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Zhenqiu Liu, Qiwen Fang, Jialu Zuo, Jun Wang, Yue Chen, Veenu Minhas, Charles Wood, Na He, Tiejun Zhang
Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Shanghai, China from January 2013-December 2014 to explore epidemiologic features of HHV8 and HSV2 among MSM. Serum samples were collected and tested for HHV8 by immunofluoresence assay and HSV2 antibodies by ELISA...
October 21, 2016: Journal of Medical Virology
Zeliha Esin Celik, Murat Celik, Erdem Sen, Hakan Cebeci, Ozlem Ata, Cagdas Yavas
Kaposi sarcoma (KS), a vascular tumor caused by infection with human herpesvirus 8 (HHV8), is a systemic disease that can present with cutaneous lesions with or without visceral involvement. Very few cases of KS, most of which were associated with AIDS, have been reported in the adrenal gland. Anaplastic transformation of KS is a rare clinical presentation known as an aggressive disease with local recurrence and metastatic potential. We report here a 47-year-old HIV negative male presented with extra-adrenal symptoms and had an incidentally detected anaplastic adrenal KS exhibited aggressive clinical course...
2016: Case Reports in Pathology
J Pascual, A Royuela, A M Fernández, I Herrero, J F Delgado, A Solé, L Guirado, T Serrano, J de la Torre-Cisneros, A Moreno, E Cordero, R Gallego, C Lumbreras, J M Aguado
Appropriate post-transplant immunosuppressive regimens that avoid acute rejection, while reducing risk of viral reactivation, have been sought, but remain a chimera. Recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (mTORi) is of great interest. Although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive therapy in the presence of a viral infection...
September 7, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
N Kuroda, C Ohe, S Deepika, K Yorita, S Mikami, M Furuya, Y Nagashima, O Hes, A Agaimy, M Michal, M B Amin
Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Justin C Cikomola, Karl Vandepoele, Philippe B Katchunga, Antoine S Kishabongo, Elizaveta Y Padalko, Marijn M Speeckaert, Joris R Delanghe
Prevalences of human herpesvirus-8 (HHV-8) infection and diabetes mellitus are very common in certain parts of Africa, containing iron-rich soils. We hypothesized that some genetic factors could have a link with susceptibility to HHV-8 infection. We focused on ferroportin Q248H mutation (rs11568350), transferrin (TF) polymorphism and fructosamine-3 kinase (FN3K) 900C/G polymorphism (rs1056534). The study population consisted of 210 type 2 diabetic adults and 125 healthy controls recruited in Bukavu (South Kivu)...
November 2016: Acta Tropica
Elisabetta Caselli, Alessandro Borghi, Martina Maritati, Roberta Gafà, Giovanni Lanza, Dario Di Luca, Annarosa Virgili, Carlo Contini
BACKGROUND: We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding suggested for the first time a possible association of C. pneumoniae and/or HHV8 infection, or both together, with PCALCL pathogenesis in non-immunocompromised and HIV-negative subjects...
2016: Infectious Agents and Cancer
Liqun Yin, Jie Xu, Min Li, Vishnu Reddy, Quan Zhou, Huanxin Liu, Peiguo Chu, Qianyun Zhang, Qin Huang, Zifen Gao, Xiayuan Liang, Huan-You Wang, Zenggang Pan
AIMS: Rare cases of B-cell lymphomas do not express conventional B-cell markers (CD20, CD79a, and Pax5), and these types of lymphomas include ALK-positive large B-cell lymphoma, plasmablastic lymphoma, primary effusion lymphoma, and the solid variant of primary effusion lymphoma, extracavitary HHV8-positive large B-cell lymphoma. Establishing accurate diagnoses of these B-cell lymphomas can be challenging, and often requires a large panel of immunohistochemical stains, molecular assays, and cytogenetic studies...
June 20, 2016: Histopathology
Hao-Wei Wang, Stefania Pittaluga, Elaine S Jaffe
Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity that causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can also lead to atypical lymphoproliferations and potential progression to lymphoma...
September 2016: Seminars in Diagnostic Pathology
Junghoon Shin, Jeong-Ok Lee, Ji-Young Choe, Soo-Mee Bang, Jong-Seok Lee
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin's lymphoma (NHL) arising from a B-cell lineage characterized by the formation of malignant effusion in body cavities without evidence of a detectable tumor. The effusion contains tumor cells universally infected with human herpesvirus 8 (HHV8), which is the critical factor differentiating PEL from HHV8-unrelated PEL-like lymphoma (PEL-LL). This report describes a 77-year-old male patient with pleural effusion and ascites, containing lymphoma cells expressing a B-cell phenotype, but without markers of HHV8 in immunocytochemical analysis...
June 10, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
J-L Nguewa, E Lontchi-Yimagou, F Agbelika, M AitDjoudi, P Boudou, S Choukem, E Sobngwi, J-F Gautier
BACKGROUND AND OBJECTIVES: Peripheral tissue resistance to insulin action is a characteristic of type 2 diabetes mellitus (T2DM). It has also been reported that some chronic viral infections can contribute to insulin resistance. Human herpesvirus (HHV)-8 infection has been detected in T2DM patients in previous studies. Our study investigated whether the presence of the virus is associated with insulin resistance in patients with ketosis-prone type 2 diabetes (KPD), as reported with other viruses...
June 1, 2016: Diabetes & Metabolism
Chiara Cattaneo, Margherita Oberti, Cristina Skert, Angela Passi, Mirko Farina, Alessandro Re, Paola Tozzi, Erika Borlenghi, Giuseppe Rossi
Adult onset hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which can develop as a complication of many disorders. Early diagnosis is essential in order to avoid a fatal outcome. To confirm the diagnosis of acquired HLH made in a single institution series of adult patients with HLH-04 criteria, we applied the HScore and evaluated prognostic factors associated with clinical outcome. The median age of 35 patients was 54 (range 17-81), M/F ratio was 20/15. In 26/35 (74.3%) patients, an underlying haematological disease was present (2 Multicentric Castleman Disease, 10 B-cell Non-Hodgkin Lymphoma [NHL] and 14 T/NK-cell NHL); an autoimmune disorder was observed in four (11...
June 3, 2016: Hematological Oncology
Paul D Swenson, Azza El-Sabaeny, Vanessa Thomas-Moricz, Megan Allen, Anabel Groskopf, Alice Jiang, Damon Getman
BACKGROUND: Herpes simplex viruses (HSV) are double-stranded DNA human herpesviruses (HHVs) that have the capacity to cause significant morbidity and mortality in humans. Like HHV5 (Cytomegalovirus) and HHV8 (Kaposi's sarcoma virus), HSV type 1 (HSV-1), and HSV type 2 (HSV-2) (HHV1, HHV2) selectively package certain viral messenger RNAs inside mature virions, as well as expressing those mRNAs in infected cells. OBJECTIVES: To evaluate the clinical and analytical performance of Aptima HSV 1&2 assay (AHSV), a newly developed automated real time transcription-mediated amplification (TMA) nucleic acid amplification test (NAAT) for HSV-1 and 2 UL42 mRNAs, compared to viral culture and HSV DNA NAAT...
July 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Anait L Melikyan, Elena K Egorova, Hunan L Julhakyan, Alla L Kovrigina, Valeriy G Savchenko
Castleman disease (CD) is rare lymphoproliferative disorder with local lesionsor with multiple lessions (multicentric CD [MCD]-usually with plasma cell or mix cell morphology). Patients with human herpesvirus (HHV) type 8-positive MCD were included in a separate group owing to its extremely aggressive course and the high risk of transformation into HHV8(+) plasmablastic lymphoma. At our hematologic center, from 1996 to the present, the clinical and morphologic features of 87 patients with CD were analyzed. Immunohistochemical examination revealed DNA HHV8(+) lymph node tissue in patients with plasma cell and mixed cell morphology...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
A Gregory Bruce, Jeremy A Horst, Timothy M Rose
The envelope-associated glycoprotein B (gB) is highly conserved within the Herpesviridae and plays a critical role in viral entry. We analyzed the evolutionary conservation of sequence and structural motifs within the Kaposi׳s sarcoma-associated herpesvirus (KSHV) gB and homologs of Old World primate rhadinoviruses belonging to the distinct RV1 and RV2 rhadinovirus lineages. In addition to gB homologs of rhadinoviruses infecting the pig-tailed and rhesus macaques, we cloned and sequenced gB homologs of RV1 and RV2 rhadinoviruses infecting chimpanzees...
July 2016: Virology
Amy Y Liu, Christopher S Nabel, Brian S Finkelman, Jason R Ruth, Razelle Kurzrock, Frits van Rhee, Vera P Krymskaya, Dermot Kelleher, Arthur H Rubenstein, David C Fajgenbaum
BACKGROUND: Multicentric Castleman's disease describes a group of poorly understood lymphoproliferative disorders driven by proinflammatory hypercytokinaemia. Patients have heterogeneous clinical features, characteristic lymph node histopathology, and often deadly multiple organ dysfunction. Human herpesvirus 8 (HHV8) causes multicentric Castleman's disease in immunosuppressed patients. The cause of HHV8-negative multicentric Castleman's disease is idiopathic; such cases are called idiopathic multicentric Castleman's disease...
April 2016: Lancet Haematology
Alessandro Borghi, Maria D'Accolti, Roberta Rizzo, Annarosa Virgili, Dario Di Luca, Monica Corazza, Elisabetta Caselli
Human herpesvirus 8 (HHV8) has been hypothesized to be a potential cofactor for the development of diverse cutaneous vascular proliferative lesions, including eruptive cherry angiomas. Recent reports evidenced the influence of killer cell immunoglobulin-like receptor (KIR) gene diversity in defining the susceptibility to symptomatic herpesvirus infections. In this study, skin samples from vascular lesions and healthy controls were characterized simultaneously for the presence of HHV8 and for the KIR genotype, focusing upon the presence of the KIR2DL2/DS2 and KIR2DL3 genes, which have been associated to herpesvirus susceptibility...
July 2016: Archives of Dermatological Research
Faisal Inayat, Hafeez Ul Hassan Virk, Ahmad R Cheema, Muhammad Wasif Saif
Background. Plasmablastic lymphoma (PBL) is a rare B-cell neoplasm. It predominantly occurs in the oral cavity of human immunodeficiency virus (HIV)-positive patients and exhibits a highly aggressive clinical behavior. Case Presentation. We describe an unusual case of a 37-year-old HIV-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. Histopathological examination of the lesions showed diffuse and cohesive pattern of large B-cells resembling immunoblasts or plasmablasts...
2016: Case Reports in Oncological Medicine
Dimitris P Stamatiou, Stavros P Derdas, Odysseas L Zoras, Demetrios A Spandidos
Thyroid cancer is considered the most common malignancy that affects the endocrine system. Generally, thyroid cancer derives from follicular epithelial cells, and thyroid cancer is divided into well-differentiated papillary (80% of cases) and follicular (15% of cases) carcinoma. Follicular thyroid cancer is further divided into the conventional and oncocytic (Hürthle cell) type, poorly differentiated carcinoma and anaplastic carcinoma. Both poorly differentiated and anaplastic carcinoma can arise either de novo, or secondarily from papillary and follicular thyroid cancer...
March 2016: Oncology Letters
Maria Luiza Piesiaków, Beata Imko-Walczuk, Karolina Osiecka, Marta Kiełbowicz, Alicja Dębska-Ślizień
The latest literature report specifies multifactoral etiology of skin cancer in population of patients after organs transplats. Carcirogenic viruses are one of etiopathogenesis components. Viruses of a vital meaning for skin oncogenesis are called Human papillomavirus - HPV, Human herpesvirus 8 - HHV8 i Merkel cell polyomavirus - MCV. Report on connections exisisting between viruses HPV and skin cancers in the population of patients after organs transplants confirms clinical connection between viruses papillas and cancers centres occuring in similar locations and more frequent appearance of attributes characteristic for HPV infection within the limits of changes in the type of Squamous cell carcinoma (SCC)...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Pravinkumar Purushothaman, Prerna Dabral, Namrata Gupta, Roni Sarkar, Subhash C Verma
Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a major etiological agent for multiple severe malignancies in immune-compromised patients. KSHV establishes lifetime persistence in the infected individuals and displays two distinct life cycles, generally a prolonged passive latent, and a short productive or lytic cycle. During latent phase, the viral episome is tethered to the host chromosome and replicates once during every cell division. Latency-associated nuclear antigen (LANA) is a predominant multifunctional nuclear protein expressed during latency, which plays a central role in episome tethering, replication and perpetual segregation of the episomes during cell division...
2016: Frontiers in Microbiology
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