keyword
MENU ▼
Read by QxMD icon Read
search

circadian phenotype

keyword
https://www.readbyqxmd.com/read/28650662/glucose-restriction-combined-with-autophagy-inhibition-and-chemotherapy-in-hct-116-spheroids-decreases-cell-clonogenicity-and-viability-regulated-by-tumor-suppressor-genes
#1
Monica M Schroll, Gabriel J LaBonia, Katelyn R Ludwig, Amanda B Hummon
Drug resistance is a prevalent phenomenon that decreases the efficacy of cancer treatments and contributes to cancer progression and metastasis. Weakening drug resistant cancer cells prior to chemotherapy is a potential strategy to combat chemoresistance. One approach to damage resistant cancer cells is modulation of nutritional intake. The combination of nutrient restriction with targeted compound treatment results in pronounced molecular changes. This study provides valuable information about augmenting existing chemotherapeutic regimes with simultaneous glucose restriction and autophagy inhibition in colorectal cancer cells...
June 26, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28645892/meis1-effects-on-motor-phenotypes-and-the-sensorimotor-system-in-mice
#2
Aaro V Salminen, Lillian Garrett, Barbara Schormair, Jan Rozman, Florian Giesert, Kristina M Niedermeier, Lore Becker, Birgit Rathkolb, Ildikó Rácz, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Andreas Zimmer, Valérie Gailus-Durner, Miguel Torres, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Sabine M Hölter, Juliane Winkelmann
MEIS1 is a developmental transcription factor linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and with significant impact on the quality-of-life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation. Therefore, haploinsufficiency of Meis1 could be the most potential system for modeling RLS in animals...
June 23, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28607386/maternal-and-early-life-circadian-disruption-have-long-lasting-negative-consequences-on-offspring-development-and-adult-behavior-in-mice
#3
Benjamin L Smarr, Azure D Grant, Luz Perez, Irving Zucker, Lance J Kriegsfeld
Modern life involves chronic circadian disruption through artificial light and these disruptions are associated with numerous mental and physical health maladies. Because the developing nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian disruption would negatively impact offspring development and adult function. Pregnant mice were subjected to chronic circadian disruption from the time of uterine implantation through weaning. To dissociate in utero from postnatal effects, a subset of litters was cross-fostered at birth from disrupted dams to control dams and vice versa...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28604637/gibberellic-acid-signaling-is-required-to-induce-flowering-of-chrysanthemums-grown-under-both-short-and-long-days
#4
Bin Dong, Ye Deng, Haibin Wang, Ri Gao, Githeng'u K Stephen, Sumei Chen, Jiafu Jiang, Fadi Chen
Flower bud formation and flowering in chrysanthemums occur under short day conditions (SD), but the molecular basis for the switch to reproductive growth is less well understood than in model plants. Here, a spontaneous mutant able to flower under long days is described. In an attempt to reveal the pathway(s) involved in the formation of flower buds under contrasting daylengths, transcriptome sequencing was carried out in plants grown both under SD and long day conditions (LD). A number of differentially transcribed genes involved in the various known flowering pathways were identified...
June 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28603481/effects-of-dim-light-at-night-on-food-intake-and-body-mass-in-developing-mice
#5
Yasmine M Cissé, Juan Peng, Randy J Nelson
Appropriately timed light is critical for circadian organization; exposure to dim light at night (dLAN) disrupts temporal organization of endogenous biological timing. Exposure to dLAN in adult mice is associated with elevated body mass and changes in metabolism putatively driven by voluntary changes in the time of food intake. We predicted that exposure of young mice to LAN could affect adult metabolic function. At 3 weeks (Experiment 1) or 5 weeks (Experiment 2) of age, mice were either maintained in standard light-dark (DARK) cycles or exposed to nightly dLAN (5 lux)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28592704/the-added-value-of-exhaled-breath-temperature-in-respiratory-medicine
#6
Todor A Popov, Tanya Kralimarkova, Marina Labor, Davor Plavec
Recognition of the huge economic burden chronic respiratory diseases pose for society motivated fundamental and clinical research leading to insight into the role of airway inflammation in various disease entities and their phenotypes. However, no easy, cheap and patient-friendly methods to assess it have found a place in routine clinical practice. Measurement of exhaled breath temperature (EBT) has been suggested as a non-invasive method to detect inflammatory processes in the airways as a result of increased blood flow within the airway walls...
June 8, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28591177/identification-and-characterization-of-constans-like-col-gene-family-in-upland-cotton-gossypium-hirsutum-l
#7
Darun Cai, Hui Liu, Na Sang, Xianzhong Huang
The CONSTANS/FLOWERING LOCUS T (CO/FT) regulon plays a central role in the control of flowering time in photoperiod-sensitive plants. Flowering time in wild cotton (Gossypium spp.) has strict photoperiod sensitivity, but domesticated cotton is day-neutral. Information on the molecular characterization of the CO and CO-like (COL) genes in cotton is very limited. In this study, we identified 42 COL homologs (GhCOLs) in the G. hirsutum genome, and many of them were previously unreported. We studied their chromosome distribution, phylogenetic relationships, and structures of genes and proteins...
2017: PloS One
https://www.readbyqxmd.com/read/28583847/timeless-confers-cisplatin-resistance-in-nasopharyngeal-carcinoma-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway-and-promoting-the-epithelial-mesenchymal-transition
#8
Sai-Lan Liu, Huan-Xin Lin, Chu-Yong Lin, Xiao-Qing Sun, Li-Ping Ye, Fang Qiu, Wen Wen, Xin Hua, Xian-Qiu Wu, Jun Li, Li-Bing Song, Ling Guo
This study investigated the expression, clinicopathological significance and mechanism of action of TIMELESS, a mammalian homolog of a Drosophila circadian rhythm gene, in nasopharyngeal carcinoma. Quantitative real-time PCR, western blotting and immunohistochemistry revealed TIMELESS was upregulated in NPC cell lines (n = 8 vs. NP69 cells), and freshly-frozen (n = 6) and paraffin-embedded human NPC specimens (n = 108 vs. normal samples/non-tumor cells). TIMELESS expression was associated with T category (P = 0...
June 3, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28580282/hepatic-gene-therapy-rescues-high-fat-diet-responses-in-circadian-clock-mutant-mice
#9
Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H Tsang, Johanna L Barclay, Henrik Oster
OBJECTIVE: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the obesogenic phenotype of Clock mutant mice, however, remains unknown. METHODS: Metabolic parameters of wild-type (WT) and Clock(Δ19) mutant mice (MT) were investigated under ad libitum and nighttime restricted HFD feeding...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28576398/characterization-of-circadian-copd-symptoms-by-phenotype-methodology-of-the-storico-observational-study
#10
G W Canonica, F Blasi, N Scichilone, L Simoni, A Zullo, C Giovannetti, C Briguglio, S Barsanti, R Antonelli Incalzi
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The symptoms of COPD are troublesome, variable, can occur during all parts of the 24-h day and have a substantial impact on patients' health status, quality of life and healthcare resource utilization. Reducing symptoms, improving health status and increasing physical activity are major goals in the management of stable COPD. In order to provide effective, patient-oriented care, patients should be evaluated on the basis of lung function, frequency of symptoms and patient-perceived impact of symptoms on their lives and treatment decisions made on a case-by-case basis...
May 30, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28542864/circadian-clustering-of-spontaneous-epileptic-seizures-emerges-after-pilocarpine-induced-status-epilepticus
#11
Julika Pitsch, Albert J Becker, Susanne Schoch, Johannes Alexander Müller, Marco de Curtis, Vadym Gnatkovsky
OBJECTIVE: Seizures in mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis are thought to develop with various latency intervals after an initial transient brain insult. To study seizure dynamics after an initial transient precipitating insult in a systematic fashion, we utilized continuous video-electroencephalography (EEG) monitoring after the induction of status epilepticus (SE) in a mouse MTLE model. METHODS: Continuous 24/7 video/telemetric hippocampal EEG recordings in the systemic pilocarpine MTLE mouse model...
May 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28539174/drug-metabolism-in-the-elderly-a-multifactorial-problem
#12
REVIEW
R H Waring, R M Harris, S C Mitchell
Whether or not an individual's drug metabolising capacity declines with advancing age is a vexing question. There is no clear evidence that drug metabolism itself ('the biologically-assisted chemical alteration of the administered parent molecule') is less efficient in healthy old age than at younger ages, whereas a decreased capacity may be associated with ill-health and frailty. However, elderly individuals do show a reduced enzyme induction capability and are less able to tolerate overdoses. It appears that the majority of deleterious clinical outcomes related to drug therapy in an elderly (usually ill or frail) population may be ascribed to various anatomical and physiological age-related changes...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28486137/cloning-and-characterization-of-a-novel-gigantea-gene-in-sweet-potato
#13
Wei Tang, Hui Yan, Zai-Xing Su, Sung-Chul Park, Ya-Ju Liu, Yun-Gang Zhang, Xin Wang, Meng Kou, Dai-Fu Ma, Sang-Soo Kwak, Qiang Li
The transition from vegetative to reproductive growth, a key event in the lifecycle of a plant, is affected by environmental stresses. The flowering-time regulator GIGANTEA (GI) may be contributing to susceptibility of the regulation of photoperiodic flowering, circadian rhythm control, and abiotic stress resistance in Arabidopsis. However, the role of GI in sweet potato remains unknown. Here, we isolated and characterized a GI gene (IbGI) from sweet potato (Ipomoea batatas [L.] Lam). The IbGI cDNA sequence was isolated based on information from a sweet potato transcriptome database...
April 27, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28483056/photoperiod-insensitive-floral-transition-in-chrysanthemum-induced-by-constitutive-expression-of-chimeric-repressor-cslhy-srdx
#14
Atsushi Oda, Yohei Higuchi, Tamotsu Hisamatsu
A wide variety of physiological processes including flowering are controlled by the circadian clock in plants. In Arabidopsis, LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) constitute the central oscillator, and their gain of function and loss of function disrupt the circadian clock and affect flowering time through FLOWERING LOCUS T (FT), a gene encoding a florigen. Chrysanthemum is a typical short-day (SD) plant and responds to shortening of day length by the transition from the vegetative to reproductive phase...
June 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28473844/functional-characterization-of-a-putative-glycine-max-elf4-in-transgenic-arabidopsis-and-its-role-during-flowering-control
#15
Juliana Marcolino-Gomes, Thiago J Nakayama, Hugo B C Molinari, Marcos F Basso, Liliane M M Henning, Renata Fuganti-Pagliarini, Frank G Harmon, Alexandre L Nepomuceno
Flowering is an important trait in major crops like soybean due to its direct relation to grain production. The circadian clock mediates the perception of seasonal changes in day length and temperature to modulate flowering time. The circadian clock gene EARLY FLOWERING 4 (ELF4) was identified in Arabidopsis thaliana and is believed to play a key role in the integration of photoperiod, circadian regulation, and flowering. The molecular circuitry that comprises the circadian clock and flowering control in soybeans is just beginning to be understood...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28473760/persistent-effects-of-developmental-exposure-to-17%C3%AE-ethinylestradiol-on-the-zebrafish-danio-rerio-brain-transcriptome-and-behavior
#16
Tove Porseryd, Kristina Volkova, Nasim Reyhanian Caspillo, Thomas Källman, Patrik Dinnetz, Inger Porsh Hällström
The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also been observed to be transmitted to several generations of unexposed progeny. To investigate the possible biological mechanisms of the persistent anxiogenic phenotype, we exposed zebrafish embryos for 80 days post fertilization to 0, 3, and 10 ng/L EE2 (measured concentrations 2...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28470121/shift-work-and-cognitive-flexibility-decomposing-task-performance
#17
Philip Cheng, Gabriel Tallent, Thomas John Bender, Kieulinh Michelle Tran, Christopher L Drake
Deficits in cognitive functioning associated with shift work are particularly relevant to occupational performance; however, few studies have examined how cognitive functioning is associated with specific components of shift work. This observational study examined how circadian phase, nocturnal sleepiness, and daytime insomnia in a sample of shift workers ( N = 30) were associated with cognitive flexibility during the night shift. Cognitive flexibility was measured using a computerized task-switching paradigm, which produces 2 indexes of flexibility: switch cost and set inhibition...
April 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28456660/assessing-mouse-behaviour-throughout-the-light-dark-cycle-using-automated-in-cage-analysis-tools
#18
Rasneer S Bains, Sara Wells, Rowland R Sillito, J Douglas Armstrong, Heather L Cater, Gareth Banks, Patrick M Nolan
An important factor in reducing variability in mouse test outcomes has been to develop assays that can be used for continuous automated home cage assessment. Our experience has shown that this has been most evidenced in long-term assessment of wheel-running activity in mice. Historically, wheel-running in mice and other rodents have been used as a robust assay to determine, with precision, the inherent period of circadian rhythms in mice. Furthermore, this assay has been instrumental in dissecting the molecular genetic basis of mammalian circadian rhythms...
April 26, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28455608/expansion-of-cd11b-ly6g-high-and-cd11b-cd49d-myeloid-cells-with-suppressive-potential-in-mice-with-chronic-inflammation-and-light-at-night-induced-circadian-disruption
#19
Yuliya V Perfilyeva, Nurshat Abdolla, Yekaterina O Ostapchuk, Raikhan Tleulieva, Vladimir C Krasnoshtanov, Nikolai N Belyaev
OBJECTIVE: Myeloid-derived suppressor cells (MDSCs) are important negative regulators of immune processes in cancer and other pathological conditions. We suggested that MDSCs play a key role in pathogenesis of chronic inflammation, which precedes and, to a certain extent, induces carcinogenesis. The present study aimed at investigation of MDSCs arising during chronic inflammation and light-at-night (LN)-induced stress, which is shown to accelerate chronic diseases. SUBJECTS: 67 CD-1 mice and in vitro MDSC cultures...
April 28, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28449557/wnt-and-gsk3-signaling-pathways-in-bipolar-disorder-clinical-and-therapeutic-implications
#20
REVIEW
Ather Muneer
The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial effects. The enzyme glycogen synthase kinase 3 (GSK3) has come into focus, as lithium and several other mood stabilizing medications inhibit its activity. This kinase and its key upstream modulator, Wnt are dysregulated in mood disorders and there is a growing impetus to delineate the chief substrates involved in the development of these illnesses...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
keyword
keyword
82633
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"