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JOURNAL ARTICLE
Chandan Kumar Jha
Abnormal cardiac functionality produces irregular heart rhythms which are commonly known as arrhythmias. In some conditions, arrhythmias are treated as very dangerous which may lead to sudden cardiac arrest. The incidence and prevalence of cardiac anomalies seeks early detection of arrhythmias using automated classification techniques. In the past, numerous automated arrhythmia detection techniques have been developed that are based on electrocardiogram (ECG) signal analysis. Focusing on the prospective research in this field, this article reports a comprehensive review of existing techniques that are obtained using search engines such as IEEE explore, Google scholar and science direct...
April 2, 2024: Computer Methods in Biomechanics and Biomedical Engineering
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JOURNAL ARTICLE
Gregory Acampora, Yi Zhang
We report a 30-case series from the Pain Management Center at the Massachusetts General Hospital where we have applied a guideline to convert chronic treatment for pain from full agonist opioids (FAO) to buprenorphine (BUP). Of the patients, 24 (80 percent) elected to continue BUP over FAO. Five conversions were stopped for side effects (fatigue) and/or lack of sufficient pain reduction. One patient elected not to participate on the day that the conversion was to begin. There were no major adverse events. We conclude that conversion to BUP should be considered as an alternative to treat patients on chronic opioids for pain...
2024: Journal of Opioid Management
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JOURNAL ARTICLE
Jun Zhao, Yujie Feng, Guang-Wei Liu
OBJECTIVE: The primary objective of this paper is to investigate the research hotspots and future trends of immune-related adverse events induced by immune checkpoint inhibitors, offering valuable insights for researchers in this field. METHODOLOGY: Using the visual analysis software, this study conducted quantitative statistics and visualization research on the relevant literature concerning immune-related adverse events caused by immune checkpoint inhibitors in the Web of Science Core Collection Database...
March 30, 2024: Heliyon
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JOURNAL ARTICLE
A deep learning approach using an ensemble model to autocreate an image-based hip fracture registry.
Jacobien H F Oosterhoff, Soomin Jeon, Bardiya Akhbari, David Shin, Daniel G Tobert, Synho Do, Soheil Ashkani-Esfahani
OBJECTIVES: With more than 300,000 patients per year in the United States alone, hip fractures are one of the most common injuries occurring in the elderly. The incidence is predicted to rise to 6 million cases per annum worldwide by 2050. Many fracture registries have been established, serving as tools for quality surveillance and evaluating patient outcomes. Most registries are based on billing and procedural codes, prone to under-reporting of cases. Deep learning (DL) is able to interpret radiographic images and assist in fracture detection; we propose to conduct a DL-based approach intended to autocreate a fracture registry, specifically for the hip fracture population...
December 2023: OTA international: the open access journal of orthopaedic trauma
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JOURNAL ARTICLE
Divyansh Agarwal, Tina Bharani, Wynne Armand, Jonathan E Slutzman, John T Mullen
BACKGROUND: As the US healthcare sector contributes to 5-10% of national CO2 emissions, with a substantial contribution from surgical services, a collective effort is important to minimize the climate footprint of surgery. Solid plastic waste generated from single-use items in operating rooms is a major contributor to greenhouse gas emissions. To address this problem, we implemented a pilot study to replace single-use scrub caps with reusable caps. METHODS: Ninety-two surgical trainees at the Massachusetts General Hospital, Boston, were provided reusable personalized scrub caps...
September 14, 2023: Langenbeck's Archives of Surgery
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JOURNAL ARTICLE
Benjamin Steinhorn, Jeanine Wiener-Kronish
BACKGROUND: Use of sodium-glucose transporter-2 (SGLT2) inhibitors has dramatically increased over the past decade. This medication class predisposes patients to euglycaemic diabetic ketoacidosis, particularly during times of physiologic stress, including fasting and surgery. Beyond case reports and series, a systematic description of perioperative metabolic effects of SGLT2 inhibitors is lacking. METHODS: We examined the degree of anion gap acidosis, controlling for non-ketone anions, in patients undergoing surgery at Massachusetts General Hospital in 2016-22...
October 2023: British Journal of Anaesthesia
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JOURNAL ARTICLE
Philipp Karschnia, Isabel C Arrillaga-Romany, April Eichler, Deborah A Forst, Elizabeth Gerstner, Justin T Jordan, Ina Ly, Scott R Plotkin, Nancy Wang, Maria Martinez-Lage, Sebastian F Winter, Joerg-Christian Tonn, Kai Rejeski, Louisa von Baumgarten, Daniel P Cahill, Brian V Nahed, Ganesh M Shankar, Jeremy S Abramson, Jeffrey A Barnes, Areej El-Jawahri, Ephraim P Hochberg, P Connor Johnson, Jacob D Soumerai, Ronald W Takvorian, Yi-Bin Chen, Matthew J Frigault, Jorg Dietrich
BACKGROUND: Chimeric antigen receptor (CAR) T-cells targeting CD19 have been established as a leading engineered T-cell therapy for B-cell lymphomas; however, data for patients with central nervous system (CNS) involvement are limited. METHODS: We retrospectively report on CNS-specific toxicities, management, and CNS response of 45 consecutive CAR T-cell transfusions for patients with active CNS lymphoma at the Massachusetts General Hospital over a five-year period...
July 4, 2023: Neuro-oncology
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JOURNAL ARTICLE
Justin C McCarty, Roberto Lorenzi-Mendez, Seth Fruge, Ryoko Hamaguchi, Amy S Colwell
BACKGROUND: Patients seeking cosmetic abdominoplasty often have umbilical hernias. Optimal management and safety of concomitant umbilical hernia repair with abdominoplasty is not well described. OBJECTIVES: The goal of this study was to compare complication rates following abdominoplasty with or without umbilical hernia repair. METHODS: A retrospective propensity score-matched cohort study of patients who underwent an abdominoplasty at Massachusetts General Hospital was performed...
June 2, 2023: Aesthetic Surgery Journal
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JOURNAL ARTICLE
Dan Feldman, Linda Rodgers-Fouche, Stephanie Hicks, Daniel C Chung
BACKGROUND: Colonic adenomatous polyposis of unknown etiology (CPUE) is an adenomatous polyposis phenotype that resembles Familial Adenomatous Polyposis (FAP) even though no germline pathogenic variant is identified. AIM: We sought to better characterize the clinical features and outcomes in a cohort of CPUE patients. METHODS: This is a retrospective case series of patients 18 years old or older with aden-omatous oligopolyposis (between 10-100 adenomas) and negative genetic testing, identified through the Hereditary Gastrointestinal Cancer Database at Massachusetts General Hospital, a tertiary academic referral center...
December 28, 2022: World Journal of Gastroenterology: WJG
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JOURNAL ARTICLE
Lael M Yonker, Zoe Swank, Yannic C Bartsch, Madeleine D Burns, Abigail Kane, Brittany P Boribong, Jameson P Davis, Maggie Loiselle, Tanya Novak, Yasmeen Senussi, Chi-An Cheng, Eleanor Burgess, Andrea G Edlow, Janet Chou, Audrey Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, Moshe Arditi, Boris Julg, Adrienne G Randolph, Galit Alter, Alessio Fasano, David R Walt
BACKGROUND: Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail. METHODS: From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General for Children or Boston Children's Hospital for myocarditis, presenting with chest pain with elevated cardiac troponin T after SARS-CoV-2 vaccination...
March 14, 2023: Circulation
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MULTICENTER STUDY
Andreas Charidimou, Gregoire Boulouis, Matthew P Frosch, Jean-Claude Baron, Marco Pasi, Jean Francois Albucher, Gargi Banerjee, Carmen Barbato, Fabrice Bonneville, Sebastian Brandner, Lionel Calviere, François Caparros, Barbara Casolla, Charlotte Cordonnier, Marie-Bernadette Delisle, Vincent Deramecourt, Martin Dichgans, Elif Gokcal, Jochen Herms, Mar Hernandez-Guillamon, Hans Rolf Jäger, Zane Jaunmuktane, Jennifer Linn, Sergi Martinez-Ramirez, Elena Martínez-Sáez, Christian Mawrin, Joan Montaner, Solene Moulin, Jean-Marc Olivot, Fabrizio Piazza, Laurent Puy, Nicolas Raposo, Mark A Rodrigues, Sigrun Roeber, Jose Rafael Romero, Neshika Samarasekera, Julie A Schneider, Stefanie Schreiber, Frank Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, Pascale Varlet, Alain Viguier, Joanna M Wardlaw, Andrew Warren, Frank A Wollenweber, Marialuisa Zedde, Mark A van Buchem, M Edip Gurol, Anand Viswanathan, Rustam Al-Shahi Salman, Eric E Smith, David J Werring, Steven M Greenberg
BACKGROUND: Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease, characterised pathologically by progressive deposition of amyloid β in the cerebrovascular wall. The Boston criteria are used worldwide for the in-vivo diagnosis of CAA but have not been updated since 2010, before the emergence of additional MRI markers. We report an international collaborative study aiming to update and externally validate the Boston diagnostic criteria across the full spectrum of clinical CAA presentations...
August 2022: Lancet Neurology
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JOURNAL ARTICLE
Rojan Varghese, Kaajal Patel, Heather Burke, Alexis Cohen-Oram, Shixie Jiang, Theodore A Stern
<AbstractText>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry...
May 12, 2022: Primary Care Companion to CNS Disorders
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REVIEW
Julie MacLean, Sara A Finkelstein, Sara Paredes-Echeverri, David L Perez, Jessica Ranford
Functional neurological disorder (FND) is a condition at the intersection of neurology and psychiatry, with some patients experiencing sensory hypersensitivities and other sensory processing difficulties. It has been postulated that poor integration and modulation of sensory information with cognitive, affective and behavioral processes may play a role in the pathophysiology of FND. In this article, we first succinctly review the role for occupational therapy (OT) in the multidisciplinary therapeutic approach to managing patients with FND...
April 2022: Seminars in Pediatric Neurology
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JOURNAL ARTICLE
Johannes F Scheid, Matthew W Rosenbaum, Eric M Przybyszewski, Kumar Krishnan, David G Forcione, Anthony J Iafrate, Kyle D Staller, Joseph Misdraji, Jochen K Lennerz, Martha Bishop Pitman, Daniel S Pratt
BACKGROUND: Primary sclerosing cholangitis (PSC) is a well-described risk factor for the development of cholangiocarcinoma (CCA). Early detection of CCA in these patients is of great importance because it expands options for therapeutic interventions, including liver transplantation. Current diagnostic tests for the evaluation of biliary strictures are limited to biliary brushing (BB) cytology and fluorescence in situ hybridization (FISH). Next-generation sequencing (NGS) has become an important diagnostic tool in oncology and may be a useful tool for diagnosing CCA on BBs...
March 2022: Cancer Cytopathology
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JOURNAL ARTICLE
A L Akabane, G P Smith
BACKGROUND: Because typical and atypical features of small fibre polyneuropathy (SFN) in the skin have not been fully elucidated, the diagnosis is often made by the exclusion of alternative conditions rather than by its identification as a primary syndrome. OBJECTIVE: The objective of this study was to characterize dermatologic manifestations in patients with SFN. METHODS: Large retrospective series of biopsy-proven SFN cases seen at the Massachusetts General Hospital and Brigham and Women's Hospital (January 2000 to December 2019)...
January 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
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JOURNAL ARTICLE
Nathan H Raines, Matthew D Cheung, Landon S Wilson, Jeffrey C Edberg, Nathaniel B Erdmann, Alec A Schmaier, Taylor F Berryhill, Zachary Manickas-Hill, Jonathan Z Li, Xu G Yu, Anupam Agarwal, Stephen Barnes, Samir M Parikh
INTRODUCTION: Acute kidney injury (AKI) is common in COVID-19 and associated with increased morbidity and mortality. We investigated alterations in the urine metabolome to test the hypothesis that impaired nicotinamide adenine dinucleotide (NAD+ ) biosynthesis and other deficiencies in energy metabolism in the kidney, previously characterized in ischemic, toxic, and inflammatory etiologies of AKI, will be present in COVID-19-associated AKI. METHODS: This is a case-control study among the following 2 independent populations of adults hospitalized with COVID-19: a critically ill population in Boston, Massachusetts, and a general population in Birmingham, Alabama...
December 2021: KI Reports
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JOURNAL ARTICLE
Vartan Pahalyants, William S Murphy, Nicole S Gunasekera, Shinjita Das, Elena B Hawryluk, Daniela Kroshinsky
BACKGROUND: Although dermatologic complaints are frequently encountered by pediatricians, access to pediatric dermatologists remains limited. Teledermatology has been proposed to expand access to dermatologic care for children. We report our experience with a physician-to-physician store-and-forward teledermatology service (eConsults), focusing on patient and consult characteristics and their relationship with teledermatologist confidence and follow-up recommendations as well as clinical outcomes...
September 2021: Pediatric Dermatology
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JOURNAL ARTICLE
Adele C Viguera, Marlene P Freeman, Lina Góez-Mogollón, Alexandra Z Sosinsky, Sara A McElheny, Taylor R Church, Amanda V Young, Phoebe S Caplin, David Chitayat, Sonia Hernández-Díaz, Lee S Cohen
Objective: Second-generation antipsychotics (SGAs) are prescribed for a wide range of indications in women of reproductive age. The National Pregnancy Registry for Atypical Antipsychotics (NPRAA) was established to determine the risk of major malformations among infants exposed to these medications during the first trimester relative to a comparison group of unexposed infants of mothers with histories of psychiatric morbidity. Methods: Women, aged 18-45 years, with histories of psychiatric illness were prospectively followed through pregnancy and during the postpartum period...
August 3, 2021: Journal of Clinical Psychiatry
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JOURNAL ARTICLE
Reza Zonozi, Karen Laliberte, Noah R Huizenga, Jillian K Rosenthal, Anushya Jeyabalan, A Bernard Collins, Frank B Cortazar, John L Niles
RATIONALE & OBJECTIVE: B-cell depletion with rituximab has emerged as a first-line therapy for primary membranous nephropathy (MN). However, most patients do not achieve complete remission with rituximab monotherapy. In this case series, we report longer-term remission and relapse rates, anti-phospholipase A2 receptor (PLA2 R) antibody levels, B-cell levels, and serious adverse events in patients with primary MN who received rituximab combined with an initial short course of low-dose oral cyclophosphamide and a course of rapidly tapered prednisone...
December 2021: American Journal of Kidney Diseases
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JOURNAL ARTICLE
Alyssa M Peckham, Laura G Kehoe, Jessica R Gray, Sarah E Wakeman
BACKGROUND: In clinical trial settings, extended-release buprenorphine (XR-BUP) is noninferior to sublingual buprenorphine and may offer some advantages. However, real-world experiences of XR-BUP are limited and outcomes are unknown for low-threshold clinics with high-risk populations. Practical guidance is lacking on overcoming treatment challenges, such as inability for some to stabilize on sublingual (SL) BUP for seven days prior to XR-BUP and ongoing craving/withdrawal symptoms during treatment...
July 2021: Journal of Substance Abuse Treatment
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