Jing Luo, Qiang Gao, Hailong Qiu, Shuai Zhang, Wanwan Zou, Ping Wang, Lishi Zhou, Lingling Liu, Feng Xu, Xiaohua Li, Bin Lin, Rong Zeng, Daoheng Sun, Jianzheng Cen, Jian Zhuang
BACKGROUND: Myogenin is well known as a crucial transcription factor in skeletal muscle development, yet its other biological functions remain unexplored. Previous research showed that myogenin suppresses apoptosis induced by angiotensin II in human induced pluripotent stem cell-derived cardiomyocytes, and offered a new perspective on myogenin's role in cardioprotection. However, the detailed mechanism of this cardioprotection, especially under oxidative stress, is still unclear. METHODS: In this study, hydrogen peroxide (H2O2) was used to generate reactive oxygen species in myogenin-overexpressing cardiomyocytes...
February 4, 2024: Frontiers in Bioscience (Landmark Edition)