Julien De Wolf, Carla Gouin, Luc Jouneau, Matthieu Glorion, Antoine Premachandra, Florentina Pascale, Maxime Huriet, Jérôme Estephan, Jean-Jacques Leplat, Giorgia Egidy, Christophe Richard, Valérie Gelin, Céline Urien, Antoine Roux, Morgan Le Guen, Isabelle Schwartz-Cornil, Edouard Sage
Ex-vivo lung perfusion (EVLP) has extended the number of transplantable lungs by reconditioning marginal organs. However, EVLP is performed at 37°C without homeostatic regulation leading to metabolic wastes' accumulation in the perfusate and, as a corrective measure, the costly perfusate is repeatedly replaced during the standard of care procedure. As an interesting alternative, a hemodialyzer could be placed on the EVLP circuit, which was previously shown to rebalance the perfusate composition and to maintain lung function and viability without appearing to impact the global gene expression in the lung...
2024: Frontiers in Immunology