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https://www.readbyqxmd.com/read/29049350/an-integrative-in-silico-approach-for-therapeutic-target-identification-in-the-human-pathogen-corynebacterium-diphtheriae
#1
Syed Babar Jamal, Syed Shah Hassan, Sandeep Tiwari, Marcus V Viana, Leandro de Jesus Benevides, Asad Ullah, Adrián G Turjanski, Debmalya Barh, Preetam Ghosh, Daniela Arruda Costa, Artur Silva, Richard Röttger, Jan Baumbach, Vasco A C Azevedo
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually decreased with improved living standards and further alleviated when many immunization programs were introduced. However, numerous drug-resistant strains emerged recently that consequently decreased the efficacy of current therapeutics and vaccines, thereby obliging the scientific community to start investigating new therapeutic targets in pathogenic microorganisms...
2017: PloS One
https://www.readbyqxmd.com/read/29029379/role-of-24-epibrassinolide-ebl-in-mediating-heavy-metal-and-pesticide-induced-oxidative-stress-in-plants-a-review
#2
REVIEW
Babar Shahzad, Mohsin Tanveer, Zhao Che, Abdul Rehman, Sardar Alam Cheema, Anket Sharma, He Song, Shams Ur Rehman, Dong Zhaorong
Industrialization and urbanization have posed serious threats to the environment. Excessive release of heavy metals from industrial effluents and overuse of pesticides in modern agriculture are limiting crop production by polluting environment and deteriorating food quality. Sustaining food quality under heavy metals and pesticide stress is crucial to meet the increasing demands for food. 24-Epibrassinolide (EBL), a ubiquitously occurring plant growth hormone shows great potential to alleviate heavy metals and pesticide stress in plants...
October 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29028718/the-author-replies
#3
Babar A Khan
No abstract text is available yet for this article.
November 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29026828/objective-outcomes-of-minimally-invasive-temporalis-tendon-transfer-for-prolonged-complete-facial-paralysis
#4
Michal Brichacek, Babar Sultan, Kofi D Boahene, Lisa Ishii, Patrick J Byrne
OBJECTIVES: We describe an approach to reanimation of complete, prolonged facial paralysis using minimally invasive temporalis tendon transfer (MIT3) by the melolabial or transoral approach. Objective outcome measures are evaluated based on symmetry, and grading of preoperative/post-operative results and the scar at the melolabial fold. STUDY DESIGN: Retrospective cohort study. METHODS: Twenty-five patients undergoing the MIT3 technique were studied...
August 2017: Plastic Surgery
https://www.readbyqxmd.com/read/28991949/post-intensive-care-unit-psychiatric-comorbidity-and-quality-of-life
#5
Sophia Wang, Chris Mosher, Anthony J Perkins, Sujuan Gao, Sue Lasiter, Sikandar Khan, Malaz Boustani, Babar Khan
The prevalence of psychiatric symptoms ranges from 17% to 44% in intensive care unit (ICU) survivors. The relationship between the comorbidity of psychiatric symptoms and quality of life (QoL) in ICU survivors has not been carefully examined. This study examined the relationship between psychiatric comorbidities and QoL in 58 survivors of ICU delirium. Patients completed 3 psychiatric screens at 3 months after discharge from the hospital, including the Patient Health Questionnaire-9 (PHQ-9) for depression, the Generalized Anxiety Disorder-7 (GAD-7) questionnaire for anxiety, and the Post-Traumatic Stress Syndrome (PTSS- 10) questionnaire for posttraumatic stress disorder...
October 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28969733/tuberculosis-of-gallbladder-mimicking-carcinoma
#6
Usman Ismat Butt, Babar Hameed, Muhammad Waris Farooka, Mahmood Ayyaz, Anila Chughtai, Muhammad Bilal Akbar
Gallbladder is a rare site of tuberculous involvement. Less than 150 cases have been documented in the last 150 years. It may mimic malignancy. Histopathology examination is the mainstay of diagnosis. Gallstones and obstruction appear to be pre-disposing factors. Treatment involves localizing other sites and starting patient on anti-tuberculosis therapy. The report describes this rare site of involvement in an adult Pakistani man.
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28963597/osteopontin-gene-polymorphism-association-with-milk-traits-and-its-expression-analysis-in-milk-of-riverine-buffalo
#7
Sidra Manzoor, Asif Nadeem, Javed Maryam, Abu Saeed Hashmi, Muhammad Imran, Masroor Ellahi Babar
Osteopontin gene is regarded as a plausible candidate in mammary gland differentiation and development, expressed by variety of cells, tissues, and biological fluids including milk. The current study was performed in two phases. In the first phase, Osteopontin gene polymorphisms were identified and associated with milk composition such as ash, milk fat, SNF, lactose, and protein. In the second phase, milk samples from five healthy mastitis-free Nili Ravi buffaloes were analyzed for expression of Osteopontin gene at transition (day 15), mid (day 90), and end (day 250) stage of their second lactation...
September 30, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28955075/prevalence-of-myths-concerning-growth-and-health-of-children-among-females-of-local-population-of-pakistan
#8
Khaula Atif, Tehmina Babar, Syed Abid Hassan Naqvi, Annam Javed, Afeera Afsheen, Karishma Ehsan
OBJECTIVE: To analyse the prevalence of myths among women regarding growth and health-related issues of children, and to study the impact of basic demographic factors in this regard. METHODS: The educational, cross-sectional, descriptive study was carried out at the Combined Military Hospital, Peshawar, Pakistan, from January 2016 to January 2017. It comprised women reporting to paediatric outpatient clinics, and the subjects were selected using convenience sampling...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28955063/assessment-of-caregiver-burden-of-patients-receiving-dialysis-treatment-in-rawalpindi
#9
Hassan Bin Usman Shah, Iffat Atif, Farah Rashid, Muhammad Waleed Babar, Faizan Arshad, Waqar Qamar, Owais Ahmed Khan, Muhammad Luqman Qadir
OBJECTIVE: To determine the burden on the caregivers of patients receiving dialysis treatment. METHODS: This cross-sectional study was carried out in four different dialysis centres of Rawalpindi, Pakistan, from June 1 to December1, 2015, and comprised attendants of patients receiving dialysis. The data was collected from the attendants of patients receiving dialysis, and caregiver burden was measured using the Zarit Burden Interview questionnaire. SPSS 22 was used for data analysis...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28953059/time-trends-and-predictors-of-acute-gastroenteritis-in-the-united-states-results-from-national-health-and-nutrition-examination-survey-2005-2014
#10
Hyun S Kim, Laura Rotundo, Thayer Nasereddin, Adaugo Ike, David Song, Arooj Babar, Mirela Feurdean, Michael F Demyen, Sushil K Ahlawat
GOALS: To investigate the time trends of the prevalence and predictors of acute gastroenteritis (AGE) in the United States from 2005 to 2014 using nationally representative data. BACKGROUND: AGE results in numerous visits to emergency departments and outpatient clinics annually in the United States with the estimated attributable cost to the US economy up to $145 billion dollars. However, time trends and predictors of AGE are not fully understood. METHODS: Data were obtained from the National Health and Nutrition Survey (NHANES) 2005 to 2014, a nationally representative health survey...
August 4, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28940722/flexible-broadband-graphene-photodetectors-enhanced-by-plasmonic-cu3-x-p-colloidal-nanocrystals
#11
Tian Sun, Yongjie Wang, Wenzhi Yu, Yusheng Wang, Zhigao Dai, Zeke Liu, Bannur Nanjunda Shivananju, Yupeng Zhang, Kai Fu, Babar Shabbir, Wanli Ma, Shaojuan Li, Qiaoliang Bao
The integration of graphene with colloidal quantum dots (QDs) that have tunable light absorption affords new opportunities for optoelectronic applications as such a hybrid system solves the problem of both quantity and mobility of photocarriers. In this work, a hybrid system comprising of monolayer graphene and self-doped colloidal copper phosphide (Cu3-x P) QDs is developed for efficient broadband photodetection. Unlike conventional PbS QDs that are toxic, Cu3-x P QDs are environmental friendly and have plasmonic resonant absorption in near-infrared (NIR) wavelength...
September 22, 2017: Small
https://www.readbyqxmd.com/read/28936048/to-realize-universal-eye-health-we-must-strengthen-implementation-research
#12
EDITORIAL
Jacqueline Ramke, Babar Qureshi, Clare E Gilbert
No abstract text is available yet for this article.
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28930521/multifactorial-role-of-long-non-coding-rnas-lncrnas-in-hematopoiesis
#13
Muhammad Babar Khawar, Rabia Mehmood, Muddasir Hassan Abbasi, Nadeem Sheikh
  Human genome project unveiled that only 1.5.-2.0.% of the genome is protein coding. ENCODE and related studies showed that most part of the genome transcribed into RNAs, and most of them do not code for a functional proteins, hence the name non-coding RNAs (ncRNAs). ncRNAs are small ncRNAs (less than 200 nucleotides) and long ncRNAs (longer than 200 nucleotides up to 10 kb). They act as a direct link between highly ordered chromosome structures, gene expression and serve as a bridge between genome and chromatin modification complexes as guides, scaffolds, and decoys...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28929040/cardiovascular-dysfunction-presenting-as-autonomic-dysreflexia-in-a-patient-with-spinal-cord-injury
#14
Ahmed H Qavi, Salman Assad, Wardha Shabbir, Maryam Kundi, Maham Habib, Sumbal Babar, Mehr Zahid
Autonomic dysreflexia (AD) is a medical emergency that is characterized by hypertension as an autonomic response to noxious stimuli in patients with a history of spinal cord injury at the level of T6 or above. We present the case of a 31-year-old Caucasian male with a history of spinal cord injury at the level of C3-C4, with symptoms described as recurring episodes of hypertension with flushing and sweating above the level of the lesion for the past five to six years. His symptoms are triggered by bowel distention, excitement, a bumpy car ride, or a simple turning of the neck to the left...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28914277/antidepressant-use-and-depressive-symptoms-in-intensive-care-unit-survivors
#15
Sophia Wang, Chris Mosher, Sujuan Gao, Kayla Kirk, Sue Lasiter, Sikander Khan, You Na Kheir, Malaz Boustani, Babar Khan
Nearly 30% of intensive care unit (ICU) survivors have depressive symptoms 2-12 months after hospital discharge. We examined the prevalence of depressive symptoms and risk factors for depressive symptoms in 204 patients at their initial evaluation in the Critical Care Recovery Center (CCRC), an ICU survivor clinic based at Eskenazi Hospital in Indianapolis, Indiana. Thirty-two percent (N = 65) of patients had depressive symptoms on initial CCRC visit. For patients who are not on an antidepressant at their initial CCRC visit (N = 135), younger age and lower education level were associated with a higher likelihood of having depressive symptoms...
September 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28888163/overexpression-of-ghdof1-improved-salt-and-cold-tolerance-and-seed-oil-content-in-gossypium-hirsutum
#16
Ying Su, Wei Liang, Zhengjie Liu, Yumei Wang, Yanpeng Zhao, Babar Ijaz, Jinping Hua
A homologous GhDof1, which belongs to a large family of plant-specific transcription factor DOF, was isolated from Upland cotton (Gossypium hirsutum L.). GhDof1 protein was located in the nucleus of onion epidermal cells, the core domain of transcriptional activity existed in the C-terminal, and the activity elements of GhDof1 promoter existed in the regions of -645∼ -469bp and -286∼ -132bp of transcriptional start codon. GhDof1 constitutively expressed in leaves, roots and stems, accumulated highest in leaves...
July 28, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28886802/using-reflectance-confocal-microscopy-in-skin-cancer-diagnosis
#17
REVIEW
Attiya Haroon, Shahram Shafi, Babar K Rao
Biopsy and histologic evaluation have been the gold standard to diagnose skin tumors. Reflectance confocal microcopy (RCM) is a noninvasive, innovative diagnostic technique that enables visualization of different skin layers at an almost histologic resolution. RCM has been proven beneficial in management of various cutaneous lesions. This article highlights the clinical significance and future of RCM to diagnose common skin cancers. However, RCM cannot replace currently standard histopathologic diagnosis. More studies are required to better compare the sensitivity and specificity of skin cancer diagnosis using RCM...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28861334/severe-pneumocystis-jiroveci-pneumonia-in-a-patient-on-temozolomide-therapy-a-case-report-and-review-of-literature
#18
Babar Ahmad Khan, Sania Khan, Benjamin White, Ambika Eranki
A 66 year old man was diagnosed with CNS diffuse large B-cell lymphoma, and underwent treatment with Temozolomide, Dexamethasone, Rituximab, and radiation therapy, and prolonged steroid taper with Dexamethasone. Approximately one month after this, he presented with severe acute hypoxemic respiratory failure, and was admitted to the Medical Intensive Care Unit. Imaging showed diffuse ground glass opacities. Patient underwent diagnostic bronchoalveolar lavage which was positive for Pneumocystis jiroveci. He did not respond well to appropriate therapy and was transitioned to comfort care per his family's wishes, and expired...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28860094/qol-and-work-capacity-is-unrelated-to-approach-or-complications-after-pituitary-surgery
#19
Erik Uvelius, Nazia Castelo, Babar Kahlon, Christer Svensson, Anders Cervin, Peter Höglund, Stig Valdemarsson, Peter Siesjö
OBJECTIVE: Endoscopic pituitary surgery has shown favorable clinical outcomes. Less is known about the impact of surgical approaches on health related quality of life (HRQoL) and work capacity. The present study was undertaken to compare transsphenoidal microscope-assisted surgery to endoscopic transsphenoidal surgery regarding preoperative and surgical factors for the final outcome of HRQoL and work capacity. METHODS: In a retrospective study on patients operated for pituitary adenoma, outcome was compared between those operated before and after transition to endoscopic surgery at our department...
August 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28852529/evaluating-insulin-information-provided-on-discharge-summaries-in-a-secondary-care-hospital-in-the-united-kingdom
#20
Amie Bain, Lois Nettleship, Sallianne Kavanagh, Zaheer-Ud-Din Babar
BACKGROUND: Prescribing errors at the time of hospital discharge are common and could potentially lead to avoidable patient harm, especially when they involve insulin, a high-risk medicine widely used for the treatment of diabetes mellitus. When information regarding insulin therapy is not sufficiently communicated to a patient's primary care provider, continuity of care for patients with diabetes may be compromised. The objectives of this study were to investigate the nature and prevalence of insulin-related medication discrepancies contained in hospital discharge summaries for patients with diabetes...
2017: Journal of Pharmaceutical Policy and Practice
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