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https://www.readbyqxmd.com/read/27890991/pulmonary-alveolar-proteinosis-experience-from-a-tertiary-care-center-and-systematic-review-of-indian-literature
#1
Vijay Hadda, Pawan Tiwari, Karan Madan, Anant Mohan, Nishkarsh Gupta, Sachidanand Jee Bharti, Vinod Kumar, Rakesh Garg, Anjan Trikha, Deepali Jain, Sudheer Arava, Gopi C Khilnani, Randeep Guleria
BACKGROUND: Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by deposition of lipoproteinaceous material within alveoli, with a variable clinical course. Here, we report an experience of management of PAP at our center. A systematic review of previously reported cases from India is also included in the article. MATERIALS AND METHODS: This study included patients with primary PAP managed at our center from 2009 to 2015. Diagnosis of primary PAP was based on histopathologic diagnosis on bronchoalveolar lavage or transbronchial lung biopsy and absence of causes of secondary PAP...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27884873/optimization-of-robust-hplc-method-for-quantitation-of-ambroxol-hydrochloride-and-roxithromycin-using-a-doe-approach
#2
Rashmin B Patel, Nilay M Patel, Mrunali R Patel, Ajay B Solanki
The aim of this work was to develop and optimize a robust HPLC method for the separation and quantitation of ambroxol hydrochloride and roxithromycin utilizing Design of Experiment (DoE) approach. The Plackett-Burman design was used to assess the impact of independent variables (concentration of organic phase, mobile phase pH, flow rate and column temperature) on peak resolution, USP tailing and number of plates. A central composite design was utilized to evaluate the main, interaction, and quadratic effects of independent variables on the selected dependent variables...
November 24, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27866808/combined-beta-glucosylceramide-and-ambroxol-hydrochloride-in-patients-with-gaucher-related-parkinson-disease-from-clinical-observations-to-drug-development
#3
Yuval Ishay, Ari Zimran, Jeffrey Szer, Tama Dinur, Yaron Ilan, David Arkadir
Both patients with non-neuronopathic Gaucher disease (GD) and heterozygous GBA mutation carrier are at increased risk for Parkinson disease (PD). The risk for PD in these groups does not linearly increase with glucosylceramide (GC) accumulation or with acid β-glucocerebrosidase (GCase) activity. This observation, together with other clinical systemic observations raises the possibility that extra-cellular GC actually has beneficial, anti-inflammatory, properties. Based on this hypothesis, we suggest here that the administration of supplementary oral GC to GBA carriers at risk for PD may slow inflammatory-driven secondary neuronal death...
November 12, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27866517/-impact-and-effect-of-preoperative-short-term-pulmonary-rehabilitation-training-on-%C3%A2-lung-cancer-patients-with-mild-to-moderate-chronic-obstructive-pulmonary-disease-%C3%A2-a-randomized-trial
#4
Yutian Lai, Jianhua Su, Mei Yang, Kun Zhou, Guowei Che
BACKGROUND: Pulmonary rehabilitation (PR) is proposed as an effective strategy to decrease surgical morbidity. However, appropriate rehabilitation plan, initiation time, and optimal duration of PR remain unclear. Lung cancer patients with chronic obstructive pulmonary disease (COPD) are considered high-risk population for postoperative pulmonary complications (PPCs) because of poor lung fitness and cardiopulmonary endurance. This study aims to assess the impact of a one-week, systematic and highly-intensive rehabilitation on surgical lung cancer patients with mild to moderate COPD...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27859541/ambroxol-effects-in-glucocerebrosidase-and-%C3%AE-synuclein-transgenic-mice
#5
Anna Migdalska-Richards, Liam Daly, Erwan Bezard, Anthony H V Schapira
OBJECTIVE: Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule chaperone that has been shown to increase glucocerebrosidase activity in vitro. This study investigated the effect of ambroxol treatment on glucocerebrosidase activity and on α-synuclein and phosphorylated α-synuclein protein levels in mice...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27791464/autophagy-impairment-with-lysosomal-and-mitochondrial-dysfunction-is-an-important-characteristic-of-oxidative-stress-induced-senescence
#6
Haoran Tai, Zhe Wang, Hui Gong, Xiaojuan Han, Jiao Zhou, Xiaobo Wang, Xiawei Wei, Yi Ding, Ning Huang, Jianqiong Qin, Jie Zhang, Shuang Wang, Fei Gao, Zofia M Chrzanowska-Lightowlers, Rong Xiang, Hengyi Xiao
Macroautophagy/autophagy has profound implications for aging. However, the true features of autophagy in the progression of aging remain to be clarified. In the present study, we explored the status of autophagic flux during the development of cell senescence induced by oxidative stress. In this system, although autophagic structures increased, the degradation of SQSTM1/p62 protein, the yellow puncta of mRFP-GFP-LC3 fluorescence and the activity of lysosomal proteolytic enzymes all decreased in senescent cells, indicating impaired autophagic flux with lysosomal dysfunction...
October 28, 2016: Autophagy
https://www.readbyqxmd.com/read/27539639/parkinson-disease-linked-gba-mutation-effects-reversed-by-molecular-chaperones-in-human-cell-and-fly-models
#7
Alvaro Sanchez-Martinez, Michelle Beavan, Matthew E Gegg, Kai-Yin Chau, Alexander J Whitworth, Anthony H V Schapira
GBA gene mutations are the greatest cause of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase) but the mechanisms by which loss of GCase contributes to PD remain unclear. Inhibition of autophagy and the generation of endoplasmic reticulum (ER) stress are both implicated. Mutant GCase can unfold in the ER and be degraded via the unfolded protein response, activating ER stress and reducing lysosomal GCase. Small molecule chaperones that cross the blood brain barrier help mutant GCase refold and traffic correctly to lysosomes are putative treatments for PD...
August 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27418656/rheological-study-of-healthy-chicken-s-pooled-tracheobronchial-secretions-and-its-modification-by-mucolytics-drugs
#8
Lizbeth Carrillo, Héctor Sumano, Luis Medina-Torres, Graciela Tapia, Lilia Gutiérrez
The rheological properties of pooled tracheobronchial secretions (TBS) of chicken, including mucus, have not been characterized. Yet mucolytic drugs are frequently used in poultry medicine. To define such properties, TBS from healthy untreated and from chickens treated with various mucolytic drugs was studied. Three hundred, three-week-old Rhode Island Red chickens were divided into five groups, with three repetitions each (n = 20) as follows: ambroxol (GAmb), ethylene diamine dihydro-iodide (GEddi), carbocysteine (GCs), bromhexine (GBr), and an untreated control group (CG)...
July 14, 2016: Poultry Science
https://www.readbyqxmd.com/read/27340385/immunomodulatory-effects-of-ambroxol-on-airway-hyperresponsiveness-and-inflammation
#9
Katsuyuki Takeda, Nobuaki Miyahara, Shigeki Matsubara, Christian Taube, Kenichi Kitamura, Astushi Hirano, Mitsune Tanimoto, Erwin W Gelfand
Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage (BAL) fluid were determined. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge...
June 2016: Immune Network
https://www.readbyqxmd.com/read/27281448/efficacy-and-safety-of-ambroxol-lozenges-in-the-treatment-of-acute-uncomplicated-sore-throat-a-pooled-analysis
#10
C de Mey, S Koelsch, E Richter, T Pohlmann, R Sousa
A pooled analysis is presented of 7 placebo-controlled RCT that investigated lozenges containing ambroxol for pain relief in acute sore throat.2 242 patients were treated with different ambroxol doses or control treatments, 2 183 were evaluable for efficacy. The present analysis is focused on the recommended dose of 20 mg (AXL20): 856 patients were treated with AXL20, 847 with matched placebo lozenges (PL).The average reduction in pain intensity over the first 3 h after the first AXL20 ranged from 38% to 52% of the maximum achievable effect (MAE)...
July 2016: Drug Research
https://www.readbyqxmd.com/read/27162249/the-contribution-of-mutant-gba-to-the-development-of-parkinson-disease-in-drosophila
#11
Gali Maor, Or Cabasso, Olga Krivoruk, Joe Rodriguez, Hermann Steller, Daniel Segal, Mia Horowitz
Gaucher disease (GD) results from mutations in the acid β-glucocerebrosidase (GCase) encoding gene, GBA, which leads to accumulation of glucosylceramides. GD patients and carriers of GD mutations have a significantly higher propensity to develop Parkinson disease (PD) in comparison to the non-GD population. In this study, we used the fruit fly Drosophila melanogaster to show that development of PD in carriers of GD mutations results from the presence of mutant GBA alleles. Drosophila has two GBA orthologs (CG31148 and CG31414), each of which has a minos insertion, which creates C-terminal deletion in the encoded GCase...
May 9, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27129716/simultaneous-determination-of-ambroxol-and-salbutamol-in-human-plasma-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#12
Zhening Guo, Yangsheng Chen, Xiaoliang Ding, Chenrong Huang, Liyan Miao
A rapid, selective and sensitive liquid chromatography-tandem mass spectrometry assay method was developed for simultaneous determination of ambroxol and salbutamol in human plasma using citalopram hydrobromide as internal standard (IS). Sample was alkalinized with ammonia water (33:67, v/v) and extracted by single liquid-liquid extraction with ethyl acetate. Separation was achieved on Waters ACQUITY UPLC BEH C18 column using gradient program at a flow rate of 0.2 mL/min. Detection was performed using electrospray ionization in positive ion multiple reaction monitoring (MRM) mode by monitoring the ion transitions form m/z 378...
April 30, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27102839/ambroxol-inhibits-mucoid-conversion-of-pseudomonas-aeruginosa-and-contributes-to-the-bactericidal-activity-of-ciprofloxacin-against-mucoid-p-aeruginosa-biofilms
#13
Wenlei Wang, Jialin Yu, Yu He, Zhengli Wang, Fang Li
Pseudomonas aeruginosa is an opportunistic human pathogen that can cause severe infections in immunocompromised individuals. Because it forms biofilms, which protect against host immune attack and increase resistance to conventional antibiotics, mucoid P. aeruginosa is nearly impossible to eradicate. Moreover, mucoid conversion of P. aeruginosa in cystic fibrosis (CF) patients leads to poor outcomes. This conversion is mainly due to mucA gene mutation, which is thought to be induced by polymorphonuclear leukocytes (PMNs) and the reactive oxygen species they release...
July 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27075562/suitability-of-e-tongue-sensors-to-assess-taste-masking-of-pediatric-liquids-by-different-beverages-considering-their-physico-chemical-properties
#14
Laura Isabell Immohr, Claas Hedfeld, Artur Lang, Miriam Pein-Hackelbusch
Manipulation of liquid oral drugs by mixing them into foodstuff is a common procedure for taste-masking of OTC pharmaceuticals when administered to children. However, the taste-masking capability of such application media is not systematically evaluated, and recommendations for suitable media are hardly published. In this study, a sensor array of commercially available and self-developed electronic tongue sensors was employed to assess the taste-masking efficiency of eight different beverages (tap water, apple juice, carrot juice, fennel tea, fruit tea, milk, cocoa, and Alete meal to drink) on the OTC pharmaceuticals Ambroxol-ratiopharm®, Cetirizin AL, and Laxoberal® by multivariate data analysis...
April 13, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27042680/ambroxol-chaperone-therapy-for-neuronopathic-gaucher-disease-a-pilot-study
#15
Aya Narita, Kentarou Shirai, Shinji Itamura, Atsue Matsuda, Akiko Ishihara, Kumi Matsushita, Chisako Fukuda, Norika Kubota, Rumiko Takayama, Hideo Shigematsu, Anri Hayashi, Tomohiro Kumada, Kotaro Yuge, Yoriko Watanabe, Saori Kosugi, Hiroshi Nishida, Yukiko Kimura, Yusuke Endo, Katsumi Higaki, Eiji Nanba, Yoko Nishimura, Akiko Tamasaki, Masami Togawa, Yoshiaki Saito, Yoshihiro Maegaki, Kousaku Ohno, Yoshiyuki Suzuki
OBJECTIVE: Gaucher disease (GD) is a lysosomal storage disease characterized by a deficiency of glucocerebrosidase. Although enzyme-replacement and substrate-reduction therapies are available, their efficacies in treating the neurological manifestations of GD are negligible. Pharmacological chaperone therapy is hypothesized to offer a new strategy for treating the neurological manifestations of this disease. Specifically, ambroxol, a commonly used expectorant, has been proposed as a candidate pharmacological chaperone...
March 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27007998/bioequivalence-assessment-of-ambroxol-orally-disintegrating-tablet-after-a-single-oral-dose-administration-to-healthy-volunteers
#16
RANDOMIZED CONTROLLED TRIAL
Yaojun Ni, Lili Hou, Liang Chen, Jiang Fan
OBJECTIVE: In this study, a modified LC-MS/MS method was used to determine plasma ambroxol concentration and thereby examine the bioequivalence of two ambroxol medications among healthy Chinese male volunteers. METHODS: The study used a single-dose, randomized, open-label design principle and calculated pharmacokinetic parameters for the comparison of the two formulations. RESULTS: Administration of a single oral dose of either the test drug or reference drug was found to be safe in healthy subjects...
May 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26938435/inside-out-core-network-of-transcription-factors-drives-axon-regeneration
#17
COMMENT
Choya Yoon, Roman J Giger
In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.
March 2, 2016: Neuron
https://www.readbyqxmd.com/read/26881857/inhalation-of-ambroxol-inhibits-cigarette-smoke-induced-acute-lung-injury-in-a-mouse-model-by-inhibiting-the-erk-pathway
#18
Ling-tian Ge, Ya-nan Liu, Xi-xi Lin, Hui-juan Shen, Yong-liang Jia, Xin-wei Dong, Yun Sun, Qiang-min Xie
Oral and injection administration of ambroxol has been clinically used to treat airway disease. However, little is known about its potentials in inhalation therapy. In present studies, we tested the effects of ambroxol by inhalation with intravenous administration, and explored the underlying working mechanism. The mice received 10 cigarettes exposure every day for 4 days. Inhaled solution of ambroxol was aerosolized 20 min before the exposure of cigarette smoke (CS). The effect of ambroxol on the expression of mucoprotein 5 AC (MUC5AC) and proinflammatory cytokines in NCI-H292 cells stimulated with cigarette smoke extract (CSE)...
April 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/26872986/ambroxol-inhalation-ameliorates-lps-induced-airway-inflammation-and-mucus-secretion-through-the-extracellular-signal-regulated-kinase-1-2-signaling-pathway
#19
Shui-juan Zhang, Juan-xia Jiang, Qian-qian Ren, Yong-liang Jia, Jian Shen, Hui-juan Shen, Xi-xi Lin, Hong Lu, Qiang-min Xie
Ambroxol, a metabolite of bromhexine, is shown to exert several pharmacological activities, including secretolytic, anti-inflammatory and antioxidant actions. Oral and intravenous administration of ambroxol is useful for the airway inflammatory diseases. However, little is known about its potential in inhalation therapy for lipopolysaccharide (LPS)-induced mucous hypersecretion and inflammatory response. In the present study, we compared the pharmacological effects of ambroxol by inhalation with intravenous administration and preliminarily explored its mechanism of action...
March 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26837157/-pharmacy-based-sore-throat-therapy-according-to-current-guidelines
#20
Ludger Klimek, Annette Sperl
Sore throat should be treated symptomatically in self-medication. Due to the mainly viral origin of the disease and the lack of efficiency data, local antibiotics or antiseptics should not be recommended. systemic analgesics as acetylsalicylic acid, acetaminophen, flurbiprofen, or ibuprofen are valid treatment options. Clinical trials suggest that ibuprofen shows the best benefit-risk profile. Flurbiprofen could show efficiency in current trials but head-to-head data with other analgesics (e.g. ibuprofen) are missing...
December 2015: Medizinische Monatsschrift Für Pharmazeuten
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