Yi-Fang He, Xia-Li Wang, Shuang-Ping Deng, Yan-Li Wang, Qing-Qing Huang, Shu Lin, Guo-Rong Lyu
Stem cells have self-renewal, replication, and multidirectional differentiation potential, while progenitor cells are undifferentiated, pluripotent or specialized stem cells. Stem/progenitor cells secrete various factors, such as cytokines, exosomes, non-coding RNAs, and proteins, and have a wide range of applications in regenerative medicine. However, therapies based on stem cells and their secreted exosomes present limitations, such as insufficient source materials, mature differentiation, and low transplantation success rates, and methods addressing these problems are urgently required...
2023: Frontiers in Endocrinology