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Kayla Thomason, Md Ali Babar, John E Erickson, Michael Mulvaney, Chris Beecher, Greg MacDonald
Genetic improvement for stress tolerance requires a solid understanding of biochemical processes involved with different physiological mechanisms and their relationships with different traits. The objective of this study was to demonstrate genetic variability in altered metabolic levels in a panel of six wheat genotypes in contrasting temperature regimes, and to quantify the correlation between those metabolites with different traits. In a controlled environment experiment, heat stress (35:28 ± 0.08°C) was initiated 10 days after anthesis...
2018: PloS One
Lubaina Ehsan, Mariam Rashid, Najveen Alvi, Khadija Awais, Omair Nadeem, Aleezay Asghar, Fatimah Sajjad, Malika Fatima, Asim Qidwai, Shabneez Hussain, Erum Hasan, Nick Brown, Sadaf Altaf, Babar Hasan, Salman Kirmani
BACKGROUND: Endocrinopathy due to iron overload is the most common morbidity whereas myocardial siderosis causing toxic cardiomyopathy is the leading cause of mortality among patients with transfusion dependent thalassemia major (TDTM). If detected early, this can be treated with aggressive chelation. T2* cardiac magnetic resonance imaging (CMR) guided chelation protocols are now the gold standard but have limited availability in low and middle-income countries. We hypothesized that markers of endocrine dysfunction would correlate with T2* CMR and can be used to predict the severity of myocardial siderosis and guide chelation therapy...
June 12, 2018: Pediatric Blood & Cancer
Julia R Schneider, Kay O Kulason, Muhammad Babar Khan, Timothy G White, Kevin Kwan, Lukas Faltings, Andrew J Kobets, Shamik Chakraborty, Jason A Ellis, Rafael A Ortiz, Christopher G Filippi, David J Langer, John A Boockvar
No abstract text is available yet for this article.
June 8, 2018: Neurosurgery
Thuy Mason, Claire Trochez, Remmya Thomas, Maria Babar, Iman Hesso, Reem Kayyali
BACKGROUND: Antibiotic resistance (AR) continues to be a serious problem. Many factors contribute to AR, including inappropriate use of antibiotics, in which both healthcare professionals and patients play a contributing role. This study aimed to assess the awareness and knowledge of antibiotic usage and AR among the general public (in affluent and deprived areas) and community pharmacists' (CPs') in Greater London. METHODS: A cross-sectional survey involving members of the public was conducted between July 2014 and February 2015...
June 8, 2018: BMC Public Health
Nana Mensah Abrampah, Shamsuzzoha Babar Syed, Lisa R Hirschhorn, Bejoy Nambiar, Usman Iqbal, Ezequiel Garcia-Elorrio, Vijay Kumar Chattu, Mahesh Devnani, Edward Kelley
Quality improvement approaches can strengthen action on a range of global health priorities. Quality improvement efforts are uniquely placed to reorient care delivery systems towards integrated people-centred health services and strengthen health systems to achieve Universal Health Coverage (UHC). This article makes the case for addressing shortfalls of previous agendas by articulating the critical role of quality improvement in the Sustainable Development Goal era. Quality improvement can stimulate convergence between health security and health systems; address global health security priorities through participatory quality improvement approaches; and improve health outcomes at all levels of the health system...
April 20, 2018: International Journal for Quality in Health Care
Aijaz Ahmed Babar, Dongyang Miao, Nadir Ali, Jing Zhao, Xianfeng Wang, Jianyong Yu, Bin Ding
Textiles with excellent moisture transport characteristics play key role in regulating the comfort of the body, and use of color in textiles helps in developing aesthetically pleasing apparels. Herein, we report an aesthetically pleasing and breathable dual-layer cellulose acetate (CA)/dyed CA (DCA) nanofiber membrane with exceptional directional moisture transport performance. Outer layer was synthesized by subjecting CA nanofibers to hydrolysis and reactive dyeing processes, which converted moderately hydrophobic CA nanofibers into uniformly colored superhydrophilic CA nanofibers with an excellent wettability...
June 5, 2018: ACS Applied Materials & Interfaces
Zahra Hoodbhoy, Babar Hasan, Fyezah Jehan, Bart Bijnens, Devyani Chowdhury
Background: In Pakistan, stillbirth rates and early neonatal mortality rates are amongst the highest in the world. The aim of this study is to provide proof of concept for using a computational model of fetal haemodynamics, combined with machine learning. This model will be based on Doppler patterns of the fetal cardiovascular, cerebral and placental flows with the goal to identify those fetuses at increased risk of adverse perinatal outcomes such as stillbirth, perinatal mortality and other neonatal morbidities...
February 12, 2018: Gates open research
Abdul Wajid, William G Dundon, Tanveer Hussain, Masroor Ellahi Babar
Twenty-nine avian avulavirus-1 viruses (AAvV-1s) from healthy domestic and wild ducks, geese and black swans collected in Pakistan between 2014-2017 have been pathotyped and genetically characterized. A phylogenetic analysis revealed that 21 of the isolates belonged to sub-genotype VIIi, whereas eight isolates were highly similar to vaccine-like viruses of genotype II. In addition to confirming the continued presence of sub-genotype VIIi AAvV-1s in Pakistan, this study identifies the probable spill-over of vaccine-like viruses from vaccinated poultry to wild and domestic waterfowl and, as such, has important implications for the control and management of Newcastle disease in Pakistan...
June 2, 2018: Archives of Virology
Valentine Léopold, Etienne Gayat, Romain Pirracchio, Jindrich Spinar, Jiri Parenica, Tuukka Tarvasmäki, Johan Lassus, Veli-Pekka Harjola, Sébastien Champion, Faiez Zannad, Serafina Valente, Philip Urban, Horng-Ruey Chua, Rinaldo Bellomo, Batric Popovic, Dagmar M Ouweneel, José P S Henriques, Gregor Simonis, Bruno Lévy, Antoine Kimmoun, Philippe Gaudard, Mir Babar Basir, Andrej Markota, Christoph Adler, Hannes Reuter, Alexandre Mebazaa, Tahar Chouihed
OBJECTIVE: Catecholamines have been the mainstay of pharmacological treatment of cardiogenic shock (CS). Recently, use of epinephrine has been associated with detrimental outcomes. In the present study we aimed to evaluate the association between epinephrine use and short-term mortality in all-cause CS patients. DESIGN: We performed a meta-analysis of individual data with prespecified inclusion criteria: (1) patients in non-surgical CS treated with inotropes and/or vasopressors and (2) at least 15% of patients treated with epinephrine administrated alone or in association with other inotropes/vasopressors...
June 1, 2018: Intensive Care Medicine
Muddasir Hassan Abbasi, Sana Fatima, Muhammad Babar Khawar, Shah Jahan, Nadeem Sheikh
This study was aimed to find histological changes in the extrahepatic organs, hepatic iron deposition, and gene expression of some iron regulatory proteins in rats after sterile muscle abscess during the acute intoxication of Nerium oleander leaves decoction. 10 ml/kg of the leaves extract was injected intramuscularly in Wistar rats (200-225 g, n = 4). Control animals received saline injection of matched volume. Animals were anesthetized and sacrificed after 3, 6, 12, and 24 h after administration of decoction...
2018: Canadian Journal of Gastroenterology & Hepatology
Matthew Sigakis, Babar Fiza
No abstract text is available yet for this article.
May 30, 2018: Anesthesiology
Aurangzeb Sand, Ramesh Kumar, Babar T Shaikh, Ratana Somrongthong, Assad Hafeez, Dalpat Rai
Objectives: To understand and catalogue the specific determinants of this alarming rate of malnutrition among children of Tharparkar district, Sindh Pakistan. Methods: This was a hospital based analytical survey. Data was collected through a semi-structured questionnaire by interviewing mothers of the children (age 6-59 months), admitted in the hospital. Following WHO guidelines, weight and length/ height of 105 children were recorded. Study was conducted in District Headquarters Hospital, Tharparkar district of Sindh province...
March 2018: Pakistan Journal of Medical Sciences Quarterly
Ewan Gray, Holly J Butler, Ruth Board, Paul M Brennan, Anthony J Chalmers, Timothy Dawson, John Goodden, Willie Hamilton, Mark G Hegarty, Allan James, Michael D Jenkinson, David Kernick, Elvira Lekka, Laurent J Livermore, Samantha J Mills, Kevin O'Neill, David S Palmer, Babar Vaqas, Matthew J Baker
OBJECTIVES: To determine the potential costs and health benefits of a serum-based spectroscopic triage tool for brain tumours, which could be developed to reduce diagnostic delays in the current clinical pathway. DESIGN: A model-based health pre-trial economic assessment. Decision tree models were constructed based on simplified diagnostic pathways. Models were populated with parameters identified from rapid reviews of the literature and clinical expert opinion...
May 24, 2018: BMJ Open
Islam Eljilany, Faris El-Dahiyat, Louise Elizabeth Curley, Zaheer-Ud-Din Babar
BACKGROUND: The importance of pharmacoeconomics and health economics has been augmented. It has the potential to provide evidence to aid in optimal decision-making in the funding of cost-effective medicines and services in Gulf Cooperation Council countries (G.C.C). OBJECTIVE: To evaluate the quality and quantity of health economic research published until the end of 2017 in G.C.C. METHOD: Studies were included according to inclusion and exclusion criteria...
May 19, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Muhammad Babar Javed, William Shotyk
Employing protocols developed for polar snow and ice, water samples were collected upstream, midstream and downstream of open pit bitumen mines and upgraders along the Lower Athabasca River (AR). The purpose was to: i) estimate the bioaccessibility of trace elements associated with particulate matter in the AR using sequential extraction, and ii) determine whether their forms have been measurably impacted by industrial activities. Of the trace metals known to be enriched in bitumen (V, Ni, Mo and Re), a substantial proportion of V (78-93%) and Ni (35-81%) was found in the residual fraction representing stable minerals...
May 10, 2018: Environmental Pollution
Syed Shahzad Hasan, Chia Siang Kow, Louise E Curley, Darrin L Baines, Zaheer-Ud-Din Babar
Anticoagulants refer to a variety of agents that inhibit one or more steps in the coagulation cascade. Generally, clinical conditions that require the prescribing of an oral anticoagulant increase in frequency with age. However, a major challenge of anticoagulation use among older patients is that this group of patients also experience the highest bleeding risk. To date, economic evaluation of prescribing of anticoagulants that includes the novel or newer oral anticoagulants (NOACs) in older adults has not been conducted and is warranted...
May 9, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Thasleem Moolakkadath, Mohd Aqil, Abdul Ahad, Syed Sarim Imam, Babar Iqbal, Yasmin Sultana, Mohd Mujeeb, Zeenat Iqbal
The present study was conducted for the optimization of transethosomes formulation for dermal fisetin delivery. The optimization of the formulation was carried out using "Box-Behnken design". The independent variables were Lipoid S 100, ethanol and sodium cholate. The prepared formulations were characterized for vesicle size, entrapment efficiency and in vitro skin penetration study. The vesicles-skin interaction, confocal laser scanning microscopy and dermatokinetic studies were performed with optimized formulation...
May 7, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Babar Asma, Leblanc Vicky, Dudonne Stephanie, Desjardins Yves, Howell Amy, Dodin Sylvie
BACKGROUND: Urinary tract infections (UTIs) are amongst the most common bacterial infections affecting women. Although antibiotics are the treatment of choice for UTI, cranberry derived products have been used for many years to prevent UTIs, with limited evidence as to their efficacy. Our objective is to assess the efficacy of a cranberry extract capsule standardized in A-type linkage proanthocyanidins (PACs) for the prevention of recurrent urinary tract infection. METHODS: We will perform a 1:1 randomized, controlled, double blind clinical trial in women aged 18 years or more who present ≥2 UTIs in 6 months or ≥ 3 UTIs in 12 months...
May 2, 2018: BMC Urology
Justin C Sherwin, Gokulan Ratnarajan, Babar Elahi, Anna Bilkiewicz-Pawelec, John F Salmon
IMPORTANCE: Ocular surface disease (OSD) is common and can reduce treatment compliance and quality of life. BACKGROUND: To determine whether a punctal plug improves OSD and reduces IOP in patients using prostaglandin-analogue monotherapy. DESIGN: Randomised-controlled trial PARTICIPANTS: Sixty eligible subjects aged >18 years with symptomatic OSD from glaucoma clinics were invited to participate. Lacrimal or glaucoma surgery, lid malposition and contact lens wear were exclusion criteria...
April 26, 2018: Clinical & Experimental Ophthalmology
Babar Kayani, Sujith Konan, Jurek R T Pietrzak, Fares S Haddad
BACKGROUND: The objective of this study was to compare macroscopic bone and soft tissue injury between robotic-arm assisted total knee arthroplasty (RA-TKA) and conventional jig-based total knee arthroplasty (CJ-TKA) and create a validated classification system for reporting iatrogenic bone and periarticular soft tissue injury after TKA. METHODS: This study included 30 consecutive CJ-TKAs followed by 30 consecutive RA-TKAs performed by a single surgeon. Intraoperative photographs of the femur, tibia, and periarticular soft tissues were taken before implantation of prostheses...
March 27, 2018: Journal of Arthroplasty
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