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https://www.readbyqxmd.com/read/28805477/estimated-exposures-to-perfluorinated-compounds-in-infancy-predict-attenuated-vaccine-antibody-concentrations-at-age-5-years
#1
Philippe Grandjean, Carsten Heilmann, Pal Weihe, Flemming Nielsen, Ulla B Mogensen, Amalie Timmermann, Esben Budtz-Jørgensen
Perfluorinated alkylate substances (PFASs) are highly persistent and may cause immunotoxic effects. PFAS-associated attenuated antibody responses to childhood vaccines may be affected by PFAS exposures during infancy, where breastfeeding adds to PFAS exposures. Of 490 members of a Faroese birth cohort, 275 and 349 participated in clinical examinations and provided blood samples at ages 18 months and 5 years. PFAS concentrations were measured at birth and at the clinical examinations. Using information on duration of breastfeeding, serum-PFAS concentration profiles during infancy were estimated...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28805106/measuring-fetal-brain-and-lung-transcripts-in-amniotic-fluid-supernatant-a-comparison-of-digital-pcr-and-rt-qpcr-methods
#2
Lisa Hui, Sally Beard, Natalie J Hannan
PURPOSE: Amniotic fluid (AF) cell-free RNA is a promising source of information regarding fetal physiology. Digital PCR (dPCR) is a direct approach to nucleic acid detection that reports absolute transcript copy number. The aim of this study was to compare quantification of cell-free fetal brain and lung RNA transcripts in AF by reverse transcription-qPCR and dPCR. MATERIAL AND METHODS: Prospective hospital-based study performed in 2016-2017. Pulmonary genes were quantified in term AF samples collected at elective cesarean birth; neurodevelopmental genes were measured in preterm samples (< 34 weeks) obtained from women undergoing clinically-indicated amniocentesis...
August 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28804964/birth-outcomes-of-children-fathered-by-men-treated-with-systemic-corticosteroids-during-the-conception-period-a-cohort-study-based-on-nationwide-data
#3
M D Larsen, S Friedman, B Magnussen, B M Nørgård
Information on the safety of paternal use of medications prior to the time of conception is limited, and there is little available evidence regarding possible adverse effects of paternal use of systemic corticosteroids (SCS). In this cohort study, based on nationwide data, we examined the association between paternal use of SCS prior to conception and adverse birth outcomes. The study includes data from all singletons born in Denmark from 1January 1997 through 2013 (N=1,013,994). Children fathered by men who redeemed a prescription of SCS within 3 months before conception (N=2,380) constituted the exposed groups...
August 14, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28804876/insulin-resistance-in-pregnant-women-with-and-without-polycystic-ovary-syndrome-and-measures-of-body-composition-in-offspring-at-birth-and-3-years-of-age
#4
Sara Kristín Finnbogadóttir, Dorte Glintborg, Tina Kold Jensen, Henriette Kyhl, Ellen A Nohr, Marianne Andersen
Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance in the non-pregnant state, but little is known about insulin sensitivity in the pregnant state. Our objective was to compare insulin resistance in pregnant women with and without PCOS and explore the impact of PCOS on body composition in offspring at birth and at 3 years of age MATERIAL AND METHODS: A prospective cohort study including 2548 live born singleton mother-child pairs residing in Odense municipality, Denmark, during 2010-2013...
August 14, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28802911/childhood-maltreatment-and-high-dietary-fat-intake-behaviors-in-adulthood-a-birth-cohort-study
#5
Amanuel Alemu Abajobir, Steve Kisely, Gail Williams, Lane Strathearn, Jake Moses Najman
Childhood maltreatment has been associated with a wide range of chronic medical conditions including obesity, other metabolic events and eating disorders. However, little is known about the association between childhood maltreatment and high dietary fat intake. This study addresses the extent to which co-occurring and specific forms of substantiated childhood maltreatment are associated with self-reported high dietary fat intake in adulthood and whether there is a gender-childhood maltreatment interaction in predicting this association...
August 10, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28802298/increased-pre-school-overweight-and-obesity-prevalence-between-2004-and-2013-is-associated-with-appetite-eating-frequency-and-supportive-facilities-the-jiaxing-birth-cohort-in-china
#6
Huijuan Liu, Ju-Sheng Zheng, Jing Li, Yu Chen, Wei Zhao, Tao Huang, Bo Yang, Duo Li
BACKGROUND AND OBJECTIVES: Childhood obesity is increasing. However, little is known about the changes in di-etary factors and supportive facilities associated with childhood obesity. We aimed to document the changes in various dietary factors and supportive facilities and their associations with obesity among pre-school children. METHODS AND STUDY DESIGN: Among 42,531 children 4-5 years old, recruited between 2004 and 2013 in the Jiax-ing Birth Cohort, we examined the changes in the prevalence of various dietary factors and supportive facilities and overweight/obesity over 10 years...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28802183/very-low-birth-weight-is-associated-with-brain-structure-abnormalities-and-cognitive-function-impairments-a-systematic-review
#7
Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Reza Dehghani, Gisou Mohaddes, Leili Abedi, Ramin Bughchechi, Alireza Majdi, Javad Mahmoudi
Very low birth weight (VLBW) children are at risk of structural brain abnormalities and neurocognitive deficits. Since survival rate of the very low birth weight infants has increased over the past decade, a better understanding of the long-term neurocognitive outcomes is needed. The present systematic review investigated the association between VLBW and cognitive function as well as brain structure. PubMed/Medline, Google Scholar, Scopus and Web of Science databases were searched up from January 2000 to January 2015...
August 9, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28802181/temporal-change-to-self-rated-health-in-the-swiss-population-from-1997-to-2012-the-roles-of-age-gender-and-education
#8
T Volken, F Wieber, P Rüesch, M Huber, R J Crawford
OBJECTIVES: Our study aimed to describe the temporal changes in self-rated health status (SRH) from 1997 to 2012 in adults aged 25 to 84 residing in Switzerland, with a view to identifying groups at risk for declining health. STUDY DESIGN: Secondary analysis of population-based cross-sectional health surveys. METHODS: Data were collected from the cross-sectional, population-based, five-year Swiss Health Survey, from 1997, 2002, 2007 and 2012...
August 9, 2017: Public Health
https://www.readbyqxmd.com/read/28801627/increased-risk-of-low-birth-weight-in-women-with-placental-malaria-associated-with-p-falciparum-var2csa-clade
#9
Jaymin C Patel, Nicholas J Hathaway, Christian M Parobek, Kyaw L Thwai, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Achille Massougbodji, Nadine Fievet, Jeffery A Bailey, Feiko O Ter Kuile, Philippe Deloron, Stephanie M Engel, Steve M Taylor, Jonathan J Juliano, Nicaise Tuikue Ndam, Steven R Meshnick
Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated by P. falciparum protein VAR2CSA, a leading PAM-specific vaccine target. The extent of its antigen diversity and impact on clinical outcomes remain poorly understood. Through amplicon deep-sequencing placental malaria samples from women in Malawi and Benin, we assessed sequence diversity of VAR2CSA's ID1-DBL2x region, containing putative vaccine targets and estimated associations of specific clades with adverse birth outcomes...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801430/association-between-pregravid-physical-activity-and-family-history-of-stroke-and-risk-of-stillbirth-population-based-cohort-study
#10
Grace M Egeland, Grethe S Tell, Øyvind Næss, Jannicke Igland, Kari Klungsøyr
OBJECTIVES: To evaluate whether family history of disease and pregravid lifestyle and cardiovascular risk factors are associated with subsequent stillbirth delivery. DESIGN: Prepregnancy cohort study. SETTING: Cohort Norway regional health surveys (1994-2003) linked to Medical Birth Registry of Norway for deliveries through 2012. PARTICIPANTS: 13 497 singleton births (> 22 weeks gestation) in 8478 women. MAIN OUTCOME MEASURE: Risk of stillbirth evaluated by Poisson regression...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801232/nlrp6-and-asc-dependent-inflammasomes-do-not-shape-the-commensal-gut-microbiota-composition
#11
Michail Mamantopoulos, Francesca Ronchi, Filip Van Hauwermeiren, Sara Vieira-Silva, Bahtiyar Yilmaz, Liesbet Martens, Yvan Saeys, Stefan K Drexler, Amir S Yazdi, Jeroen Raes, Mohamed Lamkanfi, Kathy D McCoy, Andy Wullaert
The gut microbiota regulate susceptibility to multiple human diseases. The Nlrp6-ASC inflammasome is widely regarded as a hallmark host innate immune axis that shapes the gut microbiota composition. This notion stems from studies reporting dysbiosis in mice lacking these inflammasome components when compared with non-littermate wild-type animals. Here, we describe microbial analyses in inflammasome-deficient mice while minimizing non-genetic confounders using littermate-controlled Nlrp6-deficient mice and ex-germ-free littermate-controlled ASC-deficient mice that were all allowed to shape their gut microbiota naturally after birth...
August 2, 2017: Immunity
https://www.readbyqxmd.com/read/28800769/maternal-sleep-and-small-for-gestational-age-infants-in-the-japan-environment-and-children-s-study-a-cohort-study
#12
Seiichi Morokuma, Mototsugu Shimokawa, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Ayako Senju, Toshihiro Kawamoto, Koichi Kusuhara
OBJECTIVES: Small for gestational age infants have an increased risk of immediate complications, short-term morbidity and mortality, and long-term neurologic and metabolic disorders in adulthood. Previous research has shown that reduced sleep duration is a risk factor for SGA birth. However, only a few studies have evaluated maternal sleep as a risk factor for SGA birth. In the present study, we investigated the relationship between the amount and quality of mothers' sleep and infants' birth weight...
August 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28800568/causes-and-consequences-of-gestational-diabetes-in-south-asians-living-in-canada-results-from-a-prospective-cohort-study
#13
Sonia S Anand, Milan Gupta, Koon K Teo, Karleen M Schulze, Dipika Desai, Nora Abdalla, Michael Zulyniak, Russell de Souza, Gita Wahi, Mateen Shaikh, Joseph Beyene, Eileen de Villa, Katherine Morrison, Sarah D McDonald, Hertzel Gerstein
BACKGROUND: The reasons for the increased risk of gestational diabetes among South Asian women are not well understood. We sought to identify the determinants of gestational diabetes and its impact on newborn health in a prospective birth cohort of South Asian women and their babies. METHODS: As part of the South Asian Birth Cohort (START) prospective birth cohort study in Ontario, we recruited 1012 South Asian women with singleton pregnancies in the second trimester of pregnancy between July 11, 2011, and Nov...
August 9, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#14
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28800405/neonatal-weight-matters-an-examination-of-weight-changes-in-full-term-breastfeeding-newborns-during-the-first-2-weeks-of-life
#15
Diane DiTomasso, Andrea L Paiva
BACKGROUND: Weight changes in the early weeks of life are important indicators of newborn wellness. Yet, little is known about weight loss patterns for breastfeeding newborns. Research aim: This study aimed to compare weight changes and exclusive breastfeeding rates in newborns who lost ≤ 7% and > 7% of their body weight after birth. METHODS: A prospective, observational cohort study was completed. Newborns who lost ≤ 7% made up Group 1 and newborns who lost > 7% of birth weight made up Group 2...
August 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28800032/malignant-melanoma-incidence-trends-in-a-mediterranean-population-following-socioeconomic-transition-and-war-results-of-age-period-cohort-analysis-in-croatia-1989-2013
#16
Jelena Barbaric, Mathieu Laversanne, Ariana Znaor
The aim of this study was to analyse trends of malignant melanoma incidence in Croatia for men and women of different age groups by birth cohorts and time periods, and to interpret them in the context of national socioeconomic changes over time and the possible implications for future prevention in South-Eastern European postcommunist countries with high mortality rates. We used the Croatian National Cancer Registry data to analyse incidence trends of malignant melanoma of the skin (ICD-9 code 172 and ICD-10 code C43) in men and women aged 25-79 years by age-period-cohort modelling...
August 10, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28799289/prenatal-exposure-to-fever-is-associated-with-autism-spectrum-disorder-in-the-boston-birth-cohort
#17
Martha Brucato, Christine Ladd-Acosta, Mengying Li, Deanna Caruso, Xiumei Hong, Jamie Kaczaniuk, Elizabeth A Stuart, M Daniele Fallin, Xiaobin Wang
Autism spectrum disorder (ASD) is phenotypically and etiologically heterogeneous, with evidence for genetic and environmental contributions to disease risk. Research has focused on the prenatal period as a time where environmental exposures are likely to influence risk for ASD. Epidemiological studies have shown significant associations between prenatal exposure to maternal immune activation (MIA), caused by infections and fever, and ASD. However, due to differences in study design and exposure measurements no consistent patterns have emerged revealing specific times or type of MIA exposure that are most important to ASD risk...
August 11, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28799276/mode-of-delivery-for-singleton-extreme-preterm-breech-fetuses-a-10%C3%A2-year-retrospective-review-from-a-single-tertiary-obstetric-centre
#18
Frances Hills, Mandy Way, Renuka Sekar
BACKGROUND: Preterm breech delivery is associated with a higher perinatal mortality rate compared with preterm vertex delivery, and some studies suggest caesarean section leads to lower mortality rates. Few studies include infants delivered less than 26 weeks gestation, and where included, results are often not stratified by gestational age. There is also a lack of consistent reporting on neonatal and maternal morbidity outcome measures. AIMS: To determine if mode of delivery for singleton extreme preterm breech fetuses is associated with a difference in perinatal mortality, neonatal and maternal morbidity...
August 11, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28799178/retrospective-cohort-study-shows-that-the-risks-for-retinopathy-of-prematurity-included-birth-age-and-weight-medical-conditions-and-treatment
#19
Aliaa Adel Ali, Nancy Gomaa, Ahmed Reda Awadein, Huda Hussein Al-Hayouti, Ahmed Hegazy
AIM: This study described the characteristics and risk factors of neonates who developed retinopathy of prematurity (ROP) and severe treatable ROP in two Egyptian neonatal intensive care units (NICUs). METHODS: This retrospective cohort study comprised 108 preterm neonates who were screened for ROP after being admitted to the two NICUs run by Cairo University Hospital from June 2014 to May 2015. Patients were examined using digital fundus photography and indirect ophthalmoscopy was performed if ROP was detected...
August 11, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28798989/perceived-postoperative-support-differentiates-responders-from-non-responders-3%C3%A2-years-after-laparoscopic-roux-en-y-gastric-bypass
#20
Ulrike B J M Ter Braak, Chris Hinnen, Marjolein M C de Jong, Arnold van de Laar
BACKGROUND: Bariatric surgery is an effective intervention for the majority of patients with morbid obesity, but a significant minority fails to achieve substantial weight loss. In the search of possible predictors of weight loss following bariatric surgery, preoperative factors turn out to have limited predictive power. This study will examine the impact of two postoperative factors on weight loss: perceived social support and stressful life events. METHODS: From the entire 2013 cohort that underwent laparoscopic Roux-and-Y gastric bypass (LRYGB) in a general hospital in the Netherlands, a group of 56 non-responders and a matched group of 56 responders were selected, using an alterable weight loss (%AWL)-based percentile chart...
August 11, 2017: Obesity Surgery
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