Dominique M Bovée, Estrellita Uijl, David Severs, Eloisa Rubio-Beltrán, Richard van Veghel, Antoinette Maassen van den Brink, Jaap A Joles, Robert Zietse, Catherina A Cuevas, A H Jan Danser, Ewout J Hoorn
Chronic kidney disease contributes to hypertension, but the mechanisms are incompletely understood. To address this, we applied the 5/6th nephrectomy rat model to characterize hypertension and the response to dietary salt and renin-angiotensin inhibition. 5/6th nephrectomy caused low-renin, salt-sensitive hypertension with hyperkalemia and unsuppressed aldosterone. Compared with sham rats, 5/6th nephrectomized rats had lower Na+ /H+ exchanger isoform 3, Na+ -K+ -2Cl- cotransporter, Na+ -Cl- cotransporter, α-epithelial Na+ channel (ENaC), and Kir4...
April 1, 2021: American Journal of Physiology. Renal Physiology