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https://www.readbyqxmd.com/read/28545064/transcriptomic-analysis-of-the-response-of-pseudomonas-fluorescens-to-epigallocatechin-gallate-by-rna-seq
#1
Xiaoxiang Liu, Bimiao Shen, Peng Du, Nan Wang, Jiaxue Wang, Jianrong Li, Aihua Sun
Epigallocatechin gallate (EGCG) is a main constituent of green tea polyphenols that are widely used as food preservatives and are considered to be safe for consumption. However, the underlying antimicrobial mechanism of EGCG and the bacterial response to EGCG are not clearly understood. In the present study, a genome-wide transcriptional analysis of a typical spoilage bacterium, Pseudomonas fluorescens that responded to EGCG was performed using RNA-seq technology. A total of 26,365,414 and 23,287,092 clean reads were generated from P...
2017: PloS One
https://www.readbyqxmd.com/read/28544761/composites-of-bacterial-cellulose-and-small-molecule-decorated-gold-nanoparticles-for-treating-gram-negative-bacteria-infected-wounds
#2
Ying Li, Yue Tian, Wenshu Zheng, Yan Feng, Rong Huang, Jingxin Shao, Rongbing Tang, Peng Wang, Yuexiao Jia, Jiangjiang Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility...
May 23, 2017: Small
https://www.readbyqxmd.com/read/28544570/relative-susceptibility-of-airway-organisms-to-antimicrobial-effects-of-nitric-oxide
#3
Alan D Workman, Ryan M Carey, Michael A Kohanski, David W Kennedy, James N Palmer, Nithin D Adappa, Noam A Cohen
BACKGROUND: Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathogens to NO at physiologic concentrations. In this study we evaluated the effects of NO on 4 common airway bacteria and 1 fungus, and examined the potential implications of discrepancies in sensitivity...
May 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544494/4-substituted-thieno-2-3-d-pyrimidines-as-potent-antibacterial-agents-rational-design-microwave-assisted-synthesis-biological-evaluation-and-molecular-docking-studies
#4
Rupinder K Gill, Harpreet Singh, Tilak Raj, Anuradha Sharma, Gagandeep Singh, Jitender Bariwal
In an attempt to discover a new class of antibacterial agents with improved efficacy and to overcome the drug resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave assisted methodology and evaluated for their in vitro antibacterial activity against various pathogenic bacterial strains. Compounds 12b and 13c showed the promising inhibitory potencies against S. aureus, B. subtilis, P. aeruginosa and E. coli with MICs ranging from 2 to 10 μg/ml. Compound 13c was also found to be highly potent against methicillin resistant S...
May 23, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28544077/identification-and-analysis-of-5-enolpyruvylshikimate-3-phosphate-synthase-epsps-gene-from-glyphosate-resistant-ochrobactrum-intermedium-sq20
#5
Sadiqa Firdous, Samina Iqbal, Samina Anwar, Hina Jabeen
BACKGROUND: Glyphosate is a herbicide that acts by inhibition of the enzyme, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), entailed in catalysis of an essential step in the biosynthesis of aromatic amino acids. The objective of the current study was to isolate glyphosate resistant bacterial strains and subsequent characterization of the gene(s) encoding glyphosate resistance in these isolates. By enrichment culture technique, a glyphosate resistant bacterium, Ochrobactrum intermedium Sq20 was isolated from glyphosate contaminated indigenous soil and characterized...
May 25, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28543810/in-vitro-bactericidal-activity-of-blue-light-465-nm-phototherapy-on-meticillin-susceptible-and-meticillin-resistant-staphylococcus-pseudintermedius
#6
Amy H Schnedeker, Lynette K Cole, Gwendolen Lorch, Sandra F Diaz, John Bonagura, Joshua B Daniels
BACKGROUND: Staphylococcus pseudintermedius is the most common cause of bacterial skin infections in dogs. Meticillin-resistant infections have become more common and are challenging to treat. Blue light phototherapy may be an option for treating these infections. HYPOTHESIS/OBJECTIVES: The objective of this study was to measure the in vitro bactericidal activity of 465 nm blue light on meticillin-susceptible Staphylococcus pseudintermedius (MSSP) and meticillin-resistant Staphylococcus pseudintermedius (MRSP)...
May 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28542614/evaluation-of-the-sepsis-flow-chip-assay-for-the-diagnosis-of-blood-infections
#7
Antonio Galiana, Javier Coy, Adelina Gimeno, Noemi Marco Guzman, Francisco Rosales, Esperanza Merino, Gloria Royo, Juan Carlos Rodríguez
BACKGROUND: Blood infections are serious complex conditions that generally require rapid diagnosis and treatment. The big challenge is to reduce the time necessary to make a diagnosis with current clinical microbiological methods so as to improve the treatment given to patients. METHODS: In this study, we assess for the first time the Sepsis Flow Chip assay, which is a novel diagnostic assay for simultaneous rapid-detection of the vast majority of bloodstream pathogens, including Gram-positive and Gram-negative bacteria and fungi, in the same assay, and for the detection of most common antibiotic resistance genes...
2017: PloS One
https://www.readbyqxmd.com/read/28542602/antimicrobial-resistance-status-of-enterococcus-from-australian-cattle-populations-at-slaughter
#8
Robert S Barlow, Kate E McMillan, Lesley L Duffy, Narelle Fegan, David Jordan, Glen E Mellor
Antimicrobial agents are used in cattle production systems for the prevention and control of bacterial associated diseases. A consequence of their use is the potential development of antimicrobial resistance (AMR). Enterococcus faecium and Enterococcus faecalis that are resistant to antimicrobials are of increased concern to public health officials throughout the world as they may compromise the ability of various treatment regimens to control disease and infection in human medicine. Australia is a major exporter of beef; however it does not have an ongoing surveillance system for AMR in cattle or foods derived from these animals...
2017: PloS One
https://www.readbyqxmd.com/read/28542496/zinc-blocks-sos-induced-antibiotic-resistance-via-inhibition-of-reca-in-escherichia-coli
#9
Bryan E Bunnell, Jillian F Escobar, Kirsten L Bair, Mark D Sutton, John K Crane
Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E. coli, the SOS response strongly induces the production of Shiga toxins (Stx) and of the bacteriophages that encode the Stx genes. In E. coli, induction of the SOS response is accompanied by a higher mutation rate, called the mutator response, caused by a shift to error-prone DNA polymerases when DNA damage is too severe to be repaired by canonical DNA polymerases...
2017: PloS One
https://www.readbyqxmd.com/read/28542482/down-regulation-of-macrophage-ifngr1-exacerbates-systemic-l-monocytogenes-infection
#10
Emily M Eshleman, Christine Delgado, Staci J Kearney, Rachel S Friedman, Laurel L Lenz
Interferons (IFNs) target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhance macrophage inflammatory and anti-microbial activity. Type I IFNs can dampen macrophage responsiveness to IFNγ and are associated with increased susceptibility to numerous bacterial infections. The precise mechanisms responsible for these effects remain unclear. Type I IFNs silence macrophage ifngr1 transcription and thus reduce cell surface expression of IFNGR1...
May 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28542110/pneumonia-after-liver-transplantation
#11
Stephanie A K Angarita, Tara A Russell, Fady M Kaldas
PURPOSE OF REVIEW: Pneumonia occurs in 8-23% of patients after liver transplantation and contributes considerably to their morbidity and mortality. With the increasing acuity of liver transplantation patients in the current era, pneumonias, particularly ventilator-associated pneumonias, and multidrug-resistant pathogens, are of growing concern. RECENT FINDINGS: Postliver transplantation pneumonia cause varies with the timing of infection. In the early period (<1 month postliver transplantation), nosocomial pneumonias, including ventilator-associated pneumonias and multidrug-resistant species are most common...
May 24, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28541480/alternative-evolutionary-paths-to-bacterial-antibiotic-resistance-cause-distinct-collateral-effects
#12
C Barbosa, V Trebosc, C Kemmer, P Rosenstiel, R Beardmore, H Schulenburg, G Jansen
When bacteria evolve resistance against a particular antibiotic, they may simultaneously gain increased sensitivity against a second one. Such collateral sensitivity may be exploited to develop novel, sustainable antibiotic treatment strategies aimed at containing the current, dramatic spread of drug resistance. To date, the presence and molecular basis of collateral sensitivity has only been studied in few bacterial species and is unknown for opportunistic human pathogens such as Pseudomonas aeruginosa. In the present study, we assessed patterns of collateral effects by experimentally evolving 160 independent populations of P...
May 23, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28541442/cbl-interacting-protein-kinase-6-negatively-regulates-immune-response-to-pseudomonas-syringae-in-arabidopsis
#13
Atish Sardar, Ashis Kumar Nandi, Debasis Chattopadhyay
Cytosolic calcium ion (Ca2+) is an essential mediator of the plant innate immune response. Here, we report that a calcium-regulated protein kinase Calcineurin B-like protein (CBL)-interacting protein kinase 6 (CIPK6) functions as a negative regulator of immunity against the bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana. Arabidopsis lines with compromised expression of CIPK6 exhibited enhanced disease resistance to the bacterial pathogen and to P. syringae harboring certain but not all avirulent effectors, while restoration of CIPK6 expression resulted in abolition of resistance...
May 24, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28540946/zinc-transporters-ybtx-and-znuabc-are-required-for-the-virulence-of-yersinia-pestis-in-bubonic-and-pneumonic-plague-in-mice
#14
Alexander G Bobrov, Olga Kirillina, Marina Y Fosso, Jacqueline D Fetherston, M Clarke Miller, Tiva T VanCleave, Joseph A Burlison, William K Arnold, Matthew B Lawrenz, Sylvie Garneau-Tsodikova, Robert D Perry
A number of bacterial pathogens require the ZnuABC Zinc (Zn(2+)) transporter and/or a second Zn(2+) transport system to overcome Zn(2+) sequestration by mammalian hosts. Previously we have shown that in addition to ZnuABC, Yersinia pestis possesses a second Zn(2+) transporter that involves components of the yersiniabactin (Ybt), siderophore-dependent iron transport system. Synthesis of the Ybt siderophore and YbtX, a member of the major facilitator superfamily, are both critical components of the second Zn(2+) transport system...
May 25, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28540732/mouse-model-of-colonization-of-the-digestive-tract-with-acinetobacter-baumannii-and-subsequent-pneumonia
#15
Noémie Coron, Silvie Pavlickova, Angélique Godefroy, Hélène Pailhoriès, Marie Kempf, Viviane Cassisa, Laurent Marsollier, Estelle Marion, Marie-Laure Joly-Guillou, Matthieu Eveillard
AIM: Implementing a mouse model of Acinetobacter baumannii (AB) digestive colonization and studying the propensity of an intestinal reservoir of AB to be at the origin of pneumonia. MATERIALS & METHODS: After a disruption of the digestive flora by piperacillin-tazobactam, two multidrug-resistant AB strains were intranasally inoculated to two cohorts of ten mice daily. For each strain, five mice were rendered transiently neutropenic. RESULTS & CONCLUSION: One strain persisted several weeks in the digestive tract, even after stopping piperacillin-tazobactam injections, leading to the hypothesis that some AB strains can authentically colonize the gut...
May 25, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28540556/the-use-of-bacterial-bioremediation-of-metals-in-aquatic-environments-in-the-twenty-first-century-a-systematic-review
#16
Feliphe Lacerda Souza de Alencar, Julio Alejandro Navoni, Viviane Souza do Amaral
Metal pollution is a current environmental issue as a consequence of unregulated anthropic activiy. A wide range of bioremediation strategies have been successfully implemented to recover contaminated areas. Among them, bacterial bioremediation stands out as a promising tool to confront these types of concerns. This study aimed to compare and discuss worldwide scientific evolution of bacterial potential for metal bioremediation in aquatic ecosystems. The study consisted of a systematic review, elaborated through a conceptual hypothesis model, during the period from 2000 to 2016, using PubMed, MEDLINE, and SciELO databases as data resources...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28540496/phenotyping-of-vigs-mediated-gene-silencing-in-rice-using-a-vector-derived-from-a-dna-virus
#17
Ravi Kant, Indranil Dasgupta
Target genes in rice can be optimally silenced if inserted in antisense or hairpin orientation in the RTBV-derived VIGS vector and plants grown at 28 °C and 80% humidity after inoculation. Virus induced gene silencing (VIGS) is a method used to transiently silence genes in dicot as well as monocot plants. For the important monocot species rice, the Rice tungro bacilliform virus (RTBV)-derived VIGS system (RTBV-VIGS), which uses agroinoculation to initiate silencing, has not been standardized for optimal use...
May 24, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28539918/the-sapa-protein-is-involved-in-resistance-to-antimicrobial-peptide-pr-39-and-virulence-of-actinobacillus-pleuropneumoniae
#18
Fang Xie, Yalei Wang, Gang Li, Shuanghong Liu, Ning Cui, Siguo Liu, Paul R Langford, Chunlai Wang
Antimicrobial peptides are essential to the innate immune defense of the mammal against bacterial infection. However, pathogenic bacteria have evolved multiple strategies to resist and evade antimicrobial peptides, which is vital to bacterial survival and colonization in hosts. PR-39 is a linear porcine antimicrobial peptide containing 39 amino acid residues with a high proline content. Resistance to antimicrobial peptide PR-39 has been observed in Actinobacillus pleuropneumoniae. However, little is known about the factors required for this resistance...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28539715/antiprotozoal-antibacterial-and-antidiarrheal-properties-from-the-flowers-of-chiranthodendron-pentadactylon-and-isolated-flavonoids
#19
Fernando Calzada, Teresa Juárez, Normand García-Hernández, Miguel Valdes, Oscar Ávila, Lilian Yepez Mulia, Claudia Velázquez
BACKGROUND: Chiranthodendron pentadactylon Larreat. (Sterculiaceae) is a Mexican plant used in traditional medicine for the treatment of heart disease symptoms and infectious diarrhea. OBJECTIVE: To evaluate in vitro antiprotozoal and antibacterial activities and in vivo antidiarrheal activity from the flowers of C. pentadactylon using the extract, fractions, and major isolated flavonoids. MATERIALS AND METHODS: Bioassay-guided fractionation of the methanol extract of C...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539638/salmonella-produce-microrna-like-rna-fragment-sal-1-in-the-infected-cells-to-facilitate-intracellular-survival
#20
Hongwei Gu, Chihao Zhao, Tianfu Zhang, Hongwei Liang, Xiao-Ming Wang, Yi Pan, Xi Chen, Quan Zhao, Donghai Li, Fenyong Liu, Chen-Yu Zhang, Ke Zen
Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival in the infected cells. Previous studies were mostly focused on either bacteria itself or host cells, the interaction mechanism of host-pathogen awaits further exploration. In the present study, we show that Salmonella can exploit mammalian cell non-classical microRNA processing machinery to further process bacterial small non-coding RNAs into microRNA-like fragments. Sal-1, one such fragment with the highest copy number in the infected cells, is derived from Salmonella 5'-leader of the ribosomal RNA transcript and has a 'stem' structure-containing precursor...
May 24, 2017: Scientific Reports
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