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Ambroxol

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https://www.readbyqxmd.com/read/28466418/ambroxol-for-fibromyalgia-one-group-pretest-posttest-open-label-pilot-study
#1
Laura-Aline Martínez-Martínez, Luis-Fernando Pérez, Lizbeth-Teresa Becerril-Mendoza, Pedro Rodríguez-Henriquez, Omar-Eloy Muñoz, Gumaro Acosta, Luis H Silveira, Angélica Vargas, María-Isabel Barrera-Villalpando, Manuel Martínez-Lavín
A consistent line of investigation proposes that fibromyalgia is a sympathetically maintained neuropathic pain syndrome. Dorsal root ganglia sodium channels may play a major role in fibromyalgia pain transmission. Ambroxol is a secretolytic agent used in the treatment of various airway disorders. Recently, it was discovered that this compound is also an efficient sodium channel blocker with potent anti-neuropathic pain properties. We evaluated the add-on effect of ambroxol to the treatment of fibromyalgia. We studied 25 patients with fibromyalgia...
May 2, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28458453/suppressive-effects-of-the-expectorant-drug-ambroxol-hydrochloride-on-quartz-induced-lung-inflammation-in-f344-rats
#2
Shohei Kanie, Masanao Yokohira, Keiko Yamakawa, Yuko Nakano-Narusawa, Shota Yoshida, Nozomi Hashimoto, Katsumi Imaida
Surfactant proteins (SPs) are essential to respiratory structure and function. The expectorant drug ambroxol hydrochloride is clinically prescribed to stimulate pulmonary surfactant and airway serous secretion. Therefore, ambroxol hydrochloride may affect SP production and pulmonary inflammation. Lung toxicity of fine particles of various materials has been examined previously in our in vivo bioassay using the intratracheal (i.t.) instillation approach. In the present study, we evaluated modulatory effects of ambroxol hydrochloride on quartz-induced lung inflammation in F344 rats...
April 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28444776/in-vitro-effects-of-ambroxol-on-cryptococcus-adherence-planktonic-cells-and-biofilms
#3
Qingtao Kong, Xue Du, Suyang Huang, Rui Yang, Chengzhen Zhang, Yongnian Shen, Weida Liu, Hong Sang
The antifungal effects of ambroxol (Amb; the metabolite VIII of bromhexine) against Cryptococcus planktonic cells and mature biofilms were investigated in this study. Amb showed antifungal activity against planktonic cells and mature biofilms. Disk diffusion test similarly showed antifungal profile for planktonic cells. Furthermore, Amb was found to be synergetic with fluconazole against planktonic cells and reduced the adherence of cells to polystyrene. Our results suggest that Amb can inhibit cryptococcal cells and biofilms, indicating its potential role in the prevention and treatment of cryptococcosis...
April 26, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28439502/ambroxol-hydrochloride-combined-with-fluconazole-reverses-the-resistance-of-candida-albicans-to-fluconazole
#4
Xiuyun Li, Yuanhao Zhao, Xin Huang, Cuixiang Yu, Yilei Yang, Shujuan Sun
In this study, we found that ambroxol hydrochloride (128 μg/mL) exhibits synergistic antifungal effects in combination with fluconazole (2 μg/mL) against resistant planktonic Candida albicans (C. albicans) cells. This combination also exhibited synergistic effects against resistant C. albicans biofilms in different stages (4, 8, and 12 h) according to the microdilution method. In vitro data were further confirmed by the success of this combination in treating Galleria mellonella infected by resistant C. albicans...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28436553/stevens-johnson-syndrome-probably-induced-by-ambroxol
#5
A Combalia, N Moreno, P Iranzo, M Tuset, J-M Mascaró
No abstract text is available yet for this article.
April 24, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28352342/different-ventilation-modes-combined-with-ambroxol-in-the-treatment-of-respiratory-distress-syndrome-in-premature-infants
#6
Bin Zhou, Jing-Fang Zhai, Jie-Bin Wu, Bao Jin, Yan-Yan Zhang
The aim of the present study was to compare the effectiveness of different modes of mechanical ventilation in combination with secretolytic therapy with ambroxol in premature infants with respiratory distress syndrome. Seventy-three premature infants with hyaline membrane disease (HMD) (stage III-IV), also known as respiratory distress syndrome, who were supported by mechanical ventilation in the neonatal intensive care unit (NICU) of Xuzhou Central Hospital, were involved in the present study, between January 2013 and February 2015...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28328824/early-use-of-noninvasive-techniques-for-clearing-respiratory-secretions-during-noninvasive-positive-pressure-ventilation-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-hypercapnic-encephalopathy-a-prospective-cohort-study
#7
Jinrong Wang, Zhaobo Cui, Shuhong Liu, Xiuling Gao, Pan Gao, Yi Shi, Shufen Guo, Peipei Li
Noninvasive positive-pressure ventilation (NPPV) might be superior to conventional mechanical ventilation (CMV) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPDs). Inefficient clearance of respiratory secretions provokes NPPV failure in patients with hypercapnic encephalopathy (HE). This study compared CMV and NPPV combined with a noninvasive strategy for clearing secretions in HE and AECOPD patients.The present study is a prospective cohort study of AECOPD and HE patients enrolled between October 2013 and August 2015 in a critical care unit of a major university teaching hospital in China...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295625/oral-ambroxol-increases-brain-glucocerebrosidase-activity-in-a-nonhuman-primate
#8
Anna Migdalska-Richards, Wai Kin D Ko, Qin Li, Erwan Bezard, Anthony H V Schapira
Mutations in the glucocerebrosidase 1 (GBA1) gene are related to both Parkinson disease (PD) and Gaucher disease (GD). In both cases, the condition is associated with deficiency of glucocerebrosidase (GCase), the enzyme encoded by GBA1. Ambroxol is a small molecule chaperone that has been shown in mice to cross the blood-brain barrier, increase GCase activity and reduce alpha-synuclein protein levels. In this study, we analyze the effect of ambroxol treatment on GCase activity in healthy nonhuman primates. We show that daily administration of ambroxol results in increased brain GCase activity...
July 2017: Synapse
https://www.readbyqxmd.com/read/28052590/intracerebral-microdialysis-coupled-to-lc-ms-ms-for-the-determination-tramadol-and-its-major-pharmacologically-active-metabolite-o-desmethyltramadol-in-rat-brain-microdialysates
#9
Mingzhou Liu, Peng Wang, Xuming Yu, Guicheng Dong, Jiang Yue
A rapid and sensitive method involving liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) coupled to an intracerebral microdialysis technique was developed for the determination and pharmacokinetic investigation of tramadol and its major active metabolite O-desmethyltramadol (ODT) in rat brain. The microdialysis samples were separated on a C18 column and eluted with a mobile phase of acetonitrile-water-formic acid (50:50:0.1; v/v/v) at a flow rate of 0.3 mL/min. The ESI-MS/MS spectra were performed in electrospray positive ion mode, and the analytes were detected by multiple reaction monitoring (MRM) of the transitions m/z [M + H](+) 264...
January 4, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28040066/effects-of-ambroxol-hydrochloride-on-concentrations-of-paclitaxel-and-carboplatin-in-lung-cancer-patients-at-different-administration-times
#10
J Li, W Yi, P Jiang, R Sun, T Li
Our previous preliminary study revealed a synergistic effect of ambroxol hydrochloride with chemotherapeutic agents such as paclitaxel and carboplatin in lung cancer. However, the optimal conditions such as administration time and drug concentration of ambroxol hydrochloride to achieve the maximum synergistic effect remained unclear. Therefore, concentration changes of the chemotherapy drugs paclitaxel and carboplatin in the sputum were observed after ambroxol hydrochloride administration at different times in order to determine the most effective time frame of ambroxol hydrochloride administration...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28007403/the-additive-effect-on-the-antiepileptic-treatment-of-ambroxol-in-type-3-gaucher-patient-the-early-observation
#11
Lukasz Pawlinski, Maciej T Malecki, Beata Kiec-Wilk
No abstract text is available yet for this article.
December 11, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27890991/pulmonary-alveolar-proteinosis-experience-from-a-tertiary-care-center-and-systematic-review-of-indian-literature
#12
Vijay Hadda, Pawan Tiwari, Karan Madan, Anant Mohan, Nishkarsh Gupta, Sachidanand Jee Bharti, Vinod Kumar, Rakesh Garg, Anjan Trikha, Deepali Jain, Sudheer Arava, Gopi C Khilnani, Randeep Guleria
BACKGROUND: Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by deposition of lipoproteinaceous material within alveoli, with a variable clinical course. Here, we report an experience of management of PAP at our center. A systematic review of previously reported cases from India is also included in the article. MATERIALS AND METHODS: This study included patients with primary PAP managed at our center from 2009 to 2015. Diagnosis of primary PAP was based on histopathologic diagnosis on bronchoalveolar lavage or transbronchial lung biopsy and absence of causes of secondary PAP...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27884873/optimization-of-robust-hplc-method-for-quantitation-of-ambroxol-hydrochloride-and-roxithromycin-using-a-doe-approach
#13
Rashmin B Patel, Nilay M Patel, Mrunali R Patel, Ajay B Solanki
The aim of this work was to develop and optimize a robust HPLC method for the separation and quantitation of ambroxol hydrochloride and roxithromycin utilizing Design of Experiment (DoE) approach. The Plackett-Burman design was used to assess the impact of independent variables (concentration of organic phase, mobile phase pH, flow rate and column temperature) on peak resolution, USP tailing and number of plates. A central composite design was utilized to evaluate the main, interaction, and quadratic effects of independent variables on the selected dependent variables...
March 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27866808/combined-beta-glucosylceramide-and-ambroxol-hydrochloride-in-patients-with-gaucher-related-parkinson-disease-from-clinical-observations-to-drug-development
#14
Yuval Ishay, Ari Zimran, Jeffrey Szer, Tama Dinur, Yaron Ilan, David Arkadir
Both patients with non-neuronopathic Gaucher disease (GD) and heterozygous GBA mutation carrier are at increased risk for Parkinson disease (PD). The risk for PD in these groups does not linearly increase with glucosylceramide (GC) accumulation or with acid β-glucocerebrosidase (GCase) activity. This observation, together with other clinical systemic observations raises the possibility that extra-cellular GC actually has beneficial, anti-inflammatory, properties. Based on this hypothesis, we suggest here that the administration of supplementary oral GC to GBA carriers at risk for PD may slow inflammatory-driven secondary neuronal death...
November 12, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27866517/-impact-and-effect-of-preoperative-short-term-pulmonary-rehabilitation-training-on-%C3%A2-lung-cancer-patients-with-mild-to-moderate-chronic-obstructive-pulmonary-disease-%C3%A2-a-randomized-trial
#15
RANDOMIZED CONTROLLED TRIAL
Yutian Lai, Jianhua Su, Mei Yang, Kun Zhou, Guowei Che
BACKGROUND: Pulmonary rehabilitation (PR) is proposed as an effective strategy to decrease surgical morbidity. However, appropriate rehabilitation plan, initiation time, and optimal duration of PR remain unclear. Lung cancer patients with chronic obstructive pulmonary disease (COPD) are considered high-risk population for postoperative pulmonary complications (PPCs) because of poor lung fitness and cardiopulmonary endurance. This study aims to assess the impact of a one-week, systematic and highly-intensive rehabilitation on surgical lung cancer patients with mild to moderate COPD...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27859541/ambroxol-effects-in-glucocerebrosidase-and-%C3%AE-synuclein-transgenic-mice
#16
Anna Migdalska-Richards, Liam Daly, Erwan Bezard, Anthony H V Schapira
OBJECTIVE: Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule chaperone that has been shown to increase glucocerebrosidase activity in vitro. This study investigated the effect of ambroxol treatment on glucocerebrosidase activity and on α-synuclein and phosphorylated α-synuclein protein levels in mice...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27791464/autophagy-impairment-with-lysosomal-and-mitochondrial-dysfunction-is-an-important-characteristic-of-oxidative-stress-induced-senescence
#17
Haoran Tai, Zhe Wang, Hui Gong, Xiaojuan Han, Jiao Zhou, Xiaobo Wang, Xiawei Wei, Yi Ding, Ning Huang, Jianqiong Qin, Jie Zhang, Shuang Wang, Fei Gao, Zofia M Chrzanowska-Lightowlers, Rong Xiang, Hengyi Xiao
Macroautophagy/autophagy has profound implications for aging. However, the true features of autophagy in the progression of aging remain to be clarified. In the present study, we explored the status of autophagic flux during the development of cell senescence induced by oxidative stress. In this system, although autophagic structures increased, the degradation of SQSTM1/p62 protein, the yellow puncta of mRFP-GFP-LC3 fluorescence and the activity of lysosomal proteolytic enzymes all decreased in senescent cells, indicating impaired autophagic flux with lysosomal dysfunction...
January 2, 2017: Autophagy
https://www.readbyqxmd.com/read/27539639/parkinson-disease-linked-gba-mutation-effects-reversed-by-molecular-chaperones-in-human-cell-and-fly-models
#18
Alvaro Sanchez-Martinez, Michelle Beavan, Matthew E Gegg, Kai-Yin Chau, Alexander J Whitworth, Anthony H V Schapira
GBA gene mutations are the greatest cause of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase) but the mechanisms by which loss of GCase contributes to PD remain unclear. Inhibition of autophagy and the generation of endoplasmic reticulum (ER) stress are both implicated. Mutant GCase can unfold in the ER and be degraded via the unfolded protein response, activating ER stress and reducing lysosomal GCase. Small molecule chaperones that cross the blood brain barrier help mutant GCase refold and traffic correctly to lysosomes are putative treatments for PD...
August 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27418656/rheological-study-of-healthy-chicken-s-pooled-tracheobronchial-secretions-and-its-modification-by-mucolytics-drugs
#19
Lizbeth Carrillo, Héctor Sumano, Luis Medina-Torres, Graciela Tapia, Lilia Gutiérrez
The rheological properties of pooled tracheobronchial secretions (TBS) of chicken, including mucus, have not been characterized. Yet mucolytic drugs are frequently used in poultry medicine. To define such properties, TBS from healthy untreated and from chickens treated with various mucolytic drugs was studied. Three hundred, three-week-old Rhode Island Red chickens were divided into five groups, with three repetitions each (n = 20) as follows: ambroxol (GAmb), ethylene diamine dihydro-iodide (GEddi), carbocysteine (GCs), bromhexine (GBr), and an untreated control group (CG)...
November 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/27340385/immunomodulatory-effects-of-ambroxol-on-airway-hyperresponsiveness-and-inflammation
#20
Katsuyuki Takeda, Nobuaki Miyahara, Shigeki Matsubara, Christian Taube, Kenichi Kitamura, Astushi Hirano, Mitsune Tanimoto, Erwin W Gelfand
Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage (BAL) fluid were determined. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge...
June 2016: Immune Network
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