Indra A Van Assche, Kristel Van Calsteren, Jurgen Lemiere, Jana Hohmann, Jeroen Blommaert, Evangeline A Huis In 't Veld, Elyce Cardonick, Charlotte LeJeune, Nelleke P B Ottevanger, Els P O Witteveen, Martine van Grotel, Marry M van den Heuvel-Eibrink, Lieven Lagae, Maarten Lambrecht, Frédéric Amant
BACKGROUND: The main data available on the safety of radiation during pregnancy originate from animal studies and from studies of survivors of atomic or nuclear disasters. The effect of radiotherapy to treat maternal cancer on fetal development is uncertain. This report presents a unique cohort and aims to determine the long-term neurocognitive, psychosocial and physical outcomes of offspring of mothers treated with radiotherapy during pregnancy. METHODS: In this international, multicentre, mixed retrospective-prospective cohort study, we recruited participants between Aug 5, 2006, and Aug 24, 2023, aged between 1·5 and 46 years, at three referral centres in Belgium, the Netherlands, and the USA...
April 16, 2024: Lancet Child & Adolescent Health