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Cristina Garibaldi, Cristiana Fodor, Giulia Riva, Damaris Patricia Rojas, Samantha Dicuonzo, Elisa Pace, Giuseppe Fanetti, Paolo De Marco, Veronica Dell'acqua, Giulia Marvaso, Maria Cristina Leonardi, Roberta Lazzari, Federica Cattani, Marta Cremonesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
PURPOSE: To evaluate inter-fraction tumor localization errors (TE) in the RapidArc® treatment of pelvic cancers based on CBCT. Appropriate CTV-to PTV margins in a non-IGRT scenario have been proposed. METHODS: Data of 928 patients with prostate, gynecological, and rectum/anal canal cancers were retrospectively analyzed to determine systematic and random localization errors. Two protocols were used: daily online IGRT (d-IGRT) and weekly IGRT. The latter consisted in acquiring a CBCT for the first 3 fractions and subsequently once a week...
February 2018: Physica Medica: PM
H T Sun, R J Yang, P Jiang, W J Jiang, J N Li, N Meng, J J Wang
OBJECTIVE: To compare the dosimetric differences between volumetric modulated arc therapy and intensity modulated radiotherapy for breast cancer patients after breast-conserving surgery. METHODS: Ten patients who received radiotherapy after breast-conserving surgery were selected. Eclipse planning system was used to design volumetric rotating intensity-modulated (2F-RapidArc) and two field intensity-modulated radiation therapy (2F-IMRT) planning for each patient...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Tuomas Koivumäki, Antonella Fogliata, Michele Zeverino, Eeva Boman, Joanna Sierpowska, Raphaël Moeckli, Véronique Vallet, Luca Cozzi, Janne Heikkilä, Anssi Väänänen, Kristiina Vuolukka, Saara Sillanmäki, Jan Seppälä
PURPOSE: The dosimetric differences between four radiation therapy techniques for left sided whole breast irradiation were evaluated side by side in the same patient population. METHODS: Radiotherapy treatment plans were retrospectively created with Accuray TomoDirect (TD), Elekta Volumetric Modulated Arc Therapy (E-VMAT), Varian RapidArc (RA) and Field-in-field (FinF) technique for 20 patients, who had received left breast irradiation during deep-inspiration breath-hold...
January 2018: Physica Medica: PM
Karim Mashhour, Maha Kamaleldin, Wedad Hashem
Purpose: The aim of this study was to dosimetrically evaluate and compare double arc RapidArc (RA) with conventional IMRT (7 fields) plans for irradiation of locally advanced head and neck cancers (LAHNC), focusing on target coverage and doses received by organs at risk (OAR). Methods: Computed tomography scans of 20 patients with LAHNC were obtained. Contouring of the target volumes and OAR was done. Two plans were made for each patient, one using IMRT and the other double arc RA, and calculated doses to planning target volume (PTV) and OAR were compared...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Aileen Duffton, Azmat Sadozye, Lynsey Devlin, Nicholas MacLeod, Carolynn Lamb, Suzanne Currie, Philip McLoone, Marimuthu Sankaralingam, John Foster, Stephanie Paterson, Stefanie Keatings, David Dodds
OBJECTIVE: To investigate feasibility and safety of stereotactic ablative radiotherapy in the management of prostate cancer while employing MR/CT fusion for delineation, fiducial marker seeds for positioning and Varian RapidArc with flattening filter free (FFF) delivery. METHODS: 41 patients were treated for low-intermediate risk prostate cancer with initial prostate-specific antigen of ≤20 ng ml-1, Gleason score 6-7. Patients had MR/CT fusion for delineation of prostate ±seminal vesicles...
February 1, 2018: British Journal of Radiology
Siddhartha Laskar, Avinash Pilar, Nehal Khanna, Yogesh Ghadi
Purpose: To report an innovative technique of interstitial brachytherapy developed for treatment of orbital soft tissue tumors. Material and methods: A 4-month-old child diagnosed with rhabdomyosarcoma of orbit was treated with multiagent chemotherapy (CTh) and brachytherapy. Pre-planning computed tomography (CT) images were obtained and clinical target volume (CTV) was defined using the pre-treatment magnetic resonance imaging (MRI). Brachytherapy plan was generated for deciding optimal catheter placement...
October 2017: Journal of Contemporary Brachytherapy
Arun Chairmadurai, Harish Chandra Goel, Sandeep Kumar Jain, Pawan Kumar
This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose-volume parameters...
December 2017: Radiological Physics and Technology
Maha Kamaleldin, Nader A Elsherbini, Wael M Elshemey
The aim of this study is to evaluate the impact of anisotropic analytical algorithm (AAA) and 2 reporting systems (AXB-Dm and AXB-Dw) of Acuros XB algorithm (AXB) on clinical plans of nasopharyngeal patients using intensity-modulated radiotherapy (IMRT) and RapidArc (RA) techniques. Six plans of different algorithm-technique combinations are performed for 10 patients to calculate dose-volume histogram (DVH) physical parameters for planning target volumes (PTVs) and organs at risk (OARs). The number of monitor units (MUs) and calculation time are also determined...
September 27, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Jean-Emmanuel Bibault, Sophie Dussart, Pascal Pommier, Magali Morelle, Marius Huguet, Pierre Boisselier, Bernard Coche-Dequeant, Marc Alfonsi, Etienne Bardet, Michel Rives, Valentin Calugaru, Enrique Chajon, Georges Noel, Hinda Mecellem, Stephanie Servagi Vernat, Lionel Perrier, Philippe Giraud
PURPOSE: The Advanced Radiotherapy Oto-Rhino-Laryngologie (ART-ORL) study (NCT02024035) was performed to prospectively evaluate the clinical and economic aspects of helical TomoTherapy and volumetric modulated arc therapy (RapidArc, Varian Medical Systems, Palo Alto, CA) for patients with head and neck cancer. METHODS AND MATERIALS: Fourteen centers participated in this prospective comparative study. Randomization was not possible based on the availability of equipment...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
Ju-Young Song, Jae-Uk Jeong, Mee Sun Yoon, Sung-Ja Ahn, Woong-Ki Chung, Taek-Keun Nam
The dosimetric characteristics of MobiusFX, which uses the treatment machine log file to calculate the dose inside the patient body, were analyzed for use in the RapidArc delivery quality assurance (DQA) process. The accuracy and usefulness of MobiusFX in clinical cases was evaluated by comparing the dose calculated by MobiusFX with that calculated by the conventional measurement dose based program, 3DVH. The results of gamma evaluation with three different criteria (3%-3 mm, 4%-3 mm, 5%-3 mm) were analyzed, and the dose changes were calculated while simulating variable position errors (6 mm, 3 mm) and dosimetric output increases (6%, 3%)...
2017: PloS One
Gabriella Macchia, Francesco Deodato, Savino Cilla, Silvia Cammelli, Alessandra Guido, Martina Ferioli, Giambattista Siepe, Vincenzo Valentini, Alessio Giuseppe Morganti, Gabriella Ferrandina
AIM: This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified...
2017: OncoTargets and Therapy
Carolin Schubert, Oliver Waletzko, Christian Weiss, Dirk Voelzke, Sevda Toperim, Arnd Roeser, Silvia Puccini, Marc Piroth, Christian Mehrens, Jan-Dirk Kueter, Kirsten Hierholz, Karsten Gerull, Antonella Fogliata, Andreas Block, Luca Cozzi
PURPOSE: To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy applied to prostate cancer in a multicentric cooperative group. The RapidPlan (RP) knowledge-based engine was tested for the planning of Volumetric modulated arc therapy with RapidArc on prostate cancer patients. The study was conducted in the frame of the German RapidPlan Consortium (GRC). METHODS AND MATERIALS: 43 patients from one institute of the GRC were used to build and train a RP model...
2017: PloS One
Carmen Llacer-Moscardo, Olivier Riou, David Azria, Ludovic Bedos, Norbert Ailleres, Francois Quenet, Philippe Rouanet, Marc Ychou, Pascal Fenoglietto
BACKGROUND: Motion management is a major challenge in abdominal SBRT. We present our study of SBRT for liver tumors using intrafraction motion review (IMR) allowing simultaneous KV information and MV delivery to synchronize the beam during gated RapidArc treatment. MATERIALS AND METHODS: Between May 2012 and March 2015, 41 patients were treated by liver SBRT using gated RapidArc technique in a Varian Novalis Truebeam STx linear accelerator. PTV was created by expanding 5 mm from the ITV...
March 2017: Reports of Practical Oncology and Radiotherapy
A Fogliata, G Reggiori, A Stravato, F Lobefalo, C Franzese, D Franceschini, S Tomatis, P Mancosu, M Scorsetti, L Cozzi
BACKGROUND: To evaluate a knowledge based planning model for RapidPlan (RP) generated for advanced head and neck cancer (HNC) patient treatments, as well its ability to possibly improve the clinical plan quality. The stability of the model was assessed also for a different beam geometry, different dose fractionation and different management of bilateral structures (parotids). METHODS: Dosimetric and geometric data from plans of 83 patients presenting HNC were selected for the model training...
April 27, 2017: Radiation Oncology
Sun Hyun Bae, Mi-Sook Kim, Won Il Jang, Kum Bae Kim, Kwang Hwan Cho, Woo Chul Kim, Chang Yeol Lee, Eun Seog Kim, Chul Won Choi, A Ram Chang, Sunmi Jo, Jin-Young Kim
Objective: The Korean Radiation Oncology Group (12-02) investigated the outcome of stereotactic ablative radiotherapy for hepatocellular carcinoma ≤5 cm using 60 Gy in three fractions. To evaluate dosimetric differences and compliance in a multicenter trial, a planning dummy run procedure was performed. Methods: All six participating institutions were provided the contours of two dummy run cases. Plans were performed following the study protocol to cover the planning target volume with a minimum of 90% of the prescription dose and to satisfy the constraints for organs at risk...
June 1, 2017: Japanese Journal of Clinical Oncology
Elisabetta Cagni, Andrea Botti, Renato Micera, Maria Galeandro, Roberto Sghedoni, Matteo Orlandi, Cinzia Iotti, Luca Cozzi, Mauro Iori
PURPOSE: Helical Tomotherapy (HT) plans were used to create two RapidPlan knowledge-based (KB) models to generate plans with different techniques and to guide the optimization in a different treatment planning system for prostate plans. Feasibility and performance of these models were evaluated. MATERIAL AND METHODS: two sets of 35 low risk (LR) and 30 intermediate risk (IR) prostate cancer cases who underwent HT treatments were selected to train RapidPlan models...
April 2017: Physica Medica: PM
Hajime Monzen, Kazuki Kubo, Mikoto Tamura, Masaru Hayakawa, Yasumasa Nishimura
We developed a novel low-radiation-absorbent lok-bar (HM-bar) that is used to secure the immobilizers to the couch. The aim of this study was to investigate the X-ray scattering and absorption properties of the HM-bar in computed tomography (CT) simulation and radiotherapy dose delivery using the Varian Exact™ lok-bar (VL-bar) as a benchmark. CT images were obtained with or without lok-bar, and then each image was visually evaluated for artifacts. The attenuation rates for each lok-bar were measured using a farmer-type ionization chamber (PTW30013) and the I'mRT phantom (IBA Dosimetry GmbH)...
April 6, 2017: Journal of Applied Clinical Medical Physics
Sarah Differding, Edmond Sterpin, Nicolas Hermand, Bianca Vanstraelen, Sandra Nuyts, Nathalie de Patoul, Jean-Marc Denis, John Aldo Lee, Vincent Grégoire
PURPOSE: Validation of dose escalation through FDG-PET dose painting (DP) for oropharyngeal squamous cell carcinoma (SCC) requires randomized clinical trials with large sample size, potentially involving different treatment planning and delivery systems. As a first step of a joint clinical study of DP, a planning comparison was performed between Tomotherapy HiArt® (HT) and Varian RapidArc® (RA). METHODS: The planning study was conducted on five patients with oropharyngeal SCC...
March 23, 2017: Radiation Oncology
Chockkalingam Krishnappan, Chandrasekaran Anu Radha, Vendhan Subramani, Madhan Kumar Gunasekaran
The purpose of this study is to evaluate the degree of dose distribution distortion in advanced treatments like IMRT and RapidArc when patient plans are swapped across dosimetrically equivalent so-called "beam-matched" machines. For this purpose the entire work is divided into two stages. At forefront stage all basic beam properties of 6 MV X-rays like PDD, profiles, output factors, TPR20/10 and MLC transmission of two beam-matched machines - Varian Clinac iX and Varian 600 C/D Unique - are compared and evaluated for differences...
September 2016: Journal of Applied Clinical Medical Physics
Ilma Xhaferllari, Omar El-Sherif, Stewart Gaede
Volumetric-modulated arc therapy (VMAT) is emerging as a leading technology in treating early-stage, non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR). However, two other modalities capable of delivering intensity-modulated radiation therapy (IMRT) include fixed-beam and helical TomoTherapy (HT). This study aims to provide an extensive dosimetric comparison among these various IMRT techniques for treating early-stage NSCLC with SABR. Ten early-stage NSCLC patients were retrospectively optimized using three fixed-beam techniques via nine to eleven beams (high and low modulation step-and-shoot (SS), and sliding window (SW)), two VMAT techniques via two partial arcs (SmartArc (SA) and RapidArc (RA)), and three HT techniques via three different fan beam widths (1 cm, 2...
September 2016: Journal of Applied Clinical Medical Physics
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