Fang Chen, Hao Yu, Hong Zhang, Yaqing Nong, Qian Wang, Haiman Jing, Ying Han, Junjie Wu, Zheng Zhou, Li Yang, Zhiyuan Xu, Yaya Liu, Pingfu Fu, Jian-Yue Jin, Victor Hsue, Amy Chang, Feng-Ming Spring Kong
BACKGROUND: This study aimed to investigate radiation-induced lymphopenia and its potential risk factors in patients with breast cancer receiving adjuvant radiotherapy. METHODS: Breast cancer patients received adjuvant radiotherapy (RT) at our hospital with peripheral lymphocyte counts (PLC) at pre-and immediately after RT (post-RT) were eligible. The primary endpoints were any grade of lymphopenia post-RT and nadir-PLC/pre-PLC <0.8. Patient characteristics, tumor factors, and treatment factors were collected for risk assessment...
August 2021: Annals of Translational Medicine