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https://www.readbyqxmd.com/read/29350084/exploring-assistive-technology-use-to-support-cognition-in-college-students-with-histories-of-mild-traumatic-brain-injury
#1
Jessica Brown, Madeline Wollersheim
PURPOSE: College students with mild traumatic brain injury (mTBI) may experience chronic cognitive deficits necessitating use of external supports for daily task completion. The purpose of this study was to explore cognitive support system selection and use by students with histories of mTBI when completing novel prospective memory tasks. MATERIALS AND METHODS: We implemented a multiple case study, sequential explanatory mixed-methods design with three participants...
January 19, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29346599/magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-for-the-treatment-of-hypothalamic-hamartomas-a-retrospective-review
#2
David S Xu, Tsinsue Chen, Randall J Hlubek, Ruth E Bristol, Kris A Smith, Francisco A Ponce, John F Kerrigan, Peter Nakaji
BACKGROUND: Hypothalamic hamartomas (HH) are rare lesions associated with treatment-resistant epilepsy. Open surgery results in modest seizure control (about 50%) but has a significant associated morbidity. Radiosurgery is limited to a subset of patients due to latent therapeutic effects. Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) offers a novel minimally invasive option. OBJECTIVE: To evaluate a single center's outcomes for the LITT treatment of HH...
January 13, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29343447/altered-b-lymphocyte-homeostasis-and-functions-in-systemic-sclerosis
#3
REVIEW
Alexandra Forestier, Thomas Guerrier, Mathieu Jouvray, Jonathan Giovannelli, Guillaume Lefèvre, Vincent Sobanski, Carine Hauspie, Eric Hachulla, Pierre-Yves Hatron, Hélène Zephir, Patrick Vermersch, Myriam Labalette, David Launay, Sylvain Dubucquoi
Beyond the production of autoantibodies, B-cells are thought to play a role in systemic sclerosis (SSc) by secreting proinflammatory/profibrotic cytokines. B-cells are a heterogeneous population with different subsets distinguished by their phenotypes and cytokine production. Data about B-cell subsets, cytokine production and intracellular pathways leading to this production are scarce in SSc. The aim of our study was to describe B-cell homeostasis, activation, proliferation, cytokine production in B-cells and serum and B-cell intracellular signaling pathways in SSc...
January 14, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29340943/a-prospective-investigation-of-rumination-and-executive-control-in-predicting-overgeneral-autobiographical-memory-in-adolescence
#4
Tracy M Stewart, Simon C Hunter, Sinéad M Rhodes
The CaR-FA-X model (Williams et al., 2007), or capture and rumination (CaR), functional avoidance (FA), and impaired executive control (X), is a model of overgeneral autobiographical memory (OGM). Two mechanisms of the model, rumination and executive control, were examined in isolation and in interaction in order to investigate OGM over time. Across two time points, six months apart, a total of 149 adolescents (13-16 years) completed the minimal-instruction autobiographical memory test, a measure of executive control with both emotional and nonemotional stimuli, and measures of brooding rumination and reflective pondering...
January 16, 2018: Memory & Cognition
https://www.readbyqxmd.com/read/29338860/learning-curve-of-image-guided-video-assisted-thoracoscopic-surgery-for-small-pulmonary-nodules-a-prospective-analysis-of-30-initial-patients
#5
Ming-Ju Hsieh, Chih-Tsung Wen, Hsin-Yueh Fang, Yu-Wen Wen, Chien-Cheng Lin, Yin-Kai Chao
OBJECTIVES: The use of image-guided video-assisted thoracoscopic surgery for simultaneous localization and removal of small solitary pulmonary nodules in a hybrid operation room using C-arm cone-beam computed tomography is gaining momentum. We sought to assess the effect of the learning curve on procedural parameters and clinical outcomes of image-guided video-assisted thoracoscopic surgery for treating patients with small solitary pulmonary nodules. METHODS: Clinical variables and treatment outcomes of the 30 initial patients with solitary pulmonary nodules who were treated with image-guided video-assisted thoracoscopic surgery at Chang Gung Memorial Hospital (Taiwan) were prospectively analyzed...
December 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29336281/naive-and-effector-b-cell-subtypes-are-increased-in-chronic-rhinosinusitis-with-polyps
#6
Dijana Miljkovic, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Recent studies demonstrated that B cells and their chemoattractants are elevated in the nasal mucosa of patients with chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP). However, the presence of naive B cells and of plasmablasts and memory B-cell subsets in the mucosa and periphery of the same patient with CRS is yet to be characterized. OBJECTIVE: Here we sought to quantify naive, plasmablasts, and memory B cells in mucosal tissue and peripheral blood of patients with CRSwNP, patients with CRS without nasal polyps (CRSsNP), and control patients...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336125/association-of-chronic-subjective-tinnitus-with-neuro-cognitive-performance
#7
Sunita Gudwani, Sanjay K Munjal, Naresh K Panda, Adarsh Kohli
INTRODUCTION: Chronic subjective tinnitus is associated with cognitive disruptions affecting perception, thinking, language, reasoning, problem solving, memory, visual tasks (reading) and attention. OBJECTIVE: To evaluate existence of any association between tinnitus parameters and neuropsychological performance to explain cognitive processing. MATERIALS AND METHODS: Study design was prospective, consisting 25 patients with idiopathic chronic subjective tinnitus and gave informed consent before planning their treatment...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29335604/dentate-network-activity-is-necessary-for-spatial-working-memory-by-supporting-ca3-sharp-wave-ripple-generation-and-prospective-firing-of-ca3-neurons
#8
Takuya Sasaki, Verónica C Piatti, Ernie Hwaun, Siavash Ahmadi, John E Lisman, Stefan Leutgeb, Jill K Leutgeb
Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while rats performed a dentate-dependent working memory task on an eight-arm radial maze revealed that the activity of dentate neurons and the incidence rate of SWRs both increased during reward consumption. We then found reduced reward-related CA3 SWR generation without direct input from dentate granule neurons...
January 15, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29331060/regional-hippocampal-vulnerability-in-early-multiple-sclerosis-dynamic-pathological-spreading-from-dentate-gyrus-to-ca1
#9
Vincent Planche, Ismail Koubiyr, José E Romero, José V Manjon, Pierrick Coupé, Mathilde Deloire, Vincent Dousset, Bruno Brochet, Aurélie Ruet, Thomas Tourdias
BACKGROUND: Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate. METHOD: We prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1-year longitudinal study, together with 55 matched healthy controls at baseline. Participants were tested for memory performance and scanned with 3 T MRI to assess the volume of 5 distinct hippocampal subfields using automatic segmentation techniques...
January 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29329293/cognitive-deficits-and-educational-loss-in-children-with-schistosome-infection-a-systematic-review-and-meta-analysis
#10
Amara E Ezeamama, Amaya L Bustinduy, Allan K Nkwata, Leonardo Martinez, Noel Pabalan, Michael J Boivin, Charles H King
BACKGROUND: By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits. METHODOLOGY/PRINCIPAL FINDINGS: This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29327312/examining-the-prospective-relationship-between-pre-disaster-respiratory-sinus-arrhythmia-and-post-disaster-posttraumatic-stress-disorder-symptoms-in-children
#11
Amy J Mikolajewski, Michael S Scheeringa
Previous studies have examined the concurrent relationship between posttraumatic stress disorder (PTSD) and a range of psychophysiological variables, including respiratory sinus arrhythmia (RSA). However, there is a lack of research examining the prospective development of trauma symptomatology, and the directionality of the association between RSA level and PTSD has yet to be determined. The current study is the first prospective study to examine whether RSA level and RSA reactivity are risk factors for PTSD symptoms in children...
January 12, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29326289/prevalence-of-hippocampal-enlarged-perivascular-spaces-in-a-sample-of-patients-with-hypertension-and-their-relation-with-vascular-risk-factors-and-cognitive-function
#12
Joan Jiménez-Balado, Iolanda Riba-Llena, Edurne Garde, Marta Valor, Belen Gutiérrez, Francesc Pujadas, Pilar Delgado
OBJECTIVES: The clinical importance of hippocampal enlarged perivascular spaces (H-EPVS) remains uncertain. We aimed to study their association with vascular risk factors, cognitive function and mild cognitive impairment (MCI). METHODS: Data were obtained from the ISSYS (Investigating Silent Strokes in hYpertensives, a magnetic resonance imaging Study) cohort, which is a prospective study of patients with hypertension aged 50-70 with no prior stroke or dementia...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29324915/self-report-instruments-of-cognitive-failures-as-screening-tools-for-subjective-cognitive-impairment-in-older-adults
#13
Vasileios Papaliagkas, G Papantoniou, Magda Tsolaki, Despina Moraitou
BACKGROUND: The term "Subjective Cognitive Impairment (SCI)" is the most widely accepted term for cognitive complaints of otherwise apparently healthy older adults. It is presently clear that SCI might be a risk factor for the development of Mild Cognitive Impairment and dementia. As regards SCI measurement and potential diagnosis, several studies showed that SCI is a condition in which people score in the normal range on common tests but believe they experience cognitive decline. Hence, to assess the characteristic of the SCI subtle cognitive decline, self-report measures were developed to estimate "self-experience" of minimal decline in cognition seem the most appropriate tools...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324238/immunization-with-recombinant-flid-confers-protection-against-helicobacter-pylori-infection-in-mice
#14
Amir Ghasemi, Nazanin Mohammad, Josef Mautner, Mehrnaz Taghipour Karsabet, Abolfazl Ardjmand, Rezvan Moniri
Nearly half of the world's population is infected with Helicobacter pylori. Clinical manifestations of this infection range from gastritis and peptic ulcers to gastric adenocarcinoma and lymphoma. Due to the emerging of antibiotic resistant strains and poor patient compliance of the antibiotic therapy, there is increasing interest in the development of a protective vaccine against H. pylori infection. The bacterial protein FliD forms a capping structure on the end of each flagellum which is critical to prevent depolymerization and structural degradation...
January 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29319602/an-interactional-profile-to-assist-the-differential-diagnosis-of-neurodegenerative-and-functional-memory-disorders
#15
Markus Reuber, Daniel J Blackburn, Chris Elsey, Sarah Wakefield, Kerry A Ardern, Kirsty Harkness, Annalena Venneri, Danielle Jones, Chloe Shaw, Paul Drew
OBJECTIVE: Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behavior of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with functional memory disorder (FMD). METHODS: In part 1 of this study, a diagnostic scoring aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29318922/the-influence-of-emotional-cues-on-prospective-memory-a-systematic-review-with-meta-analyses
#16
Thomas J Hostler, Chantelle Wood, Christopher J Armitage
Remembering to perform a behaviour in the future, prospective memory, is essential to ensuring that people fulfil their intentions. Prospective memory involves committing to memory a cue to action (encoding), and later recognising and acting upon the cue in the environment (retrieval). Prospective memory performance is believed to be influenced by the emotionality of the cues, however the literature is fragmented and inconsistent. We conducted a systematic search to synthesise research on the influence of emotion on prospective memory...
January 10, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29318079/the-effect-of-an-in-hospital-comprehensive-geriatric-assessment-on-short-term-mortality-during-orthogeriatric-hip-fracture-program-which-patients-benefit-the-most
#17
Hanna M Pajulammi, Harri K Pihlajamäki, Tiina H Luukkaala, Janne J Jousmäki, Pekka H Jokipii, Maria S Nuotio
Aims: To examine the association of patient-related factors with the effect of an in-hospital comprehensive geriatric assessment (CGA) on hip fracture mortality. Methods: Population-based, prospective data were collected on 1425 consecutive hip fracture patients aged ≥65 in a central hospital providing orthogeriatric service. Outcome was mortality at 1 month after hip fracture associated with receiving versus not receiving CGA. Results: Of the patients receiving CGA compared to those who did not, 8...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29317593/loneliness-5-years-ante-mortem-is-associated-with-disease-related-differential-gene-expression-in-postmortem-dorsolateral-prefrontal-cortex
#18
Turhan Canli, Lei Yu, Xiaoqing Yu, Hongyu Zhao, Debra Fleischman, Robert S Wilson, Philip L De Jager, David A Bennett
Subjective social isolation, loneliness, is associated with poor mental and physical health, but the underlying molecular mechanisms are poorly understood. Here we analyzed loneliness data collected on average 5 years ante-mortem and RNA gene expression at death in postmortem dorsolateral prefrontal cortex (DLPFC) from 181 participants in the Rush Memory and Aging Project (MAP), a longitudinal, prospective cohort study of common chronic conditions of aging. Our analytic protocol controlled for biographical variables (age, sex, education), psychological and health variables (depressive symptoms, interval between assessment and autopsy, slope of cognitive decline, AD pathology, presence of infarcts) and RNA integrity...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29317463/task-errors-by-emergency-physicians-are-associated-with-interruptions-multitasking-fatigue-and-working-memory-capacity-a-prospective-direct-observation-study
#19
Johanna I Westbrook, Magda Raban, Scott R Walter, Heather Douglas
BACKGROUND: Interruptions and multitasking have been demonstrated in experimental studies to reduce individuals' task performance. These behaviours are frequently used by clinicians in high-workload, dynamic clinical environments, yet their effects have rarely been studied. OBJECTIVE: To assess the relative contributions of interruptions and multitasking by emergency physicians to prescribing errors. METHODS: 36 emergency physicians were shadowed over 120 hours...
January 9, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29316833/self-appraisals-and-episodic-memory-different-psychological-factors-related-to-patient-versus-informant-reports-of-apathy-in-severe-traumatic-brain-injury
#20
Annabelle Arnould, Lucien Rochat, Philippe Azouvi, Martial van der Linden
INTRODUCTION: Apathy is a core feature in patients with traumatic brain injury (TBI). The psychological processes underlying apathy are still unclear, and the few studies conducted on this subject have essentially focused on cognitive processes and informant reports of apathetic manifestations. The aims of the present study were to examine self-reports versus informant reports of diminished initiative/interest, as well as their relationship with different cognitive factors (attention/executive mechanisms, episodic memory, and multitasking) and personal identity factors (self-esteem and self-efficacy beliefs)...
January 9, 2018: Journal of Clinical and Experimental Neuropsychology
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