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https://www.readbyqxmd.com/read/27883051/lipid-coated-microbubbles-and-low-intensity-pulsed-ultrasound-enhance-chondrogenesis-of-human-mesenchymal-stem-cells-in-3d-printed-scaffolds
#1
Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar
Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27814934/effect-of-low-intensity-pulsed-ultrasound-on-a-rat-model-of-dentin-dental-pulp-injury-and-repair
#2
Fei Wang, Yueheng Li, Zhengyan Yang, Keke Lu, Jing Zuo, Zhi Zhou
This study investigated histopathologic changes in dental pulp after treatment with low-intensity pulsed ultrasound (LIPUS). Fifty rats were randomly divided into an experimental group (n = 25) and a blank control group (n = 25). In the experimental group, a cavity was prepared in the bilateral maxillary first molars. The upper right first molars were stimulated with LIPUS (30 mW/cm(2), 1.5 MHz) for 20 min/d. The cavities prepared in the left teeth were used as experimental controls (i.e., no LIPUS)...
January 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27797787/re-evaluation-of-low-intensity-pulsed-ultrasound-in-treatment-of-tibial-fractures-trust-randomized-clinical-trial
#3
Jason W Busse, Mohit Bhandari, Thomas A Einhorn, Emil Schemitsch, James D Heckman, Paul Tornetta, Kwok-Sui Leung, Diane Heels-Ansdell, Sun Makosso-Kallyth, Gregory J Della Rocca, Clifford B Jones, Gordon H Guyatt
OBJECTIVE:  To determine whether low intensity pulsed ultrasound (LIPUS), compared with sham treatment, accelerates functional recovery and radiographic healing in patients with operatively managed tibial fractures. DESIGN:  A concealed, randomized, blinded, sham controlled clinical trial with a parallel group design of 501 patients, enrolled between October 2008 and September 2012, and followed for one year. SETTING:  43 North American academic trauma centers...
October 25, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27785362/low-intensity-pulsed-ultrasound-stimulation-in-different-regions-in-the-viability-of-myocutaneous-flaps
#4
Fernanda Luiza de Almeida Albuquerque, Lais Mara Siqueira das Neves, Elaine Caldeira de Oliveira Guirro
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) has presented good results in the healing of chronic wounds. The objective of this study was to compare the effect of LIPUS on the viability of transverse rectus abdominal muscle (TRAM) flap in different regions (central and epigastric) in rats. METHODS: Twenty-one Wistar male rats were homogeneously distributed into three groups as follows: group 1 (control), animals submitted to surgery only; group 2, animals submitted to surgery and application of LIPUS at the center of the flap; and group 3, animals submitted to surgery and application of LIPUS at the flap area corresponding to the right inferior epigastric artery pedicle...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27774951/-low-intensity-pulsed-ultrasound-promotes-extracellular-matrix-synthesis-of-human-osteoarthritis-chondrocytes
#5
Dengkui DU, Shirong Chen, Gang Yi, Pan Wang, Ying Tang, Liwen Zheng, Junnan Chen
Objective To investigate the effect of low-intensity pulsed ultrasound (LIPUS) on the extracellular matrix synthesis of human osteoarthritis (OA) chondrocytes and explore the underlying mechanism. Methods Human osteoarthritis chondrocytes were collected from abandoned articular cartilage. Then the cells were cultured and identified by toluidine blue staining and immunocytochemical staining of type 2 collagen. The passage 2 cells were randomly divided into 3 groups: control OA group, 30 mW/cm(2) LIPUS-treated OA group, 30 mW/cm(2) LIPUS combined with 5 μmol/L LY294002-treated OA group...
November 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27729291/low-intensity-pulsed-ultrasound-lipus-treatment-of-cultured-chondrocytes-stimulates-production-of-ccn-family-protein-2-ccn2-a-protein-involved-in-the-regeneration-of-articular-cartilage-mechanism-underlying-this-stimulation
#6
Takashi Nishida, Satoshi Kubota, Eriko Aoyama, Nobuyasu Yamanaka, Karen M Lyons, Masaharu Takigawa
OBJECTIVE: CCN family protein 2/connective tissue growth factor (CCN2/CTGF) promotes cartilage regeneration in experimental osteoarthritis (OA) models. However, CCN2 production is very low in articular cartilage. The aim of this study was to investigate whether or not CCN2 was promoted by cultured chondrocytes treated with low-intensity pulsed ultrasound (LIPUS) and to clarify its mechanism. METHODS: Human chondrocytic cell line HCS-2/8, rat primary epiphyseal and articular cartilage cells, and Ccn2-deficient chondrocytes that impaired chondrocyte differentiation, were treated with LIPUS for 20 min at 3...
October 8, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27686373/regenerate-bone-stimulation-following-limb-lengthening-a-meta-analysis
#7
Julio J Jauregui, Anthony V Ventimiglia, Preston W Grieco, David B Frumberg, John E Herzenberg
BACKGROUND: Limb lengthening with external fixation is performed to treat patients with leg length discrepancy or short stature. Although the procedure has a high rate of success, one potential drawback from limb lengthening is the amount of time spent in the fixation device while regenerate bone consolidates. Although some studies have assessed different treatment modalities, there has not been a study that has systematically evaluated whether low intensity pulsed ultrasound (LIPUS) or pulsed electromagnetic fields (PEMF) have significant effects on regenerate bone growth...
September 29, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27665982/effect-of-low-intensity-pulsed-ultrasound-lipus-on-mandibular-condyle-growth-in-rats-analyzed-with-micro-ct
#8
Kyozo Sasaki, Mitsuru Motoyoshi, Eri Horinuki, Yoshinori Arai, Noriyoshi Shimizu
This study examined the effects of a bite-jumping appliance combined with low-intensity pulsed ultrasound (LIPUS) stimulation on the mandibular condyle of growing rats using micro CT (mCT) and histological examinations. Twelve Wistar rats were divided into three groups of four individuals each: Group 1 was an untreated control group, Group 2 received bite-jumping appliances, and Group 3 received bite-jumping appliances and LIPUS stimulation (15 min/day, 2 weeks) to the temporomandibular region. We measured the length and three-dimensional bone volume of each rat's mandibular condyle using mCT...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27641221/heal-rate-of-metatarsal-fractures-a-propensity-matching-study-of-patients-treated-with-low-intensity-pulsed-ultrasound-lipus-vs-surgical-and-other-treatments
#9
Peter Nolte, Robert Anderson, Elton Strauss, Zhe Wang, Liuyi Hu, Zekun Xu, R Grant Steen
INTRODUCTION: Whether to treat metatarsal fractures conservatively or surgically is controversial. We test a hypothesis that metatarsal fractures treated conservatively with non-invasive low-intensity pulsed ultrasound (LIPUS) obtain heal rates comparable to current surgical techniques. PATIENTS AND METHODS: This is a retrospective observational cohort study, using patient outcomes from a prospectively-collected LIPUS registry required by the U.S. Food & Drug Administration...
September 13, 2016: Injury
https://www.readbyqxmd.com/read/27625295/low-intensity-pulsed-ultrasound-upregulates-pro-myelination-indicators-of-schwann-cells-enhanced-by-co-culture-with-adipose-derived-stem-cells
#10
Yuan Yue, Xingmei Yang, Liang Zhang, Xun Xiao, Neel R Nabar, Yunfeng Lin, Liang Hao, Dongjiao Zhang, Jingyi Huo, Jingle Li, Xiaoxiao Cai, Min Wang
OBJECTIVES: Peripheral nerve injuries are a common occurrence, resulting in considerable patient suffering; it also represents a major economic burden on society. To improve treatment options following peripheral nerve injuries, scientists aim to find a way to promote Schwann cell (SC) myelination to help nerves to carry out their functions effectively. In this study, we investigated myelination ability of SCs, regulated by co-culture with adipose-derived stem cells (ASCs) or low-intensity pulsed ultrasound (LIPUS), and synergistic effects of combined treatments...
September 14, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27600474/effect-of-low-intensity-pulsed-ultrasound-after-mesenchymal-stromal-cell-injection-to-treat-osteochondral-defects-an-in%C3%A2-vivo-study
#11
Shoki Yamaguchi, Tomoki Aoyama, Akira Ito, Momoko Nagai, Hirotaka Iijima, Junichi Tajino, Xiangkai Zhang, Kiyan Wataru, Hiroshi Kuroki
We investigated the effect of low-intensity pulsed ultrasound (LIPUS) treatment combined with mesenchymal stromal cell (MSC) injection for cartilage repair and subchondral bone reconstitution for treatment of osteochondral defects. An osteochondral defect was created on both femur grooves of Wistar rats. Four weeks later, bone marrow MSCs were injected into the right knee joint. The rats were divided into two intervention groups: without or with LIPUS irradiation. Cartilage repair was evaluated histologically based on the Wakitani cartilage repair score...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27597635/improved-human-bone-marrow-mesenchymal-stem-cell-osteogenesis-in-3d-bioprinted-tissue-scaffolds-with-low-intensity-pulsed-ultrasound-stimulation
#12
Xuan Zhou, Nathan J Castro, Wei Zhu, Haitao Cui, Mitra Aliabouzar, Kausik Sarkar, Lijie Grace Zhang
3D printing and ultrasound techniques are showing great promise in the evolution of human musculoskeletal tissue repair and regeneration medicine. The uniqueness of the present study was to combine low intensity pulsed ultrasound (LIPUS) and advanced 3D printing techniques to synergistically improve growth and osteogenic differentiation of human mesenchymal stem cells (MSC). Specifically, polyethylene glycol diacrylate bioinks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalline hydroxyapatite (nHA) were used to fabricate 3D scaffolds with different geometric patterns via novel table-top stereolithography 3D printer...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27592560/low-intensity-pulsed-ultrasound-enhances-nerve-growth-factor-induced-neurite-outgrowth-through-mechanotransduction-mediated-erk1-2-creb-trx-1-signaling
#13
Lu Zhao, Yi Feng, Hong Hu, Aiwei Shi, Lei Zhang, Mingxi Wan
Enhancing the action of nerve growth factor (NGF) is a potential therapeutic approach to neural regeneration. To facilitate neural regeneration, we investigated whether combining low-intensity pulsed ultrasound (LIPUS) and NGF could promote neurite outgrowth, an essential process in neural regeneration. In the present study, PC12 cells were subjected to a combination of LIPUS (1 MHz, 30 or 50 mW/cm(2), 20% duty cycle and 100-Hz pulse repetition frequency, 10 min every other day) and NGF (50 ng/mL) treatment, and then neurite outgrowth was compared...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27587817/draft-genome-sequence-of-methanohalophilus-mahii-strain-dal1-reconstructed-from-a-hydraulic-fracturing-produced-water-metagenome
#14
Daniel Lipus, Amit Vikram, Daniel E Ross, Kyle Bibby
We report here the 1,882,100-bp draft genome sequence of Methanohalophilus mahii strain DAL1, recovered from Marcellus Shale hydraulic fracturing-produced water using metagenomic contig binning. Genome annotation revealed several key methanogenesis genes and provides valuable information on archaeal activity associated with hydraulic fracturing-produced water environments.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27536722/experiential-learning-through-participatory-action-research-in-public-health-supports-community-based-training-of-future-health-professionals
#15
Lisa K Marriott, Adam C Lipus, Laurie Choate, Jamie Smith, Leigh Coppola, William E Cameron, Jackilen Shannon
Engaging community members in research can help cultivate effective partnerships while providing experiential training and continuing education opportunities. Several studies have involved communities in this way, though many have been small in the scale of community involvement or have included little detail of the institutional review board process by which community members became approved researchers in the study. This article presents findings on an evaluation of the training procedures and experiences of 703 first-time community-based volunteer researchers who were recruited in their communities and trained on-site to enroll research participants, collect data, and provide individualized consultation of results at travelling health education and research fairs...
December 2015: Pedagogy in Health Promotion
https://www.readbyqxmd.com/read/27500435/enhancement-of-bone-healing-by-low-intensity-pulsed-ultrasound-a-systematic-review
#16
Sjoerd Rutten, Michel P J van den Bekerom, Inger N Sierevelt, Petrus A Nolte
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is frequently used to enhance or to accelerate fracture-healing, but its clinical role and effectiveness as a treatment modality remain uncertain. We performed a systematic review and meta-analysis of randomized controlled trials to determine the efficiency of LIPUS on bone-healing and/or fracture union, as well as on functional recovery. METHODS: The databases of PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, and Embase were searched for trials concerning LIPUS stimulation and bone-healing or fracture repair, in any language, published from the inception of the database to January 2, 2015...
March 29, 2016: JBJS Reviews
https://www.readbyqxmd.com/read/27457653/metatranscriptome-analysis-of-active-microbial-communities-in-produced-water-samples-from-the-marcellus-shale
#17
Amit Vikram, Daniel Lipus, Kyle Bibby
Controlling microbial activity is a primary concern during the management of the large volumes of wastewater (produced water) generated during high-volume hydraulic fracturing. In this study we analyzed the transcriptional activity (metatranscriptomes) of three produced water samples from the Marcellus Shale. The goal of this study was to describe active metabolic pathways of industrial concern for produced water management and reuse, and to improve understanding of produced water microbial activity. Metatranscriptome analysis revealed active biofilm formation, sulfide production, and stress management mechanisms of the produced water microbial communities...
October 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27443802/comparison-between-various-densities-of-pore-titanium-meshes-and-e-polytetrafluoroethylene-eptfe-membrane-regarding-bone-regeneration-induced-by-low-intensity-pulsed-ultrasound-lipus-in-rabbit-nasal-bone
#18
Masatoshi Higuchi, Akinori Moroi, Kunio Yoshizawa, Akihiko Kosaka, Hiroumi Ikawa, Ran Iguchi, Yuriko Saida, Asami Hotta, Takamitsu Tsutsui, Koichiro Ueki
PURPOSE: The purpose of this study was to compare bone regenerative capability following use of polytetrafluoroethylene (ePTFE) membrane against that when various densities of pore titanium meshes are used with and without low intensity pulsed ultrasound (LIPUS). MATERIALS AND METHODS: Adult male white rabbits were divided into 8 groups. In 4 groups, after incising along the nasal bone, four 3 × 8 mm bone defects were made in both sides and covered by an ePTFE membrane (group E: n = 15), a high density pore titanium mesh (group H: n = 15), a low density pore titanium mesh (group L: n = 15), and no mesh (control) (group C: n = 15)...
September 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27441774/13-effect-of-low-intensity-pulsed-ultrasound-lipus-on-remote-bone-marrow-in-rats-with-healing-socket
#19
Kouki Hidaka, Chihiro Miyamoto, Akira Kawata, Makiko Saita, Ryota Kawamata, Yojiro Maehata, Masato Minabe, Satoko W Takahashi, Shun-Suke Takahashi, Yuko Mikuni-Takagaki
OBJECTIVE: We reported at the previous annual meeting that LIPUS treatment of the molar tooth sockets of retired breeder rats accelerated alveolar bone healing, and that associated humoral effects were seen with elevated blood flow. Namely, LIPUS induced VEGF/angiogenesis along with elevated baseline blood flow rate, which was further associated with a sudden depression of blood flow rate in the socket immediately after cessation of LIPUS treatment. Prior injection with EP4 PGE2 receptor antagonist, but not EP3 antagonist, abolished this LIPUS-induced depression, and topical application of PGE2 to the socket epithelium mimicked the LIPUS-induced depression...
August 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27441773/12-influence-of-wound-dressing-on-the-fracture-healing-effect-of-low-intensity-pulsed-ultrasound-lipus
#20
Koji Naruse, Masataka Uchino, Noriko Hirakawa, Masahiro Toyama, Genyo Miyajima, Manabu Mukai, Ken Urabe, Kentaro Uchida, Moritoshi Itoman
OBJECTIVE: We have conducted a basic study on the influences on ultrasonic properties when LIPUS is applied through wound dressing. According to the results of ex vivo experiments conducted to date, LIPUS showed ultrasonic properties such as transmittance, coefficient of transmission, and a non-uniformity ratio through film wound dressing better than other wound dressing, and it was considered that LIPUS's effect for fracture healing was not influenced by film wound dressing. Then, we discussed the influence on the effect of LIPUS through film wound dressing...
August 2016: Journal of Orthopaedic Trauma
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