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https://www.readbyqxmd.com/read/28984815/benefits-of-respiratory-gated-18f-fdg-pet-acquisition-in-lung-disease
#1
Pascal Bailly, Roger Bouzerar, Trevor Shields, Marc-Etienne Meyer, Joël Daouk
BACKGROUND: Fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is a reliable imaging modality for the diagnosis of malignant lung nodules and to assess the latter's prognosis. However, physiological respiratory motion deteriorates PET images and thus decreases the technique's diagnostic and prognostic values. This issue can be overcome by applying respiratory gating to the F-FDG PET/CT acquisitions. PURPOSE: The aim of this study was to evaluate the ability of respiratory-gated F-FDG PET/CT to diagnose malignant lung nodules and to predict recurrence and patient survival...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28972817/free-breathing-dynamic-19-f-gas-mr-imaging-for-mapping-of-regional-lung-ventilation-in-patients-with-copd
#2
Marcel Gutberlet, Till F Kaireit, Andreas Voskrebenzev, Florian Lasch, Julia Freise, Tobias Welte, Frank Wacker, Jens M Hohlfeld, Jens Vogel-Claussen
Purpose To quantify regional lung ventilation in patients with chronic obstructive pulmonary disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [(19)F]) gas magnetic resonance (MR) imaging. Materials and Methods In this institutional review board-approved prospective study, 27 patients with COPD were examined by using breath-hold (19)F gas wash-in MR imaging during inhalation of a normoxic fluorinated gas mixture (perfluoropropane) and by using free-breathing dynamic (19)F gas washout MR imaging after inhalation of the gas mixture was finished for a total of 25-30 L...
October 3, 2017: Radiology
https://www.readbyqxmd.com/read/28949122/role-of-positron-emission-tomography-in-thyroid-and-neuroendocrine-tumours
#3
Giorgio Treglia, Alexander S Kroiss, Arnoldo Piccardo, Filippo Lococo, Prasanna Santhanam, Alessio Imperiale
BACKGROUND: Positron emission tomography (PET) is an established imaging method in oncology. PET/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MRI) are hybrid techniques which combine morphological information obtained by CT and MRI with functional data provided by PET. Several radiotracers evaluating different metabolic pathways or receptor status can be used as PET radiotracers to assess endocrine tumours such as thyroid tumours or neuroendocrine neoplasms (NENs)...
September 25, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28932562/standardized-uptake-value-and-radiological-density-attenuation-as-predictive-and-prognostic-factors-in-patients-with-solitary-pulmonary-nodules-our-experience-on-1-592-patients
#4
Duilio Divisi, Mirko Barone, Luca Bertolaccini, Gaetano Rocco, Piergiorgio Solli, Roberto Crisci
BACKGROUND: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography ((18)F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28922334/common-malignant-brain-tumors-can-18f-fdg-pet-ct-aid-in-differentiation
#5
Nilendu C Purandare, Ameya Puranik, Sneha Shah, Archi Agrawal, Tejpal Gupta, Aliasgar Moiyadi, Prakash Shetty, Epari Shridhar, Rakesh Jalali, Venkatesh Rangarajan
OBJECTIVES: The objectives of this study were to evalute the metabolic characteristics of common malignant space-occupying lesions (SOL) of the brain and to determine the utility of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in differentiating between the common types of malignant brain SOL. PATIENTS AND METHODS: All patients with brain SOL who were referred for an F-FDG PET/CT scan by a multidisciplinary team were included in this retrospective study. The metabolic characteristics of the brain lesions in the form of maximum standardized uptake value (SUVmax) along with tumor-to-background activity ratios were determined and differences were compared using nonparametric statistical tests...
September 15, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28885542/correlation-of-the-apparent-diffusion-coefficient-and-the-standardized-uptake-value-in-neoplastic-lesions-a-meta-analysis
#6
Guohua Shen, Huan Ma, Bin Liu, Pengwei Ren, Anren Kuang
OBJECTIVE: Diffusion-weighted imaging and fluorine-18-fluorodeoxyglucose PET are increasingly being recognized as feasible oncological techniques. The apparent diffusion coefficient (ADC) measured by diffusion-weighted imaging and the standardized uptake value (SUV) from fluorine-18-fluorodeoxyglucose PET have similar clinical applications. The aim of this study was to assess the correlation between these two parameters in various cancers. MATERIALS AND METHODS: Several major databases were searched for eligible studies...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28885539/a-comparison-of-18f-fdg-pet-mr-with-pet-ct-in-pulmonary-tuberculosis
#7
Benjamin A Thomas, James S Molton, Francesca Leek, Yan Pang, John J Totman, Nicholas I Paton, David W Townsend
PURPOSE: PET/computed tomography (CT) has been shown to detect lesions in patients with pulmonary tuberculosis (PTB) and may be useful for assessing PTB disease in clinical research studies. However, radiation dose is of concern for clinical research in individuals with an underlying curable disease. This study aimed to determine whether PET/MR is equivalent to PET/CT in PTB. MATERIALS AND METHODS: Ten patients with microbiologically confirmed PTB were recruited...
November 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28883253/interstitial-lung-disease-as-an-initial-manifestation-of-giant-cell-arteritis
#8
Chisato Konishi, Kazuhiko Nakagawa, Erika Nakai, Kenta Nishi, Ryoichi Ishikawa, Shinya Uematsu, Satoshi Nakao, Masato Taki, Kyohei Morita, Hwang Moon Hee, Chie Yoshimura, Toshiaki Wakayama, Yasuo Nishizaka
Interstitial lung disease (ILD) has rarely been reported as a manifestation of giant cell arteritis (GCA). We herein report a unique case of GCA in a 76-year-old woman who presented with ILD as an initial manifestation of GCA. Ten years before admission, she had been diagnosed with granulomatous ILD of unknown etiology. Corticosteroid therapy induced remission. One year after the cessation of corticosteroid therapy, she was admitted with a persistent fever. After admission, she developed left oculomotor paralysis...
October 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28878849/prognostic-value-of-tumor-to-blood-standardized-uptake-ratio-in-patients-with-resectable-non-small-cell-lung-cancer
#9
Seunghyeon Shin, Kyoungjune Pak, In Joo Kim, Bum Soo Kim, Seong Jang Kim
OBJECTIVES: Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUVmax). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery. METHODS: Seventy-seven patients who underwent curative resection for NSCLC between January 2010 to December 2013 were enrolled in this study...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28864950/correlation-of-early-pet-findings-with-tumor-response-to-molecular-targeted-agents-in-patients-with-advanced-driver-mutated-non-small-cell-lung-cancer
#10
Tomonobu Koizumi, Toshirou Fukushima, Daisuke Gomi, Takashi Kobayashi, Nodoka Sekiguchi, Keiko Mamiya, Kazunari Tateishi, Akane Katou, Kazuhiro Oguchi
Recent advances in positron emission tomography with fluorine-18-fluorodeoxyglucose (FDG-PET) have facilitated not only the diagnosis and staging of lung cancer, but also the prediction of treatment outcome. The present study was designed to assess the usefulness of early FDG-PET examination for predicting subsequent tumor size reduction in response to molecular targeted agents in metastatic non-small cell lung cancer (NSCLC) with sensitive gene anomalies. I. In 29 targeted lesions of 10 NSCLC patients, changes in FDG uptake before and on day 7 after the initiation of molecular targeted therapy (gefitinib, n = 7; crizotinib, n = 3) were compared with subsequent radiographic tumor size reduction by RECIST...
September 1, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28830222/pulmonary-mucosa-associated-lymphoid-tissue-lymphoma-18-f-fdg-pet-ct-and-ct-findings-in-28-patients
#11
Domenico Albano, Andrea Borghesi, Giovanni Bosio, Mattia Bertoli, Roberto Maroldi, Raffaele Giubbini, Francesco Bertagna
OBJECTIVE: The aim of the study was to evaluate the CT and fluorine-18-fluorodeoxyglucose positron emission tomography/CT ((18)F-FDG PET/CT) imaging findings of lung mucosa associated lymphoid tissue (MALT) lymphoma. METHODS: 28 patients with histologically confirmed pulmonary MALT lymphoma who underwent a chest CT and (18)F-FDG PET/CT for staging were retrospectively analysed. The CT images were evaluated to determine morphological pattern of appearance, laterality, localization, number, size, presence of thoracic lymphadenopaties and secondary/combined findings...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28817456/role-of-various-semiquantitative-parameters-of-18f-fdg-pet-ct-studies-for-interim-treatment-response-evaluation-in-non-small-cell-lung-cancer
#12
Akshima Sharma, Anant Mohan, Ashu Seith Bhalla, Sreenivas Vishnubhatla, Anil Kumar Pandey, Chandra Sekhar Bal, Rakesh Kumar
PURPOSE: The aim of this study was to prospectively evaluate the role of various semiquantitative parameters obtained from fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT in interim treatment response assessment in biopsy-proven non-small-cell lung cancer (NSCLC) and to find the best parameter, if any. MATERIALS AND METHODS: Totally, 32 patients (male/female: 25/7) with biopsy proven NSCLC and a mean age of 54.71±12.65 years were enrolled in the study. Each patient underwent whole-body F-FDG PET/CT scan after injecting 5...
October 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28756970/phase-separated-surfactant-monolayers-exploiting-immiscibility-of-fluorocarbons-and-hydrocarbons-to-pattern-interfaces
#13
REVIEW
Matthew F Paige, Ala'a F Eftaiha
The mutual immiscibility of hydrogenated and fluorinated surfactants at interfaces frequently leads to phase-separation, which provides a useful and flexible method for patterning air-water and solid-air interfaces. In this article, we review recent advances in the use of hydrogenated-fluorinated surfactant mixtures to achieve interfacial patterning. For even relatively simple systems comprised of binary mixed monolayers of hydrogenated and perfluorinated fatty acids, a diverse range of film morphologies can be generated at the air-water interface and successfully transferred onto solid substrates...
July 20, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28716641/synthesis-and-evaluation-of-osimertinib-derivatives-as-potent-egfr-inhibitors
#14
Hongying Gao, Zimo Yang, Xinglin Yang, Yu Rao
Osimertinib has been identified as a promising therapeutic drug targeting for EGFR T790M mutant non-small cell lung cancer (NSCLC). A new series of N-oxidized and fluorinated osimertinib derivatives were designed and synthesized. The cellular anti-proliferative activity, kinase inhibitory activity and the activation of EGFR signaling pathways of 1-6 in vitro were determined against L858R/T790M and wild-type EGFR, the antitumor efficacy in NCI-H1975 xenografts in vivo were further studied. Compound 2, the newly synthesized N-oxide metabolite in N,N,N'-trimethylethylenediamine side chain of osimertinib, showed a comparable kinase selectivity in vitro and a slightly better antitumor efficacy in vivo to osimertinib, making it valuable and suitable for the potential lung cancer therapy...
September 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28698138/a-novel-fluorinated-thiosemicarbazone-derivative-2-3-4-difluorobenzylidene-hydrazinecarbothioamide-induces-apoptosis-in-human-a549-lung-cancer-cells-via-ros-mediated-mitochondria-dependent-pathway
#15
Yue Zhao, Chuanlong Guo, Lijun Wang, Shuaiyu Wang, Xiangqian Li, Bo Jiang, Ning Wu, Shuju Guo, Renshuai Zhang, Kun Liu, Dayong Shi
Thiosemicarbazone, a class of compounds with excellent biological activity, especially antitumor activity, have attracted wide attention. In this study, a novel fluorinated thiosemicarbazone derivative, 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide (compound 1) was synthesized and its antitumor activities were further investigated on a non-small cell lung cancer cell line (A549) along with its underlying mechanisms. Compound 1 showed significant anti-proliferative activity on A549 cells, which was further proved by colony formation experiment...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28697196/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-findings-in-a-pediatric-mucoepidermoid-carcinoma-and-differential-diagnosis
#16
Jianhao Xie, Chao Ma, Jun Tang
An 11 years old boy was referred to our hospital. He complained for the last three months for intermittent cough and shortness of breath after exercise which worsened recently. Airways computed tomography (CT) showed an abnormal endobronchial tumor, obstructing the right main bronchus and also atelectasis in the upper lobe of the right lung. Bronchoscopy showed a wet on its surface mass obstructing the right main bronchus. Biopsy showed a mucoepidermoid carcinoma (MEC). The fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan showed in the same area a mass with slightly increased (18)F-FDG uptake (maximum standardized uptake value, SUVmax: 3...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28696964/impact-of-ebus-tbna-on-pet-ct-imaging-of-mediastinal-nodes
#17
Pradeesh Sivapalan, Therese Maria Henriette Naur, Sara Colella, Klaus Richter Larsen, Lars Konge, Paul Frost Clementsen
BACKGROUND: Positron emission tomography-computed tomography (PET-CT) with fluorine-18-fluorodeoxyglucose has a high sensitivity in detecting malignancy in patients suspected of lung cancer but a low specificity as inflammatory reactions can also result in metabolic activity. Furthermore, it is assumed that invasive pulmonary procedures with biopsies from benign lesions can induce metabolic activity resulting in false-positive results. However, this hypothesis lacks solid evidence. We aimed to evaluate how often endobronchial ultrasound (EBUS) with biopsies from benign lesions are followed by false-positive results...
July 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28690012/prognostic-value-of-metabolic-parameters-of-metastatic-lymph-nodes-on-18-f-fdg-pet-ct-in-patients-with-limited-stage-small-cell-lung-cancer-with-lymph-node-involvement
#18
Feng Jin, Bo Qu, Zheng Fu, Yan Zhang, Anqin Han, Li Kong, Jinming Yu
INTRODUCTION: We assessed the prognostic value of the metabolic parameters of different lesions, including primary tumors and metastatic lymph nodes (LNs), measured by fluorine-18 fluorodeoxyglucose positron emission tomography (PET)/computed tomography in patients with limited-stage small-cell lung cancer (LS-SCLC) with LN metastasis. MATERIALS AND METHODS: The present retrospective study included 46 patients with clinical stage II-III N1-N2 LS-SCLC who had undergone pretreatment fluorine-18 fluorodeoxyglucose PET/computed tomography scanning from January 2011 to December 2014...
June 22, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28678114/comparative-effectiveness-18f-fdg-pet-ct-versus-ct-for-post-treatment-follow-up-of-patients-with-lung-cancer
#19
Sara Sheikhbahaei, Se J Ahn, Brenda Young, Mehdi Taghipour, Charles Marcus, Rathan M Subramaniam
PURPOSE: This study aimed to evaluate the comparative effectiveness of follow-up fluorine-18-fluorodeoxyglucose (F-FDG)-PET/CT and chest CT in the detection of local, regional, and distant metastatic diseases in lung cancer. PATIENTS AND METHODS: Follow-up F-FDG-PET/CT and chest-CT pairs of biopsy-proven lung cancer patients were reviewed retrospectively (May 2004-June 2013). Histopathological, clinical, or imaging follow-up data of at least 6 months was considered the reference standard...
August 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28670185/presentation-of-unusual-tracheal-metastasis-on-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-after-9-years-in-postnephrectomy-patient-of-renal-cell-carcinoma-a-case-report-and-review-of-literature
#20
Rahul Vithalrao Parghane, Ashwani Sood, Kim Vaiphei, Ashutosh Nath Aggarwal, Bhagwant Rai Mittal
Tracheal metastases from renal cell carcinoma (RCC) are extremely rare. Most common primary malignancy metastasizing to this unusual location usually comes from lung region while it is rare to have tracheal metastases from nonpulmonary malignancies such as breast, thyroid, colorectal carcinoma, and melanoma. The lesions detected on fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) scan, especially in the head and neck region, soft tissue, and muscular compartment during follow-up of RCC patients raise the possibility of metastatic lesions in these regions, though rarely encountered...
July 2017: World Journal of Nuclear Medicine
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