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https://www.readbyqxmd.com/read/28940899/low-intensity-pulsed-ultrasound-activates-erk1-2-and-pi3k-akt-signalling-pathways-and-promotes-the-proliferation-of-human-amnion-derived-mesenchymal-stem-cells
#1
Li Ling, Tianqin Wei, Lianli He, Yaping Wang, Yan Wang, Xiushan Feng, Wenqian Zhang, Zhengai Xiong
OBJECTIVES: This study was to investigate the effect and mechanism of low-intensity pulsed ultrasound (LIPUS) on the proliferation of human amnion-derived mesenchymal stem cells (hAD-MSCs). METHODS: Human amnion-derived mesenchymal stem cells were isolated from the amnion of term placentas and identified by flow cytometry and differentiation culture. Proliferation of hAD-MSCs was investigated by Cell Counting Kit-8, cell cycle and EdU assays. Western blotting was used to determine the protein expression levels...
September 22, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28939348/transcranial-ultrasound-stimulation-promotes-brain-derived-neurotrophic-factor-and-reduces-apoptosis-in-a-mouse-model-of-traumatic-brain-injury
#2
Wei-Shen Su, Chun-Hu Wu, Szu-Fu Chen, Feng-Yi Yang
BACKGROUND: The protein expressions of brain-derived neurotrophic factor (BDNF) can be elevated by transcranial ultrasound stimulation in the rat brain. OBJECTIVE: The purpose of this study was to investigate the effects and underlying mechanisms of BDNF enhancement by low-intensity pulsed ultrasound (LIPUS) on traumatic brain injury (TBI). METHODS: Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured region daily for a period of 4 days...
September 7, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28931989/effect-of-low-intensity-pulsed-ultrasound-therapy-on-a-rat-knee-joint-contracture-model
#3
Masanori Watanabe, Satoshi Kojima, Masahiro Hoso
[Purpose] Histopathological investigation of the effects of low-intensity pulsed ultrasound (LIPUS) on joint components using a rat knee joint contracture model. [Subjects and Methods] Nineteen, 9-week-old Wistar male rats were divided into a control group (n=6) and an experimental group. Rats in the experimental group underwent cast immobilization of the right rear limb for 8 weeks. They were then randomly divided into a non-treatment group (n=6), which was raised under normal conditions for 4 weeks, and a treatment group (n=7), which underwent LIPUS for 4 weeks...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28928844/inhibitory-effects-of-low-intensity-pulsed-ultrasound-sonication-on-the-proliferation-of-osteosarcoma-cells
#4
Toshihiro Matsuo, Keiji Sato, Takuya Matsui, Shigeyuki Sawada, Yoshitaka Muramatsu, Katsuhisa Kawanami, Masataka Deie
To date, there is limited data on the biological effects of low-intensity pulsed ultrasound (LIPUS) on primary malignant bone tumors. The purpose of the present study was to investigate the antitumor effects of LIPUS on osteosarcoma cells. The effects of LIPUS on cell viability, induction of apoptosis, mitochondrial membrane potential and intracellular signaling molecules in the LM8 osteosarcoma cell line were investigated. LIPUS inhibited cell viability (P=0.0022) and mitochondrial membrane potential (P=0...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28904322/a-preliminary-study-of-effects-of-low-intensity-pulsed-ultrasound-lipus-irradiation-on-dentoalveolar-ankylosis
#5
Tomoyasu Kiyokawa, Mitsuru Motoyoshi, Mizuki Inaba, Remi Sano, Akari Saiki, Go Torigoe, Masatake Asano, Noriyoshi Shimizu
The purpose of this experiment was to investigate whether low-intensity pulsed ultrasound (LIPUS) irradiation can inhibit dentoalveolar ankylosis in transplanted rat teeth. LIPUS irradiation (the pulsed ultrasound signal had a frequency of 3.0 MHz, a spatial average intensity of 30 mW/cm(2), and a pulse ratio of 1:4) was performed on the face over the re-planted teeth of rats for 4 weeks. After the rats were euthanized, we measured mobility (Periotest value [PTV]) of the transplanted and control teeth using a Periotest...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28866219/effect-of-low-intensity-pulsed-ultrasound-on-the-biological-behavior-of-osteoblasts-on-porous-titanium-alloy-scaffolds-an-in-vitro-and-in-vivo-study
#6
Hongjuan Cao, Lifang Feng, Zhenxian Wu, Wentao Hou, Shujun Li, Yulin Hao, Lin Wu
Low-intensity pulsed ultrasound (LIPUS) has been used in patients with fresh fractures, delayed union and non-union to enhance bone healing and improve functional outcome. However, there were few studies concerning the effects of LIPUS on the biological behavior of osteoblasts on porous scaffolds. This study aimed to evaluate the effects of LIPUS on the biological behavior of osteoblasts on porous titanium-6aluminum-4vanadium (Ti6Al4V) alloy scaffolds in vitro and in vivo. Scaffolds were randomly divided into an ultrasound group and a control group...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28854496/the-efficacy-and-safety-of-combination-therapy-of-low-intensity-pulsed-ultrasound-stimulation-in-the-treatment-of-unstable-both-radius-and-ulna-fractures-in-children
#7
Tsuyoshi Ota, Soichiro Itoh, Kimihiro Yamashita
BACKGROUND: There are few reports of Low-intensity pulsed ultrasound (LIPUS) treatment for fresh forearm fractures in children. OBJECTIVES: LIPUS stimulation was applied after surgery of forearm fractures in children and the efficacy and safety of combination therapy of LIPUS treatment were evaluated. PATIENTS AND METHODS: Children with both radius and ulna fracture, twenty-five diaphysis (mid-R&U) and nineteen metaphysis (dist-R&U) fractures, were treated with intramedullary nailing followed by cast and splint mobilization...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28852995/-key-topics-in-austrian-child-and-adolescent-psychiatry-2007-2017
#8
Andreas Karwautz, Cvetka F Lipuš, Martin Fuchs
The medical speciality "Child and Adolescent Psychiatry" exists since 2007. 2015 a new training regulation defined an increment to "Child and Adolescent Psychiatry and Psychotherapeutic Medicine". To document the achievements in research within the last 10 years for the first time, all papers listed in Pubmed and all books published by the member of the ÖGKJP were summarized. Additionally, the clinical/scientific key aspects of all large teaching centres were documented.All members of the ÖGKJP are scientifically active in various areas of child psychiatry...
August 30, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28807447/role-of-reactive-oxygen-species-during-low-intensity-pulsed-ultrasound-application-in-mc-3-t3-e1-pre-osteoblast-cell-culture
#9
Harmanpreet Kaur, Arno G Siraki, Hasan Uludağ, Douglas N Dederich, Patrick Flood, Tarek El-Bialy
We evaluated the activation of mitogen-activated protein kinase (MAPK) activation through reactive oxygen species (ROS) by application of low-intensity ultrasound (LIPUS) to MC-3 T3 E1 pre-osteoblasts. The cells were subjected to one LIPUS application for either 10 or 20 min, and the control group was exposed to a sham transducer. For ROS inhibition, 10 μM diphenylene iodonium (DPI) was added to the cells an hour before LIPUS application. Samples were collected 1, 3, 6, 12 and 24 h after LIPUS application, and cells were evaluated for ROS generation, cell viability, gene expression and MAPK activation by immunoblot analyses...
August 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28804549/treatment-effect-of-low-intensity-pulsed-ultrasound-on-leukopenia-induced-by-cyclophosphamide-in-rabbits
#10
Baoru Liu, Yueping Luo, Dong Luo, Weichen Zhou, Yu Zhang, Ruixin He, Junshu Li, Yong Wang, Yan Wang, Wenzhi Chen
OBJECTIVE: This study aims to examine the effects of low intensity pulsed ultrasound (LIPUS) on leukopenia induced by cyclophosphamide in a rabbit model. METHODS: The leukopenia model in New Zealand rabbit was established by injecting cyclophosphamide into the ear vein. Forty leukopenia model rabbits were randomly allocated to control group (n = 20) and LIPUS group (n = 20). LIPUS group underwent 20 minutes of daily ultrasound treatment at femoral metaphysis for 7 days while control group received sham treatment...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28762588/an-investigation-of-shock-wave-therapy-and-low-intensity-pulsed-ultrasound-on-fracture-healing-under-reduced-loading-conditions-in-an-ovine-model
#11
Benjamin C Gadomski, Kirk C McGilvray, Jeremiah T Easley, Ross H Palmer, Jian Jiao, Xiaofei Li, Yi-Xian Qin, Christian M Puttlitz
The use of shock wave therapy (SWT) and low-intensity pulsed ultrasound (LIPUS) as countermeasures to the inhibited fracture healing experienced during mechanical unloading was investigated by administering treatment to the fracture sites of mature, female, Rambouillet Columbian ewes exposed to partial mechanical unloading or full gravitational loading. The amount of fracture healing experienced by the treatment groups was compared to controls in which identical surgical and testing protocols were administered except for SWT or LIPUS treatment...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28735428/effects-of-low-intensity-pulsed-ultrasound-on-soft-tissue-micro-circulation-in-the-foot
#12
Anna Katharina Kösters, Bergita Ganse, Boyko Gueorguiev, Kajetan Klos, Ali Modabber, Sven Nebelung, Bong-Sung S Kim, Matthias Knobe
PURPOSE: Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate bone healing and is considered to increase blood flow. The aim of this study was to assess changes in micro-circulation of the foots' soft tissue in response to LIPUS intervention. We hypothesised improved micro-circulation in response to LIPUS. METHODS: Micro-circulation was assessed in 2 mm and 8 mm-deep skin of 50 healthy volunteers using non-invasive laser-doppler spectrophotometry (O2C-device)...
July 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28719993/comparison-of-treatment-results-for-mallet-finger-fractures-in-children-between-low-intensity-pulsed-ultrasound-stimulation-and-ishiguro-s-method
#13
Tsuyoshi Ota, Soichiro Itoh, Yoshihiko Matsuyama
BACKGROUND: We compared the treatment results for displaced mallet finger fractures in children between low-intensity pulsed ultrasound (LIPUS) stimulation and Ishiguro's method, which involves extension block and arthrodesis of the distal interphalangeal (DIP) joint with pinning. METHODS: Eleven cases (5 females and 6 males; average age, 13.5 years) of mallet finger were operated with Ishiguro's method, and 8 cases (3 females and 5 males; average age, 13.0 years) were treated with LIPUS stimulation...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28713732/effect-of-low-intensity-pulsed-ultrasound-on-postorthognathic-surgery-healing-process
#14
Azita Tehranchi, Mohamadreza Badiee, Farnaz Younessian, Mohamadreza Badiei, Sahar Haddadpour
BACKGROUND: Orthognathic surgery can cause discomforts such as pain, inflammation, and edema. One of the challenges is bone regeneration at surgery area. The aim of this study is to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) therapy on bone regeneration and pain relief after surgery. MATERIALS AND METHODS: Following mandibular surgery of nine patients, LIPUS treatment was applied to the left or right side for 3 weeks and 20 min/day. The other side was treated with sham-LIPUS as the control group...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28688752/comparison-of-effects-of-lllt-and-lipus-on-fracture-healing-in-animal-models-and-patients-a-systematic-review
#15
REVIEW
Mohammad Bayat, Amarjit Virdi, Reza Jalalifirouzkouhi, Fatemehalsadat Rezaei
The aim of this paper is to study the in vivo potency of low-level laser therapy (LLLT) and low intensity pulsed ultrasound (LIPUS) alone, accompanied by bone grafts, or accompanied by other factors on fracture healing in animal models and patients. In this paper, we aim to systematically review the published scientific literature regarding the use of LLLT and LIPUS to accelerate fracture healing in animal models and patients. We searched the PubMed database for the terms LLLT or LIPUS and/or bone, and fracture...
July 5, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28672962/enhanced-regeneration-of-large-cortical-bone-defects-with-electrospun-nanofibrous-membranes-and-low-intensity-pulsed-ultrasound
#16
Leyi Huang, Youzhi Cai, Honghua Hu, Peng Guo, Zengfeng Xin
Poly-L-lactic acid (PLLA) nanofibrous membranes are widely utilized for tissue regeneration. Low intensity pulsed ultrasound (LIPUS) has been considered as a feasible modality for bone union. The aim of the present study was to investigate the potential synergistic effect of LIPUS and PLLA electrospun nanofibrous membranes on large cortical bone defects in rabbits in vivo. The bilateral rabbit tibia defect model was constructed using 18 adult NZ rabbits and the defect sites were treated with the nanofibrous membranes combined with LIPUS or nanofibrous membranes alone...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28651921/ultrasound-enhances-dentoalveolar-remodeling-in-an-ex%C3%A2-vivo-orthodontic-ovariectomy-induced-osteoporotic-model
#17
Khuloud S Alhazmi, Tarek El-Bialy, Ahmed R Afify, Leena A Merdad, Ali H Hassan
The aim of the study was to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on dentoalveolar structures during application of force to a cultured mandible slice taken from an ovariectomized rat model of osteoporosis. Rats were divided based on whether they had ovariectomy and/or LIPUS application into four groups: control osteoporosis group, control normal group, ultrasound-treated osteoporosis group and ultrasound-treated normal group. The mandibles were dissected, sliced and cultured before application of a 0...
June 23, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28638681/efficacy-of-extracorporeal-shockwave-therapy-and-low-intensity-pulsed-ultrasound-in-a-rat-knee-osteoarthritis-model-a-randomized-controlled-trial
#18
Volkan Yılmaz, Ömer Karadaş, Taner Dandinoğlu, Ebru Umay, Aytül Çakçı, Arif Kenan Tan
OBJECTIVE: This study aims to assess the efficacy of extracorporeal shockwave therapy (ESWT) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic rat knees. MATERIAL AND METHODS: Twenty-four rats were divided into 3 groups: group 1-control (n=8), group 2-LIPUS (n=8) and group 3-ESWT (n=8). Cartilage degeneration was provided using mono-iodo-asetate (MIA). One milligram of MIA was delivered to the right knees in group 1 and both knees in group 2 and 3. A 0...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28637991/low-intensity-pulsed-ultrasound-inhibits-lipopolysaccharide-induced-il-6-and-rankl-expression-in-osteoblasts
#19
Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Manami Ozaki, Masao Maeno, Naoto Suzuki, Shuichi Sato
Periodontal disease is caused by inflammation induced by Porphyromonas gingivalis (P.g.) lipopolysaccharide (LPS) and involves expression of proinflammatory cytokines such as interleukin (IL)-1, IL-6, tumor necrosis factor-α, and receptor activator of nuclear factor kappa B ligand (RANKL), which are implicated in bone resorption. Low-intensity pulsed ultrasound (LIPUS) is commonly used in the treatment of bone fracture. However, the mechanisms by which LIPUS inhibits LPS-induced inflammatory cytokines are poorly understood...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28632669/effect-of-low-intensity-pulsed-ultrasound-lipus-on-endochondral-ossification-via-the-wnt-signaling-pathway
#20
Ken Kumagai, Yasuteru Yamaguchi, Kazuma Miyatake, Hironori Tanabe, Sosuke Imai, Tomoyuki Saito
OBJECTIVE: We have previously demonstrated that LIPUS stimulates endochondral ossification with decreased expression of sclerostin. The Wnt signaling pathway was examined in vitro to further address the effect of LIPUS on endochondral ossification. MATERIALS AND METHODS: ATDC5 cells were plated at an initial density of 6 × 10 cells/well in a 6-multiwell plate and cultured in the presence of 5% FBS plus ITS. The bottom of the culture plate was treated every day with LIPUS for 20 minutes...
July 2017: Journal of Orthopaedic Trauma
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