keyword
MENU ▼
Read by QxMD icon Read
search

Infusion time

keyword
https://www.readbyqxmd.com/read/29792435/measuring-drug-induced-changes-in-metabolite-populations-of-live-bacteria-real-time-analysis-by-raman-spectroscopy
#1
Paul R Carey, Grant R Whitmer, Michael J Yoon, Michael N Lombardo, Marianne Pusztai-Carey, Hossein Heidari-Torkabadi, Tao Che
Raman difference spectroscopy is shown to provide a wealth of molecular detail on changes within bacterial cells caused by infusion of antibiotics or hydrogen peroxide. E. coli strains paired with chloramphenicol, DHFR propargyl-based inhibitors, meropenem, or hydrogen peroxide provide details of the depletion of protein and nucleic acid populations in real time. Additionally, other reproducible Raman features appear and are attributed to changes in cell metabolite populations. An initial candidate for one of the metabolites involves population increases of citrate, an intermediate within the TCA cycle...
May 24, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29791475/ten-year-experience-with-ophthalmic-artery-chemosurgery-ocular-and-recurrence-free-survival
#2
Jasmine H Francis, Ariana M Levin, Emily C Zabor, Y Pierre Gobin, David H Abramson
PURPOSE: To report associations between disease- and treatment-related variables and rates of recurrence-free survival and ocular survival in eyes treated with ophthalmic artery chemosurgery (OAC) for retinoblastoma. DESIGN: Pre-post study. SUBJECTS: All eyes treated with OAC for retinoblastoma at Memorial Sloan Kettering Cancer Center between May 2006 and February 2017. METHODS: This retrospective review included 452 retinoblastoma eyes treated with OAC...
2018: PloS One
https://www.readbyqxmd.com/read/29790808/comparison-of-time-to-engraftment-between-autologous-patients-receiving-washed-versus-non-washed-cryopreserved-peripheral-blood-stem-cell-products
#3
Ronit Reich-Slotky, Sarah S Makhani, Ljiljana V Vasovic, Roger N Pearse, Adriana Rossi, Adrianne Philips, Melissa M Cushing, Amrita D Singh, Koen van-Besien
Washing cryopreserved peripheral blood stem cell (PBSC) products can decrease infusion-related adverse reactions but can also result in cell loss and reduced cell viability. To assess the risk and benefit of washing products, we compared the time to neutrophil and platelet engraftment between autologous patients that received washed products (n = 201) and non-washed products (n = 89). The effect of the other variables, including age, gender, diagnosis, transplant dose, method of stem cell mobilization, and growth factor support regimen post-transplant, was assessed...
May 23, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29790424/the-fate-of-autologous-endometrial-mesenchymal-stromal-cells-after-application-in-the-healthy-equine-uterus
#4
Elisabeth Rink, Teresa Beyer, Hilari French, Elaine Watson, Christine Aurich, Xavier Donadeu
Because of their distinct differentiation, immunomodulatory and migratory capacities, endometrial mesenchymal stromal cells (MSCs) may provide an optimum source of therapeutic cells not only in relation to the uterus but also for regeneration of other tissues. This study reports the fate of endometrial MSCs following intrauterine application in mares. Stromal cell fractions were isolated from endometrial biopsies taken from seven reproductively healthy mares, expanded and fluorescence-labeled in culture. MSCs (15 x 106) or PBS were autologously infused into each uterine horn during early diestrus and subsequently tracked by fluorescence microscopy and flow cytometry of endometrial biopsies and blood samples taken periodically after infusion...
May 23, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29790404/clinical-and-neurophysiological-changes-after-targeted-intrathecal-injections-of-bone-marrow-stem-cells-in-a-c3-tetraplegic-subject
#5
Andrea Jimena Santamaria, Francisco D Benavides, Darcy L DiFede, Aisha Khan, Marietsy V Pujol, W Dalton Dietrich, Antonio Marttos, Barth A Green, Joshua M Hare, James Guest
High-level quadriplegia is a devastating condition with limited treatment options. Bone marrow derived stem cells (BMSCs) are reported to have immunomodulatory and neurotrophic effects in spinal cord injury (SCI). We report a subject with complete C2 SCI who received 3 anatomically targeted intrathecal infusions of BMSCs under a single-patient expanded access IND. She underwent intensive physical therapy and was followed for over 2 years. At end-point, her AIS grade improved from A to B and she recovered focal pressure touch sensation over several body areas...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29789589/characterization-of-different-bubble-formulations-for-blood-brain-barrier-opening-using-a-focused-ultrasound-system-with-acoustic-feedback-control
#6
Chenchen Bing, Yu Hong, Christopher Hernandez, Megan Rich, Bingbing Cheng, Imalka Munaweera, Debra Szczepanski, Yin Xi, Mark Bolding, Agata Exner, Rajiv Chopra
Focused ultrasound combined with bubble-based agents serves as a non-invasive way to open the blood-brain barrier (BBB). Passive acoustic detection was well studied recently to monitor the acoustic emissions induced by the bubbles under ultrasound energy, but the ability to perform reliable BBB opening with a real-time feedback control algorithm has not been fully evaluated. This study focuses on characterizing the acoustic emissions of different types of bubbles: Optison, Definity, and a custom-made nanobubble...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789227/cost-effectiveness-analysis-of-sensor-augmented-pump-therapy-with-low-glucose-suspend-in-patients-with-type-1-diabetes-mellitus-and-high-risk-of-hypoglycemia-in-spain
#7
Ignacio Conget, Pilar Martín-Vaquero, Stéphane Roze, Isabel Elías, Cristina Pineda, María Álvarez, Alexis Delbaere, Francisco Javier Ampudia-Blasco
OBJECTIVE: To compare the cost-effectiveness of sensor-augmented pump therapy (SAP) [continuous subcutaneous insulin infusion (CSII) plus real-time continuous glucose monitoring (RT-CGM)] with low glucose suspend (MiniMed™ Veo™) and CSII alone in patients with type 1 diabetes mellitus (T1DM) at high risk of hypoglycemia in Spain. METHODS: The IQVIA CORE Diabetes Model was used to estimate healthcare outcomes as life-years gained (LYGs) and quality-adjusted life years (QALYs), and to project lifetime costs...
May 19, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29789184/infused-cardioplegia-index-a-new-tool-to-improve-myocardial-protection-a-cohort-study
#8
J J Jiménez Rivera, C Llanos Jorge, J L Iribarren Sarrías, M Brouard Martín, J Lacalzada Almeida, J L Pérez Vela, R Avalos Pinto, R Pérez Hernández, S Ramos de la Rosa, G Yanes Bowden, R Martínez Sanz
BACKGROUND: Strategies for cardio-protection are essential in coronary artery bypass graft surgery. The authors explored the relationship between cardioplegia volume, left ventricular mass index and ischemia time by means of the infused cardioplegia index and its relationship with post-operative low cardiac output syndrome. DESIGN: All patients undergoing coronary artery bypass graft surgery between January 2013 and December 2015 were included. Low cardiac output syndrome was defined according to criteria of the SEMICYUC's consensus document...
May 19, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29788801/perioperative-noninvasive-cardiac-output-monitoring-in-parturients-with-singleton-and-twin-pregnancies-undergoing-caesarean-section-under-spinal-anesthesia-with-prophylactic-phenylephrine-drip-a-prospective-observational-cohort-study
#9
S Orbach-Zinger, E Razinsky, I Bizman, S Firman, R Gat, A Davis, E Ashwal, A Shmueli, M Vaturi, R Gabbay-Benziv, L A Eidelman
INTRODUCTION: Spinal anesthesia is considered the gold standard anesthetic technique for cesarean deliveries (CD) but is associated with a high rate of hypotension. The recent international consensus recommends continuous prophylactic phenylephrine infusion (PPI) administered throughout CD to prevent hypotension. However little information is available on the hemodynamic profiles of women with twin pregnancies as compared to singleton pregnancies perioperatively. Therefore, in this study we aim we compare maternal hemodynamic changes both intraoperatively and postoperatively with the use of the NICAS bio impendence monitor in healthy singleton versus twin parturients undergoing CD deliveries with spinal anesthesia with PPI...
May 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29788512/adequacy-of-fixed-dose-heparin-infusions-for-venous-thromboembolism-prevention-after-microsurgical-procedures
#10
Corinne M Bertolaccini, Ann Marie B Prazak, Jayant Agarwal, Isak A Goodwin, W Bradford Rockwell, Christopher J Pannucci
BACKGROUND:  In microvascular surgery, patients often receive unfractionated heparin infusions to minimize risk for microvascular thrombosis. Patients who receive intravenous (IV) heparin are believed to have adequate prophylaxis against venous thromboembolism (VTE). Whether a fixed dose of IV heparin provides detectable levels of anticoagulation, or whether the "one size fits all" approach provides adequate prophylaxis against VTE remains unknown. This study examined the pharmacodynamics of fixed-dose heparin infusions and the effects of real-time, anti-factor Xa (aFXa) level driven heparin dose adjustments...
May 22, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29788418/efficacy-of-bezlotoxumab-based-on-timing-of-administration-relative-to-start-of-antibacterial-therapy-for-clostridium-difficile-infection
#11
Thomas Birch, Yoav Golan, Giuliano Rizzardini, Erin Jensen, Lori Gabryelski, Dalya Guris, Mary Beth Dorr
Background: The fully human monoclonal antibody bezlotoxumab binds Clostridioides (Clostridium) difficile toxin B and reduces recurrence rates in patients with C. difficile infection (CDI) receiving antibacterial treatment for a primary or recurrent episode. Objectives: To investigate whether the timing of bezlotoxumab administration relative to the onset of antibacterial treatment affected clinical outcome in the Phase 3 trials MODIFY I (NCT01241552) and MODIFY II (NCT01513239)...
May 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29788275/feasibility-and-effectiveness-of-laparoscopic-transgastric-stapler-assisted-circumferential-esophageal-mucosectomy-and-simultaneous-fundoplication-in-a-pig-model
#12
D C Steinemann, P C Müller, A-C Schwarz, A Zerz, G R Linke, B P Müller-Stich
Laparoscopic transgastric stapler-assisted mucosectomy (SAM) has been described for minimally invasive circumferential en bloc resection of Barrett's esophagus (BE). Conceivably long-term disease control might be achieved by adding antireflux surgery after resection of BE by SAM. The aim of this study was to assess the feasibility of combined SAM and fundoplication in one laparoscopic procedure in six pigs. Furthermore, the competence of the gastroesophageal junction (GEJ) was assessed at baseline, after SAM, and after subsequent laparoscopic fundoplication...
May 21, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29788110/long-term-compliance-with-a-validated-intravenous-insulin-therapy-protocol-in-cardiac-surgery-patients-a-quality-improvement-project
#13
Guillaume Besch, Andrea Perrotti, Lucie Salomon du Mont, Raphaelle Tucella, Guillaume Flicoteaux, Aline Bondy, Emmanuel Samain, Sidney Chocron, Sebastien Pili-Floury
Quality problem: Safe and efficient blood glucose (BG) level control after cardiac surgery relies on an intensive care unit (ICU) team-based approach, including implementation of a dynamic insulin therapy protocol (ITP). Long-term compliance with such a complex protocol is poorly addressed in the literature. The aim of this study was to assess the long-term compliance of nurses with the ITP, 7 years after its implementation in the ICU. Initial assessment: A professional practice evaluation, integrated in a process of quality improvement program, was retrospectively conducted on 224 consecutive cardiac surgery patients over a 6-month period (PHASE 1)...
May 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29787413/halving-the-volume-of-anaconda-evaluation-of-a-new-small-volume-anesthetic-reflector-in-a-test-lung-model
#14
Hagen Bomberg, Franziska Meiser, Philipp Daume, Martin Bellgardt, Thomas Volk, Daniel I Sessler, Heinrich V Groesdonk, Andreas Meiser
BACKGROUND: Volatile anesthetics are increasingly used for sedation in intensive care units. The most common administration system is AnaConDa-100 mL (ACD-100; Sedana Medical, Uppsala, Sweden), which reflects volatile anesthetics in open ventilation circuits. AnaConDa-50 mL (ACD-50) is a new device with half the volumetric dead space. Carbon dioxide (CO2) can be retained with both devices. We therefore compared the CO2 elimination and isoflurane reflection efficiency of both devices. METHODS: A test lung constantly insufflated with CO2 was ventilated with a tidal volume of 500 mL at 10 breaths/min...
May 21, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29785755/energy-resolved-mass-spectrometry-of-chlorogenic-acids-and-its-application-to-isomer-quantification-by-direct-infusion-tandem-mass-spectrometry
#15
Javier Hernandez, Anja Müller, Rakesh Jaiswal, Juan Z Davalos, Nikolai Kuhnert
INTRODUCTION: With the advent of high-perfomance liquid chromatography (HPLC)-tandem mass spectrometry (MS) using ion trap mass analysers it is possible to acquire unambigious structural information in particular with respect to aspects of regiochemistry and stereochemistry of organic compounds present in complex mixtures such as coffee extracts. However, HPLC-MS methods are resource extensive, laborious and lacking user friendliness. OBJECTIVE: To introduce a simple parameter - the energy threshhold for fragmentation - determined using energy resolved MS and demonstrate its value for the complete structural characterisation and even relative quantification of individual isomeric chlrogenic acids in direct infusion experiments...
May 21, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29785087/transcriptomic-impacts-of-rumen-epithelium-induced-by-butyrate-infusion-in-dairy-cattle-in-dry-period
#16
Ransom L Baldwin, Robert W Li, Yankai Jia, Cong-Jun Li
The purpose of this study was to evaluate the effects of butyrate infusion on rumen epithelial transcriptome. Next-generation sequencing (NGS) and bioinformatics are used to accelerate our understanding of regulation in rumen epithelial transcriptome of cattle in the dry period induced by butyrate infusion at the level of the whole transcriptome. Butyrate, as an essential element of nutrients, is a histone deacetylase (HDAC) inhibitor that can alter histone acetylation and methylation, and plays a prominent role in regulating genomic activities influencing rumen nutrition utilization and function...
2018: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/29784852/plasma-and-intrapulmonary-concentrations-of-cefepime-and-zidebactam-following-intravenous-administration-of-wck-5222-to-healthy-adult-subjects
#17
Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, H David Friedland, Ashima Bhatia
WCK 5222 is a combination of cefepime and the novel beta-lactam enhancer zidebactam being developed for the treatment of serious Gram-negative infections. The objective of this study was to compare plasma (total), epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of cefepime and zidebactam in healthy adult subjects. The WCK 5222 dosing regimen was 2 grams cefepime/1 gram zidebactam administered as a 1-hour intravenous infusion every 8 hours for a total of 7 doses. Subjects were assigned to one bronchoalveolar lavage (BAL) sampling time at 0...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29784051/contributions-of-a-survey-and-retrospective-cohort-study-to-the-planning-of-a-randomised-controlled-trial-of-corticosteroids-in-the-treatment-of-paediatric-septic-shock
#18
Anna Liu, Kusum Menon
BACKGROUND: Randomised controlled trials (RCTs) are challenging to conduct in a paediatric critical-care environment. Background work, including surveys and observational studies, is often used to determine disease estimates, sample sizes and design protocols when planning such RCTs. Our objective was to determine the necessity of performing a survey or a retrospective chart review or both when planning an RCT on corticosteroids in the treatment of paediatric septic shock. METHODS: We compared information on corticosteroid use for moderate to severe paediatric septic shock obtained from a survey of physician beliefs and stated practices with that obtained from a retrospective cohort study...
May 21, 2018: Trials
https://www.readbyqxmd.com/read/29783950/effects-of-the-cardiac-myosin-activator-omecamtiv-mecarbil-on-severe-chronic-aortic-regurgitation-in-wistar-rats
#19
Bachar El-Oumeiri, Kathleen Mc Entee, Filippo Annoni, Antoine Herpain, Frédéric Vanden Eynden, Pascal Jespers, Guido Van Nooten, Philippe van de Borne
BACKGROUND: Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the effects of a novel cardiac myosin activator, Omecamtiv-mecarbil (OM), in rats with chronic severe AR. METHODS: AR was created by retrograde puncture of the aortic valve leaflets in 20 adults Wistar rats...
May 21, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29783879/effects-of-sodium-citrate-citric-acid-and-lactic-acid-on-human-blood-coagulation
#20
Vittorio Scaravilli, Luca Di Girolamo, Eleonora Scotti, Mattia Busana, Osvaldo Biancolilli, Patrizia Leonardi, Andrea Carlin, Caterina Lonati, Mauro Panigada, Antonio Pesenti, Alberto Zanella
INTRODUCTION: Citric acid infusion in extracorporeal blood may allow concurrent regional anticoagulation and enhancement of extracorporeal CO2 removal. Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in vitro study, citric acid, sodium citrate and lactic acid were added to venous blood from seven healthy donors, obtaining concentrations of 9 mEq/L, 12 mEq/L and 15 mEq/L. We measured gas analyses, ionized calcium (iCa++ ) concentration, activated clotting time (ACT), thromboelastography and multiplate aggregometry...
May 1, 2018: Perfusion
keyword
keyword
82589
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"