a function of the rotation angle are obtained and compared with simulated ones to retrieve the orientation...
December 28, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29334516/computer-based-training-in-eating-and-nutrition-facilitates-person-centered-hospital-care-a-group-concept-mapping-study
#11
Albert Westergren, Ellinor Edfors, Erika Norberg, Anna Stubbendorff, Gita Hedin, Martin Wetterstrand, Scott R Rosas, Peter Hagell
Studies have shown that computer-based training in eating and nutrition for hospital nursing staff increased the likelihood that patients at risk of undernutrition would receive nutritional interventions. This article seeks to provide understanding from the perspective of nursing staff of conceptually important areas for computer-based nutritional training, and their relative importance to nutritional care, following completion of the training. Group concept mapping, an integrated qualitative and quantitative methodology, was used to conceptualize important factors relating to the training experiences through four focus groups (n = 43), statement sorting (n = 38), and importance rating (n = 32), followed by multidimensional scaling and cluster analysis...
January 12, 2018: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29327640/who-should-be-responsible-for-supporting-individuals-with-mental-health-problems-a-critical-literature-review
#12
Megan A Pope, Ashok K Malla, Srividya N Iyer
BACKGROUND: Individuals with mental health problems have many support needs that are often inadequately met; however, perceptions of who should be responsible for meeting these needs have been largely unexplored. Varying perceptions may influence whether, how, and to what extent relevant stakeholders support individuals with mental health problems. AIMS: To critically evaluate the literature to determine who different stakeholders believe should be responsible for supporting individuals with mental health problems, what factors shape these perceptions, and how they relate to one another...
January 1, 2018: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29325552/health-care-access-for-rural-youth-on-equal-terms-a-mixed-methods-study-protocol-in-northern-sweden
#13
Isabel Goicolea, Dean Carson, Miguel San Sebastian, Monica Christianson, Maria Wiklund, Anna-Karin Hurtig
BACKGROUND: The purpose of this paper is to propose a protocol for researching the impact of rural youth health service strategies on health care access. There has been no published comprehensive assessment of the effectiveness of youth health strategies in rural areas, and there is no clearly articulated model of how such assessments might be conducted. The protocol described here aims to gather information to; i) Assess rural youth access to health care according to their needs, ii) Identify and understand the strategies developed in rural areas to promote youth access to health care, and iii) Propose actions for further improvement...
January 11, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29323420/on-the-influence-of-lipid-induced-optical-anisotropy-for-the-bioimaging-of-exo-or-endocytosis-with-interference-microscopic-imaging
#14
D Marques, A Miranda, A G Silva, P R T Munro, P A A DE Beule
Some implementations of interference microscopy imaging use digital holographic measurements of complex scattered fields to reconstruct three-dimensional refractive index maps of weakly scattering, semi-transparent objects, frequently encountered in biological investigations. Reconstruction occurs through application of the object scattering potential which assumes an isotropic refractive index throughout the object. Here, we demonstrate that this assumption can in some circumstances be invalid for biological imaging due to the presence of lipid-induced optical anisotropy...
January 11, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29322869/identifying-organizing-and-prioritizing-ideas-on-how-to-enhance-adl-ability
#15
Kristina Tomra Nielsen, Louise Klokker, Susanne Guidetti, Eva Ejlersen Wæhrens
BACKGROUND: There is a need to develop evidence-based occupational therapy programs aiming at enhancing the ability to perform Activities of Daily Living (ADL) among persons living with chronic conditions. Information from different sources is to be integrated in the development process. Thus, it is necessary to engage both occupational therapists and persons living with chronic conditions in suggesting ideas on how to enhance the ADL ability. OBJECTIVE: To identify, organize and prioritize ideas on how to enhance ability to perform ADL in persons with chronic conditions...
January 11, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29320467/accurate-natural-trail-detection-using-a-combination-of-a-deep-neural-network-and-dynamic-programming
#16
Shyam Prasad Adhikari, Changju Yang, Krzysztof Slot, Hyongsuk Kim
This paper presents a vision sensor-based solution to the challenging problem of detecting and following trails in highly unstructured natural environments like forests, rural areas and mountains, using a combination of a deep neural network and dynamic programming. The deep neural network (DNN) concept has recently emerged as a very effective tool for processing vision sensor signals. A patch-based DNN is trained with supervised data to classify fixed-size image patches into "trail" and "non-trail" categories, and reshaped to a fully convolutional architecture to produce trail segmentation map for arbitrary-sized input images...
January 10, 2018: Sensors
https://www.readbyqxmd.com/read/29316970/cuiless2016-a-clinical-corpus-applying-compositional-normalization-of-text-mentions
#17
John D Osborne, Matthew B Neu, Maria I Danila, Thamar Solorio, Steven J Bethard
BACKGROUND: Traditionally text mention normalization corpora have normalized concepts to single ontology identifiers ("pre-coordinated concepts"). Less frequently, normalization corpora have used concepts with multiple identifiers ("post-coordinated concepts") but the additional identifiers have been restricted to a defined set of relationships to the core concept. This approach limits the ability of the normalization process to express semantic meaning. We generated a freely available corpus using post-coordinated concepts without a defined set of relationships that we term "compositional concepts" to evaluate their use in clinical text...
January 10, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29316968/improving-the-interoperability-of-biomedical-ontologies-with-compound-alignments
#18
Daniela Oliveira, Catia Pesquita
BACKGROUND: Ontologies are commonly used to annotate and help process life sciences data. Although their original goal is to facilitate integration and interoperability among heterogeneous data sources, when these sources are annotated with distinct ontologies, bridging this gap can be challenging. In the last decade, ontology matching systems have been evolving and are now capable of producing high-quality mappings for life sciences ontologies, usually limited to the equivalence between two ontologies...
January 9, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29315361/networks-of-tau-distribution-in-alzheimer-s-disease
#19
Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezga
A stereotypical anatomical propagation of tau pathology has been described in Alzheimer's disease. According to recent concepts (network degeneration hypothesis), this propagation is thought to be indicative of misfolded tau proteins possibly spreading along functional networks. If true, tau pathology accumulation should correlate in functionally connected brain regions. Therefore, we examined whether independent components could be identified in the distribution pattern of in vivo tau pathology and whether these components correspond with specific functional connectivity networks...
January 5, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29311139/retrosplenial-cortex-indexes-stability-beyond-the-spatial-domain
#20
Stephen D Auger, Eleanor A Maguire
Retrosplenial cortex (RSC) is highly responsive to landmarks in the environment which remain fixed in a permanent location, and this has been linked with its known involvement in scene and spatial processing. However, it is unclear if RSC representations of permanence are a purely spatial phenomenon or whether they extend into behavioural and conceptual domains. To test this, during functional MRI (fMRI) scanning we had people (males and females) read three different types of sentence which described either something permanent or transient...
January 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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