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https://www.readbyqxmd.com/read/29766535/deceptively-bland-cutaneous-angiosarcoma-on-the-nose-mimicking-hemangioma-a-clinicopathologic-and-immunohistochemical-analysis
#1
Christina Mitteldorf, Mar Llamas-Velasco, Hans-Joachim Schulze, Kai-Martin Thoms, Thomas Mentzel, Michael Tronnier, Heinz Kutzner
BACKGROUND: We investigated two cases of deceptively bland cutaneous angiosarcoma, which showed a uniform clinical presentation with a rapidly growing tumor on the nose. It remains unclear whether this was a primary cutaneous manifestation or a metastasis. Both tumors initially presented a high histologic overlap with a benign vascular tumor. The diagnosis was primarily based on the rapidly progressing clinical course and on the results of the staging procedures. METHODS: Immunohistochemical stains were performed for cytokeratin (AE1/AE3 and MNF116), CD31, ERG, CD34(HPCA1/my10), D2-40/podoplanin, LYVE-1, Ki67, PHH3, αSMA(1A4), MYC, FOS-B, CAMTA-1, TFE-3, WT1, nestin, VEGFR-2(KDR), VEGFR-3(FLT4), HHV8...
May 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29746555/human-herpes-virus-8-in-hiv-1-infected-individuals-receiving-cancer-chemotherapy-and-stem-cell-transplantation
#2
Louise E Hogan, Emily Hanhauser, Kristen S Hobbs, Christine D Palmer, Yvonne Robles, Stephanie Jost, Anne S LaCasce, Jeremy Abramson, Ayad Hamdan, Francisco M Marty, Daniel R Kuritzkes, Timothy J Henrich
BACKGROUND: Human Herpes Virus 8 (HHV8) can cause Kaposi's Sarcoma (KS) in immunosuppressed individuals. However, little is known about the association between chemotherapy or hematopoietic stem cell transplantation (HSCT), circulating HHV8 DNA levels, and clinical KS in HIV-1-infected individuals with various malignancies. Therefore, we examined the associations between various malignancies, systemic cancer chemotherapy, T cell phenotypes, and circulating HHV8 DNA in 29 HIV-1-infected participants with concomitant KS or other cancer diagnoses...
2018: PloS One
https://www.readbyqxmd.com/read/29707905/human-herpes-virus-type-8-infection-dna-positivity-is-associated-with-low-insulin-secretion-a-case-control-study-in-a-sub-saharan-african-population-with-diabetes
#3
Eric Lontchi-Yimagou, Jérôme Legoff, Jean-Louis Nguewa, Philippe Boudou, Eric V Balti, Jean Jacques Noubiap, Vicky Kamwa, Barbara Atogho-Tiedeu, Marcel Azabji-Kenfack, Eric N Djahmeni, Martine Etoa, Gaelle Lemdjo, Vanessa Balla, Mesmin Y Dehayem, Fabienne Foufelle, Jean-Claude Mbanya, Jean-Francois Gautier, Eugene Sobngwi
BACKGROUND: Viruses have been considered as potential triggers for diabetes development. This study sought to assess insulin secretion and insulin sensitivity in Human Herpes Virus type 8 (HHV8) infected and non-infected sub-Saharan African people with diabetes. METHODS: We consecutively enrolled 173 people with non-autoimmune diabetes: 124 with type 2 diabetes (T2D), and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycaemic crisis. KPD was further sub-classified as new-onset ketotic phase KPD (n=34) or non-ketotic phase KPD (n=15)...
April 29, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29698475/cadm1-is-essential-for-kshv-encoded-vgpcr-and-vflip-mediated-chronic-nf-%C3%AE%C2%BAb-activation
#4
Richard Hunte, Patricia Alonso, Remy Thomas, Cassandra Alexandria Bazile, Juan Carlos Ramos, Louise van der Weyden, Juan Dominguez-Bendala, Wasif Noor Khan, Noula Shembade
Approximately 12% of all human cancers worldwide are caused by infections with oncogenic viruses. Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) is one of the oncogenic viruses responsible for human cancers, including Kaposi's sarcoma (KS), Primary Effusion Lymphoma (PEL), and the lymphoproliferative disorder multicentric Castleman's disease (MCD). Chronic inflammation mediated by KSHV infection plays a decisive role in the development and survival of these cancers. NF-κB, a family of transcription factors regulating inflammation, cell survival, and proliferation, is persistently activated in KSHV-infected cells...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29669178/the-utility-of-multiparametric-flow-cytometry-in-the-detection-of-primary-effusion-lymphoma-pel
#5
Jacobo Galán, Isaac Martin, Itziar Carmona, José María Rodriguez-Barbero, Esperanza Cuadrado, Luis García-Alonso, José Antonio García-Vela
Primary effusion lymphoma (PEL) is a rare B cell lymphoproliferative disorder that arises predominantly in body cavities causing malignant effusions.The incidence of PEL is very low, accounting for approximately 4% of all HIV-associated non-Hodgkin lymphomas. PEL has also been described in elderly patients and after solid-organ transplantation. It is associated in all cases with human herpesvirus 8 (HHV8). We describe a case of PEL in a 88-year-old HIV-negative woman who presented with progressive dyspnea and moderate right-sided pleural effusion without significate lymphadenopathies or other effusions...
April 18, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29660143/disseminated-kaposi-sarcoma-with-epithelioid-morphology-in-an-hiv-aids-patient-a-previously-unreported-variant
#6
Pukhraz Basra, Juan Paramo, John Alexis
Kaposi sarcoma is an oligoclonal HHV8-driven vascular proliferation that was first described in 1872 as an "idiopathic multiple pigmented sarcoma of the skin" by a Viennese dermatologist Dr. Moriz Kaposi (1).
April 16, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29523417/molecular-and-cellular-interplay-in-virus-induced-tumors-in-solid-organ-recipients
#7
Alessia Gallo, Monica Miele, Ester Badami, Pier Giulio Conaldi
Patients following solid organ transplantation show a higher risk of developing cancer compared to the general population. Elevated risk is likely due to the interplay of a combination of factors, such as chronic inflammation, coexisting medical conditions, immunosuppressive regimen and persistent infection with oncogenic viruses. In addition, the tumor microenvironment plays a pivotal role in cancer progression, by driving recruitment and in situ differentiation of anti-inflammatory cells of the adaptive and innate immune system such as regulatory T cells, Th17, Dendritic Cells, Myeloid Derived Suppressor Cells, Type 2 Macrophages...
February 16, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29508130/head-and-neck-kaposi-sarcoma-clinicopathological-analysis-of-11-cases
#8
Abbas Agaimy, Sarina K Mueller, Thomas Harrer, Sebastian Bauer, Lester D R Thompson
Kaposi sarcoma (KS) of the head and neck area is uncommon with limited published case series. Our routine and consultation files were reviewed for histologically and immunohistochemically proven KS affecting any cutaneous or mucosal head and neck site. Ten males and one female aged 42-78 years (median, 51 years; mean, 52 years) were retrieved. Eight patients were HIV-positive and three were HIV-negative. The affected sites were skin (n = 5), oral/oropharyngeal mucosa (n = 5), and lymph nodes (n = 3) in variable combination...
March 5, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29505765/kshv-hhv8-associated-extracavitary-primary-effusion-lymphoma-presenting-as-multiple-lymphomatous-polyposis
#9
M D Cyrus Oster, M D Theodore Stein, M D Sumire Kitahara, M D Serhan Alkan, Qin Huang
Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of solid tumor mass or dissemination during its clinical course. PEL can also rarely occur as a solid lymphoma involving nodal and extranodal sites and is referred to as extracavitary PEL. Here we report a unique case of extracavitary PEL in a 49year-old HIV-seropositive patient, who presented with vague abdominal pain and 20 pound weight loss. Esophagogastroduodenoscopy and colonoscopy revealed >100 broad based intestinal polyps ranging from 2 mm to 3cm in size, spreading from the duodenum to the rectum as a typical impression of "intestinal polyposis syndrome"...
March 2, 2018: Human Pathology
https://www.readbyqxmd.com/read/29496669/next-generation-sequencing-of-idiopathic-multicentric-and-unicentric-castleman-disease-and-follicular-dendritic-cell-sarcomas
#10
Alexandra Nagy, Aparna Bhaduri, Nahid Shahmarvand, Jahanbanoo Shahryari, James L Zehnder, Roger A Warnke, Tariq Mughal, Siraj Ali, Robert S Ohgami
Castleman disease (CD) is a rare lymphoproliferative disorder subclassified as unicentric CD (UCD) or multicentric CD (MCD) based on clinical features and the distribution of enlarged lymph nodes with characteristic histopathology. MCD can be further subtyped based on human herpes virus 8 (HHV8) infection into HHV8-associated MCD, HHV8- /idiopathic MCD (iMCD), and polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin change (POEMS)-associated MCD. In a subset of cases of UCD, an associated follicular dendritic cell sarcoma (FDCS) may be seen...
March 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29483919/human-%C3%AE-herpesvirus-infection-tumorigenesis-and-immune-control-in-mice-with-reconstituted-human-immune-system-components
#11
REVIEW
Christian Münz
The human γ-herpesviruses Epstein-Barr virus (EBV or HHV4) and Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) are each associated with around 2% of all tumors in humans worldwide. However, investigations into their infection, oncogenesis, and immune responses that protect from the associated tumors have been hampered by the exclusive tropism of these pathogens for humans. Mice with reconstituted human immune system components (HIS mice) provide the unique opportunity to study persistent infection, virus associated lymphoma formation, and cell-mediated immune control of EBV and KSHV...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29403325/tafro-syndrome-current-perspectives
#12
REVIEW
Kentaro Sakashita, Kengo Murata, Mikio Takamori
Multicentric Castleman's disease (MCD), a distinct subtype of Castleman's disease, is a rare, nonneoplastic, lymphoproliferative disorder. Patients with MCD present with systemic symptoms and multiple lymphadenopathy. Lymph node biopsy is necessary for the diagnosis of various histological MCD patterns including hyaline vascular, plasma cell, and mixed types. Human herpesvirus 8 (HHV8) infection was identified as an important etiology of MCD among immunocompromised patients such as those positive for human immunodeficiency virus...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29327711/cd3-positive-plasmablastic-b-cell-neoplasms-a-diagnostic-pitfall
#13
Zenggang Pan, Mingyi Chen, Qianyun Zhang, Endi Wang, Liqun Yin, Youyuan Xu, Qin Huang, Youzhong Yuan, Xiaohui Zhang, Gang Zheng, Ji Yuan
Rare B-cell neoplasms with plasmablastic differentiation may aberrantly express CD3 by immunohistochemical staining, which places a great challenge for diagnosis. We here studied 17 cases of CD3+ plasmablastic B-cell neoplasms, including 12 plasmablastic lymphomas and 5 plasmablastic plasma cell myelomas. All 17 cases occurred in the extranodal sites with a male predominance (13/17). Four cases were initially misinterpreted by outside institutions, among which three were diagnosed as 'peripheral T-cell lymphoma, not otherwise specified' and one was classified as 'poorly differentiated neuroendocrine carcinoma'...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29206290/primary-effusion-lymphoma-in-taiwan-shows-two-distinctive-clinicopathological-subtypes-with-rare-human-immunodeficiency-virus-association
#14
Bo-Jung Chen, Ran-Ching Wang, Chung-Han Ho, Chang-Tsu Yuan, Wan-Ting Huang, Sheau-Fang Yang, Pin-Pen Hsieh, Yun-Chih Yung, Shih-Yao Lin, Chen-Fang Hsu, Ying-Zhen Su, Chun-Chi Kuo, Shih-Sung Chuang
AIMS: To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan and the association with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV). METHODS AND RESULTS: We investigated retrospectively 26 cases with a median age of 76.5. Only one (4%) patient was infected with HIV. Cytologically, all lymphoma cells revealed typical immunoblastic to plasmablastic morphology. Immunohistochemically, HHV8 was positive in eight (32%) tumours and negative in 17 (68%) cases...
December 5, 2017: Histopathology
https://www.readbyqxmd.com/read/29177692/dermatological-complications-after-solid-organ-transplantation
#15
REVIEW
Luigi Naldi, Anna Venturuzzo, Pietro Invernizzi
Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e...
February 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29105119/lymphoproliferative-disorders-with-concurrent-hhv8-and-ebv-infection-beyond-primary-effusion-lymphoma-and-germinotropic-lymphoproliferative-disorder
#16
Wei Wang, Rashmi Kanagal-Shamanna, L Jeffrey Medeiros
AIMS: Lymphoproliferative disorders (LPD) characterised by human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV) infection are rare and two entities are included in the World Health Organisation classification: primary effusion lymphoma (PEL) and germinotropic LPD. These two entities have very different clinicopathological presentations and prognosis. Here we describe two cases of HHV8-positive, EBV-positive lymphoma with clinicopathological features that are not consistent with either PEL or germinotropic LPD...
April 2018: Histopathology
https://www.readbyqxmd.com/read/29066044/iatrogenic-solid-tumors-following-immunosuppressive-therapy
#17
REVIEW
Kossivi Dantey, Liron Pantanowitz
Immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. These are often rare tumors characterized by odd presentations. This review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. All of the malignancies covered in this review are viral-induced. They include human papillomavirus (HPV)-associated carcinomas, Epstein-Barr virus (EBV)-associated tumors, Merkel cell polyomavirus (MCPyV)-related Merkel cell carcinoma, and Human Herpesvirus 8 (HHV8)-related Kaposi sarcoma...
September 20, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29019447/survival-of-patients-with-cd20-negative-variants-of-large-b-cell-lymphoma-an-analysis-of-the-national-cancer-data-base
#18
Lindor Qunaj, Jorge J Castillo, Adam J Olszewski
Using records from the National Cancer Data Base, we studied overall survival of CD20-negative variants of diffuse large B-cell lymphoma (DLBCL): primary effusion (PEL, N = 228), plasmablastic (PBL, N = 481), ALK-positive large B-cell (ALK + LBLC, N = 15), and human herpesvirus-8-positive DLBCL (HHV8 + DLBCL, N = 77). Three-year survival was 27% for PEL, 40% for PBL, 34% for ALK + LBCL, and 63% for HHV8 + DLBCL. Compared with unspecified DLBCL, and adjusting for clinical characteristics (including the HIV status), survival was significantly worse for PEL (hazard ratio [HR], 1...
October 11, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28982264/de-novo-unclassifiable-cd20-negative-diffuse-large-b-cell-lymphoma-a-diagnostic-and-therapeutic-challenge
#19
Badr AbdullGaffar, Rania M Seliem
CD20-negative diffuse large B-cell lymphomas (DLBCLs) constitute a rare and heterogeneous group of aggressive lymphomas. Known well-documented variants include plasmablastic lymphomas, primary effusion lymphomas, anaplastic kinase-positive large B-cell lymphomas, and large B-cell lymphomas arising in human herpesvirus 8 (HHV8)-associated multicentric Castleman disease. They impose diagnostic challenges for pathologists and therapeutic confrontations for clinicians. CD20 loss in B-cell lymphomas is a well-known phenomenon after rituximab therapy...
May 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28975631/global-epidemiology-of-human-herpesvirus-8-in-men-who-have-sex-with-men-a-systematic-review-and-meta-analysis
#20
Zhenqiu Liu, Qiwen Fang, Jialu Zuo, Yue Chen, Veenu Minhas, Charles Wood, Tiejun Zhang
Men who have sex with men (MSM) were highly vulnerable to HIV/AIDS and Human herpes virus 8 (HHV8), while the epidemiologic features of HHV8 among MSM remain obscure. We therefore performed a systematic review and meta-analysis to assess the burden of HHV8 in MSM. Electronic databases were searched for publications on HHV8 epidemiologic characteristics among MSM. Random-effect meta-analysis was applied to combine the HHV8 seroprevalence in MSM and odds ratios (ORs) for associated risk factors. Meta-regression and stratified analyses were performed to detect the potential sources of heterogeneity...
March 2018: Journal of Medical Virology
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