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https://www.readbyqxmd.com/read/28440811/evaluation-of-circadian-phenotypes-utilizing-fibroblasts-from-patients-with-circadian-rhythm-sleep-disorders
#1
A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28437590/plant-dual-specificity-tyrosine-phosphorylation-regulated-kinase-optimizes-light-regulated-growth-and-development-in-arabidopsis
#2
Wen-Yu Huang, Yi-Chen Wu, Hsin-Yi Pu, Ying Wang, Geng-Jen Jang, Shu-Hsing Wu
Light controls vegetative and reproductive development of plants. For a plant, sensing the light input properly ensures coordination with the ever-changing environment. Previously, we found that LIGHT-REGULATED WD1 (LWD1) and LWD2 regulate the circadian clock and photoperiodic flowering. Here we identified Arabidopsis YET ANOTHER KINASE1 (AtYAK1), an evolutionarily conserved protein and a member of dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs), as an interacting protein of LWDs. Our study revealed that AtYAK1 is an important regulator for various light responses, including the circadian clock, photomorphogenesis and reproductive development...
April 24, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28435104/drosophila-pink1-and-parkin-loss-of-function-mutants-display-a-range-of-non-motor-parkinson-s-disease-phenotypes
#3
Hannah Julienne, Edgar Buhl, David S Leslie, James J L Hodge
Parkinson's disease (PD) is more commonly associated with its motor symptoms and the related degeneration of dopamine (DA) neurons. However, it is becoming increasingly clear that PD patients also display a wide range of non-motor symptoms, including memory deficits and disruptions of their sleep-wake cycles. These have a large impact on their quality of life, and often precede the onset of motor symptoms, but their etiology is poorly understood. The fruit fly Drosophila has already been successfully used to model PD, and has been used extensively to study relevant non-motor behaviours in other contexts, but little attention has yet been paid to modelling non-motor symptoms of PD in this genetically tractable organism...
April 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28432873/conditional-deletion-of-bmal1-accentuates-microvascular-and-macrovascular-injury
#4
Ashay D Bhatwadekar, Eleni Beli, Diao Yanpeng, Jonathan Chen, Qianyi Luo, Alpha Alex, Sergio Caballero, James M Dominguez, Tatiana E Salazar, Julia V Busik, Mark S Segal, Maria B Grant
The brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein (BMAL)-1 constitutes a major transcriptional regulator of the circadian clock. Here, we explored the impact of conditional deletion of Bmal1 in endothelium and hematopoietic cells in murine models of microvascular and macrovascular injury. We used two models of Bmal1(fx/fx);Tek-Cre mice, a retinal ischemia/reperfusion model and a neointimal hyperplasia model of the femoral artery. Eyes were enumerated for acellular capillaries and were stained for oxidative damage markers using nitrotyrosine immunohistochemistry...
April 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28432199/phagocytosis-imprints-heterogeneity-in-tissue-resident-macrophages
#5
Noelia A-Gonzalez, Juan A Quintana, Susana García-Silva, Marina Mazariegos, Arturo González de la Aleja, José A Nicolás-Ávila, Wencke Walter, Jose M Adrover, Georgiana Crainiciuc, Vijay K Kuchroo, Carla V Rothlin, Héctor Peinado, Antonio Castrillo, Mercedes Ricote, Andrés Hidalgo
Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue...
April 21, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28426387/characterization-of-bimodal-chronotype-and-its-association-with-sleep-a-population-based-study
#6
Priscila Farias Tempaku, Juliana Ramirez Arruda, Diego Robles Mazzotti, Bruno S B Gonçalves, Mário Pedrazzoli, Lia Bittencourt, Sergio Tufik
The circadian system coordinates internal events in a daily schedule to make sure that the body systems are synchronized to environmental time and internal cues. One important behavioral aspect of the circadian system is the chronotype. It is usually assessed through subjective questionnaires, being the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ) one of the most used. It classifies individuals into three major categories: morning, evening, and intermediate types. Recently, it has been hypothesized the existence of a fourth chronotype, the bimodal type, through an algorithm derived from the MEQ responses...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28422445/transcriptional-profiling-of-shr-ncrl-prefrontal-cortex-reveals-hyperactivity-associated-genes-responsive-to-amphetamine-challenge
#7
Irene Joy I Dela Peña, Ike Dela Peña, June Bryan de la Peña, Hee Jin Kim, Aeree Sohn, Chan Young Shin, Doug Hyun Han, Bung-Nyun Kim, Jong Hoon Ryu, Jae Hoon Cheong
Several studies suggest a strong genetic component of attention-deficit/hyperactivity disorder (ADHD), a complex neurodevelopmental disorder characterized by inappropriate levels of hyperactivity, impulsivity, and inattention. Determining specific genetic risk variants for each symptom dimension of ADHD may aid in the identification of the biological risk factors of the disorder. In this study, we explored the potential genetic underpinnings of the hyperactive phenotype of ADHD. To this end, we examined differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of SHR/NCrl, an animal model of ADHD, compared with its genetic control, the Wistar Kyoto (WKY/NCrl) rat and the Wistar rat, strain used to represent the "normal" heterogeneous population...
April 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28409690/salivary-cortisol-concentration-after-high-intensity-interval-exercise-time-of-day-and-chronotype-effect
#8
Matteo Bonato, Antonio La Torre, Marina Saresella, Ivana Marventano, Giampiero Merati, Jacopo Antonino Vitale
Due to personal and working necessities, the time for exercise is often short, and scheduled early in the morning or late in the afternoon. Cortisol plays a central role in the physiological and behavioral response to a physical challenge and can be considered as an index of exercise stress. Therefore, the aim of this study was to evaluate the influence of the circadian phenotype classification on salivary cortisol concentration in relation to an acute session of high-intensity interval exercise (HIIE) performed at different times of the day...
April 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28408300/%C3%AE-9-nachr-knockout-mice-exhibit-dysregulation-of-stress-responses-affect-and-reward-related-behaviour
#9
Sarasa A Mohammadi, Thomas J Burton, MacDonald J Christie
The α9α10-subtype of nicotinic acetylcholine receptor (nAChR) has recently garnered interest in biomedicine and is being pursued as an analgesic target. However, the receptor exhibits diverse tissue distribution, the function of which is known to varying degrees, and targeting this receptor for clinical treatments without a broad understanding of its function may have adverse consequences. The α9α10-nAChR is expressed in the adrenal and pituitary glands, suggesting a potential role in the stress response, but little is known about its function in this tissue...
April 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28401936/bmal1-links-the-circadian-clock-to-viral-airway-pathology-and-asthma-phenotypes
#10
A Ehlers, W Xie, E Agapov, S Brown, D Steinberg, R Tidwell, G Sajol, R Schutz, R Weaver, H Yu, M Castro, L B Bacharier, X Wang, M J Holtzman, J A Haspel
Patients with asthma experience circadian variations in their symptoms. However it remains unclear how specific aspects of this common airway disease relate to clock genes, which are critical to the generation of circadian rhythms in mammals. Here, we used a viral model of acute and chronic airway disease to examine how circadian clock disruption affects asthmatic lung phenotypes. Deletion of the core clock gene bmal1 or environmental disruption of circadian function by jet lag exacerbated acute viral bronchiolitis caused by Sendai virus (SeV) and influenza A virus in mice...
April 12, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28399169/a-photoperiod-responsive-protein-compendium-and-conceptual-proteome-roadmap-outline-in-maize-grown-in-growth-chambers-with-controlled-conditions
#11
You-Zhi Li, Xian-Wei Fan, Qiang Chen, Hao Zhong
Maize (Zea mays L.) is one of the major staple food crops of the world. However, high photoperiod sensitivity, especially for tropical germplasms, impedes attempts to improve maize agronomical traits by integration of tropical and temperate maize germplasms. Physiological and phenotypic responses of maize to photoperiod have widely been investigated based on multi-site field observations; however, proteome-based responsive mechanisms under controlled photoperiod regimes, nutrient and moisture soils are not yet well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28388556/remote-reprogramming-of-hepatic-circadian-transcriptome-by-breast-cancer
#12
Hiroaki Hojo, Sora Enya, Miki Arai, Yutaka Suzuki, Takashi Nojiri, Kenji Kangawa, Shinsuke Koyama, Shinpei Kawaoka
Cancers adversely affect organismal physiology. To date, the genes within a patient responsible for systemically spreading cancer-induced physiological disruption remain elusive. To identify host genes responsible for transmitting disruptive, cancer-driven signals, we thoroughly analyzed the transcriptome of a suite of host organs from mice bearing 4T1 breast cancer, and discovered complexly rewired patterns of circadian gene expression in the liver. Our data revealed that 7 core clock transcription factors, represented by Rev-erba and Rorg, exhibited abnormal daily expression rhythm in the liver of 4T1-bearing mice...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28388406/mutation-of-the-human-circadian-clock-gene-cry1-in-familial-delayed-sleep-phase-disorder
#13
Alina Patke, Patricia J Murphy, Onur Emre Onat, Ana C Krieger, Tayfun Özçelik, Scott S Campbell, Michael W Young
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ∼24 hr rhythms in many behavioral and physiological processes. This system is altered in delayed sleep phase disorder (DSPD), a common form of insomnia in which sleep episodes are shifted to later times misaligned with the societal norm. Here, we report a hereditary form of DSPD associated with a dominant coding variation in the core circadian clock gene CRY1, which creates a transcriptional inhibitor with enhanced affinity for circadian activator proteins Clock and Bmal1...
April 6, 2017: Cell
https://www.readbyqxmd.com/read/28383772/aberrant-expression-of-mico1-and-mico1os-in-deceased-somatic-cell-nuclear-transfer-calves
#14
Guan-Nan Wang, Wen-Zhi Yang, Da Xu, Dong-Jie Li, Cui Zhang, Wei-Na Chen, Shi-Jie Li
Incomplete reprogramming of a donor nucleus following somatic cell nuclear transfer (SCNT) results in aberrant expression of developmentally important genes, and is the primary source of the phenotypic abnormalities observed in cloned animals. Expression of non-coding RNAs in the murine Dlk1-Dio3 imprinted domain was previously shown to correlate with the pluripotency of mouse induced pluripotent stem cells. In this study, we examined the transcription of the bovine orthologs from this locus, MICO1 (Maternal intergenic circadian oscillating 1) and MICO1OS (MICO1 opposite strand), in tissues from artificially inseminated and SCNT calves that died during the perinatal period...
April 6, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28379578/an-earlier-time-of-scan-is-associated-with-greater-threat-related-amygdala-reactivity
#15
David A A Baranger, Seth Margolis, Ahmad R Hariri, Ryan Bogdan
Time-dependent variability in mood and anxiety suggest that related neural phenotypes, such as threat-related amygdala reactivity, may also follow a diurnal pattern. Here, using data from 1,043 young adult volunteers, we found that threat-related amygdala reactivity was negatively coupled with time of day, an effect which was stronger in the left hemisphere (β=-0.1083, p-fdr=0.0012). This effect was moderated by subjective sleep quality (β=-0.0715, p-fdr=0.0387); participants who reported average and poor sleep quality had relatively increased left amygdala reactivity in the morning...
April 4, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28373692/a-missense-mutation-in-katnal1-underlies-behavioural-neurological-and-ciliary-anomalies
#16
G Banks, G Lassi, A Hoerder-Suabedissen, F Tinarelli, M M Simon, A Wilcox, P Lau, T N Lawson, S Johnson, A Rutman, M Sweeting, J E Chesham, A R Barnard, N Horner, H Westerberg, L B Smith, Z Molnár, M H Hastings, R A Hirst, V Tucci, P M Nolan
Microtubule severing enzymes implement a diverse range of tissue-specific molecular functions throughout development and into adulthood. Although microtubule severing is fundamental to many dynamic neural processes, little is known regarding the role of the family member Katanin p60 subunit A-like 1, KATNAL1, in central nervous system (CNS) function. Recent studies reporting that microdeletions incorporating the KATNAL1 locus in humans result in intellectual disability and microcephaly suggest that KATNAL1 may play a prominent role in the CNS; however, such associations lack the functional data required to highlight potential mechanisms which link the gene to disease symptoms...
April 4, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28371850/interactive-effects-of-sleep-duration-and-morning-evening-preference-on-cardiovascular-risk-factors
#17
Freda Patterson, Susan Kohl Malone, Michael A Grandner, Alicia Lozano, Mackenzie Perkett, Alexandra Hanlon
: Sleep duration and morningness/eveningness (circadian preference) have separately been associated with cardiovascular risk factors (i.e. tobacco use, physical inactivity). Interactive effects are plausible, resulting from combinations of sleep homeostatic and circadian influences. These have not been examined in a population sample. : Multivariable regression models were used to test the associations between combinations of sleep duration (short [≤6 h], adequate [7-8 h], long [≥9 h]) and morning/evening preference (morning, somewhat morning, somewhat evening, evening) with the cardiovascular risk factors of tobacco use, physical inactivity, high sedentary behaviour, obesity/overweight and eating fewer than 5 daily servings of fruit and vegetables, in a cross-sectional sample of 439 933 adults enrolled in the United Kingdom Biobank project...
March 27, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28371363/diurnal-expression-of-proteins-in-the-retina-of-the-blind-cone-rod-homeobox-crx-mouse-and-the-129-sv-mouse-a-proteomic-study
#18
Morten Møller, Martin Fredensborg Rath, Maja Ludvigsen, Bent Honoré, Henrik Vorum
PURPOSE: The vertebrate retina contains a circadian clock participating in adaptations to day and night vision. This peripheral clock is independent of the master clock in the suprachiasmatic nucleus (SCN). The retinal clock is located in several cell types, including the photoreceptors. To investigate the role of the circadian clock of the photoreceptor cells in regulation of retinal protein rhythms, we analysed diurnal protein expression in the photoreceptor-deficient cone-rod homeobox knockout mouse (Crx(-/-) ) and the 129/Sv mouse...
March 28, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28364486/genetic-basis-of-chronotype-in-humans-insights-from-three-landmark-gwas
#19
David A Kalmbach, Logan D Schneider, Joseph Cheung, Sarah J Bertrand, Thiruchelvam Kariharan, Allan I Pack, Philip R Gehrman
Study Objectives: Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred timing of sleep and wake. As variations in circadian timing and system perturbations are linked to disease development, the fundamental biology of chronotype has received attention for its role in the regulation and dysregulation of sleep and related illnesses. Family studies indicate that chronotype is a heritable trait, thus directing attention toward its genetic basis...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28333924/csl-encodes-a-leucine-rich-repeat-protein-implicated-in-red-violet-light-signaling-to-the-circadian-clock-in-chlamydomonas
#20
Ayumi Kinoshita, Yoshimi Niwa, Kiyoshi Onai, Takashi Yamano, Hideya Fukuzawa, Masahiro Ishiura, Takuya Matsuo
The green alga Chlamydomonas reinhardtii shows various light responses in behavior and physiology. One such photoresponse is the circadian clock, which can be reset by external light signals to entrain its oscillation to daily environmental cycles. In a previous report, we suggested that a light-induced degradation of the clock protein ROC15 is a trigger to reset the circadian clock in Chlamydomonas. However, light signaling pathways of this process remained unclear. Here, we screened for mutants that show abnormal ROC15 diurnal rhythms, including the light-induced protein degradation at dawn, using a luciferase fusion reporter...
March 2017: PLoS Genetics
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