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https://www.readbyqxmd.com/read/27904872/background-based-delineation-of-internal-tumor-volume-in-static-positron-emission-tomography-in-a-phantom-study
#1
Yangchun Chen, Xiangrong Chen, Ji-An Liu, Fanyong Li
OBJECTIVES: Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. METHODS: Three hollow models were filled with 55.0 kBq/mL fluorine-18 fluorodeoxyglucose ((18)F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL (18)F-FDG to characterize normal lung tissues as a phantom...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27895731/advantages-and-disadvantages-of-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-carcinoma-of-unknown-primary
#2
Xiaozhou Yu, Xiaofeng Li, Xiuyu Song, Dong Dai, Lei Zhu, Yanjia Zhu, Jian Wang, Huiqin Zhao, Wengui Xu
Carcinoma of unknown primary is a type of malignant disease where the primary carcinoma cannot be identified by conventional examination, which presents challenges in diagnosis and therapy. This study aims to evaluate the detailed clinical value and indications of using fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in a large sample. A total of 449 patients who were selected under strict standards were retrospectively included in this study. F-18 FDG PET/CT accurately detected the primary carcinoma in 115 of 449 patients whose primaries could not be detected by conventional examination (25...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27884713/paclitaxel-loaded-polymeric-nanoparticles-combined-with-chronomodulated-chemotherapy-on-lung-cancer-in-vitro-and-in-vivo-evaluation
#3
Jie Hu, Shaozhi Fu, Qiuxia Peng, YunWei Han, Jie Xie, Ning Zan, Yue Chen, Juan Fan
The objective of our study was to examine the anti-tumor effect of paclitaxel (PTX)-loaded polymeric nanoparticles (PTX-NPs) combined with circadian chronomodulated chemotherapy. Our intention was to screen out the best time of the day for the drug to be administered. PTX-NPs with a diameter of approximately 168nm were prepared through a thin film dispersion technique. The PTX in PTX-NPs showed an initial fast release subsequently a slower and sustained release. The cytotoxicity of chronomodulated administration of PTX-NPs in vitro confirmed that its cytotoxic effect was lower than that of PTX injection, and showed a time-dependent effect...
November 21, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27846378/tumor-delineation-and-quantitative-assessment-of-glucose-metabolic-rate-within-histologic-subtypes-of-non-small-cell-lung-cancer-by-using-dynamic-18-f-fluorodeoxyglucose-pet
#4
Tineke W H Meijer, Lioe-Fee de Geus-Oei, Eric P Visser, Wim J G Oyen, Monika G Looijen-Salamon, Dimitris Visvikis, Ad F T M Verhagen, Johan Bussink, Dennis Vriens
Purpose To assess whether dynamic fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) has added value over static (18)F-FDG PET for tumor delineation in non-small cell lung cancer (NSCLC) radiation therapy planning by using pathology volumes as the reference standard and to compare pharmacokinetic rate constants of (18)F-FDG metabolism, including regional variation, between NSCLC histologic subtypes. Materials and Methods The study was approved by the institutional review board. Patients gave written informed consent...
November 15, 2016: Radiology
https://www.readbyqxmd.com/read/27833322/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-rare-case-of-carcinoma-stomach-with-concomitant-silicosis
#5
Arun Sasikumar, Ajith Joy, Madhavan Unni, Jayaprakash Madhavan
The role of fluorine-18 fluorodeoxyglucose. ((18)F-FDG) positron emission tomography. (PET)/computed tomography. (CT) in the initial staging of various malignancies is now well established. However, nonspecificity of FDG occasionally results in tracer uptake in benign lung lesions. The authors describe a complicated case of carcinoma stomach with multiple nodules and a cavitary lesion in lungs where (18)F-FDG PET CT done for initial staging revealed FDG avid mass in stomach, FDG avid multiple mediastinal lymph nodes and multiple intensely FDG avid bilateral lung lesions...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27833314/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-idiopathic-pulmonary-fibrosis-a-new-ray-of-hope
#6
Unnati Desai, Vinaya S Karkhanis, Sandip Basu, Jyotsna M Joshi
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with median survival of 2-3 years. It is described as fibroproliferative rather than pro-inflammatory disorder with limited treatment options. IPF diagnostics and therapeutics are a hot topic of current research. We describe a case elaborating the utility of the whole body positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose (F-18 FDG) integrated with computed tomography technique in IPF. The area of most intense pulmonary F--18 FDG uptake corresponded to regions of honeycombing suggesting metabolically active disease amenable to pharmacologic intervention...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27816633/cargo-influences-on-the-biodistribution-of-hollow-mesoporous-silica-nanoparticles-as-studied-by-quantitative-19-f-magnetic-resonance-imaging
#7
Alexander Pochert, Ina Vernikouskaya, Felix Pascher, Volker Rasche, Mika Lindén
HYPOTHESIS: Biodistribution is a key issue when it comes to medical applications of nanomaterials. Hollow mesoporous silica nanoparticles (HMSNs) loaded with fluorine compounds can be applied as positive magnetic resonance imaging (MRI) contrast agents (CAs). These CAs exhibit an unusual biodistribution which is influenced by the cargo and which could be linked to their serum protein adsorption behaviour. EXPERIMENTS: HMSNs were post-synthetically loaded with perfluoro-15-crown-5-ether (PFCE)...
February 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27736925/in-vivo-detection-and-tracking-of-t-cells-in-various-organs-in-a-melanoma-tumor-model-by-19f-fluorine-mrs-mri
#8
Christine Gonzales, Hikari A I Yoshihara, Nahzli Dilek, Julie Leignadier, Melita Irving, Pascal Mieville, Lothar Helm, Olivier Michielin, Juerg Schwitter
BACKGROUND: 19F-MRI and 19F-MRS can identify specific cell types after in-vitro or in-vivo 19F-labeling. Knowledge on the potential to track in-vitro 19F-labeled immune cells in tumor models by 19F-MRI/MRS is scarce. AIM: To study 19F-based MR techniques for in-vivo tracking of adoptively transferred immune cells after in-vitro 19F-labeling, i.e. to detect and monitor their migration non-invasively in melanoma-bearing mice. METHODS: Splenocytes (SP) were labeled in-vitro with a perfluorocarbon (PFC) and IV-injected into non-tumor bearing mice...
2016: PloS One
https://www.readbyqxmd.com/read/27732568/sirt3-is-attenuated-in-systemic-sclerosis-skin-and-lungs-and-its-pharmacologic-activation-mitigates-organ-fibrosis
#9
Kaname Akamata, Jun Wei, Mitra Bhattacharyya, Paul Cheresh, Michael Y Bonner, Jack L Arbiser, Kirtee Raparia, Mahesh P Gupta, David W Kamp, John Varga
Constitutive fibroblast activation is responsible for organ fibrosis in fibrotic disorders including systemic sclerosis (SSc), but the underlying mechanisms are not fully understood, and effective therapies are lacking. We investigated the expression of the mitochondrial deacetylase sirtuin 3 (SIRT3) and its modulation by hexafluoro, a novel fluorinated synthetic honokiol analogue, in the context of fibrosis. We find that augmenting cellular SIRT3 by forced expression in normal lung and skin fibroblasts, or by hexafluoro treatment, blocked intracellular TGF-ß signaling and fibrotic responses, and mitigated the activated phenotype of SSc fibroblasts...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27712073/highly-stable-fluorinated-nanocarriers-with-irgd-for-overcoming-the-stability-dilemma-and-enhancing-tumor-penetration-in-an-orthotopic-breast-cancer
#10
Shengnan Ma, Jie Zhou, Yuxin Zhang, Yiyan He, Qian Jiang, Dong Yue, Xianghui Xu, Zhongwei Gu
The stability dilemma and limited tumor penetration of nanocarriers in cancer chemotherapy remain two predominant challenges for their successful clinical translation. Herein, the pH-sensitive fluorocarbon functionalized nanocarriers (SFNs) with a tumor homing and penetrating peptide iRGD are reported to overcome the stability dilemma and enhance tumor accumulation and penetration in an orthotopic breast cancer. The highly stable SFNs with a low critical association concentration provide a safe and spacious harbor for hydrophobic drugs...
October 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27708059/posttranslational-mutagenesis-a-chemical-strategy-for-exploring-protein-side-chain-diversity
#11
Tom H Wright, Ben J Bower, Justin M Chalker, Gonçalo J L Bernardes, Rafal Wiewiora, Wai-Lung Ng, Ritu Raj, Sarah Faulkner, M Robert J Vallée, Anuchit Phanumartwiwath, Oliver D Coleman, Marie-Laëtitia Thézénas, Maola Khan, Sébastien R G Galan, Lukas Lercher, Matthew W Schombs, Stefanie Gerstberger, Maria E Palm-Espling, Andrew J Baldwin, Benedikt M Kessler, Timothy D W Claridge, Shabaz Mohammed, Benjamin G Davis
Posttranslational modification of proteins expands their structural and functional capabilities beyond those directly specified by the genetic code. However, the vast diversity of chemically-plausible (including unnatural but functionally relevant) side-chains is not readily accessible. We describe C (sp(3))-C (sp(3)) bond-forming reactions on proteins under biocompatible conditions, which exploit unusual carbon free radical chemistry, and use them to form Cβ-Cγ bonds with altered side chains. We demonstrate how these transformations enable a wide-diversity of natural, unnatural, posttranslationally-modified (methylated, glycosylated, phosphorylated, hydroxylated) and labeled (fluorinated, isotopically-labeled) side-chains to be added to a common, readily-accessible dehydroalanine precursor in a range of representative protein types and scaffolds...
September 22, 2016: Science
https://www.readbyqxmd.com/read/27693672/-18-f-mel050-as-a-melanin-targeted-pet-tracer-fully-automated-radiosynthesis-and-comparison-to-18-f-fdg-for-the-detection-of-pigmented-melanoma-in-mice-primary-subcutaneous-tumors-and-pulmonary-metastases
#12
Nathalie Rizzo-Padoin, Michael Chaussard, Nicolas Vignal, Ewa Kotula, Vadim Tsoupko-Sitnikov, Sofia Vaz, Fortune Hontonnou, Wang-Qing Liu, Jean-Luc Poyet, Michel Vidal, Pascal Merlet, Benoit Hosten, Laure Sarda-Mantel
INTRODUCTION: Melanoma is a highly malignant cutaneous tumor of melanin-producing cells. MEL050 is a synthetic benzamide-derived molecule that specifically binds to melanin with high affinity. Our aim was to implement a fully automated radiosynthesis of [(18)F]MEL050, using for the first time, the AllInOne™ synthesis module (Trasis), and to evaluate the potential of [(18)F]MEL050 for the detection of pigmented melanoma in mice primary subcutaneous tumors and pulmonary metastases, and to compare it with that of [(18)F]FDG...
December 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27689973/design-synthesis-and-cytotoxicity-of-5-fluoro-2-methyl-6-4-aryl-piperazin-1-yl-benzoxazoles
#13
Thuraya Al-Harthy, Wajdi Michel Zoghaib, Maren Pflüger, Miriam Schöpel, Kamil Önder, Maria Reitsammer, Harald Hundsberger, Raphael Stoll, Raid Abdel-Jalil
To design new compounds suitable as starting points for anticancer drug development, we have synthesized a novel series of benzoxazoles with pharmaceutically advantageous piperazine and fluorine moieties attached to them. The newly synthesized benzoxazoles and their corresponding precursors were evaluated for cytotoxicity on human A-549 lung carcinoma cells and non-cancer HepaRG hepatocyes. Some of these new benzoxazoles show potential anticancer activity, while two of the intermediates show lung cancer selective properties at low concentrations where healthy cells are unaffected, indicating a selectivity window for anticancer compounds...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27494286/imaging-evaluation-of-malignant-chest-wall-neoplasms
#14
Brett W Carter, Marcelo F Benveniste, Sonia L Betancourt, Patricia M de Groot, John P Lichtenberger, Behrang Amini, Gerald F Abbott
Neoplasms of the chest wall are uncommon lesions that represent approximately 5% of all thoracic malignancies. These tumors comprise a heterogeneous group of neoplasms that may arise from osseous structures or soft tissues, and they may be malignant or benign. More than 50% of chest wall neoplasms are malignancies and include tumors that may arise as primary malignancies or secondarily involve the chest wall by way of direct invasion or metastasis from intrathoracic or extrathoracic neoplasms. Although 20% of chest wall tumors may be detected at chest radiography, chest wall malignancies are best evaluated with cross-sectional imaging, principally multidetector computed tomography (CT) and magnetic resonance (MR) imaging, each of which has distinct strengths and limitations...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27479638/integrin-imaging-with-99m-tc-3prgd2-spect-ct-shows-high-specificity-in-the-diagnosis-of-lymph-node-metastasis-from-non-small-cell-lung-cancer
#15
Xiaona Jin, Naixin Liang, Mengzhao Wang, Yunxiao Meng, Bing Jia, Ximin Shi, Shanqing Li, Jinmei Luo, Yaping Luo, Quancai Cui, Kun Zheng, Zhaofei Liu, Jiyun Shi, Fang Li, Fan Wang, Zhaohui Zhu
Purpose To evaluate an integrin imaging approach based on single photon emission computed tomography (SPECT)/computed tomography (CT) by using technetium 99m ((99m)Tc)-dimeric cyclic arginine-glycine-aspartic acid (RGD) peptides with three polyethylene glycol spacers (3PRGD2) as the tracer to target the integrin αvβ3 expression in lung cancer and lymph node metastasis. Materials and Methods With ethics committee approval and written informed consent, 65 patients (41 male, 24 female; mean age, 60 years ± 11 [standard deviation]) with suspicious lung lesions were recruited with informed consent...
December 2016: Radiology
https://www.readbyqxmd.com/read/27449745/development-of-inhalable-hyaluronan-mannitol-composite-dry-powders-for-flucytosine-repositioning-in-local-therapy-of-lung-infections
#16
G Costabile, I d'Angelo, R d'Emmanuele di Villa Bianca, E Mitidieri, B Pompili, P Del Porto, L Leoni, P Visca, A Miro, F Quaglia, F Imperi, R Sorrentino, F Ungaro
Flucytosine (5-fluorocytosine, 5-FC) is a fluorinated analogue of cytosine currently approved for the systemic treatment of fungal infections, which has recently demonstrated a very promising antivirulence activity against the bacterial pathogen Pseudomonas aeruginosa. In this work, we propose novel inhalable hyaluronic acid (HA)/mannitol composite dry powders for repositioning 5-FC in the local treatment of lung infections, including those affecting cystic fibrosis (CF) patients. Different dry powders were produced in one-step by spray-drying...
September 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27439460/cholangiocarcinoma-associated-with-limbic-encephalitis-and-early-cerebral-abnormalities-detected-by-2-deoxy-2-fluorine-18-fluoro-d-glucose-integrated-with-computed-tomography-positron-emission-tomography-a-case-report
#17
Sergio L Schmidt, Juliana J Schmidt, Julio C Tolentino, Carlos G Ferreira, Sergio A de Almeida, Regina P Alvarenga, Eunice N Simoes, Guilherme J Schmidt, Nathalie H S Canedo, Leila Chimelli
BACKGROUND: Limbic encephalitis was originally described as a rare clinical neuropathological entity involving seizures and neuropsychological disturbances. In this report, we describe cerebral patterns visualized by positron emission tomography in a patient with limbic encephalitis and cholangiocarcinoma. To our knowledge, there is no other description in the literature of cerebral positron emission tomography findings in the setting of limbic encephalitis and subsequent diagnosis of cholangiocarcinoma...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27385996/pulmonary-malignant-melanoma-with-distant-metastasis-assessed-by-positron-emission-tomography-computed-tomography
#18
So Ri Kim, Ha-Yong Yoon, Gong Yong Jin, Yeong Hun Choe, Seung Yong Park, Yong Chul Lee
Melanoma is a cutaneous malignant neoplasm of melanocytes. Primary malignant melanoma (MM) of the lung is very rare. Although previous reports have described the radiologic features of pulmonary MM, its rarity means that many factors are unknown. Thus, radiologic diagnosis is very difficult. Furthermore, there is little information regarding diagnostic application and/or the usefulness of [(18)F]-fluorine-2-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography (FDG-PET-CT) for primary pulmonary MM...
July 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27347101/paraneoplastic-cushing-s-syndrome-associated-with-bronchopulmonary-carcinoid-tumor-in-youth-a-case-report-and-review-of-the-literature
#19
Wen-Ya Li, Xu-Dong Liu, Wei-Nan Li, Si-Yuan Dong, Xiao-Han Qu, Shu-Lei Gong, Ming-Rui Shao, Lin Zhang
Paraneoplastic Cushing's syndrome (CushingPS) caused by bronchopulmonary carcinoid tumors presents a diagnostic challenge for clinicians. The present study reports the case of an 18-year-old male patient presenting with rapid weight gain, polyuria, polydipsia and progressive muscle weakness. Chemical and imaging findings suggested ectopic secretion of adrenocorticotropin. Whole-body (18)fluorine-fluorodeoxyglucose ((18)FDG-PET/CT) positron-emission tomography revealed an increased uptake of (18)FDG-PET/CT in the right middle lung mass and lobar lymph node...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27331216/a-pulmonary-chondromatous-hamartoma-resembling-multiple-metastases-in-the-18-f-fdg-pet-ct-scan
#20
Li Li, Chong Jiang, Rong Tian
Multiple pulmonary hamartomas (PH) occur rarely, are mostly seen in females, and are usually leiomyomatous hamartomas. Here, we report an extremely rare case of a 30 years old male patient diagnosed as multiple pulmonary chondromatous hamartomas. He was admitted on May 2015 to our hospital for a 3 months history of cough. Multiple nodules in the right lung were detected on chest X-rays during a routine checkup 9 months ago and in a subsequent chest computed tomography (CT). However, he abandoned medical follow-up because he was asymptomatic...
May 2016: Hellenic Journal of Nuclear Medicine
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